Detailed information for compound 1422199

Basic information

Technical information
  • TDR Targets ID: 1422199
  • Name: [2-[(3,5-dichloropyridin-2-yl)amino]-2-oxoeth yl] 5-methylpyrazine-2-carboxylate
  • MW: 341.15 | Formula: C13H10Cl2N4O3
  • H donors: 1 H acceptors: 5 LogP: 1.79 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ncc(cc1Cl)Cl)COC(=O)c1ncc(nc1)C
  • InChi: 1S/C13H10Cl2N4O3/c1-7-3-17-10(5-16-7)13(21)22-6-11(20)19-12-9(15)2-8(14)4-18-12/h2-5H,6H2,1H3,(H,18,19,20)
  • InChiKey: ILAYNZGPLQIXNB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-[(3,5-dichloro-2-pyridyl)amino]-2-oxo-ethyl] 5-methylpyrazine-2-carboxylate
  • 5-methyl-2-pyrazinecarboxylic acid [2-[(3,5-dichloro-2-pyridyl)amino]-2-oxoethyl] ester
  • 5-methylpyrazinic acid [2-[(3,5-dichloro-2-pyridyl)amino]-2-keto-ethyl] ester
  • [2-[(3,5-dichloropyridin-2-yl)amino]-2-oxo-ethyl] 5-methylpyrazine-2-carboxylate
  • T0513-0676
  • ZINC03260841
  • Oprea1_493152

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) T-complex protein 1 0.0024 0.0024 0.0056
Giardia lamblia Kinase, CMGC MAPK 0.0049 0.0391 0.1543
Loa Loa (eye worm) hypothetical protein 0.0118 0.1378 0.3191
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0423 0.1671
Echinococcus granulosus tar DNA binding protein 0.0199 0.2532 0.2526
Loa Loa (eye worm) hypothetical protein 0.0101 0.1137 0.2634
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.1362 0.3154
Onchocerca volvulus Huntingtin homolog 0.0118 0.1378 0.0639
Schistosoma mansoni importin beta-1 0.003 0.0122 0.0122
Mycobacterium ulcerans epoxide hydrolase EphA 0.0164 0.2028 0.7972
Loa Loa (eye worm) pyruvate kinase 0.0197 0.2494 0.5776
Trichomonas vaginalis pyruvate kinase, putative 0.0197 0.2494 1
Mycobacterium tuberculosis Probable lipase LipE 0.0113 0.1302 0.1175
Brugia malayi hypothetical protein 0.0147 0.1786 0.7047
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0024 0.0067
Schistosoma mansoni hypothetical protein 0.0032 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.003 0.0122 0.0282
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0198 0.019
Schistosoma mansoni hypothetical protein 0.0032 0.0147 0.0147
Loa Loa (eye worm) inositol-1 0.0036 0.0198 0.0458
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0024 0.0024
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0241 0.1428
Loa Loa (eye worm) hypothetical protein 0.0113 0.1302 0.3015
Mycobacterium leprae Probable lipase LipE 0.0113 0.1302 0.4927
Loa Loa (eye worm) RNA binding protein 0.0199 0.2532 0.5863
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0197 0.2494 0.2385
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0024 0.0024 0.0103
Brugia malayi Pyruvate kinase, muscle isozyme 0.0197 0.2494 0.9851
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0188 0.2369 0.2364
Echinococcus granulosus pyruvate kinase 0.0101 0.1128 0.1122
Onchocerca volvulus Huntingtin homolog 0.0118 0.1378 0.0639
Schistosoma mansoni bromodomain containing protein 0.0067 0.0644 0.0644
Giardia lamblia TCP-1 chaperonin subunit beta 0.0024 0.0024 0.0068
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0198 0.019
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0423 0.1671
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0029 0.0029
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0122 0.046
Schistosoma mansoni microtubule-associated protein tau 0.0722 1 1
Brugia malayi beta-lactamase family protein 0.0113 0.1302 0.5128
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0198 0.0765
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0007 0.0017
Schistosoma mansoni hypothetical protein 0.0032 0.0147 0.0147
Onchocerca volvulus Pyruvate kinase homolog 0.0197 0.2494 1
Echinococcus multilocularis pyruvate kinase 0.0101 0.1128 0.1122
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0024 0.0024
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.0241 0.0234
Entamoeba histolytica hypothetical protein 0.007 0.0684 0.4132
Mycobacterium tuberculosis Probable esterase LipL 0.0113 0.1302 0.1175
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0241 0.0234
