Detailed information for compound 1422418

Basic information

Technical information
  • TDR Targets ID: 1422418
  • Name: 4-butanoyl-N-(furan-2-ylmethyl)-1H-pyrrole-2- carboxamide
  • MW: 260.288 | Formula: C14H16N2O3
  • H donors: 2 H acceptors: 2 LogP: 1.43 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC(=O)c1c[nH]c(c1)C(=O)NCc1ccco1
  • InChi: 1S/C14H16N2O3/c1-2-4-13(17)10-7-12(15-8-10)14(18)16-9-11-5-3-6-19-11/h3,5-8,15H,2,4,9H2,1H3,(H,16,18)
  • InChiKey: KLHQMDIXJAJXCI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-butanoyl-N-(2-furylmethyl)-1H-pyrrole-2-carboxamide
  • N-(2-furylmethyl)-4-(1-oxobutyl)-1H-pyrrole-2-carboxamide
  • 4-butyryl-N-(2-furylmethyl)-1H-pyrrole-2-carboxamide
  • 8R-0306
  • Oprea1_610374
  • MLS000546534
  • SMR000179932

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens EYA transcriptional coactivator and phosphatase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni eyes absent homolog Get druggable targets OG5_129664 All targets in OG5_129664
Brugia malayi hypothetical protein Get druggable targets OG5_129664 All targets in OG5_129664
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129664 All targets in OG5_129664
Schistosoma japonicum ko:K01104 protein-tyrosine phosphatase [EC3.1.3.48], putative Get druggable targets OG5_129664 All targets in OG5_129664
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129664 All targets in OG5_129664
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) TAR-binding protein 0.026 0.1435 0.1435
Brugia malayi hypothetical protein 0.0016 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0052 0.0224 0.0224
Loa Loa (eye worm) hypothetical protein 0.0075 0.0362 0.0362
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0016
Schistosoma mansoni nuclear hormone receptor 0.0034 0.012 0.0308
Loa Loa (eye worm) hypothetical protein 0.0106 0.0542 0.0542
Brugia malayi hypothetical protein 0.0024 0.0062 0.0062
Echinococcus multilocularis chromobox protein 1 0.0074 0.0355 0.0644
Echinococcus multilocularis acetylcholinesterase 0.0446 0.2516 0.4591
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0016 0.0016 0.0039
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0401 0.2252 0.4107
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.012 0.0216
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0025 0.1168
Schistosoma mansoni BC026374 protein (S09 family) 0.0075 0.0362 0.0937
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0016 0.0016 0.0039
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.012 0.0308
Brugia malayi ecdysteroid receptor 0.0034 0.012 0.012
Onchocerca volvulus Peroxidasin homolog 0.0041 0.0161 0.0145
Loa Loa (eye worm) hypothetical protein 0.0052 0.0224 0.0224
Loa Loa (eye worm) hypothetical protein 0.0676 0.3851 0.3851
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0035 0.0618
Echinococcus granulosus acetylcholinesterase 0.0446 0.2516 1
Schistosoma mansoni nAChR subunit 0.0024 0.0062 0.0158
Onchocerca volvulus Dual oxidase homolog 0.0041 0.0161 0.0145
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0025 0.1168
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0018 0.0027 0.0103
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0052 0.0224 0.0578
Schistosoma mansoni nAChR subunit 0.0052 0.0224 0.0578
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0016 0.0027
Loa Loa (eye worm) hypothetical protein 0.0034 0.012 0.012
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0138 0.0726 0.3147
Schistosoma mansoni nAChR subunit 0.0052 0.0224 0.0578
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0164 0.4312
Loa Loa (eye worm) hypothetical protein 0.0041 0.0161 0.0161
Echinococcus granulosus transcription factor btf3 0.0041 0.0164 0.0644
Loa Loa (eye worm) hypothetical protein 0.0052 0.0224 0.0224
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0401 0.2252 0.8947
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0062 0.0062
Loa Loa (eye worm) isocitrate dehydrogenase 0.0035 0.0127 0.0127
Loa Loa (eye worm) hypothetical protein 0.0041 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.0041 0.0161 0.0161
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.012 0.0308
Brugia malayi Animal haem peroxidase family protein 0.0041 0.0161 0.0161
Onchocerca volvulus 0.0093 0.0464 0.0448
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0018 0.0027 0.0027
Onchocerca volvulus 0.0024 0.0062 0.0046
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0016 0.0016
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0028 0.0086 0.0086
Onchocerca volvulus Peroxidasin homolog 0.0041 0.0161 0.0145
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0245 0.0245
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0401 0.2252 1
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0025 0.0348
Onchocerca volvulus 0.0052 0.0224 0.0208
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0035 0.0618
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0263 0.145 0.5172
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0025 0.0043
Schistosoma mansoni nAChR subunit 0.0052 0.0224 0.0578
Schistosoma mansoni cpg binding protein 0.0031 0.0101 0.026
Brugia malayi isocitrate dehydrogenase 0.0035 0.0127 0.0127
