Detailed information for compound 142284

Basic information

Technical information
  • TDR Targets ID: 142284
  • Name: 2-[(4S)-3-oxo-8-[3-(pyridin-2-ylamino)propoxy ]-2-(2,2,2-trifluoroethyl)-4,5-dihydro-1H-2-b enzazepin-4-yl]acetic acid
  • MW: 451.439 | Formula: C22H24F3N3O4
  • H donors: 2 H acceptors: 4 LogP: 3.1 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C[C@@H]1Cc2ccc(cc2CN(C1=O)CC(F)(F)F)OCCCNc1ccccn1
  • InChi: 1S/C22H24F3N3O4/c23-22(24,25)14-28-13-17-11-18(32-9-3-8-27-19-4-1-2-7-26-19)6-5-15(17)10-16(21(28)31)12-20(29)30/h1-2,4-7,11,16H,3,8-10,12-14H2,(H,26,27)(H,29,30)/t16-/m0/s1
  • InChiKey: PVDGZHKJXXVONO-INIZCTEOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(4S)-3-oxo-8-[3-(2-pyridylamino)propoxy]-2-(2,2,2-trifluoroethyl)-4,5-dihydro-1H-2-benzazepin-4-yl]acetic acid
  • 2-[(4S)-3-oxo-8-[3-(pyridin-2-ylamino)propoxy]-2-(2,2,2-trifluoroethyl)-4,5-dihydro-1H-2-benzazepin-4-yl]ethanoic acid
  • 2-[(4S)-3-keto-8-[3-(2-pyridylamino)propoxy]-2-(2,2,2-trifluoroethyl)-4,5-dihydro-1H-2-benzazepin-4-yl]acetic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens integrin, alpha V References
Homo sapiens integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) Starlite/ChEMBL References
Homo sapiens integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum IPR013513,Integrin alpha chain, C-terminal cytoplasmic region,domain-containing Get druggable targets OG5_129341 All targets in OG5_129341
Echinococcus multilocularis integrin alpha 3 Get druggable targets OG5_129341 All targets in OG5_129341
Schistosoma japonicum Integrin beta-3 precursor, putative Get druggable targets OG5_127959 All targets in OG5_127959
Loa Loa (eye worm) integrin alpha pat-2 Get druggable targets OG5_129341 All targets in OG5_129341
Brugia malayi Integrin alpha pat-2 precursor Get druggable targets OG5_129341 All targets in OG5_129341
Schistosoma japonicum ko:K06476 integrin alpha 2B, putative Get druggable targets OG5_129341 All targets in OG5_129341
Echinococcus granulosus integrin alpha 3 Get druggable targets OG5_129341 All targets in OG5_129341
Echinococcus multilocularis integrin beta 2 Get druggable targets OG5_127959 All targets in OG5_127959
Loa Loa (eye worm) integrin beta-2 Get druggable targets OG5_127959 All targets in OG5_127959
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129341 All targets in OG5_129341
Schistosoma mansoni integrin beta subunit Get druggable targets OG5_127959 All targets in OG5_127959
Schistosoma japonicum Integrin beta-PS precursor, putative Get druggable targets OG5_127959 All targets in OG5_127959
Schistosoma japonicum ko:K06464 integrin beta 2, putative Get druggable targets OG5_127959 All targets in OG5_127959
Schistosoma mansoni integrin alpha Get druggable targets OG5_129341 All targets in OG5_129341
Brugia malayi Integrin beta pat-3 precursor Get druggable targets OG5_127959 All targets in OG5_127959
Echinococcus granulosus integrin beta 2 Get druggable targets OG5_127959 All targets in OG5_127959
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129341 All targets in OG5_129341
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis integrin alpha ps integrin, alpha V 1002 aa 908 aa 22.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) neuropeptide F receptor 0.0013 0.0003 0.0003
Brugia malayi hypothetical protein 0.0013 0.0003 0.0003
Brugia malayi MH1 domain containing protein 0.0017 0.0025 0.0025
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.002 0.0042 0.0042
Brugia malayi conserved hypotetical protein 0.0018 0.0031 0.0031
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0039 0.0136 0.0136
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0027 0.011
Echinococcus multilocularis peregrin 0.0036 0.012 0.012
Echinococcus granulosus neuropeptide receptor 0.0013 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Echinococcus granulosus geminin 0.0187 0.0898 0.0898
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0027 0.011
Echinococcus granulosus sodium:glucose cotransporter 0.004 0.014 0.014
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0211 0.0211