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.0391 0.0384
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0024 0.0024 0.0068
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0024 0.0024
Trypanosoma brucei pyruvate kinase 1, putative 0.0197 0.2494 1
Schistosoma mansoni tar DNA-binding protein 0.0199 0.2532 0.2532
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0997 0.0991
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0198 0.0765
Toxoplasma gondii t-complex protein beta subunit 0.0024 0.0024 0.0068
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0391 0.1543
Plasmodium falciparum pyruvate kinase 2 0.0101 0.1128 0.4508
Brugia malayi pyruvate kinase 0.0041 0.0279 0.1077
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0188 0.2369 0.2258
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.059 0.0583
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.0241 0.0234
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0231 0.0224
Trichomonas vaginalis chaperonin, putative 0.0024 0.0024 0.0068
Brugia malayi Pyruvate kinase, M2 isozyme 0.0197 0.2494 0.9851
Loa Loa (eye worm) hypothetical protein 0.0045 0.0333 0.077
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0113 0.1302 0.3015
Loa Loa (eye worm) hypothetical protein 0.0197 0.2494 0.5776
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0997 0.0997
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0049 0.0391 0.1543
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0997 0.231
Leishmania major hypothetical protein, conserved 0.0113 0.1302 0.5206
Leishmania major importin beta-1 subunit, putative 0.0025 0.004 0.0131
Brugia malayi hypothetical protein 0.0033 0.0163 0.0614
Schistosoma mansoni aldehyde dehydrogenase 0.0188 0.2369 0.2369
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.0391 0.0384
Brugia malayi Inositol-1 0.0036 0.0198 0.0754
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.0684 0.0677
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0423 0.1671
Trypanosoma brucei hypothetical protein, conserved 0.0113 0.1302 0.5206
Brugia malayi RNA binding protein 0.0199 0.2532 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.0391 0.0906
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0324 0.4318 1
Brugia malayi RNA, U transporter 1 0.0086 0.0922 0.3621
Loa Loa (eye worm) hypothetical protein 0.0118 0.1378 0.3191
Loa Loa (eye worm) pyruvate kinase-PB 0.0137 0.1645 0.381
Trypanosoma cruzi pyruvate kinase 2, putative 0.0197 0.2494 1
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0423 0.1671
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0199 0.2532 0.5863
Entamoeba histolytica pyruvate kinase, putative 0.0137 0.1645 1
Trypanosoma brucei protein kinase, putative 0.0049 0.0391 0.1543
Toxoplasma gondii aldehyde dehydrogenase 0.0188 0.2369 0.9499
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0241 0.094
Mycobacterium ulcerans esterase/lipase LipP 0.0113 0.1302 0.4809
Loa Loa (eye worm) hypothetical protein 0.0069 0.0679 0.1572
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0024 0.0024 0.0068
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0018 0.001
Schistosoma mansoni pyruvate kinase 0.0197 0.2494 0.2494
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0024 0.0067
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0198 0.0765
Leishmania major T-complex protein 1, beta subunit, putative 0.0024 0.0024 0.0068
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0113 0.1302 0.1302
Schistosoma mansoni pyruvate kinase 0.0197 0.2494 0.2494
Plasmodium falciparum importin beta, putative 0.003 0.0122 0.046
Brugia malayi Bromodomain containing protein 0.0079 0.0821 0.3225
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0164 0.2028 0.1912
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.1362 0.3154
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0241 0.0234
Echinococcus multilocularis pyruvate kinase 0.0101 0.1128 0.1122
Leishmania major hypothetical protein, conserved 0.0051 0.0423 0.1671
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0113 0.1302 0.1175
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0188 0.2369 0.9499
