Detailed information for compound 1422233

Basic information

Technical information
  • TDR Targets ID: 1422233
  • Name: (5E)-3-[2-[(1,1-dioxo-1,2-benzothiazol-3-yl)a mino]ethyl]-5-[(2-fluorophenyl)methylidene]-1 ,3-thiazolidine-2,4-dione
  • MW: 431.461 | Formula: C19H14FN3O4S2
  • H donors: 1 H acceptors: 4 LogP: 2.73 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1S/C(=C/c2ccccc2F)/C(=O)N1CCNC1=NS(=O)(=O)c2c1cccc2
  • InChi: 1S/C19H14FN3O4S2/c20-14-7-3-1-5-12(14)11-15-18(24)23(19(25)28-15)10-9-21-17-13-6-2-4-8-16(13)29(26,27)22-17/h1-8,11H,9-10H2,(H,21,22)/b15-11+
  • InChiKey: YOUWTESXHCRIJV-RVDMUPIBSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (5E)-3-[2-[(1,1-dioxo-1,2-benzothiazol-3-yl)amino]ethyl]-5-[(2-fluorophenyl)methylene]thiazolidine-2,4-dione
  • (5E)-3-[2-[(1,1-diketo-1,2-benzothiazol-3-yl)amino]ethyl]-5-(2-fluorobenzylidene)thiazolidine-2,4-quinone
  • AM-879/40737405
  • ZINC00977602
  • 3-{2-[(1,1-dioxido-1,2-benzisothiazol-3-yl)amino]ethyl}-5-(2-fluorobenzylidene)-1,3-thiazolidine-2,4-dione
  • MLS000573918
  • SMR000195505

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.023 0.1428 0.1993
Trypanosoma cruzi lanosterol synthase, putative 0.037 0.237 0.5018
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0476 0.3084 0.3457
Plasmodium vivax geranylgeranyltransferase, putative 0.023 0.1428 0.1993
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0138 0.0809 0.0879
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.023 0.1428 0.1993
Trypanosoma cruzi hypothetical protein, conserved 0.0189 0.1153 0.1108
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0601 0.392 1
Schistosoma mansoni hypothetical protein 0.0476 0.3084 0.3479
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0601 0.392 0.4404
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0549 0.3574 0.7305
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0601 0.392 0.8019
Echinococcus granulosus tar DNA binding protein 0.1336 0.886 1
Loa Loa (eye worm) hypothetical protein 0.1505 1 1
Giardia lamblia Rab geranylgeranyltransferase 0.023 0.1428 0.0995
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.023 0.1428 0.288
Echinococcus multilocularis lamin 0.0033 0.0102 0.0079
Echinococcus multilocularis isocitrate dehydrogenase 0.0138 0.0809 0.0879
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.056 0.3646 0.912
Schistosoma mansoni lamin 0.0033 0.0102 0.0113
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0189 0.1153 0.127
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0476 0.3084 0.3084
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0601 0.392 1
Trypanosoma brucei hypothetical protein, conserved 0.0189 0.1153 0.1108
Toxoplasma gondii hypothetical protein 0.0193 0.1179 0.1192
Echinococcus multilocularis GPCR, family 2 0.0476 0.3084 0.3457
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0189 0.1153 0.1108
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0033 0.0101 0.0079
Brugia malayi Isocitrate dehydrogenase 0.0138 0.0809 0.0809
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0102 0.0102
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0022 0.0032 0.0032
Echinococcus multilocularis voltage gated potassium channel 0.0033 0.0101 0.0079
Schistosoma mansoni voltage-gated potassium channel 0.0033 0.0101 0.0112
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0371 0.2374 0.5032
Brugia malayi RNA recognition motif domain containing protein 0.1336 0.886 0.886
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0744 0.488 1
Schistosoma mansoni hypothetical protein 0.0476 0.3084 0.3479
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0022 0.0032 0.0032
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0601 0.392 0.4423
Brugia malayi isocitrate dehydrogenase 0.0138 0.0809 0.0809
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0549 0.3574 0.3574
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0033 0.0101 0.0079
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0189 0.1153 0.127
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0189 0.1153 0.1108
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0098
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0138 0.0809 0.0879
Schistosoma mansoni tar DNA-binding protein 0.1336 0.886 1
Trypanosoma cruzi lanosterol synthase, putative 0.037 0.237 0.5018
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.023 0.1428 0.1582
Brugia malayi Probable ClpP-like protease 0.056 0.3646 0.3646
Trypanosoma cruzi protein farnesyltransferase, putative 0.0601 0.392 1
Trypanosoma brucei lanosterol synthase 0.037 0.237 0.5018
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.023 0.1428 0.1993
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0189 0.1153 0.127
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0744 0.488 0.488
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.023 0.1428 0.0738
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0601 0.392 0.8019