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0027 0.011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0031
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0037 0.0216
Brugia malayi hypothetical protein 0.002 0.0038 0.0038
Brugia malayi nuclear receptor NHR-88 0.0018 0.0031 0.0031
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0019 0.0108
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Brugia malayi Frizzled/Smoothened family membrane region containing protein 0.0016 0.0021 0.0021
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0105 0.0807
Echinococcus multilocularis potassium channel subfamily K 8 0.0118 0.0543 0.0543
Loa Loa (eye worm) hypothetical protein 0.0043 0.0159 0.0159
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0032 0.0095
Loa Loa (eye worm) hypothetical protein 0.0359 0.1777 0.1777
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0037 0.0148
Schistosoma mansoni metabotropic glutamate receptor 0.0043 0.0156 0.0154
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0031
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0636 0.3197 1
Loa Loa (eye worm) TWK-28 protein 0.0118 0.0543 0.0543
Onchocerca volvulus 0.0013 0.0003 0.0011
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0315 0.0313
Plasmodium falciparum potassium channel 0.0118 0.0543 0.1695
Leishmania major 4-coumarate:coa ligase-like protein 0.0169 0.0804 0.4914
Giardia lamblia Hypothetical protein 0.0118 0.0543 1
Schistosoma mansoni twik family of potassium channels-related 0.0118 0.0543 0.0542
Echinococcus granulosus cpg binding protein 0.006 0.0245 0.0245
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0495 0.2475 0.7734
Onchocerca volvulus 0.0013 0.0003 0.0011
Loa Loa (eye worm) neuropeptide F receptor 0.0013 0.0003 0.0003
Trichomonas vaginalis bromodomain-containing protein, putative 0.0088 0.0387 0.1556
Onchocerca volvulus 0.0013 0.0003 0.0011
Entamoeba histolytica hypothetical protein 0.0187 0.0898 0.8686
Loa Loa (eye worm) hypothetical protein 0.0039 0.0137 0.0137
Loa Loa (eye worm) CYP4Cod1 0.0014 0.0011 0.0011
Echinococcus granulosus FTZ F1 alpha 0.0039 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0137 0.0552
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0022 0.0022
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0234 0.0941
Onchocerca volvulus 0.0118 0.0543 0.2186
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0169 0.0804 0.2489
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0475 0.1458
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.023 0.1117 0.6831
Loa Loa (eye worm) hypothetical protein 0.0025 0.0068 0.0068
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0173 0.0173
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0037 0.0037
Echinococcus granulosus potassium channel subfamily K 8 0.0118 0.0543 0.0543
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0035 0.0035
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 35 0.0118 0.0543 0.0543
Brugia malayi hypothetical protein 0.0118 0.0543 0.0543
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0018 0.0031 0.003
Schistosoma mansoni hypothetical protein 0.0098 0.0438 0.0437
Schistosoma mansoni polycystin 1-related 0.002 0.0038 0.0037
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.023 0.1117 0.6831
Schistosoma mansoni rab6-interacting 0.002 0.0038 0.0037
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0335 0.1347
Loa Loa (eye worm) hypothetical protein 0.029 0.1424 0.1424
Schistosoma mansoni frizzled-like receptor 0.0016 0.0021 0.0019
Plasmodium vivax cyclophilin, putative 0.0023 0.0057 0.0174
Plasmodium vivax SET domain protein, putative 0.0064 0.0264 0.0822
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0039 0.0136 0.0136
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0219 0.0219
Schistosoma mansoni sodium/solute symporter 0.004 0.014 0.0139
Brugia malayi hypothetical protein 0.003 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.003 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0335 0.1347
Schistosoma mansoni frizzled 0.0016 0.0021 0.0019
Schistosoma mansoni acetyl-CoA synthetase 0.005 0.0192 0.019
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0098 0.0438 0.0438
