Detailed information for compound 1422636

Basic information

Technical information
  • TDR Targets ID: 1422636
  • Name: 2-chloro-5-[[5-[(2,3-dibromo-4-hydroxy-5-meth oxyphenyl)methylidene]-4-oxo-1,3-thiazol-2-yl ]amino]benzoic acid
  • MW: 562.616 | Formula: C18H11Br2ClN2O5S
  • H donors: 3 H acceptors: 4 LogP: 4.98 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1cc(/C=C/2\SC(=NC2=O)Nc2ccc(c(c2)C(=O)O)Cl)c(c(c1O)Br)Br
  • InChi: 1S/C18H11Br2ClN2O5S/c1-28-11-4-7(13(19)14(20)15(11)24)5-12-16(25)23-18(29-12)22-8-2-3-10(21)9(6-8)17(26)27/h2-6,24H,1H3,(H,26,27)(H,22,23,25)/b12-5-
  • InChiKey: IKFUZLXDBMLEGG-XGICHPGQSA-N  


Substructure search Similarity search

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Synonyms

  • 2-chloro-5-[[(5Z)-5-[(2,3-dibromo-4-hydroxy-5-methoxyphenyl)methylidene]-4-oxo-1,3-thiazol-2-yl]amino]benzoic acid
  • 2-chloro-5-[[5-[(2,3-dibromo-4-hydroxy-5-methoxy-phenyl)methylene]-4-oxo-thiazol-2-yl]amino]benzoic acid
  • 2-chloro-5-[[(5Z)-5-[(2,3-dibromo-4-hydroxy-5-methoxy-phenyl)methylene]-4-oxo-thiazol-2-yl]amino]benzoic acid
  • 2-chloro-5-[[5-[(2,3-dibromo-4-hydroxy-5-methoxyphenyl)methylene]-4-oxo-2-thiazolyl]amino]benzoic acid
  • 2-chloro-5-[[(5Z)-5-[(2,3-dibromo-4-hydroxy-5-methoxyphenyl)methylene]-4-oxo-2-thiazolyl]amino]benzoic acid
  • 2-chloro-5-[[5-(2,3-dibromo-4-hydroxy-5-methoxy-benzylidene)-4-keto-thiazol-2-yl]amino]benzoic acid
  • 2-chloro-5-[[(5Z)-5-(2,3-dibromo-4-hydroxy-5-methoxy-benzylidene)-4-keto-thiazol-2-yl]amino]benzoic acid
  • 2-chloro-5-[[5-[(2,3-dibromo-4-hydroxy-5-methoxy-phenyl)methylidene]-4-oxo-1,3-thiazol-2-yl]amino]benzoic acid
  • 2-chloro-5-[[(5Z)-5-[(2,3-dibromo-4-hydroxy-5-methoxy-phenyl)methylidene]-4-oxo-1,3-thiazol-2-yl]amino]benzoic acid
  • BAS 01155689

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Leishmania mexicana pyruvate kinase, putative Starlite/ChEMBL No references
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens v-ets avian erythroblastosis virus E26 oncogene homolog Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens Rap guanine nucleotide exchange factor (GEF) 4 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) kappa Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens EYA transcriptional coactivator and phosphatase 2 Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Simian virus 40 Large T antigen Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens Rac GTPase activating protein 1 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132551 All targets in OG5_132551
Schistosoma japonicum Pyruvate kinase isozyme R, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum ko:K09536 DnaJ homolog, subfamily C, member 16, putative Get druggable targets OG5_132364 All targets in OG5_132364
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Plasmodium vivax pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi RhoGAP domain containing protein Get druggable targets OG5_132551 All targets in OG5_132551
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus dnaJ subfamily C 6 Get druggable targets OG5_132364 All targets in OG5_132364
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129664 All targets in OG5_129664
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Giardia lamblia Pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pyruvate kinase, M2 isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Mycobacterium tuberculosis Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Plasmodium yoelii pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni hypothetical protein Get druggable targets OG5_132364 All targets in OG5_132364
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K03511 DNA polymerase kappa subunit, putative Get druggable targets OG5_127393 All targets in OG5_127393
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis dnaJ subfamily C 6 Get druggable targets OG5_132364 All targets in OG5_132364
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Babesia bovis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pyruvate kinase, muscle isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania donovani pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Giardia lamblia Rho GAP, putative Get druggable targets OG5_132551 All targets in OG5_132551
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi Fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni ets-related Get druggable targets OG5_131947 All targets in OG5_131947
Echinococcus multilocularis dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Cryptosporidium parvum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis DNA polymerase IV / kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Mycobacterium leprae Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi DnaJ domain containing protein Get druggable targets OG5_132364 All targets in OG5_132364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus Rac GTPase activating protein 1 Get druggable targets OG5_132551 All targets in OG5_132551
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129664 All targets in OG5_129664
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis DNA polymerase eta, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania infantum DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum IPR000437,Prokaryotic membrane lipoprotein lipid attachment site;IPR008936,Rho GTPase activation protein,domain-containing Get druggable targets OG5_132551 All targets in OG5_132551
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei pyruvate kinase 1 Get druggable targets OG5_126685 All targets in OG5_126685
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K01104 protein-tyrosine phosphatase [EC3.1.3.48], putative Get druggable targets OG5_129664 All targets in OG5_129664
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma mansoni eyes absent homolog Get druggable targets OG5_129664 All targets in OG5_129664
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127393 All targets in OG5_127393
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum expressed protein Get druggable targets OG5_132551 All targets in OG5_132551
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) pyruvate kinase-PB Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania infantum DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii pyruvate kinase PyK1 Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) DnaJ domain-containing protein Get druggable targets OG5_132364 All targets in OG5_132364
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi RhoGAP domain containing protein Get druggable targets OG5_132551 All targets in OG5_132551
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum expressed protein Get druggable targets OG5_132364 All targets in OG5_132364
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi polk-prov protein Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni rac gtpase activating protein Get druggable targets OG5_132551 All targets in OG5_132551
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog Get druggable targets OG5_131726 All targets in OG5_131726
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi hypothetical protein Get druggable targets OG5_129664 All targets in OG5_129664
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi N-terminal motif family protein Get druggable targets OG5_131726 All targets in OG5_131726
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum Pyruvate kinase (EC 2.7.1.40), related Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131726 All targets in OG5_131726
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis protein kinase inhibitor, putative Get druggable targets OG5_132364 All targets in OG5_132364