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0189 0.1153 0.1108
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0189 0.1153 0.1108
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.056 0.3646 1
Schistosoma mansoni voltage-gated potassium channel 0.0033 0.0101 0.0112
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0476 0.3084 0.3457
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.056 0.3646 0.5
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.023 0.1428 0.288
Toxoplasma gondii hypothetical protein 0.036 0.2303 0.4803
Echinococcus granulosus GPCR family 2 0.0476 0.3084 0.3457
Brugia malayi Cyclic-nucleotide gated cation channel 0.0022 0.0032 0.0032
Giardia lamblia Rab geranylgeranyltransferase 0.0549 0.3574 0.8748
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.1336 0.886 0.886
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.056 0.3646 0.912
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0367 0.2349 0.4744
Brugia malayi Latrophilin receptor protein 2 0.0476 0.3084 0.3084
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0549 0.3574 0.8887
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.023 0.1428 0.1611
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.056 0.3646 0.4094
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0189 0.1153 0.2313
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0022 0.0032 0.0034
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0601 0.392 0.4404
Loa Loa (eye worm) hypothetical protein 0.023 0.1428 0.1428
Loa Loa (eye worm) isocitrate dehydrogenase 0.0138 0.0809 0.0809
Onchocerca volvulus 0.0189 0.1153 1
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0549 0.3574 0.4011
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0112 0.0637 0.0637
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0189 0.1153 0.13
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0601 0.392 1
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0601 0.392 0.8019
Echinococcus multilocularis musashi 0.0033 0.0102 0.0079
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0112 0.0637 0.0686
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0189 0.1153 0.1153
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0601 0.392 0.392
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0022 0.0032 0.0034
Schistosoma mansoni hypothetical protein 0.0476 0.3084 0.3479
Leishmania major geranylgeranyltransferase, putative 0.023 0.1428 0.1993
Schistosoma mansoni tar DNA-binding protein 0.1336 0.886 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.056 0.3646 0.912
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0601 0.392 0.8019
Leishmania major lanosterol synthase, putative 0.014 0.0824 0.005
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0138 0.0809 0.0879
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0601 0.392 0.7423
Brugia malayi RNA binding protein 0.1336 0.886 0.886
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0549 0.3574 0.7305
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0744 0.488 0.5492
Echinococcus granulosus lamin dm0 0.0033 0.0102 0.0079
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.056 0.3646 0.4094
Loa Loa (eye worm) hypothetical protein 0.0033 0.0102 0.0102
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.036 0.2303 0.4684
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0102 0.0102
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0601 0.392 1
Schistosoma mansoni hypothetical protein 0.1029 0.6799 0.7673
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.023 0.1428 0.1428
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.056 0.3646 0.5
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0105 0.0588 0.1146
Schistosoma mansoni tar DNA-binding protein 0.1336 0.886 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0101 0.0101
Brugia malayi latrophilin 2 splice variant baaae 0.1029 0.6799 0.6799
Brugia malayi intermediate filament protein 0.0033 0.0102 0.0102
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0033 0.0101 0.0101
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0601 0.392 0.8019
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0138 0.0809 0.0879
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0193 0.1179 0.1192
Echinococcus granulosus lamin 0.0033 0.0102 0.0079
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0476 0.3084 0.3457
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.023 0.1428 0.1993
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0549 0.3574 0.6494
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0367 0.2349 0.9871
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0032 0.0034
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0549 0.3574 0.4011
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0189 0.1153 0.1108
Schistosoma mansoni voltage-gated potassium channel 0.0123 0.0707 0.0796
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0102 0.0102