Onchocerca volvulus Putative nachr subunit 0.0052 0.0224 0.0208
Brugia malayi Carboxylesterase family protein 0.0075 0.0362 0.0362
Loa Loa (eye worm) tyrosinase 1 0.0093 0.0464 0.0464
Loa Loa (eye worm) hypothetical protein 0.0052 0.0224 0.0224
Loa Loa (eye worm) hypothetical protein 0.0024 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0041 0.0161 0.0161
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0097 0.4472
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0165 0.4363
Brugia malayi hypothetical protein 0.0024 0.0062 0.0062
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0138 0.0726 0.0815
Echinococcus multilocularis tar DNA binding protein 0.026 0.1435 0.2616
Loa Loa (eye worm) hypothetical protein 0.0024 0.0062 0.0062
Brugia malayi Animal haem peroxidase family protein 0.0041 0.0161 0.0161
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.012 0.012
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0165 0.0149
Brugia malayi RNA binding protein 0.026 0.1435 0.1435
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0052 0.0224 0.0578
Loa Loa (eye worm) hypothetical protein 0.0024 0.0062 0.0062
Onchocerca volvulus 0.0093 0.0464 0.0448
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0446 0.2516 0.6533
Entamoeba histolytica transcription factor BTF3, putative 0.0041 0.0164 1
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0016 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0024 0.0062 0.0062
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0052 0.0224 0.0885
Brugia malayi steroid hormone receptor 0.0034 0.012 0.012
Schistosoma mansoni acetylcholine receptor-related 0.0024 0.0062 0.0158
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0025 0.1168
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.012 0.0216
Onchocerca volvulus Peroxidase homolog 0.0041 0.0161 0.0145
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0214 0.1169 0.1169
Loa Loa (eye worm) hypothetical protein 0.0041 0.0161 0.0161
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0014 0.0005 0.0006
Echinococcus multilocularis carboxylesterase 5A 0.0446 0.2516 0.4591
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0127 0.5881
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.0005 0.0005
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0025 0.0348
Brugia malayi Isocitrate dehydrogenase 0.0035 0.0127 0.0127
Brugia malayi RNA recognition motif domain containing protein 0.026 0.1435 0.1435
Brugia malayi Latrophilin receptor protein 2 0.0313 0.1742 0.1742
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0028 0.0086 0.0086
Echinococcus multilocularis nAChR subunit 0.0052 0.0224 0.0406
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0138 0.0726 0.3147
Onchocerca volvulus Phospholipase A2 homolog 0.1735 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0034 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0016
Schistosoma mansoni neurotransmitter gated ion channel 0.0024 0.0062 0.0158
Schistosoma mansoni thyroid hormone receptor 0.0034 0.012 0.0308
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0024 0.0062 0.0242
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0035 0.0127 0.0458
Brugia malayi CXXC zinc finger family protein 0.0031 0.0101 0.0101
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.026 0.1055
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0313 0.1742 0.692
Brugia malayi CHD4 protein 0.0014 0.0005 0.0005
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.012 0.0308
Schistosoma mansoni tar DNA-binding protein 0.026 0.1435 0.3723
Plasmodium falciparum thioredoxin reductase 0.005 0.0216 0.0858
Onchocerca volvulus 0.0024 0.0062 0.0046
Schistosoma mansoni gliotactin 0.0075 0.0362 0.0937
Loa Loa (eye worm) hypothetical protein 0.0024 0.0062 0.0062
Toxoplasma gondii hypothetical protein 0.0138 0.0726 0.3147
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0216 0.0858
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.012 0.0471
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0093 0.0464 0.0464
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0052 0.0224 0.0224
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0025 0.1168
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0025 0.0062
Schistosoma mansoni eyes absent homolog 0.0106 0.0542 0.1404
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0052 0.0224 0.0224
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0016 0.0027
Onchocerca volvulus 0.0075 0.0362 0.0346
Echinococcus multilocularis glycine receptor subunit beta 0.0052 0.0224 0.0406
Toxoplasma gondii thioredoxin reductase 0.005 0.0216 0.0858
Plasmodium falciparum glutathione reductase 0.005 0.0216 0.0858
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0033 0.0113 0.0113
Echinococcus multilocularis glycine receptor subunit beta 0.0052 0.0224 0.0406
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0016 0.0039
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Brugia malayi latrophilin 2 splice variant baaae 0.0676 0.3851 0.3851
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.012 0.0308
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.012 0.0216