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K00873 pyruvate kinase [EC2.7.1.40], putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis Rac GTPase activating protein 1 Get druggable targets OG5_132551 All targets in OG5_132551
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Chlamydia trachomatis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum ko:K09435 transcriptional regulator ERG, putative Get druggable targets OG5_131947 All targets in OG5_131947
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia DINP protein human, muc B family Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania major DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132551 All targets in OG5_132551
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Rac GTPase-activating protein 1, putative Get druggable targets OG5_132551 All targets in OG5_132551
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus pyruvate kinase pyruvate kinase, putative 498 aa 515 aa 27.6 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0039 0.0677 0.0899
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0095 0.0092
Loa Loa (eye worm) hypothetical protein 0.001 0.0084 0.0108
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0008 0.0032 0.0144
Schistosoma mansoni ATPase 0.001 0.0084 0.0084
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.001 0.0084 0.038
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.093 0.4176
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0008 0.0032 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0036 0.0118
Toxoplasma gondii exonuclease III APE 0.0023 0.0341 0.26
Schistosoma mansoni importin-beta 2 0.0007 0.001 0.001
Toxoplasma gondii HEAT repeat-containing protein 0.0007 0.001 0.0076
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0677 0.0677
Toxoplasma gondii histone lysine methyltransferase SET1 0.007 0.131 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.1369 0.1827
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0013 0.0132 0.0242
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.001 0.0084 0.0101
Giardia lamblia Kinase, PLK 0.0114 0.2213 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0677 0.0899
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0341 0.3593
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0589 0.0788
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0008 0.0032 0.0028
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.001 0.0084 0.0101
Echinococcus multilocularis dna polymerase kappa 0.0073 0.1369 0.1366
Mycobacterium tuberculosis Conserved protein 0.0039 0.0677 0.1288
Trypanosoma brucei unspecified product 0.0028 0.0452 0.0601
Trichomonas vaginalis cation-transporting ATPase, putative 0.001 0.0084 0.0337
Schistosoma mansoni kinase 0.0058 0.1063 0.1063
Trypanosoma brucei unspecified product 0.0065 0.1206 0.1629
Loa Loa (eye worm) hypothetical protein 0.0012 0.0124 0.0161
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0076 0.0073
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0192 0.0249
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0677 0.3028
Schistosoma mansoni DNA polymerase IV / kappa 0.0013 0.0134 0.0134
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0341 0.0422
Schistosoma mansoni cation-transporting atpase 13a1 (G-box binding protein) 0.001 0.0084 0.0084
Schistosoma mansoni zinc finger protein 0.0006 0.0003 0.0003
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.1219 0.1216
Plasmodium vivax calcium-transporting ATPase, putative 0.001 0.0084 0.0807
Brugia malayi RhoGAP domain containing protein 0.0012 0.0127 0.0232
Echinococcus multilocularis Protein son of sevenless 0.0008 0.0032 0.0028
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0677 0.159
Brugia malayi hypothetical protein 0.0106 0.2056 0.3863
Schistosoma mansoni elf1 0.0013 0.0135 0.0135
Brugia malayi Pyruvate kinase, M2 isozyme 0.004 0.0701 0.1312
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.0469 0.2084
Trypanosoma brucei P-type H+-ATPase, putative 0.001 0.0084 0.0101
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0011 0.0095 0.0095
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.7495 1
Plasmodium falciparum pyruvate kinase 0.004 0.0701 0.83
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.093 0.7101
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.2213 0.3001
Leishmania major proton motive ATPase, putative 0.001 0.0084 0.0101
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.001 0.0084 0.038
Brugia malayi RasGEF domain containing protein 0.0008 0.0032 0.0053
Onchocerca volvulus 0.0035 0.0586 0.1285
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2213 1
Echinococcus granulosus ETS transcription factor Elf 2 0.0013 0.0135 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0036 0.0118
Entamoeba histolytica hypothetical protein 0.0008 0.0032 0.0144
Echinococcus multilocularis phosphoserine phosphatase 0.001 0.0084 0.0081
Leishmania major copper-transporting ATPase-like protein, putative 0.001 0.0084 0.0101
Schistosoma mansoni cpg binding protein 0.0037 0.0626 0.0626
Echinococcus multilocularis phosphoserine phosphatase 0.001 0.0084 0.0081
Echinococcus multilocularis cpg binding protein 0.0037 0.0626 0.0623
Echinococcus multilocularis regulator of G protein signaling 7 0.0011 0.0095 0.0092
Echinococcus granulosus copper transporting ATPase 1 0.001 0.0084 0.0081
Echinococcus multilocularis cation transporting ATPase 13A1 0.001 0.0084 0.0081
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.001 0.0084 0.0643
Schistosoma mansoni z-protein (S1r protein) 0.0011 0.0095 0.0095
Echinococcus multilocularis pyruvate kinase 0.004 0.0701 0.0698
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.001 0.0084 0.0072
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.2213 0.2211
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.0192 0.0828
Echinococcus granulosus phospholipid transporting ATPase VA 0.001 0.0084 0.0081
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.1032 0.4641
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0192 0.0249
Schistosoma mansoni smad1 5 8 and 0.001 0.0076 0.0076
Trypanosoma brucei DNA polymerase IV, putative 0.0073 0.1369 0.1852
Brugia malayi hypothetical protein 0.0182 0.3615 0.6797
Leishmania major pyruvate kinase 0.004 0.0701 0.0941
Brugia malayi Protein kinase domain containing protein 0.0013 0.0132 0.0242
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.3413 0.462
Entamoeba histolytica plasma membrane calcium-transporting ATPase 1, putative 0.001 0.0084 0.038
Schistosoma mansoni terminal deoxycytidyl transferase 0.0041 0.0711 0.0711
Plasmodium falciparum copper-transporting ATPase 0.001 0.0084 0.0892
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.0711 0.0711
Toxoplasma gondii ABC1 family protein 0.0039 0.0677 0.517
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0894 0.0894
Loa Loa (eye worm) hypothetical protein 0.0012 0.0124 0.0161
Giardia lamblia Pyruvate kinase 0.0021 0.0299 0.1008
Loa Loa (eye worm) hypothetical protein 0.001 0.0084 0.0108
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0192 0.022
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0677 0.3028
Brugia malayi C1-like domain containing protein 0.0013 0.0132 0.0242
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0341 0.0337
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.1369 0.1852
Mycobacterium tuberculosis Cation transporter P-type ATPase a CtpA 0.001 0.0084 0.0093
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.1056 0.1053
Brugia malayi MH2 domain containing protein 0.001 0.0076 0.0137
