Detailed information for compound 1422214

Basic information

Technical information
  • TDR Targets ID: 1422214
  • Name: 1-tert-butyl-3-(4-fluorophenyl)-4-(2-methylph enyl)piperazine-2,5-dione
  • MW: 354.418 | Formula: C21H23FN2O2
  • H donors: 0 H acceptors: 2 LogP: 3.76 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)C1C(=O)N(CC(=O)N1c1ccccc1C)C(C)(C)C
  • InChi: 1S/C21H23FN2O2/c1-14-7-5-6-8-17(14)24-18(25)13-23(21(2,3)4)20(26)19(24)15-9-11-16(22)12-10-15/h5-12,19H,13H2,1-4H3
  • InChiKey: IZVNZHLVLWQUKU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-tert-butyl-3-(4-fluorophenyl)-4-(2-methylphenyl)piperazine-2,5-quinone
  • 1-tert-Butyl-3-(4-fluoro-phenyl)-4-o-tolyl-piperazine-2,5-dione
  • ASN 05802874
  • MLS000709780
  • SMR000286947

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0025 0.0056 0.0078
Echinococcus granulosus Smad4 0.0084 0.0541 0.1736
Toxoplasma gondii hypothetical protein 0.0072 0.044 0.8401
Schistosoma mansoni smad1 5 8 and 0.0084 0.0541 0.1242
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0025 0.0056 0.0078
Brugia malayi isocitrate dehydrogenase 0.0082 0.0523 0.0523
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0097 0.0646 0.2814
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0012 0.0027
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.002 0.0012 0.0228
Loa Loa (eye worm) MH2 domain-containing protein 0.0084 0.0541 0.0541
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0103 0.0694 0.0966
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0082 0.0523 0.0728
Echinococcus multilocularis GPCR, family 2 0.0062 0.0363 0.1167
Loa Loa (eye worm) hypothetical protein 0.0198 0.1474 0.1474
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0282 0.217 0.6967
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0025 0.0056 0.0179
Brugia malayi Pax transcription activation domain interacting protein 0.002 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0135 0.096 0.096
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0056 0.0078
Trichomonas vaginalis CAMK family protein kinase 0.0282 0.217 0.4985
Mycobacterium ulcerans hypothetical protein 0.0103 0.0694 0.1572
Echinococcus granulosus smad 0.0084 0.0541 0.1736
Trichomonas vaginalis CAMK family protein kinase 0.0282 0.217 0.4985
Loa Loa (eye worm) glutaminase 0.0547 0.4352 0.4352
Echinococcus multilocularis nibrin 0.002 0.0012 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0012 0.0027
Brugia malayi hypothetical protein 0.0032 0.0111 0.0111
Trypanosoma cruzi protein farnesyltransferase, putative 0.0068 0.0405 0.0564
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0068 0.0405 0.0564
Schistosoma mansoni glutaminase 0.0547 0.4352 1
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0097 0.0646 1
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0012 0.0027
Loa Loa (eye worm) MH1 domain-containing protein 0.0038 0.0158 0.0158
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0068 0.0405 0.0931
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0255 0.0355
Echinococcus granulosus tar DNA binding protein 0.0397 0.3114 1
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0025 0.0056 0.0864
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0025 0.0056 0.0179
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0025 0.0054 0.0125
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0012 0.0027
Toxoplasma gondii ATPase, AAA family protein 0.002 0.0012 0.0228
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0068 0.0405 0.1301
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0082 0.0523 0.8097
Schistosoma mansoni smad 0.0038 0.0158 0.0364
Loa Loa (eye worm) RNA binding protein 0.0397 0.3114 0.3114
Echinococcus multilocularis mothers against decapentaplegic 5 0.0084 0.0541 0.1736
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0082 0.0523 0.0728
Schistosoma mansoni tar DNA-binding protein 0.0397 0.3114 0.7155
Echinococcus multilocularis citrate lyase subunit beta protein 0.0103 0.0694 0.2229
Trichomonas vaginalis CAMK family protein kinase 0.0282 0.217 0.4985
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0097 0.0646 0.0646
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0026 0.0066 0.0213
Brugia malayi N-terminal motif family protein 0.0189 0.1408 0.1408
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0025 0.0054 0.0125
Loa Loa (eye worm) MH2 domain-containing protein 0.1234 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0028 0.0083 0.0191
Trypanosoma cruzi protein farnesyltransferase, putative 0.0068 0.0405 0.0564
Loa Loa (eye worm) nuclear factor I 0.0046 0.0232 0.0232
Trichomonas vaginalis CAMK family protein kinase 0.014 0.0998 0.2293
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0282 0.217 0.3019
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0103 0.0694 0.0966
Loa Loa (eye worm) TAR-binding protein 0.0397 0.3114 0.3114