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0127 0.0229
Brugia malayi TAR-binding protein 0.026 0.1435 0.1435
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0025 0.1168
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.03 0.0777
Loa Loa (eye worm) hypothetical protein 0.0989 0.5669 0.5669
Loa Loa (eye worm) hypothetical protein 0.0028 0.0086 0.0086
Schistosoma mansoni peroxidasin 0.0041 0.0161 0.0415
Schistosoma mansoni chromobox protein 0.0074 0.0355 0.0917
Loa Loa (eye worm) hypothetical protein 0.0028 0.0086 0.0086
Echinococcus multilocularis nAChR subunit 0.0028 0.0086 0.0154
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0128 0.0665 0.0448
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.012 0.012
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0016 0.0016 0.0016
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0024 0.0062 0.0062
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0245 0.0245
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0216 0.0216
Echinococcus multilocularis geminin 0.02 0.1085 0.1978
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0263 0.145 1
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0052 0.0224 0.0224
Schistosoma mansoni hypothetical protein 0.02 0.1085 0.2814
Echinococcus granulosus para nitrobenzyl esterase 0.0075 0.0362 0.1434
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0016 0.0016 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.012 0.012
Loa Loa (eye worm) ACC-1 protein 0.0052 0.0224 0.0224
Brugia malayi hypothetical protein 0.0018 0.0027 0.0027
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0016 0.0027
Brugia malayi Carboxylesterase family protein 0.0075 0.0362 0.0362
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.012 0.012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0016
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0115 0.0591 0.3968
Schistosoma mansoni hypothetical protein 0.0313 0.1742 0.4521
Echinococcus granulosus glycine receptor subunit beta 0.0052 0.0224 0.0885
Echinococcus granulosus tar DNA binding protein 0.026 0.1435 0.5698
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0989 0.5669 0.5669
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0052 0.0224 0.0885
Echinococcus granulosus carboxylesterase 5A 0.0446 0.2516 1
Schistosoma mansoni hypothetical protein 0.0676 0.3851 1
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.012 0.012
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.026 0.1435 0.1435
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0075 0.0362 0.1434
Loa Loa (eye worm) hypothetical protein 0.0028 0.0086 0.0086
Mycobacterium tuberculosis Carboxylesterase LipT 0.0075 0.0362 0.2364
Loa Loa (eye worm) hypothetical protein 0.0024 0.0062 0.0062
Loa Loa (eye worm) acetylcholinesterase 1 0.0446 0.2516 0.2516
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0052 0.0224 0.0578
Plasmodium vivax basic transcription factor 3b, putative 0.0041 0.0164 0.0621
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0025 0.1168
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.1735 1 1
Loa Loa (eye worm) hypothetical protein 0.0093 0.0464 0.0464
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0052 0.0224 0.0224
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Loa Loa (eye worm) animal heme peroxidase 0.0041 0.0161 0.0161
Echinococcus granulosus nAChR subunit 0.0052 0.0224 0.0885
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0052 0.0224 0.0224
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0184 0.0168
Loa Loa (eye worm) hypothetical protein 0.0075 0.0362 0.0362
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0216 0.0392
Loa Loa (eye worm) ACC-1 protein 0.0052 0.0224 0.0224
Onchocerca volvulus 0.0041 0.0161 0.0145
Loa Loa (eye worm) animal heme peroxidase 0.0041 0.0161 0.0161
Brugia malayi excitatory GABA receptor EXP-1A 0.0052 0.0224 0.0224
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0016
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0016 0.0016 0.0027
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0184 0.4888
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.012 0.012
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0095 0.2343
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0401 0.2252 1
Schistosoma mansoni zinc finger protein 0.0016 0.0016 0.0039
Schistosoma mansoni tyrosinase precursor 0.0093 0.0464 0.1202
Loa Loa (eye worm) ShTK domain-containing protein 0.0093 0.0464 0.0464
Schistosoma mansoni tar DNA-binding protein 0.026 0.1435 0.3723
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.012 0.012
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0035 0.0127 0.0458
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0075 0.0362 0.2364
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.012 0.012
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0025 0.1168
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0093 0.0464 0.0464
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0245 0.0968
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0401 0.2252 1
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0097 0.0321
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0093 0.0464 0.0464