Schistosoma mansoni ets 0.0013 0.0135 0.0135
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0007 0.0018 0.001
Loa Loa (eye worm) hypothetical protein 0.0106 0.2056 0.274
Brugia malayi Protein kinase c protein 2 0.0013 0.0132 0.0242
Schistosoma mansoni vav2 0.0012 0.0124 0.0124
Schistosoma mansoni dishevelled 0.0011 0.0095 0.0095
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0011 0.0095 0.0122
Trypanosoma cruzi copper-transporting ATPase, putative 0.001 0.0084 0.0072
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0132 0.0132
Loa Loa (eye worm) E1-E2 ATPase 0.001 0.0084 0.0108
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.2213 0.298
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0677 0.3028
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0677 0.3028
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0677 0.7251
Loa Loa (eye worm) hypothetical protein 0.0039 0.0677 0.0899
Echinococcus granulosus pyruvate kinase 0.004 0.0701 0.0698
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.2213 0.4159
Loa Loa (eye worm) hypothetical protein 0.0013 0.0135 0.0176
Echinococcus granulosus dna polymerase kappa 0.0073 0.1369 0.1366
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.1509 0.2018
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.1056 0.1056
Loa Loa (eye worm) RasGEF domain-containing protein 0.0008 0.0032 0.0038
Loa Loa (eye worm) hypothetical protein 0.0028 0.0451 0.0597
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0793 0.1066
Loa Loa (eye worm) D-ets-2 protein 0.0013 0.0135 0.0176
Echinococcus multilocularis translational activator gcn1 0.0007 0.001 0.0007
Entamoeba histolytica pyruvate kinase, putative 0.0028 0.0451 0.2037
Entamoeba histolytica diacylglycerol kinase, putative 0.0012 0.0124 0.0562
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0011 0.0095 0.0172
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0926 0.1222
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.093 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0341 0.0422
Loa Loa (eye worm) Smad1 0.001 0.0076 0.0097
Loa Loa (eye worm) DnaJ domain-containing protein 0.0074 0.1391 0.1853
Plasmodium vivax pyruvate kinase 2, putative 0.0021 0.0299 0.3139
Brugia malayi hypothetical protein 0.0011 0.0095 0.0172
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.7351 1
Schistosoma mansoni pyruvate kinase 0.004 0.0701 0.0701
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0677 0.1288
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.093 0.4176
Loa Loa (eye worm) hypothetical protein 0.0039 0.0677 0.0899
Schistosoma mansoni ap endonuclease 0.0023 0.0341 0.0341
Onchocerca volvulus 0.0182 0.3615 0.8311
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0012 0.0127 0.0127
Onchocerca volvulus 0.0039 0.0677 0.1497
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0341 0.1539
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0134 0.017
Echinococcus multilocularis ras GTP exchange factor 0.0008 0.0032 0.0028
Toxoplasma gondii P-type ATPase PMA1 0.001 0.0084 0.0643
Loa Loa (eye worm) RecQ helicase 0.0029 0.0469 0.0622
Schistosoma mansoni ATPase 0.001 0.0084 0.0084
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0341 0.0634
Brugia malayi Ras association domain family 1 isoform A 0.0012 0.0124 0.0228
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2213 1
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.001 0.0084 0.0072
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0076 0.0076
Brugia malayi Fli-1 protein 0.0265 0.5317 1
Toxoplasma gondii hypothetical protein 0.0059 0.1081 0.8252
Brugia malayi transcription factor E74 isoform 0.0013 0.0135 0.0248
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.1369 0.1852
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0012 0.0124 0.0121
Loa Loa (eye worm) hypothetical protein 0.0012 0.0124 0.0161
Leishmania major P-type H -ATPase, putative 0.001 0.0084 0.0101
Brugia malayi Importin beta-1 subunit 0.0035 0.0589 0.1102
Echinococcus multilocularis Smad4 0.001 0.0076 0.0073
Schistosoma mansoni Smad4 0.001 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0106 0.2056 0.274
Chlamydia trachomatis pyruvate kinase 0.004 0.0701 1
Echinococcus granulosus ETS transcription factor Elf 1 0.0013 0.0135 0.0132
Schistosoma mansoni diacylglycerol kinase theta 0.0012 0.0124 0.0124
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0469 0.2084
Brugia malayi RasGEF domain containing protein 0.0008 0.0032 0.0053
Brugia malayi RasGEF domain containing protein 0.0008 0.0032 0.0053
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0677 0.0909
Toxoplasma gondii phospholipid-translocating P-type ATPase, flippase subfamily protein 0.001 0.0084 0.0643
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0765 0.1002
Trypanosoma cruzi P-type H+-ATPase, putative 0.001 0.0084 0.0072
Loa Loa (eye worm) hypothetical protein 0.0058 0.1056 0.1405
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0012 0.0124 0.0121
Trypanosoma brucei pyruvate kinase 1 0.004 0.0701 0.0941
Echinococcus multilocularis ets variant gene 4 0.0013 0.0135 0.0132
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0615 0.0824
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0701 0.1551
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0008 0.0032 0.0144
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.001 0.0084 0.0101
Echinococcus granulosus Smad4 0.001 0.0076 0.0073
Loa Loa (eye worm) hypothetical protein 0.0218 0.4344 0.5794
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0041 0.0711 0.0945
Schistosoma mansoni protein kinase C 0.0012 0.0124 0.0124
Brugia malayi Probable cation-transporting ATPase C10C6.6 in chromosome IV 0.001 0.0084 0.0152
Echinococcus granulosus ETS transcription factor Elf 5 0.0013 0.0135 0.0132
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0132 0.0132
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0012 0.0124 0.0161
Echinococcus multilocularis phospholipid transporting ATPase IIB 0.001 0.0084 0.0081
Loa Loa (eye worm) MBCTL1 0.0066 0.1219 0.1623
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0008 0.0032 0.0144
Schistosoma mansoni smad 0.001 0.0076 0.0076
Brugia malayi Pleckstrin Homology Domain 0.0012 0.0124 0.0228
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0008 0.0032 0.0144
Trypanosoma brucei copper-transporting ATPase-like protein, putative 0.001 0.0084 0.0101
Echinococcus granulosus cation transporting atpase worm 0.001 0.0084 0.0081
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0218 0.4344 1
Loa Loa (eye worm) ets-domain-containing protein 0.0013 0.0135 0.0176
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.001 0.0084 0.0643
Schistosoma mansoni bromodomain containing protein 0.0006 0.0003 0.0003
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0008 0.0032 0.0032
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0677 0.1288
Echinococcus multilocularis Diacylglycerol kinase theta 0.0012 0.0124 0.0121
Schistosoma mansoni diacylglycerol kinase theta 0.0012 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0012 0.0124 0.0161
Trypanosoma brucei DNA polymerase IV, putative 0.0065 0.1206 0.1629
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.1369 0.1827
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0008 0.0032 0.0028
Loa Loa (eye worm) hypothetical protein 0.0045 0.0793 0.1054
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.012 0.0117
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0454 0.2014
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0012 0.0125 0.0229
Echinococcus multilocularis son of sevenless 1 0.0008 0.0032 0.0028