Schistosoma mansoni hypothetical protein 0.0022 0.0031 0.0072
Schistosoma mansoni serine/threonine protein kinase 0.0282 0.217 0.4985
Brugia malayi hypothetical protein 0.0049 0.0255 0.0255
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0068 0.0405 0.0931
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0025 0.0056 0.0179
Chlamydia trachomatis DNA ligase 0.002 0.0012 0.5
Loa Loa (eye worm) Smad1 0.0084 0.0541 0.0541
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0082 0.0523 0.0728
Giardia lamblia Rab geranylgeranyltransferase 0.0025 0.0056 0.0257
Trypanosoma cruzi polo-like protein kinase, putative 0.0282 0.217 0.3019
Entamoeba histolytica serine/threonine protein kinase, putative 0.0282 0.217 0.9445
Toxoplasma gondii hypothetical protein 0.0025 0.0056 0.1067
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0082 0.0523 0.1681
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0056 0.0078
Echinococcus granulosus mothers against decapentaplegic 5 0.0084 0.0541 0.1736
Loa Loa (eye worm) hypothetical protein 0.0097 0.0646 0.0646
Mycobacterium tuberculosis Conserved protein 0.0103 0.0694 1
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0068 0.0405 0.1764
Schistosoma mansoni Smad4 0.0084 0.0541 0.1242
Echinococcus multilocularis mothers against decapentaplegic 6 0.0038 0.0158 0.0508
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0025 0.0056 0.0078
Onchocerca volvulus 0.0158 0.1146 0.5255
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0026 0.0066 0.0066
Treponema pallidum DNA ligase (lig) 0.002 0.0012 0.5
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0082 0.0523 0.1681
Toxoplasma gondii isocitrate dehydrogenase 0.0082 0.0523 1
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0025 0.0056 0.0864
Schistosoma mansoni voltage-gated potassium channel 0.0028 0.0083 0.0191
Loa Loa (eye worm) glutaminase 2 0.0547 0.4352 0.4352
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0282 0.217 0.6967
Schistosoma mansoni Smad4 0.0038 0.0158 0.0364
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0068 0.0405 0.7743
Schistosoma mansoni tar DNA-binding protein 0.0397 0.3114 0.7155
Trypanosoma cruzi hypothetical protein, conserved 0.0892 0.7187 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0082 0.0523 0.1681
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0068 0.0405 0.0931
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.0012 0.0017
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0189 0.1408 0.6471
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0012 0.0027
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0062 0.0363 0.1167
Brugia malayi RNA binding protein 0.0397 0.3114 0.3114
Brugia malayi topoisomerase 0.002 0.0012 0.0012
Giardia lamblia Kinase, PLK 0.0282 0.217 1
Brugia malayi latrophilin 2 splice variant baaae 0.0135 0.096 0.096
Echinococcus granulosus nibrin 0.002 0.0012 0.0038
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0068 0.0405 0.0405
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0198 0.1474 0.1474
Brugia malayi MH1 domain containing protein 0.0084 0.0541 0.0541
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0031 0.01
Echinococcus multilocularis smad 0.0084 0.0541 0.1736
Echinococcus granulosus mothers against decapentaplegic 6 0.0038 0.0158 0.0508
Brugia malayi TAR-binding protein 0.0397 0.3114 0.3114
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0198 0.1474 0.1474
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0025 0.0056 0.0078
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.002 0.0012 0.0012
Giardia lamblia Rab geranylgeranyltransferase 0.0097 0.0646 0.2979
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0068 0.0405 0.0931
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.002 0.0012 0.5
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0012 0.0027
Brugia malayi Latrophilin receptor protein 2 0.0062 0.0363 0.0363
Schistosoma mansoni chromosome transmission fidelity factor 0.002 0.0012 0.0027
Entamoeba histolytica hypothetical protein 0.0298 0.2297 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0038 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0038 0.0158 0.0158
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0103 0.0694 0.1595
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0068 0.0405 0.0931
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0255 0.4873
Schistosoma mansoni hypothetical protein 0.0062 0.0363 0.0835
Loa Loa (eye worm) hypothetical protein 0.0158 0.1146 0.1146
Echinococcus granulosus replication factor c subunit 1 0.002 0.0012 0.0038
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0012
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0062 0.0363 0.1167
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0025 0.0056 0.0128
Trichomonas vaginalis CAMK family protein kinase 0.0282 0.217 0.4985
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0097 0.0646 0.0646