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0035 0.0618
Schistosoma mansoni hypothetical protein 0.0435 0.2452 0.6364
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.012 0.0216
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0052 0.0224 0.0406
Loa Loa (eye worm) hypothetical protein 0.0028 0.0086 0.0086
Onchocerca volvulus 0.0028 0.0086 0.0069
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0245 0.0632
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0052 0.0224 0.0224
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0052 0.0224 0.0885
Schistosoma mansoni tar DNA-binding protein 0.026 0.1435 0.3723
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0024 0.0062 0.0242
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0052 0.0224 0.0578
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0035 0.0618
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0052 0.0224 0.0406
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0016
Brugia malayi nuclear hormone receptor 0.0034 0.012 0.012
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0075 0.0362 0.0937
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Brugia malayi Animal haem peroxidase family protein 0.0041 0.0161 0.0161
Brugia malayi nuclear receptor NHR-67 0.0016 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.02 0.1085 0.2814
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0097 0.0321
Brugia malayi Cation transporter family protein 0.0052 0.0224 0.0224
Brugia malayi ShTK domain containing protein 0.0093 0.0464 0.0464
Echinococcus multilocularis GPCR, family 2 0.0313 0.1742 0.3177
Schistosoma mansoni nAChR subunit 0.0052 0.0224 0.0578
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0052 0.0224 0.0885
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0025 0.0112
Echinococcus multilocularis dnaJ subfamily B 0.0435 0.2452 0.4472
Loa Loa (eye worm) hypothetical protein 0.0041 0.0161 0.0161
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0052 0.0224 0.0406
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0034 0.012 0.0471
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0128 0.0665 0.4491
Schistosoma mansoni retinoic acid receptor RXR 0.0034 0.012 0.0308
Loa Loa (eye worm) hypothetical protein 0.0052 0.0224 0.0224
Onchocerca volvulus 0.0075 0.0362 0.0346
Brugia malayi nuclear hormone receptor family member nhr-6 0.0016 0.0016 0.0016
Brugia malayi nuclear receptor NHR-88 0.0016 0.0016 0.0016
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0115 0.0591 0.3968
Loa Loa (eye worm) hypothetical protein 0.003 0.0097 0.0097
Brugia malayi Carboxylesterase family protein 0.0446 0.2516 0.2516
Loa Loa (eye worm) hypothetical protein 0.0028 0.0086 0.0086
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0127 0.5881
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0216 0.134
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0355 0.9785
Echinococcus multilocularis neuroligin 0.0075 0.0362 0.0658
Schistosoma mansoni hypothetical protein 0.0313 0.1742 0.4521
Brugia malayi conserved hypotetical protein 0.0016 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0052 0.0224 0.0224
Onchocerca volvulus Bile acid receptor homolog 0.0034 0.012 0.0104
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0956 0.548 1
Brugia malayi nuclear hormone receptor 0.0016 0.0016 0.0016
Schistosoma mansoni nuclear receptor nhr-48 0.0016 0.0016 0.0039
Schistosoma mansoni nAChR subunit 0.0052 0.0224 0.0578
Brugia malayi Cation transporter family protein 0.0052 0.0224 0.0224
Loa Loa (eye worm) hypothetical protein 0.0191 0.1031 0.1031
Echinococcus multilocularis BC026374 protein (S09 family) 0.0075 0.0362 0.0658
Loa Loa (eye worm) hypothetical protein 0.0052 0.0224 0.0224
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.012 0.012
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0024 0.0062 0.0062
Mycobacterium tuberculosis Probable reductase 0.0115 0.0591 0.3968
Brugia malayi chromobox protein homolog 3 0.0042 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0024 0.0062 0.0062
Brugia malayi tailless protein 0.0016 0.0016 0.0016
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0062 0.0062
Echinococcus granulosus peptidase Clp S14 family 0.0263 0.145 0.5758
Brugia malayi Animal haem peroxidase family protein 0.0041 0.0161 0.0161
Leishmania major trypanothione reductase 0.005 0.0216 1
Schistosoma mansoni tar DNA-binding protein 0.026 0.1435 0.3723
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0035 0.0618
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.012 0.0471
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0052 0.0224 0.0578
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0025 0.1168
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0024 0.0062 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0164 0.4312
Schistosoma mansoni thyroid hormone receptor 0.0034 0.012 0.0308
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0075 0.0362 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0016
Echinococcus multilocularis peroxidasin 0.0041 0.0161 0.0291
Echinococcus multilocularis isocitrate dehydrogenase 0.0035 0.0127 0.0229
Onchocerca volvulus 0.0041 0.0161 0.0145