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.001 0.0084 0.0081
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0589 0.4495
Echinococcus multilocularis Rac GTPase activating protein 1 0.0089 0.1695 0.1693
Schistosoma mansoni regulator of G protein signaling 0.0011 0.0095 0.0095
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0052 0.0048
Echinococcus granulosus regulator of G protein signaling 7 0.0011 0.0095 0.0092
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0894 0.0891
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0095 0.0092
Echinococcus granulosus bloom syndrome protein 0.0029 0.0469 0.0466
Echinococcus multilocularis unc 13 (munc13) 0.0012 0.0124 0.0121
Loa Loa (eye worm) hypothetical protein 0.0012 0.0124 0.0161
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0677 0.1288
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0036 0.0118
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.1219 0.1216
Plasmodium vivax cation transporting ATPase, putative 0.001 0.0084 0.0807
Echinococcus multilocularis phospholipid transporting ATPase VA 0.001 0.0084 0.0081
Leishmania major DNA polymerase eta, putative 0.0072 0.1342 0.1814
Schistosoma mansoni pyruvate kinase 0.0021 0.0299 0.0299
Echinococcus multilocularis bloom syndrome protein 0.0029 0.0469 0.0466
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.3463 0.651
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0008 0.0032 0.0028
Echinococcus granulosus cpg binding protein 0.0037 0.0626 0.0623
Mycobacterium leprae Probable lipase LipE 0.0039 0.0677 0.9617
Echinococcus multilocularis pyruvate kinase 0.0021 0.0299 0.0296
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.1509 0.1509
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0341 0.15
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.1369 0.1852
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0677 0.0677
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.283 0.3773
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.3362 0.336
Loa Loa (eye worm) hypothetical protein 0.0066 0.1219 0.1623
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.1219 0.1216
Echinococcus granulosus GA binding protein alpha chain 0.0087 0.1668 0.1665
Trichomonas vaginalis helicase, putative 0.0008 0.0036 0.0118
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0842 1
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0132 0.0132
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0012 0.0124 0.0121
Loa Loa (eye worm) hypothetical protein 0.0012 0.0124 0.0161
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0052 0.0048
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0842 0.356
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0894 0.0891
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0043 0.0765 0.5841
Loa Loa (eye worm) RasGEF domain-containing protein 0.0008 0.0032 0.0038
Leishmania major pyruvate kinase 0.004 0.0701 0.0941
Loa Loa (eye worm) hypothetical protein 0.004 0.0701 0.0931
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.1056 0.2375
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0454 0.0577
Leishmania major DNA damage repair protein, putative 0.0013 0.0134 0.017
Leishmania major importin beta-1 subunit, putative 0.0028 0.0454 0.0605
Plasmodium vivax P-type ATPase4, putative 0.001 0.0084 0.0807
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.3463 0.3463
Trypanosoma cruzi proton motive ATPase 1, putative 0.001 0.0084 0.0072
Brugia malayi E1-E2 ATPase family protein 0.001 0.0084 0.0152
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0711 0.1356
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0134 0.017
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0036 0.0118
Schistosoma mansoni pyruvate kinase 0.004 0.0701 0.0701
Echinococcus granulosus transportin 1 0.0007 0.001 0.0007
Echinococcus multilocularis ETS transcription factor Elf 2 0.0013 0.0135 0.0132
Loa Loa (eye worm) hypothetical protein 0.0008 0.0032 0.0038
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.1056 0.1405
Mycobacterium ulcerans beta-lactamase 0.0039 0.0677 0.159
Schistosoma mansoni importin beta-1 0.0035 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0012 0.0124 0.0161
Echinococcus multilocularis myotubularin protein 13 0.0012 0.0124 0.0121
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.001 0.0084 0.038
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0008 0.0032 0.0028
Schistosoma mansoni ap endonuclease 0.0023 0.0341 0.0341
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1383 0.1383
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.1369 0.1852
Loa Loa (eye worm) hypothetical protein 0.0012 0.0124 0.0161
Brugia malayi diacylglycerol kinase 0.0012 0.0124 0.0228
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0036 0.0118
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0049 0.0874 0.1685
Brugia malayi beta-lactamase 0.0039 0.0677 0.1268
Loa Loa (eye worm) hypothetical protein 0.001 0.0084 0.0108
Echinococcus multilocularis phosphoserine phosphatase 0.001 0.0084 0.0081
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0894 0.0891
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.012 0.0918
Schistosoma mansoni atypical protein kinase C 0.0013 0.0132 0.0132
Trichomonas vaginalis cation-transporting ATPase, putative 0.001 0.0084 0.0337
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0008 0.0032 0.0144
Schistosoma mansoni DNA helicase recq5 0.0012 0.012 0.012
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.1056 0.1056
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0874 0.1177
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0124 0.0124
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0013 0.0135 0.0176
Mycobacterium tuberculosis Conserved protein 0.0039 0.0677 0.1288
Brugia malayi pyruvate kinase 0.0008 0.0049 0.0086
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.0344 0.0344
Toxoplasma gondii diacylglycerol kinase, putative 0.0012 0.0124 0.0949
Trypanosoma brucei DNA polymerase IV, putative 0.0073 0.1369 0.1852
Toxoplasma gondii haloacid dehalogenase family hydrolase domain-containing protein 0.001 0.0084 0.0643
Brugia malayi protein kinase C II. 0.0013 0.0132 0.0242
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.283 0.3773
Echinococcus granulosus protein kinase c iota type 0.0013 0.0132 0.0129
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2213 1
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.1056 0.1056
Loa Loa (eye worm) beta-lactamase 0.0039 0.0677 0.0899
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0092 0.0167
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0134 0.014
Echinococcus multilocularis snurportin 1 0.0372 0.7495 0.7494
Trichomonas vaginalis phospholipid-transporting ATPase, putative 0.001 0.0084 0.0337
Echinococcus granulosus Protein son of sevenless 0.0008 0.0032 0.0028
Loa Loa (eye worm) hypothetical protein 0.001 0.0084 0.0108
Loa Loa (eye worm) hypothetical protein 0.0011 0.0095 0.0122
Echinococcus multilocularis regulator of G protein signaling 7 0.0011 0.0095 0.0092
Mycobacterium tuberculosis Possible metal cation transporting P-type ATPase CtpH 0.001 0.0084 0.0093
Echinococcus granulosus calcium transporting ATPase type 2C member 0.001 0.0084 0.0081
Trypanosoma cruzi phospholipid-transporting ATPase-like protein, putative 0.001 0.0084 0.0072
Echinococcus multilocularis protein kinase c eta type 0.0012 0.0124 0.0121
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.2213 0.5059
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0036 0.0118
Loa Loa (eye worm) hypothetical protein 0.0035 0.0589 0.0781