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0013 0.0003 0.0001
Schistosoma mansoni twik family of potassium channels-related 0.0118 0.0543 0.0542
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0003 0.0001
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0012 0.0001 0.0001
Echinococcus multilocularis somatostatin receptor 0.0013 0.0003 0.0003
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0025 0.0025
Echinococcus multilocularis twik family of potassium channels 0.0118 0.0543 0.0543
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0039 0.0136 0.0136
Onchocerca volvulus 0.005 0.0192 0.0772
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0137 0.0552
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0003 0.0003
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0088 0.0387 0.7119
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0192 0.0568
Schistosoma mansoni integrin alpha 0.0369 0.183 0.1829
Leishmania major cathepsin L-like protease 0.0018 0.0027 0.0158
Echinococcus multilocularis beta adrenergic receptor kinase 0.0039 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.005 0.0192 0.0192
Schistosoma mansoni hypothetical protein 0.0028 0.0082 0.0081
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0146 0.0685 0.0685
Onchocerca volvulus 0.0018 0.0027 0.011
Onchocerca volvulus 0.005 0.0192 0.0772
Echinococcus multilocularis neuropeptides capa receptor 0.0013 0.0003 0.0003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0146 0.0685 0.0685
Echinococcus multilocularis serotonin receptor 0.0013 0.0003 0.0003
Echinococcus granulosus small conductance calcium activated potassium 0.0118 0.0543 0.0543
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0013 0.0003 0.0003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.028 0.1704
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0169 0.0804 0.2489
Loa Loa (eye worm) acetyltransferase 0.0298 0.1465 0.1465
Schistosoma mansoni hypothetical protein 0.0053 0.0211 0.0209
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.0444 0.4284
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0003 0.0001
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0027 0.0081
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0003 0.0003
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.023 0.1117 0.6831
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0035 0.0134
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0038 0.0038
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0039 0.0136 0.0135
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0019 0.0108
Echinococcus multilocularis 0.0014 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0118 0.0543 0.0543
Brugia malayi PXA domain containing protein 0.0039 0.0137 0.0137
Loa Loa (eye worm) fibroinase 0.0018 0.0027 0.0027
Loa Loa (eye worm) TYRA-2 protein 0.0013 0.0003 0.0003
Brugia malayi PXA domain containing protein 0.0039 0.0137 0.0137
Echinococcus multilocularis fmrfamide receptor 0.0013 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0054 0.0213 0.0213
Loa Loa (eye worm) hypothetical protein 0.0118 0.0543 0.0543
Brugia malayi DNA-directed RNA polymerase II second largest subunit, putative 0.0012 0.0002 0.0002
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.005 0.0192 0.1166
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0031
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0037 0.0081
Loa Loa (eye worm) phosphofructokinase 0.0214 0.1034 0.1034
Schistosoma mansoni topbp1 0.003 0.0093 0.0091
Brugia malayi hypothetical protein 0.0018 0.0031 0.0031
Toxoplasma gondii cytochrome p450 superfamily protein 0.0014 0.0011 0.0201
Schistosoma mansoni amine GPCR 0.0013 0.0003 0.0001
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0018 0.0031 0.0031
Toxoplasma gondii ATPase, AAA family protein 0.003 0.0093 0.1704
Echinococcus multilocularis integrin alpha 3 0.0283 0.1389 0.1389
Echinococcus granulosus expressed protein 0.0023 0.0057 0.0057
Plasmodium vivax 6-phosphofructokinase, putative 0.0058 0.0234 0.0727
Echinococcus granulosus frizzled 0.0016 0.0021 0.0021
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0169 0.0804 0.6787