Echinococcus granulosus GPCR family 2 0.0032 0.0147 0.0139
Mycobacterium ulcerans hypothetical protein 0.0113 0.1302 0.4809
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0391 0.1543
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.004 0.0131
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0122 0.046
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0241 0.094
Plasmodium vivax importin-beta 2, putative 0.003 0.0122 0.046
Trichomonas vaginalis D-aminoacylase, putative 0.0113 0.1302 0.5206
Trypanosoma brucei pyruvate kinase 1 0.0197 0.2494 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0997 0.0997
Loa Loa (eye worm) TAR-binding protein 0.0199 0.2532 0.5863
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.1137 0.4476
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0147 0.0139
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0241 0.094
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0147 0.0139
Schistosoma mansoni hypothetical protein 0.0343 0.4588 0.4588
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.0684 0.0677
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0147 0.0552
Echinococcus multilocularis importin subunit beta 1 0.003 0.0122 0.0115
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0029 0.0021
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0198 0.5
Plasmodium vivax pyruvate kinase 2, putative 0.0101 0.1128 0.4508
Mycobacterium tuberculosis Conserved protein 0.0113 0.1302 0.1175
Plasmodium falciparum T-complex protein 1 subunit beta 0.0024 0.0024 0.0068
Loa Loa (eye worm) pyruvate kinase 0.0197 0.2494 0.5776
Brugia malayi pyruvate kinase, muscle isozyme 0.0041 0.0279 0.1077
Chlamydia trachomatis pyruvate kinase 0.0197 0.2494 0.5
Loa Loa (eye worm) hypothetical protein 0.0113 0.1302 0.3015
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0024 0.0024 0.0017
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0423 0.1671
Brugia malayi MH2 domain containing protein 0.0117 0.1362 0.5366
Echinococcus granulosus pyruvate kinase 0.0197 0.2494 0.2488
Entamoeba histolytica hypothetical protein 0.0025 0.004 0.0198
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0423 0.1671
Schistosoma mansoni hypothetical protein 0.0032 0.0147 0.0147
Schistosoma mansoni hypothetical protein 0.0023 0.0018 0.0018
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0198 0.1162
Schistosoma mansoni tar DNA-binding protein 0.0199 0.2532 0.2532
Mycobacterium leprae Probable pyruvate kinase PykA 0.0197 0.2494 1
Mycobacterium tuberculosis Conserved protein 0.0113 0.1302 0.1175
Schistosoma mansoni hypothetical protein 0.0343 0.4588 0.4588
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0198 0.0765
Echinococcus multilocularis pyruvate kinase 0.0197 0.2494 0.2488
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0241 0.094
Mycobacterium ulcerans aldehyde dehydrogenase 0.0188 0.2369 0.9457
Loa Loa (eye worm) hypothetical protein 0.0113 0.1302 0.3015
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0198 0.0765
Mycobacterium ulcerans aldehyde dehydrogenase 0.0188 0.2369 0.9457
Brugia malayi hypothetical protein 0.007 0.0684 0.268
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0024 0.0024 0.0017
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0997 0.3921
Brugia malayi beta-lactamase family protein 0.0113 0.1302 0.5128
Trichomonas vaginalis penicillin-binding protein, putative 0.0113 0.1302 0.5206
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0049 0.0391 0.1543
Trichomonas vaginalis D-aminoacylase, putative 0.0113 0.1302 0.5206
Schistosoma mansoni hypothetical protein 0.007 0.0684 0.0684
Trichomonas vaginalis penicillin-binding protein, putative 0.0113 0.1302 0.5206
Brugia malayi Bromodomain containing protein 0.0041 0.0267 0.1028
Onchocerca volvulus 0.0147 0.1786 0.4064
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0391 0.1543
Schistosoma mansoni tar DNA-binding protein 0.0199 0.2532 0.2532
Schistosoma mansoni hypothetical protein 0.0324 0.4318 0.4318
Echinococcus multilocularis GPCR, family 2 0.0032 0.0147 0.0139