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0068 0.0405 0.627
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.002 0.0012 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0282 0.217 0.4985
Schistosoma mansoni DNA ligase IV 0.002 0.0012 0.0027
Echinococcus multilocularis mothers against decapentaplegic 2 0.0038 0.0158 0.0508
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0097 0.0646 0.1485
Echinococcus granulosus TGF beta signal transducer SmadC 0.0084 0.0541 0.1736
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0068 0.0405 0.1301
Trichomonas vaginalis CAMK family protein kinase 0.014 0.0998 0.2293
Brugia malayi serine/threonine-protein kinase plk-2 0.0282 0.217 0.217
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0012 0.0017
Brugia malayi MH2 domain containing protein 0.0084 0.0541 0.0541
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0097 0.0646 0.2075
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.0012 0.0027
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0097 0.0646 0.1485
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0025 0.0056 0.0078
Leishmania major hypothetical protein, conserved 0.0892 0.7187 1
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0056 0.0078
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0282 0.217 0.217
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0012
Entamoeba histolytica hypothetical protein 0.0298 0.2297 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0082 0.0523 0.0523
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.002 0.0012 0.0052
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0298 0.2297 0.7376
Brugia malayi hypothetical protein 0.002 0.0012 0.0012
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0062 0.0363 0.1167
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0026 0.0066 0.0066
Brugia malayi MH1 domain containing protein 0.0084 0.0541 0.0541
Trypanosoma cruzi polo-like protein kinase, putative 0.0282 0.217 0.3019
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0012
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0025 0.0056 0.0078
Trichomonas vaginalis CAMK family protein kinase 0.0282 0.217 0.4985
Leishmania major farnesyltransferase beta subunit 0.0068 0.0405 0.0564
Brugia malayi DKFZp564C0469 protein 0.002 0.0012 0.0012
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0097 0.0646 0.1485
Brugia malayi glutaminase DH11.1 0.0547 0.4352 0.4352
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0103 0.0694 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0255 0.0255
Onchocerca volvulus 0.0025 0.0056 0.0203
Loa Loa (eye worm) hypothetical protein 0.0189 0.1408 0.1408
Trichomonas vaginalis glutaminase, putative 0.0547 0.4352 1
Schistosoma mansoni tar DNA-binding protein 0.0397 0.3114 0.7155
Brugia malayi Calcitonin receptor-like protein seb-1 0.0198 0.1474 0.1474
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0012 0.0017
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0009
Loa Loa (eye worm) latrophilin receptor protein 2 0.0062 0.0363 0.0363
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0068 0.0405 0.0931
Onchocerca volvulus Serine\/threonine kinase homolog 0.0282 0.217 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0026 0.0066 0.0213
Toxoplasma gondii isocitrate dehydrogenase 0.0082 0.0523 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0084 0.0541 0.1736
Brugia malayi RNA recognition motif domain containing protein 0.0397 0.3114 0.3114
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0049 0.0254 0.3936
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0012
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0068 0.0405 0.627
Entamoeba histolytica hypothetical protein 0.002 0.0012 0.0052
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0097 0.0646 0.1485
Echinococcus granulosus GPCR family 2 0.0062 0.0363 0.1167
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0025 0.0056 0.0179
Schistosoma mansoni Smad4 0.0038 0.0158 0.0364
Schistosoma mansoni tar DNA-binding protein 0.0397 0.3114 0.7155
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0298 0.2297 0.7376
Brugia malayi Isocitrate dehydrogenase 0.0082 0.0523 0.0523
Brugia malayi MH2 domain containing protein 0.0084 0.0541 0.0541
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0082 0.0523 0.1681
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.0012 0.0027
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0025 0.0056 0.0078
Schistosoma mansoni topbp1 0.002 0.0012 0.0027
Plasmodium vivax replication factor C subunit 1, putative 0.002 0.0012 0.0185
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0072 0.044 0.101
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0082 0.0523 0.1681
Loa Loa (eye worm) hypothetical protein 0.0046 0.0232 0.0232
Schistosoma mansoni smad 0.0084 0.0541 0.1242
Echinococcus multilocularis replication factor c subunit 1 0.002 0.0012 0.0038