Schistosoma mansoni ets-related 0.0013 0.0135 0.0135
Loa Loa (eye worm) pyruvate kinase 0.0008 0.0049 0.0061
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.3413 0.4636
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0036 0.0118
Schistosoma mansoni copper ABC transporter ATPase 0.001 0.0084 0.0084
Echinococcus multilocularis pyruvate kinase 0.0021 0.0299 0.0296
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0036 0.0118
Plasmodium vivax copper-transporting ATPase, putative 0.001 0.0084 0.0807
Loa Loa (eye worm) RasGEF domain-containing protein 0.0015 0.0177 0.0232
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2213 1
Echinococcus granulosus phospholipid transporting ATPase IIB 0.001 0.0084 0.0081
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0677 0.9617
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.002 0.0277 0.29
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0011 0.0095 0.0172
Schistosoma mansoni dep domain containing protein 0.0011 0.0095 0.0095
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0894 0.1189
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.7351 1
Trypanosoma cruzi Calcium ATPase SERCA-like 0.001 0.0084 0.0072
Echinococcus multilocularis ewsr:fli fusion protein type 0.0013 0.0135 0.0132
Schistosoma mansoni eyes absent homolog 0.0106 0.2056 0.2056
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.012 0.022
Schistosoma mansoni hypothetical protein 0.0013 0.0135 0.0135
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0008 0.0032 0.0144
Loa Loa (eye worm) hypothetical protein 0.0039 0.0677 0.0899
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0036 0.0118
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0341 0.1204
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0013 0.0135 0.0176
Echinococcus multilocularis segment polarity protein dishevelled 0.0011 0.0095 0.0092
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.3813 0.7608
Echinococcus granulosus raf serine:threonine protein kinase 0.0012 0.0124 0.0121
Toxoplasma gondii haloacid dehalogenase family hydrolase domain-containing protein 0.001 0.0084 0.0643
Brugia malayi RhoGEF domain containing protein 0.0012 0.0124 0.0228
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.2213 1
Schistosoma mansoni dishevelled 0.0011 0.0095 0.0095
Echinococcus granulosus myotubularin protein 13 0.0012 0.0124 0.0121
Loa Loa (eye worm) DIX domain-containing protein 0.0011 0.0095 0.0122
Echinococcus granulosus regulator of G protein signaling 7 0.0011 0.0095 0.0092
Echinococcus multilocularis ETS transcription factor Elf 5 0.0013 0.0135 0.0132
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0894 0.0894
Echinococcus multilocularis cation transporting ATPase 13A3 0.001 0.0084 0.0081
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.001 0.0084 0.0081
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.001 0.0084 0.0337
Trichomonas vaginalis cation-transporting ATPase, putative 0.001 0.0084 0.0337
Trichomonas vaginalis ATPase, class VI, type 11C, putative 0.001 0.0084 0.0337
Brugia malayi N-terminal motif family protein 0.0008 0.0032 0.0053
Brugia malayi polk-prov protein 0.0045 0.0793 0.1485
Mycobacterium tuberculosis Conserved protein 0.0039 0.0677 0.1288
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0134 0.014
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.1056 0.1053
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.001 0.0084 0.038
Brugia malayi diacylglycerol kinase 0.0012 0.0124 0.0228
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.012 0.0918
Echinococcus granulosus translational activator gcn1 0.0007 0.001 0.0007
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.0397 0.4651
Schistosoma mansoni bromodomain containing protein 0.0006 0.0003 0.0003
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0821 0.0818
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2213 1
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0701 0.1551
Schistosoma mansoni atpase class VI type 11c 0.001 0.0084 0.0084
Brugia malayi MH2 domain containing protein 0.0144 0.283 0.532
Echinococcus granulosus ETS domain containing protein Elk 1 0.0013 0.0135 0.0132
Echinococcus granulosus pyruvate kinase 0.0021 0.0299 0.0296
Brugia malayi Variant SH3 domain containing protein 0.0012 0.0124 0.0228
Trypanosoma brucei unspecified product 0.0028 0.0452 0.0601
Plasmodium falciparum DNA repair protein REV1, putative 0.0013 0.0134 0.1496
Loa Loa (eye worm) importin-beta domain-containing protein 0.0007 0.001 0.0009
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0341 0.3972
Schistosoma mansoni DNA polymerase eta 0.0072 0.1342 0.1342
Toxoplasma gondii phospholipid-translocating P-type ATPase, flippase subfamily protein 0.001 0.0084 0.0643
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0036 0.0118
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0052 0.0052
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0272 0.2077
Schistosoma mansoni hypothetical protein 0.0012 0.0124 0.0124
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.0469 0.0877
Onchocerca volvulus 0.0011 0.0095 0.0146
Brugia malayi hypothetical protein 0.0011 0.0095 0.0172
Schistosoma mansoni gabp alpha 0.0087 0.1668 0.1668
Echinococcus granulosus dnaJ subfamily C 6 0.0074 0.1391 0.1388
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0341 0.0337
Schistosoma mansoni cation-transporting ATPase 0.001 0.0084 0.0084
Brugia malayi RNA, U transporter 1 0.0099 0.1905 0.3578
Echinococcus multilocularis pyruvate kinase 0.004 0.0701 0.0698
Brugia malayi Na,K-ATPase alpha subunit 0.001 0.0084 0.0152
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.001 0.0084 0.0108
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0012 0.0127 0.0165
Echinococcus multilocularis transportin 1 0.0007 0.001 0.0007
Schistosoma mansoni protein kinase C mu 0.0013 0.0132 0.0132
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0677 0.1288
Trypanosoma brucei DNA polymerase eta, putative 0.0072 0.1342 0.1814
Brugia malayi mbt repeat family protein 0.0058 0.1056 0.198
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0008 0.0032 0.0032
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0041 0.0711 0.0708
Brugia malayi DIX domain containing protein 0.0011 0.0095 0.0172
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.001 0.0084 0.0337
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.1056 0.1053
Echinococcus multilocularis raf serine:threonine protein kinase 0.0012 0.0124 0.0121
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0008 0.0032 0.0144
Giardia lamblia Sgs1 DNA helicase, putative 0.0012 0.012 0.0169
Echinococcus multilocularis pyruvate kinase 0.0021 0.0299 0.0296
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0701 0.3135
Brugia malayi N-terminal motif family protein 0.0218 0.4344 0.8168
Brugia malayi MH1 domain containing protein 0.001 0.0076 0.0137
Loa Loa (eye worm) fli-1 protein 0.0265 0.5317 0.7093
Brugia malayi Ets-domain containing protein 0.0087 0.1668 0.3132
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0926 0.1222
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0677 0.0882
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.001 0.0084 0.0072
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.1369 0.1827
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.001 0.0084 0.038
Echinococcus multilocularis protein kinase c epsilon type 0.0013 0.0132 0.0129
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0012 0.012 0.1325
Schistosoma mansoni phosphoserine phosphatase 0.001 0.0084 0.0084
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0232 0.4622 0.462