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0138 0.0726 0.3147
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0016
Brugia malayi Cation transporter family protein 0.0052 0.0224 0.0224
Loa Loa (eye worm) hypothetical protein 0.0052 0.0224 0.0224
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.012 0.0308
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.012 0.012
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0263 0.145 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0401 0.2252 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0127 0.5881
Loa Loa (eye worm) hypothetical protein 0.0052 0.0224 0.0224
Mycobacterium tuberculosis Probable dehydrogenase 0.0115 0.0591 0.3968
Echinococcus granulosus geminin 0.02 0.1085 0.4308
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0052 0.0224 0.0406
Brugia malayi nuclear receptor RXR 0.0016 0.0016 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0165 0.4363
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0313 0.1742 0.3177
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0035 0.0127 0.0229
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0216 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0016 0.0016 0.0027
Brugia malayi hypothetical protein 0.0018 0.0027 0.0027
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0035 0.0618
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0216 0.0854
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0025 0.1168
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0025 0.1168
Onchocerca volvulus 0.0075 0.0362 0.0346
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0028 0.0086 0.0086
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0025 0.1168
Brugia malayi photoreceptor-specific nuclear receptor 0.0312 0.1737 0.1737
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0052 0.0224 0.0224
Onchocerca volvulus 0.0052 0.0224 0.0208
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.012 0.0471
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0018 0.0027 0.0047
Trypanosoma cruzi transcription factor btf3, putative 0.0041 0.0164 0.7565
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0024 0.0062 0.0111
Loa Loa (eye worm) hypothetical protein 0.0075 0.0362 0.0362
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0016 0.0039
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0052 0.0224 0.0224
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0401 0.2252 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0989 0.5669 0.5669
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0401 0.2252 1
Echinococcus granulosus nuclear receptor nhr 48 0.0016 0.0016 0.0059
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0052 0.0224 0.0406
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0052 0.0224 0.0224
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0016
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0052 0.0224 0.0224
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0097 0.4472
Echinococcus granulosus chromobox protein 1 0.0074 0.0355 0.1404
Schistosoma mansoni transcription factor btf3 0.0041 0.0164 0.0421
Schistosoma mansoni hypothetical protein 0.0313 0.1742 0.4521
Echinococcus granulosus glycine receptor subunit beta 0.0052 0.0224 0.0885
Brugia malayi hypothetical protein 0.0019 0.0035 0.0035
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0041 0.0161 0.0161
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0005 0.0008
Brugia malayi hypothetical protein 0.0075 0.0362 0.0362
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Loa Loa (eye worm) blistered cuticle protein 3 0.0041 0.0161 0.0161
Onchocerca volvulus 0.0093 0.0464 0.0448
Onchocerca volvulus Protein ultraspiracle homolog 0.0034 0.012 0.0104
Schistosoma mansoni nAChR subunit 0.0052 0.0224 0.0578
Loa Loa (eye worm) hypothetical protein 0.0446 0.2516 0.2516
Echinococcus granulosus glycine receptor subunit alpha 1 0.0052 0.0224 0.0885
Echinococcus granulosus BC026374 protein S09 family 0.0075 0.0362 0.1434
Loa Loa (eye worm) hypothetical protein 0.0093 0.0464 0.0464
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0016
Echinococcus granulosus glycine receptor subunit alpha 1 0.0052 0.0224 0.0885
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0313 0.1742 0.692
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0052 0.0224 0.0406
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0035 0.0618
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0025 0.5
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0025 0.1168
Echinococcus granulosus thyroid hormone receptor alpha 0.0016 0.0016 0.0059
Brugia malayi Carboxylesterase family protein 0.0075 0.0362 0.0362
Entamoeba histolytica hypothetical protein 0.0041 0.0164 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0016
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0075 0.0362 0.2364
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.012 0.0308
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0075 0.0362 0.0937
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0052 0.0224 0.0224
Echinococcus granulosus FTZ F1 alpha 0.0034 0.012 0.0471
Loa Loa (eye worm) ICD-1 protein 0.0041 0.0164 0.0164