Schistosoma mansoni tar DNA-binding protein 0.0397 0.3114 0.7155
Brugia malayi hypothetical protein 0.002 0.0012 0.0012
Schistosoma mansoni smad1 5 8 and 0.0084 0.0541 0.1242
Brugia malayi MH2 domain containing protein 0.0038 0.0158 0.0158
Loa Loa (eye worm) transcription factor SMAD2 0.1234 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0012
Plasmodium falciparum replication factor C subunit 1, putative 0.002 0.0012 0.0185
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0255 0.3946
Brugia malayi hypothetical protein 0.0298 0.2297 0.2297
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0255 0.0355
Trypanosoma cruzi FHA domain containing protein, putative 0.002 0.0012 0.0017
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0025 0.0056 0.0128
Leishmania major hypothetical protein, conserved 0.0049 0.0255 0.0355
Entamoeba histolytica hypothetical protein 0.0298 0.2297 1
Brugia malayi Smad1 0.0084 0.0541 0.0541
Loa Loa (eye worm) hypothetical protein 0.0062 0.0363 0.0363
Schistosoma mansoni topbp1 0.002 0.0012 0.0027
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0084 0.0541 0.1242
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0103 0.0694 0.1572
Schistosoma mansoni kinase 0.0143 0.1028 0.2363
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0082 0.0523 0.1202
Giardia lamblia Replication factor C, subunit 1 0.002 0.0012 0.0055
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0103 0.0694 0.0966
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0031 0.01
Schistosoma mansoni smad1 5 8 and 0.0084 0.0541 0.1242
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0025 0.0056 0.0056
Entamoeba histolytica hypothetical protein 0.0298 0.2297 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0082 0.0523 0.0728
Trichomonas vaginalis CAMK family protein kinase 0.0282 0.217 0.4985
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0082 0.0523 0.0728
Echinococcus multilocularis isocitrate dehydrogenase 0.0082 0.0523 0.1681
Schistosoma mansoni hypothetical protein 0.0298 0.2297 0.5278
Mycobacterium ulcerans hypothetical protein 0.0103 0.0694 0.1572
Brugia malayi hypothetical protein 0.0158 0.1146 0.1146
Echinococcus granulosus citrate lyase subunit beta protein 0.0103 0.0694 0.2229
Trichomonas vaginalis replication factor C large subunit, putative 0.002 0.0012 0.0027
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0082 0.0523 0.7539
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.0012 0.0017
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0255 0.0355
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0255 0.3946
Schistosoma mansoni hypothetical protein 0.0062 0.0363 0.0835
Brugia malayi MH1 domain containing protein 0.0046 0.0232 0.0232
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0062 0.0363 0.1167
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0082 0.0523 0.8097
Trypanosoma brucei hypothetical protein, conserved 0.0892 0.7187 1
Schistosoma mansoni hypothetical protein 0.0062 0.0363 0.0835
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0255 0.3946
Schistosoma mansoni hypothetical protein 0.0135 0.096 0.2206
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0097 0.0646 1
Mycobacterium ulcerans glutaminase 0.0547 0.4352 1
Schistosoma mansoni transcription factor LCR-F1 0.0298 0.2297 0.5278
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0103 0.0694 0.1572
Echinococcus granulosus mothers against decapentaplegic 2 0.0038 0.0158 0.0508
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0062 0.0363 0.0363
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0025 0.0056 0.0056
Echinococcus multilocularis tar DNA binding protein 0.0397 0.3114 1
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0068 0.0405 0.0931
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0038 0.0158 0.0678
Trypanosoma brucei polo-like protein kinase 0.0282 0.217 0.3019
Brugia malayi mothers against decapentaplegic homolog 3 0.0038 0.0158 0.0158
Giardia lamblia Prenyltransferase 0.0068 0.0405 0.1868
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0103 0.0694 0.1572
Trypanosoma cruzi hypothetical protein, conserved 0.0892 0.7187 1
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0025 0.0056 0.0243
Brugia malayi MH1 domain containing protein 0.0046 0.0232 0.0232
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0397 0.3114 0.3114
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0012
Loa Loa (eye worm) MH1 domain-containing protein 0.0084 0.0541 0.0541
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0097 0.0646 0.2075
Echinococcus multilocularis Smad4 0.0084 0.0541 0.1736
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0012 0.0027
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0068 0.0405 0.0405
Schistosoma mansoni hypothetical protein 0.0062 0.0363 0.0835

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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