Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Schistosoma japonicum | ko:K04588 secretin receptor, putative | Get druggable targets OG5_139196 | All targets in OG5_139196 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0043 | 0.1887 | 0.1887 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0105 | 0.6168 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1887 | 0.5 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0055 | 0.2709 | 0.2709 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0161 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 0.338 | 0.338 |
Brugia malayi | TAR-binding protein | 0.0065 | 0.338 | 0.338 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0161 | 1 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0196 | 0.0196 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0196 | 0.0196 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.3047 | 0.3047 |
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 0.338 | 0.338 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0196 | 0.0196 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 0.338 | 0.338 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0105 | 0.6168 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1887 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 0.338 | 0.338 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0196 | 0.0196 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.338 | 0.338 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0016 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1887 | 0.5 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.338 | 0.338 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0161 | 1 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0161 | 1 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0196 | 0.0196 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.1887 | 0.1887 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.338 | 0.338 |
Toxoplasma gondii | hypothetical protein | 0.0055 | 0.2709 | 0.2709 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.8864 | 0.8864 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0196 | 0.0196 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0161 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0065 | 0.338 | 0.338 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0161 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1728 | 0.1728 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3047 | 0.3047 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1728 | 0.1728 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1887 | 0.1887 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0196 | 0.0196 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0196 | 0.0196 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0161 | 1 | 1 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0055 | 0.2709 | 0.2709 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.1887 | 0.1887 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0196 | 0.0196 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.338 | 0.338 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 0.338 | 0.338 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0161 | 1 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.338 | 0.338 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.3047 | 0.3047 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0105 | 0.6168 | 0.6168 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1887 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.8864 | 0.8864 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0105 | 0.6168 | 0.6168 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0196 | 0.0196 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.8864 | 0.8864 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0196 | 0.0196 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0196 | 0.0196 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0196 | 0.0196 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1728 | 0.1728 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.1887 | 0.1887 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0161 | 1 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 0.338 | 0.338 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0161 | 1 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0161 | 1 | 0.5 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0161 | 1 | 0.5 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0161 | 1 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0161 | 1 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0196 | 0.0196 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0016 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0105 | 0.6168 | 0.4744 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.3047 | 0.3047 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.0119 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 9.2 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 20.5878 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 37.933 uM | PUBCHEM_BIOASSAY: qHTS for antagonists of the Thyroid Stimulation Hormone Receptor: Hit Validation in Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.