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0025 0.1168
Loa Loa (eye worm) hypothetical protein 0.0041 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.0041 0.0161 0.0161
Brugia malayi ecdysone receptor 0.0016 0.0016 0.0016
Loa Loa (eye worm) glutathione reductase 0.005 0.0216 0.0216
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0052 0.0224 0.0224
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0115 0.0591 0.3968
Toxoplasma gondii NAC domain-containing protein 0.0041 0.0164 0.0621
Loa Loa (eye worm) hypothetical protein 0.0042 0.0165 0.0165
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0025 0.1168
Loa Loa (eye worm) hypothetical protein 0.0041 0.0161 0.0161
Leishmania major hypothetical protein, conserved 0.003 0.0097 0.4472
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0401 0.2252 1
Trichomonas vaginalis spcc417.12 protein, putative 0.0075 0.0362 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.012 0.012
Echinococcus multilocularis acetylcholinesterase 0.0446 0.2516 0.4591
Schistosoma mansoni tyrosinase precursor 0.0093 0.0464 0.1202
Trypanosoma brucei trypanothione reductase 0.005 0.0216 1
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0025 0.1168
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0016 0.0016 0.0027
Loa Loa (eye worm) hypothetical protein 0.0028 0.0086 0.0086
Onchocerca volvulus 0.0033 0.0113 0.0097
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0052 0.0224 0.0224
Brugia malayi Peroxidasin 0.0041 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.0052 0.0224 0.0224
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0052 0.0224 0.0224
Loa Loa (eye worm) carboxylesterase 0.0075 0.0362 0.0362
Onchocerca volvulus 0.0024 0.0062 0.0046
Brugia malayi Carboxylesterase family protein 0.0446 0.2516 0.2516
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0052 0.0224 0.0224
Echinococcus multilocularis thyroid hormone receptor alpha 0.0034 0.012 0.0216
Brugia malayi beta-NAC-like protein 0.0041 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0041 0.0161 0.0161
Onchocerca volvulus 0.0052 0.0224 0.0208
Schistosoma mansoni neurotransmitter gated ion channel 0.0028 0.0086 0.0219
Loa Loa (eye worm) hypothetical protein 0.0052 0.0224 0.0224
Onchocerca volvulus 0.0075 0.0362 0.0346
Brugia malayi nuclear receptor RXR 0.0018 0.0027 0.0027
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0052 0.0224 0.0224
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.012 0.0308
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0025 0.0112
Onchocerca volvulus 0.0052 0.0224 0.0208
Loa Loa (eye worm) hypothetical protein 0.0313 0.1742 0.1742
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0035 0.0127 0.0326
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0097 0.0321
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.012 0.0471
Schistosoma mansoni hypothetical protein 0.0313 0.1742 0.4521
Loa Loa (eye worm) hypothetical protein 0.0024 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0028 0.0086 0.0086
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0024 0.0062 0.0062
Onchocerca volvulus 0.0034 0.012 0.0104
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0016 0.0016 0.0059
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0127 0.0229
Loa Loa (eye worm) hypothetical protein 0.0034 0.012 0.012
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0052 0.0224 0.0406
Loa Loa (eye worm) hypothetical protein 0.0106 0.0542 0.0542
Trypanosoma cruzi transcription factor btf3, putative 0.0041 0.0164 0.7565
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0016 0.0059
Schistosoma mansoni neuroligin 3 (S09 family) 0.0075 0.0362 0.0937
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0035 0.0127 0.5881
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0025 0.0095
Echinococcus multilocularis para nitrobenzyl esterase 0.0075 0.0362 0.0658
Loa Loa (eye worm) hypothetical protein 0.0034 0.012 0.012
Echinococcus granulosus peroxidasin 0.0041 0.0161 0.0635
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0245 0.0444
Brugia malayi hypothetical protein 0.003 0.0097 0.0097
Leishmania major basic transcription factor 3a, putative 0.0041 0.0164 0.7565
Brugia malayi hypothetical protein 0.0024 0.0062 0.0062
Brugia malayi hypothetical protein 0.0041 0.0161 0.0161
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0075 0.0362 0.0658
Schistosoma mansoni acetylcholinesterase 0.0075 0.0362 0.0937
Onchocerca volvulus Phospholipase A2 homolog 0.076 0.4337 0.4327
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0024 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0041 0.0161 0.0161
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0128 0.0665 0.4491
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0014 0.0005 0.0012
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0313 0.1742 0.1742
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0052 0.0224 0.0224
Loa Loa (eye worm) hypothetical protein 0.0052 0.0224 0.0224
Echinococcus granulosus glycine receptor subunit alpha 1 0.0052 0.0224 0.0885
Loa Loa (eye worm) hypothetical protein 0.0052 0.0224 0.0224
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0127 0.0229