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0894 0.1676
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0036 0.0118
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.001 0.0084 0.038
Trypanosoma brucei polo-like protein kinase 0.0114 0.2213 0.3001
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.001 0.0084 0.0152
Echinococcus granulosus protein C ets 2 0.0013 0.0135 0.0132
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.001 0.0084 0.0337
Loa Loa (eye worm) hypothetical protein 0.0075 0.1408 0.1874
Leishmania major hypothetical protein, conserved 0.0039 0.0677 0.0909
Trypanosoma brucei chrX additional, unordered contigs 0.0013 0.0134 0.017
Onchocerca volvulus 0.001 0.0084 0.0122
Loa Loa (eye worm) pyruvate kinase-PB 0.0028 0.0451 0.0597
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0008 0.0032 0.0099
Trypanosoma cruzi cation-transporting ATPase, putative 0.001 0.0084 0.0072
Toxoplasma gondii pyruvate kinase PyKII 0.0021 0.0299 0.2281
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0036 0.0118
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.001 0.0084 0.0337
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0677 0.1288
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0341 0.045
Echinococcus multilocularis segment polarity protein dishevelled 0.0011 0.0095 0.0092
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.001 0.0084 0.0081
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0192 0.0869
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0677 0.159
Toxoplasma gondii P-type ATPase4, putative 0.001 0.0084 0.0643
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0036 0.0118
Brugia malayi beta-lactamase family protein 0.0039 0.0677 0.1268
Echinococcus multilocularis dnaJ subfamily C 6 0.0074 0.1391 0.1388
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0008 0.0032 0.0144
Schistosoma mansoni cpg binding protein 0.0037 0.0626 0.0626
Mycobacterium ulcerans hypothetical protein 0.0013 0.0134 0.0135
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0076 0.0073
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0052 0.0048
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.1369 0.1852
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0701 0.1551
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.001 0.0084 0.0108
Echinococcus granulosus pyruvate kinase 0.004 0.0701 0.0698
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0073 0.1369 0.6169
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.001 0.0084 0.0081
Loa Loa (eye worm) hypothetical protein 0.0072 0.1342 0.1786
Leishmania major P-type H -ATPase, putative 0.001 0.0084 0.0101
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0049 0.0874 0.1177
Echinococcus multilocularis copper transporting ATPase 1 0.001 0.0084 0.0081
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2213 1
Echinococcus granulosus segment polarity protein dishevelled 0.0011 0.0095 0.0092
Schistosoma mansoni cpg binding protein 0.0035 0.0586 0.0586
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.1509 0.201
Loa Loa (eye worm) hypothetical protein 0.0012 0.0124 0.0161
Brugia malayi regulator of G-protein signaling egl-10 0.0011 0.0095 0.0172
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.1219 0.1216
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0076 0.0073
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.7351 1
Brugia malayi kap beta 3 protein 0.0007 0.001 0.0012
Echinococcus granulosus protein kinase c epsilon type 0.0013 0.0132 0.0129
Echinococcus granulosus son of sevenless 1 0.0008 0.0032 0.0028
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0132 0.0132
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0087 0.1668 0.2221
Echinococcus multilocularis protein kinase c iota type 0.0013 0.0132 0.0129
Brugia malayi MH2 domain containing protein 0.001 0.0076 0.0137
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0008 0.0032 0.0144
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0615 0.0824
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0711 0.1332
Brugia malayi CXXC zinc finger family protein 0.0035 0.0586 0.1096
Echinococcus granulosus ras GTP exchange factor 0.0008 0.0032 0.0028
Schistosoma mansoni type V p-type atpase isoform 0.001 0.0084 0.0084
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0012 0.0124 0.0121
Echinococcus multilocularis N chimaerin 0.0012 0.0127 0.0124
Plasmodium vivax pyruvate kinase, putative 0.004 0.0701 0.7507
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.001 0.0084 0.0101
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0454 0.2014
Brugia malayi potential phospholipid-transporting ATPase IIB, putative 0.001 0.0084 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0036 0.0118
Toxoplasma gondii hypothetical protein 0.0011 0.0095 0.0725
Echinococcus multilocularis phosphoserine phosphatase 0.001 0.0084 0.0081
Brugia malayi DNA-binding protein D-ETS-3 0.0013 0.0135 0.0248
Echinococcus multilocularis ETS transcription factor Elf 2 0.0013 0.0135 0.0132
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0677 0.0899
Brugia malayi pyruvate kinase, muscle isozyme 0.0008 0.0049 0.0086
Echinococcus multilocularis phosphoserine phosphatase 0.001 0.0084 0.0081
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0134 0.014
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0011 0.0095 0.0092
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.0008 0.0032 0.0099
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0021 0.0298 0.2273
Schistosoma mansoni ras GTP exchange factor 0.0008 0.0032 0.0032
Brugia malayi MH1 domain containing protein 0.001 0.0076 0.0137
Loa Loa (eye worm) hypothetical protein 0.0013 0.0135 0.0176
Echinococcus multilocularis pyruvate kinase 0.0032 0.0527 0.0524
Echinococcus multilocularis GA binding protein alpha chain 0.0087 0.1668 0.1665
Toxoplasma gondii pyruvate kinase PyK1 0.004 0.0701 0.535
Loa Loa (eye worm) hypothetical protein 0.0011 0.0095 0.0122
Echinococcus multilocularis phosphoserine phosphatase 0.001 0.0084 0.0081
Mycobacterium ulcerans hypothetical protein 0.0192 0.3813 1
Brugia malayi Smad1 0.001 0.0076 0.0137
Trypanosoma cruzi DNA polymerase eta, putative 0.0072 0.1342 0.1789
Schistosoma mansoni hypothetical protein 0.0074 0.1391 0.1391
Giardia lamblia Pyruvate kinase 0.004 0.0701 0.2896
Schistosoma mansoni protein kinase C mu 0.0012 0.0124 0.0124
Schistosoma mansoni hypothetical protein 0.0494 1 1
Echinococcus granulosus ETS transcription factor Elf 2 0.0013 0.0135 0.0132
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0008 0.0032 0.0144
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0013 0.0135 0.0132
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0134 0.017
Loa Loa (eye worm) hypothetical protein 0.0011 0.0095 0.0122
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0076 0.0097
Schistosoma mansoni hypothetical protein 0.0013 0.0135 0.0135
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.012 0.0117
Echinococcus granulosus segment polarity protein dishevelled 0.0011 0.0095 0.0092
Loa Loa (eye worm) hypothetical protein 0.001 0.0084 0.0108
Echinococcus granulosus pyruvate kinase 0.0021 0.0299 0.0296
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.1509 0.6818
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0134 0.014
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0232 0.4622 0.462
Toxoplasma gondii heavy metal translocating P-type ATPase subfamily protein 0.001 0.0084 0.0643
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0076 0.0097
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2213 1
Echinococcus granulosus Rac GTPase activating protein 1 0.0089 0.1695 0.1693