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0601 0.392 0.392
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.056 0.3646 0.5
Echinococcus multilocularis peptidase Clp (S14 family) 0.0367 0.2349 0.2625
Trypanosoma cruzi hypothetical protein, conserved 0.023 0.1428 0.1993
Schistosoma mansoni lamin 0.0033 0.0102 0.0113
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.023 0.1428 0.1993
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0601 0.392 0.8019
Brugia malayi TAR-binding protein 0.1336 0.886 0.886
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.056 0.3646 0.5
Trypanosoma cruzi protein farnesyltransferase, putative 0.0601 0.392 1
Schistosoma mansoni hypothetical protein 0.0476 0.3084 0.3479
Schistosoma mansoni peptidase Clp (S14 family) 0.056 0.3646 0.4114
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0189 0.1153 0.127
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.056 0.3646 0.912
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0193 0.1179 0.1192
Brugia malayi Calcitonin receptor-like protein seb-1 0.1505 1 1
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0744 0.488 0.488
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0022 0.0032 0.0034
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0744 0.488 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0112 0.0637 0.0637
Loa Loa (eye worm) hypothetical protein 0.1029 0.6799 0.6799
Echinococcus multilocularis tar DNA binding protein 0.1336 0.886 1
Trypanosoma cruzi hypothetical protein, conserved 0.023 0.1428 0.1993
Schistosoma mansoni voltage-gated potassium channel 0.0123 0.0707 0.0796
Schistosoma mansoni tar DNA-binding protein 0.1336 0.886 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0112 0.0637 0.0686
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0138 0.0809 0.0911
Schistosoma mansoni tar DNA-binding protein 0.1336 0.886 1
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0549 0.3574 0.7305
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0549 0.3574 0.4032
Loa Loa (eye worm) hypothetical protein 0.0022 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0549 0.3574 0.3574
Plasmodium falciparum geranylgeranyltransferase, putative 0.023 0.1428 0.1993
Loa Loa (eye worm) latrophilin receptor protein 2 0.0476 0.3084 0.3084
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0744 0.488 0.5492
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.037 0.237 1
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0189 0.1153 0.1153
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0189 0.1153 0.1108
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0744 0.488 0.5507
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0476 0.3084 0.3457
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0549 0.3574 0.3574
Loa Loa (eye worm) hypothetical protein 0.0476 0.3084 0.3084
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0105 0.0588 0.1146
Loa Loa (eye worm) hypothetical protein 0.056 0.3646 0.3646
Trypanosoma cruzi hypothetical protein, conserved 0.0189 0.1153 0.1108
Echinococcus multilocularis lamin dm0 0.0033 0.0102 0.0079
Toxoplasma gondii hypothetical protein 0.0189 0.1153 0.1108
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0138 0.0809 0.0879
Leishmania major farnesyltransferase beta subunit 0.0601 0.392 1
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0189 0.1153 0.1108
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0744 0.488 0.5507
Loa Loa (eye worm) hypothetical protein 0.023 0.1428 0.1428
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0189 0.1153 0.1108
Schistosoma mansoni intermediate filament proteins 0.0033 0.0102 0.0113
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1505 1 1
Echinococcus granulosus voltage gated potassium channel 0.0033 0.0101 0.0079
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.056 0.3646 1
Echinococcus granulosus peptidase Clp S14 family 0.0367 0.2349 0.2625
Loa Loa (eye worm) TAR-binding protein 0.1336 0.886 0.886
Giardia lamblia Prenyltransferase 0.0601 0.392 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.0538 0.0538
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0189 0.1153 0.1108
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0549 0.3574 0.8887
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0367 0.2349 0.9871
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.056 0.3646 0.5
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0022 0.0032 0.0034
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0022 0.0032 0.0034
Loa Loa (eye worm) RNA binding protein 0.1336 0.886 0.886
Echinococcus granulosus intermediate filament protein 0.0033 0.0102 0.0079
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.023 0.1428 0.1993

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 37.6505 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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