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0401 0.2252 1
Onchocerca volvulus 0.0052 0.0224 0.0208
Loa Loa (eye worm) RNA binding protein 0.026 0.1435 0.1435
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0115 0.0591 0.3968
Mycobacterium ulcerans carboxylesterase, LipT 0.0075 0.0362 0.1608
Toxoplasma gondii isocitrate dehydrogenase 0.0035 0.0127 0.0458
Schistosoma mansoni tar DNA-binding protein 0.026 0.1435 0.3723
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0245 0.0632
Loa Loa (eye worm) hypothetical protein 0.0034 0.012 0.012
Onchocerca volvulus 0.0031 0.0101 0.0085
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0245 0.0968
Schistosoma mansoni chromobox protein 0.0074 0.0355 0.0917
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0052 0.0224 0.0885
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0025 0.0112
Onchocerca volvulus 0.0093 0.0464 0.0448
Loa Loa (eye worm) hypothetical protein 0.0075 0.0362 0.0362
Plasmodium falciparum basic transcription factor 3b, putative 0.0041 0.0164 0.0621
Loa Loa (eye worm) hypothetical protein 0.0401 0.2252 0.2252
Echinococcus multilocularis transcription factor btf3 0.0041 0.0164 0.0296
Loa Loa (eye worm) hypothetical protein 0.0052 0.0224 0.0224
Loa Loa (eye worm) hypothetical protein 0.0041 0.0161 0.0161
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0052 0.0224 0.0406
Brugia malayi Animal haem peroxidase family protein 0.0041 0.0161 0.0161
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0214 0.1169 0.1169
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0052 0.0224 0.0885
Brugia malayi Common central domain of tyrosinase family protein 0.0093 0.0464 0.0464
Brugia malayi Carboxylesterase family protein 0.0075 0.0362 0.0362
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0401 0.2252 1
Brugia malayi Probable ClpP-like protease 0.0401 0.2252 0.2252
Loa Loa (eye worm) hypothetical protein 0.0052 0.0224 0.0224
Loa Loa (eye worm) hypothetical protein 0.0075 0.0362 0.0362
Loa Loa (eye worm) hypothetical protein 0.0034 0.012 0.012
Brugia malayi glutathione reductase 0.005 0.0216 0.0216
Schistosoma mansoni nuclear receptor 0.0016 0.0016 0.0039
Schistosoma mansoni cpg binding protein 0.0032 0.0112 0.0286
Loa Loa (eye worm) animal heme peroxidase 0.0041 0.0161 0.0161
Mycobacterium tuberculosis Probable oxidoreductase 0.0128 0.0665 0.4491
Loa Loa (eye worm) ShTK domain-containing protein 0.0093 0.0464 0.0464
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0052 0.0224 0.0578
Loa Loa (eye worm) hypothetical protein 0.0075 0.0362 0.0362
Onchocerca volvulus 0.0052 0.0224 0.0208
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0164 0.4312
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.012 0.0216
Trypanosoma brucei transcription factor BTF3, putative 0.0041 0.0164 0.7565
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0025 0.0025
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0016 0.0016 0.0016
Loa Loa (eye worm) nuclear receptor NHR-67 0.0016 0.0016 0.0016
Echinococcus granulosus dnaJ subfamily B 0.0435 0.2452 0.9742
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0052 0.0224 0.0224
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.012 0.0308
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.012 0.012
Loa Loa (eye worm) LGC-31 protein 0.0052 0.0224 0.0224
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0446 0.2516 0.2516
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0035 0.0127 0.5881
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0052 0.0224 0.0224
Echinococcus granulosus cpg binding protein 0.0032 0.0112 0.0438
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0028 0.0086 0.0219
Loa Loa (eye worm) hypothetical protein 0.0075 0.0362 0.0362
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0101 0.0101
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0093 0.0464 0.0464
Brugia malayi Thioredoxin reductase 0.005 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.0052 0.0224 0.0224
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0052 0.0224 0.0224
Echinococcus granulosus acetylcholinesterase 0.0446 0.2516 1
Loa Loa (eye worm) DR-78 0.0016 0.0016 0.0016
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.012 0.0471
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0016 0.0016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.012 0.012
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0095 0.2343
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.012 0.0216
Loa Loa (eye worm) carboxylesterase 0.0075 0.0362 0.0362
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0027 0.0068
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0062 0.0062
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0035 0.0618
Echinococcus multilocularis peptidase Clp (S14 family) 0.0263 0.145 0.2644
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0184 0.4888
Loa Loa (eye worm) hypothetical protein 0.0024 0.0062 0.0062
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0024 0.0062 0.0062
Loa Loa (eye worm) animal heme peroxidase 0.0041 0.0161 0.0161
Loa Loa (eye worm) heterochromatin protein 1 0.0074 0.0355 0.0355
