Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid hormone receptor, beta | Starlite/ChEMBL | No references |
Homo sapiens | glucosidase, alpha | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, beta | 461 aa | 414 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0.7079 | 0.7079 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0044 | 0 | 0.5 |
Onchocerca volvulus | 0.0114 | 0.4581 | 0.5 | |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0044 | 0 | 0.5 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0044 | 0 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0197 | 1 | 1 |
Trypanosoma brucei | glucosidase, putative | 0.0044 | 0 | 0.5 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0044 | 0 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0044 | 0 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0044 | 0 | 0.5 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0197 | 1 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0169 | 0.821 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0169 | 0.821 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0164 | 0.7876 | 0.7876 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0044 | 0 | 0.5 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0197 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.7079 | 0.8622 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0044 | 0 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0044 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0044 | 0 | 0.5 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0044 | 0 | 0.5 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0044 | 0 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0044 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0164 | 0.7876 | 0.9593 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0197 | 1 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0044 | 0 | 0.5 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0152 | 0.7079 | 0.7079 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0044 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0164 | 0.7876 | 0.9593 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.0022 um | PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.5481 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | = 6.3096 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.