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.0241 0.0241
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0039 0.0241 0.094
Trichomonas vaginalis D-aminoacylase, putative 0.0113 0.1302 0.5206
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0059 0.0537 0.2099
Loa Loa (eye worm) pyruvate kinase 0.0041 0.0279 0.0647
Echinococcus granulosus geminin 0.0343 0.4588 0.4584
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0423 0.1671
Onchocerca volvulus Pyruvate kinase homolog 0.0197 0.2494 1
Brugia malayi PHD-finger family protein 0.0026 0.0065 0.0227
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0198 0.0765
Loa Loa (eye worm) hypothetical protein 0.0113 0.1302 0.3015
Schistosoma mansoni inositol monophosphatase 0.0036 0.0198 0.0198
Schistosoma mansoni ran 0.0022 0.0007 0.0007
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0198 0.0765
Loa Loa (eye worm) hypothetical protein 0.0075 0.0757 0.1753
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0122 0.046
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0049 0.0391 0.1543
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.0391 0.0384
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0024 0.0024 0.0068
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0147 0.0552
Toxoplasma gondii pyruvate kinase PyK1 0.0197 0.2494 1
Schistosoma mansoni transcription factor LCR-F1 0.007 0.0684 0.0684
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0113 0.1302 0.1175
Loa Loa (eye worm) hypothetical protein 0.0051 0.0423 0.0979
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0113 0.1302 0.4809
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0113 0.1302 0.1175
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0391 0.1543
Plasmodium vivax hypothetical protein, conserved 0.0113 0.1302 0.5206
Echinococcus multilocularis microtubule associated protein 2 0.0722 1 1
Loa Loa (eye worm) hypothetical protein 0.0113 0.1302 0.3015
Schistosoma mansoni aldehyde dehydrogenase 0.0188 0.2369 0.2369
Giardia lamblia Pyruvate kinase 0.0101 0.1128 0.4508
Schistosoma mansoni tar DNA-binding protein 0.0199 0.2532 0.2532
Echinococcus granulosus snurportin 1 0.0324 0.4318 0.4314
Brugia malayi Importin beta-1 subunit 0.003 0.0122 0.0454
Echinococcus granulosus beta LACTamase domain containing family member 0.0113 0.1302 0.1295
Echinococcus multilocularis beta LACTamase domain containing family member 0.0113 0.1302 0.1295
Mycobacterium ulcerans aldehyde dehydrogenase 0.0188 0.2369 0.9457
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0018 0.001
Loa Loa (eye worm) hypothetical protein 0.0041 0.0268 0.0621
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0241 0.0234
Loa Loa (eye worm) hypothetical protein 0.0043 0.0304 0.0703
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0997 0.0991
Giardia lamblia Pyruvate kinase 0.0197 0.2494 1
Schistosoma mansoni tar DNA-binding protein 0.0199 0.2532 0.2532
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0049 0.0391 0.1543
Echinococcus granulosus importin subunit beta 1 0.003 0.0122 0.0115
Brugia malayi TAR-binding protein 0.0199 0.2532 1
Brugia malayi hypothetical protein 0.0051 0.0423 0.1646
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0722 0.9998 1
Mycobacterium tuberculosis Probable hydrolase 0.0113 0.1302 0.1175
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0113 0.1302 0.1302
Mycobacterium ulcerans beta-lactamase 0.0113 0.1302 0.4809
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.1137 0.2634
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0241 0.094
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0241 0.0234
Echinococcus granulosus pyruvate kinase 0.0101 0.1128 0.1122
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.0241 0.0241
Brugia malayi MAP kinase sur-1 0.0049 0.0391 0.152
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0391 0.1543
Entamoeba histolytica hypothetical protein 0.007 0.0684 0.4132
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0231 0.0224
Echinococcus multilocularis geminin 0.0343 0.4588 0.4584
Loa Loa (eye worm) hypothetical protein 0.0137 0.1645 0.381