Loa Loa (eye worm) hypothetical protein 0.0024 0.0062 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.012 0.012
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.012 0.012
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0052 0.0224 0.0224
Loa Loa (eye worm) hypothetical protein 0.0052 0.0224 0.0224
Echinococcus multilocularis cpg binding protein 0.0032 0.0112 0.0201
Onchocerca volvulus Peroxidase homolog 0.0041 0.0161 0.0145
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0024 0.0062 0.0111
Loa Loa (eye worm) hypothetical protein 0.076 0.4337 0.4337
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0312 0.1737 0.1737
Loa Loa (eye worm) GABA receptor subunit 0.0028 0.0086 0.0086
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.012 0.0216
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0052 0.0224 0.0885
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0025 0.1168
Loa Loa (eye worm) hypothetical protein 0.0041 0.0161 0.0161
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0016 0.0059
Onchocerca volvulus 0.0041 0.0161 0.0145
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0313 0.1742 0.3177
Onchocerca volvulus Chorion peroxidase homolog 0.0041 0.0161 0.0145
Schistosoma mansoni nAChR subunit 0.0052 0.0224 0.0578
Brugia malayi Heterochromatin protein 1 0.0074 0.0355 0.0355
Schistosoma mansoni acetylcholine receptor subunit beta 0.0024 0.0062 0.0158
Schistosoma mansoni neurotransmitter gated ion channel 0.0024 0.0062 0.0158
Loa Loa (eye worm) hypothetical protein 0.0024 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0024 0.0062 0.0062
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0355 0.9785
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.012 0.0471
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0025 0.1168
Schistosoma mansoni nuclear receptor 0.0016 0.0016 0.0039
Brugia malayi hypothetical protein 0.0016 0.0016 0.0016
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0245 0.0444
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0052 0.0224 0.0885
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0035 0.0127 0.05
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0075 0.0362 0.0937
Brugia malayi Blistered cuticle protein 3 0.0041 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.0024 0.0062 0.0062
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.012 0.0471
Onchocerca volvulus 0.0028 0.0086 0.0069
Loa Loa (eye worm) carboxylesterase 0.0446 0.2516 0.2516
Brugia malayi hypothetical protein 0.0024 0.0062 0.0062
Echinococcus granulosus nAChR subunit 0.0028 0.0086 0.0335
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0018 0.0027 0.0068
Echinococcus granulosus GPCR family 2 0.0313 0.1742 0.692
Loa Loa (eye worm) hypothetical protein 0.0028 0.0086 0.0086
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0028 0.0086 0.0219
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0052 0.0224 0.0406
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0034 0.012 0.0104
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0024 0.0062 0.0111
Brugia malayi hypothetical protein 0.0106 0.0542 0.0542
Schistosoma mansoni peroxidasin 0.0041 0.0161 0.0415
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.012 0.0216
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0401 0.2252 1
Toxoplasma gondii isocitrate dehydrogenase 0.0035 0.0127 0.0458
Onchocerca volvulus 0.0075 0.0362 0.0346
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0401 0.2252 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0052 0.0224 0.0406
Echinococcus granulosus chromobox protein 1 0.0074 0.0355 0.1404
Schistosoma mansoni cpg binding protein 0.0032 0.0112 0.0286
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0097 0.4472
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0052 0.0224 0.0224
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0028 0.0086 0.0086
Brugia malayi nuclear receptor NHR-88 0.0034 0.012 0.012
Echinococcus multilocularis chromobox protein 1 0.0074 0.0355 0.0644
Brugia malayi hypothetical protein 0.0024 0.0062 0.0062
Loa Loa (eye worm) nuclear hormone receptor 0.0016 0.0016 0.0016
Echinococcus granulosus neuroligin 0.0075 0.0362 0.1434
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0245 0.0632
Schistosoma mansoni nAChR subunit 0.0024 0.0062 0.0158
Brugia malayi nuclear hormone receptor family member odr-7 0.0016 0.0016 0.0016
Loa Loa (eye worm) latrophilin receptor protein 2 0.0313 0.1742 0.1742
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0097 0.0321
Plasmodium vivax glutathione reductase, putative 0.005 0.0216 0.0858
Schistosoma mansoni peptidase Clp (S14 family) 0.0401 0.2252 0.5845
Schistosoma mansoni coup transcription factor 0.0034 0.012 0.0308
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0035 0.0127 0.0715
Loa Loa (eye worm) acetylcholine receptor protein 0.0024 0.0062 0.0062
Brugia malayi Calcitonin receptor-like protein seb-1 0.0989 0.5669 0.5669
Brugia malayi orphan nuclear receptor NR2E1 0.0016 0.0016 0.0016
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0016 0.0059
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0024 0.0062 0.0062

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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