Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0066 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.7228 | 0.7228 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.7228 | 0.7228 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.7228 | 0.7228 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.7228 | 0.7228 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.3882 | 0.3882 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.3882 | 0.3882 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.3882 | 0.3882 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: Confirmation qHTS Assay for Inhibitors of Cruzain. (Class of assay: confirmatory) [Related pubchem assays: 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1476 (cruzain qHTS without detergent), 1478 (cruzain qHTS with detergent)] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.