Entamoeba histolytica hypothetical protein 0.007 0.0684 0.4132
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0029 0.0021
Trichomonas vaginalis esterase, putative 0.0113 0.1302 0.5206
Schistosoma mansoni ran 0.0022 0.0007 0.0007
Trichomonas vaginalis pyruvate kinase, putative 0.0197 0.2494 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0997 0.0991
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0188 0.2369 0.2364
Echinococcus multilocularis pyruvate kinase 0.0101 0.1128 0.1122
Plasmodium vivax pyruvate kinase, putative 0.0197 0.2494 1
Echinococcus multilocularis snurportin 1 0.0324 0.4318 0.4314
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0997 0.0997
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0391 0.1543
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0391 0.0391
Echinococcus multilocularis pyruvate kinase 0.0155 0.1903 0.1897
Entamoeba histolytica hypothetical protein 0.007 0.0684 0.4132
Trichomonas vaginalis importin beta-1, putative 0.0025 0.004 0.0131
Onchocerca volvulus Pyruvate kinase homolog 0.0197 0.2494 1
Brugia malayi beta-lactamase 0.0113 0.1302 0.5128
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0113 0.1302 0.5128
Mycobacterium ulcerans lipase LipD 0.0113 0.1302 0.4809
Leishmania major pyruvate kinase 0.0197 0.2494 1
Loa Loa (eye worm) pyruvate kinase 0.0197 0.2494 0.5776
Mycobacterium tuberculosis Probable lipase LipD 0.0113 0.1302 0.1175
Leishmania major pyruvate kinase 0.0197 0.2494 1
Brugia malayi RNA recognition motif domain containing protein 0.0199 0.2532 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.004 0.0131
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.0391 0.0384
Toxoplasma gondii pyruvate kinase PyKII 0.0101 0.1128 0.4508
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0024 0.0024 0.0068
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0198 0.0765
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.004 0.0131
Loa Loa (eye worm) hypothetical protein 0.0032 0.0147 0.034
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0241 0.094
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0241 0.094
Loa Loa (eye worm) beta-lactamase 0.0113 0.1302 0.3015
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.1137 0.4476
Loa Loa (eye worm) hypothetical protein 0.0113 0.1302 0.3015
Toxoplasma gondii ABC1 family protein 0.0113 0.1302 0.5206
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.1302 0.5206
Loa Loa (eye worm) hypothetical protein 0.0039 0.0241 0.0559
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0241 0.0926
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0049 0.0391 0.1543
Schistosoma mansoni hypothetical protein 0.0069 0.0679 0.0679
Schistosoma mansoni inositol monophosphatase 0.0036 0.0198 0.0198
Echinococcus granulosus pyruvate kinase 0.0197 0.2494 0.2488
Echinococcus granulosus pyruvate kinase 0.0101 0.1128 0.1122
Brugia malayi hypothetical protein 0.0118 0.1378 0.543
Mycobacterium tuberculosis Conserved protein 0.0113 0.1302 0.1175
Echinococcus multilocularis tar DNA binding protein 0.0199 0.2532 0.2526
Mycobacterium leprae conserved hypothetical protein 0.0113 0.1302 0.4927
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0679 0.266
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0147 0.034
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0997 0.0991
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0049 0.0391 0.1543
Plasmodium falciparum pyruvate kinase 0.0197 0.2494 1
Mycobacterium ulcerans pyruvate kinase 0.0197 0.2494 1
Schistosoma mansoni pyruvate kinase 0.0101 0.1128 0.1128
Loa Loa (eye worm) hypothetical protein 0.0147 0.1786 0.4137
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.1302 0.5206
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.059 0.0583
Echinococcus multilocularis pyruvate kinase 0.0197 0.2494 0.2488
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0147 0.0139
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0147 0.0139
Trypanosoma cruzi pyruvate kinase 2, putative 0.0197 0.2494 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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