Plasmodium vivax DNA repair protein REV1, putative 0.0013 0.0134 0.1353
Echinococcus granulosus pyruvate kinase 0.0021 0.0299 0.0296
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0677 0.1288
Mycobacterium tuberculosis Probable cation transporter P-type ATPase D CtpD 0.001 0.0084 0.0093
Trypanosoma brucei P-type H+-ATPase, putative 0.001 0.0084 0.0101
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0586 0.0778
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.3413 0.4636
Entamoeba histolytica hypothetical protein 0.0012 0.0124 0.0562
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.012 0.0156
Echinococcus multilocularis dna polymerase eta 0.0072 0.1342 0.1339
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.1369 0.1852
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.001 0.0084 0.0892
Entamoeba histolytica HEAT repeat domain containing protein 0.0007 0.001 0.0045
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0677 0.0882
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0341 0.5
Loa Loa (eye worm) RasGEF domain-containing protein 0.0008 0.0032 0.0038
Schistosoma mansoni smad1 5 8 and 0.001 0.0076 0.0076
Echinococcus granulosus ewsr:fli fusion protein type 0.0013 0.0135 0.0132
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0677 0.1288
Toxoplasma gondii cation-transporting atpase family protein 0.001 0.0084 0.0643
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0341 0.15
Mycobacterium leprae Probable pyruvate kinase PykA 0.004 0.0701 1
Echinococcus multilocularis dnaJ subfamily B 0.0494 1 1
Brugia malayi ImpB/MucB/SamB family protein 0.0072 0.1342 0.2518
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0589 0.0586
Onchocerca volvulus 0.0039 0.0677 0.1497
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0036 0.0118
Onchocerca volvulus 0.0058 0.1056 0.2375
Plasmodium vivax importin-beta 2, putative 0.0035 0.0589 0.629
Trichomonas vaginalis ras GTP exchange factor, putative 0.0008 0.0032 0.0099
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0454 0.2014
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0008 0.0032 0.0032
Leishmania major DNA polymerase eta, putative 0.0043 0.0765 0.1029
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.012 0.0117
Loa Loa (eye worm) hypothetical protein 0.0146 0.2866 0.3821
Leishmania major DNA polymerase kappa, putative 0.0049 0.0874 0.1177
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0008 0.0032 0.0032
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.1369 0.1852
Schistosoma mansoni smad1 5 8 and 0.001 0.0076 0.0076
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.001 0.0084 0.0081
Echinococcus granulosus N chimaerin 0.0012 0.0127 0.0124
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.012 0.0117
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.3463 0.3461
Giardia lamblia DNA damage repair protein 0.0013 0.0134 0.0236
Trichomonas vaginalis esterase, putative 0.0039 0.0677 0.3028
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0821 0.0818
Trypanosoma brucei pyruvate kinase 1, putative 0.004 0.0701 0.0941
Loa Loa (eye worm) hypothetical protein 0.0039 0.0677 0.0899
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0013 0.0135 0.0135
Brugia malayi Ets-domain containing protein 0.0087 0.1668 0.3132
Echinococcus multilocularis ETS transcription factor Elf 1 0.0013 0.0135 0.0132
Echinococcus granulosus cation transporting ATPase 13A3 0.001 0.0084 0.0081
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.1156 0.1536
Onchocerca volvulus 0.0012 0.0124 0.0215
Brugia malayi hypothetical protein 0.001 0.0084 0.0152
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.1369 0.1852
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.1509 0.2833
Mycobacterium ulcerans hypothetical protein 0.0039 0.0677 0.159
Brugia malayi RhoGAP domain containing protein 0.0089 0.1695 0.3184
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.1509 0.1506
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0052 0.0048
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.1219 0.1219
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.001 0.0084 0.0084
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0701 0.3135
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0013 0.0132 0.0172
Schistosoma mansoni cation-transporting atpase worm 0.001 0.0084 0.0084
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0341 0.0609
Echinococcus granulosus unc 13 munc13 0.0012 0.0124 0.0121
Echinococcus granulosus snurportin 1 0.0372 0.7495 0.7494
Giardia lamblia DINP protein human, muc B family 0.0049 0.0874 0.3711
Echinococcus granulosus importin 5 0.0007 0.001 0.0007
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0012 0.0127 0.0127
Schistosoma mansoni unc-13 (munc13) 0.0012 0.0124 0.0124
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0894 0.0894
Mycobacterium ulcerans DNA polymerase IV 0.0073 0.1369 0.3446
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.001 0.0084 0.0101
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0132 0.0132
Leishmania major DNA polymerase kappa, putative 0.0013 0.0134 0.017
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0842 0.3805
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0589 0.0788
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0011 0.0095 0.0146
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.2213 0.295
Schistosoma mansoni hypothetical protein 0.0372 0.7495 0.7495
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.1509 0.2042
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0008 0.0032 0.0144
Entamoeba histolytica deoxycytidyl transferase, putative 0.0041 0.0711 0.3212
Toxoplasma gondii HEAT repeat-containing protein 0.0007 0.001 0.0076
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0041 0.0711 0.0708
Schistosoma mansoni ets-related 0.0265 0.5317 0.5317
Trichomonas vaginalis ras GTP exchange factor, putative 0.0008 0.0032 0.0099
Loa Loa (eye worm) hypothetical protein 0.0012 0.0124 0.0161
Schistosoma mansoni hypothetical protein 0.0355 0.7147 0.7147
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.001 0.0084 0.0337
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0926 0.1222
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0008 0.0032 0.0144
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.1509 0.2042
Echinococcus granulosus protein kinase c eta type 0.0012 0.0124 0.0121
Loa Loa (eye worm) hypothetical protein 0.0182 0.3615 0.4822
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0926 0.1248
Echinococcus granulosus Diacylglycerol kinase theta 0.0012 0.0124 0.0121
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0036 0.0118
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.001 0.0084 0.0337
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.093 0.7101
Loa Loa (eye worm) hypothetical protein 0.0012 0.012 0.0156
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0036 0.0118
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0013 0.0132 0.0129
Loa Loa (eye worm) kap beta 3 protein 0.0007 0.001 0.0009
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.001 0.0084 0.038
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.1369 0.1852
Echinococcus multilocularis importin 5 0.0007 0.001 0.0007
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.012 0.022
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0341 0.0687
Schistosoma mansoni rac gtpase activating protein 0.0089 0.1695 0.1695
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0615 0.0824
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.1509 0.2018
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0134 0.017
Echinococcus multilocularis cation transporting atpase worm 0.001 0.0084 0.0081
Echinococcus granulosus cation transporting ATPase 13A1 0.001 0.0084 0.0081
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.004 0.0701 0.1335
Brugia malayi RhoGAP domain containing protein 0.0077 0.1446 0.2715
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.1032 0.4641
Entamoeba histolytica diacylglycerol kinase, putative 0.0012 0.0124 0.0562
Brugia malayi Pyruvate kinase, muscle isozyme 0.004 0.0701 0.1312
Loa Loa (eye worm) hypothetical protein 0.0008 0.0032 0.0038
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0013 0.0132 0.0172
Plasmodium falciparum importin beta, putative 0.0035 0.0589 0.6955
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.1369 0.1827
Schistosoma mansoni DNA helicase recq1 0.0012 0.012 0.012
Trypanosoma cruzi P-type H+-ATPase, putative 0.001 0.0084 0.0072
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.001 0.0084 0.0072
Onchocerca volvulus 0.0039 0.0677 0.1497
Entamoeba histolytica hypothetical protein 0.0028 0.0454 0.205
Trichomonas vaginalis protein kinase inhibitor, putative 0.0074 0.1391 0.6269
Loa Loa (eye worm) pyruvate kinase 0.004 0.0701 0.0931
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0007 0.0024 0.0024
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0013 0.0132 0.0129
Echinococcus granulosus Protein kinase C brain isozyme 0.0013 0.0132 0.0129
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.2213 0.2213
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0013 0.0134 0.1026
Loa Loa (eye worm) hypothetical protein 0.0089 0.1695 0.2259
Trichomonas vaginalis DNA polymerase eta, putative 0.0073 0.1369 0.6169
Mycobacterium ulcerans lipase LipD 0.0039 0.0677 0.159
Echinococcus granulosus smad 0.001 0.0076 0.0073
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0677 0.1268
Brugia malayi N-terminal motif family protein 0.0008 0.0032 0.0053
Loa Loa (eye worm) hypothetical protein 0.0077 0.1446 0.1926
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0012 0.0124 0.0161
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0677 0.0674
Echinococcus multilocularis smad 0.001 0.0076 0.0073
Echinococcus granulosus Pleckstrin G protein interacting region 0.0011 0.0095 0.0092
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0341 0.045
Echinococcus multilocularis protein C ets 2 0.0013 0.0135 0.0132
Trichomonas vaginalis ATPase, class I, type 8B, putative 0.001 0.0084 0.0337
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.1219 0.2288
Leishmania major calcium-translocating P-type ATPase 0.001 0.0084 0.0101
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0341 0.045
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0013 0.0132 0.0172
Loa Loa (eye worm) pyruvate kinase 0.004 0.0701 0.0931
Loa Loa (eye worm) raf kinase 0.0012 0.0124 0.0161
Brugia malayi beta-lactamase family protein 0.0039 0.0677 0.1268
Echinococcus granulosus dna polymerase eta 0.0072 0.1342 0.1339
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.2213 0.2211
Loa Loa (eye worm) calcium ATPase 0.001 0.0084 0.0108
Loa Loa (eye worm) pyruvate kinase 0.004 0.0701 0.0931
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0076 0.0073
Trichomonas vaginalis cation-transporting ATPase, putative 0.001 0.0084 0.0337
Loa Loa (eye worm) acetyltransferase 0.0175 0.3463 0.4618
Brugia malayi E1-E2 ATPase family protein 0.001 0.0084 0.0152
Plasmodium falciparum pyruvate kinase 2 0.0021 0.0299 0.3471
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.1509 0.1506
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0095 0.0122
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0793 0.1066
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.001 0.0084 0.0152
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0701 0.0914
Schistosoma mansoni cation-transporting atpase worm 0.001 0.0084 0.0084
Brugia malayi protein kinase C3,putative 0.0013 0.0132 0.0242
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.001 0.0084 0.0072
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.093 0.0927
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0341 1
Mycobacterium tuberculosis Probable metal cation transporter ATPase P-type CtpE 0.001 0.0084 0.0093
Giardia lamblia Rho GAP, putative 0.0077 0.1446 0.6397
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0894 0.0891
Echinococcus granulosus importin subunit beta 1 0.0035 0.0589 0.0586
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.2213 0.298
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.1056 0.1053
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0701 0.0914
Mycobacterium tuberculosis Probable metal cation transporter P-type ATPase CtpV 0.001 0.0084 0.0093
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.7351 1
Onchocerca volvulus 0.0012 0.0124 0.0215
Trypanosoma brucei cation-transporting ATPase, putative 0.001 0.0084 0.0101
Trichomonas vaginalis cation-transporting ATPase, putative 0.001 0.0084 0.0337
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0677 0.3028
Brugia malayi DnaJ domain containing protein 0.0074 0.1391 0.2612
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0013 0.0132 0.0129
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0677 0.0674
Onchocerca volvulus 0.0012 0.0124 0.0215
Mycobacterium ulcerans pyruvate kinase 0.004 0.0701 0.1653
Entamoeba histolytica cation-transporting P-typeATPase, putative 0.001 0.0084 0.038
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.001 0.0084 0.038
Brugia malayi mbt repeat family protein 0.0058 0.1056 0.198
Mycobacterium ulcerans DNA polymerase IV 0.0073 0.1369 0.3446
Loa Loa (eye worm) hypothetical protein 0.0012 0.0124 0.0161
Mycobacterium tuberculosis Possible penicillin-binding protein 0.025 0.5 1
Brugia malayi Ets-domain containing protein 0.0013 0.0135 0.0248
Schistosoma mansoni unc-13 (munc13) 0.0012 0.0124 0.0124

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 3.27 uM PUBCHEM_BIOASSAY: Identification of SV40 T antigen inhibitors: A route to novel anti-viral reagents. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1909, AID2102, AID2501, AID2615, AID2775, AID449729, AID485276, AID485288] ChEMBL. No reference
IC50 (functional) 13.86 uM PubChem BioAssay. Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory Screens. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) = 2.2387 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.3778 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK). (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Leishmania Mexicana Pyruvate Kinase (LmPK). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.8184 uM PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.9935 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1: Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485292] ChEMBL. No reference
Potency (functional) 4.4668 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 8.4368 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Kappa: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.9173 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.8876 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 26.8545 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 30.1313 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 32.6427 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 37.933 uM PubChem BioAssay. qHTS Assay for the Inhibitors of FEN1: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485342, AID485388] ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 67.0158 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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