Plasmodium vivax acyl-CoA synthetase, putative 0.0126 0.0585 0.1826
Schistosoma mansoni opsin-like receptor 0.0013 0.0003 0.0001
Brugia malayi hypothetical protein 0.0013 0.0003 0.0003
Leishmania major cytochrome p450-like protein 0.0014 0.0011 0.0057
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.005 0.0192 0.0568
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0004 0.0014
Loa Loa (eye worm) cysteine protease 0.0018 0.0027 0.0027
Brugia malayi hypothetical protein 0.0187 0.0898 0.0898
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.003 0.0093 0.0231
Loa Loa (eye worm) glutathione reductase 0.0046 0.0173 0.0173
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39A 0.0118 0.0543 0.0543
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0088 0.0387 0.1205
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.0444 0.0444
Mycobacterium ulcerans transmembrane cation transporter 0.0118 0.0543 0.1671
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0125 0.0502
Echinococcus granulosus bloom syndrome protein 0.0021 0.0045 0.0045
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0013 0.0003 0.0001
Toxoplasma gondii histone lysine methyltransferase SET1 0.0117 0.0539 0.9914
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0013 0.0003 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0216
Brugia malayi hypothetical protein 0.0039 0.0137 0.0137
Trypanosoma cruzi calpain cysteine peptidase, putative 0.023 0.1117 0.6831
Loa Loa (eye worm) hypothetical protein 0.0118 0.0543 0.0543
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0027 0.0158
Onchocerca volvulus Protein ultraspiracle homolog 0.0039 0.0136 0.0548
Trichomonas vaginalis phosphofructokinase, putative 0.0214 0.1034 0.4161
Loa Loa (eye worm) hypothetical protein 0.0039 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.003 0.0093 0.0093
Brugia malayi phosphofructokinase 0.0214 0.1034 0.1034
Echinococcus multilocularis Smad4 0.0017 0.0025 0.0025
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0309 0.152 0.152
Echinococcus granulosus lamin 0.0055 0.0219 0.0219
Onchocerca volvulus 0.0039 0.0136 0.0548
Brugia malayi AMP-binding enzyme family protein 0.005 0.0192 0.0192
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0013 0.0003 0.0003
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.005 0.0192 0.1166
Brugia malayi photoreceptor-specific nuclear receptor 0.0039 0.0136 0.0136
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.0136 0.0136
Brugia malayi AMP-binding enzyme family protein 0.0169 0.0804 0.0804
Brugia malayi G protein-coupled receptor F59B2.13 0.0013 0.0003 0.0003
Trichomonas vaginalis antibiotic synthetase, putative 0.005 0.0192 0.0772
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0035 0.0104
Echinococcus multilocularis TWiK family of potassium channels protein 7 0.0118 0.0543 0.0543
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0004 0.0014
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0234 0.0941
Loa Loa (eye worm) hypothetical protein 0.0169 0.0804 0.0804
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.005 0.0192 0.0568
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.005 0.0192 0.0568
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0173 0.0173
Schistosoma mansoni hypothetical protein 0.0041 0.0147 0.0145
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0039 0.0137 0.0137
Brugia malayi hypothetical protein 0.0013 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0187 0.0898 0.8686
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0093 0.0557
Echinococcus granulosus frizzled 4 0.0016 0.0021 0.0021
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0038 0.0038
Echinococcus granulosus neuropeptide receptor 0.0013 0.0003 0.0003
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0013 0.0003 0.0003
Onchocerca volvulus 0.0118 0.0543 0.2186
Entamoeba histolytica fatty acid elongase, putative 0.0083 0.0361 0.3479
Schistosoma mansoni intermediate filament proteins 0.0055 0.0219 0.0217
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0264 0.0264
Loa Loa (eye worm) integrin alpha pat-2 0.0569 0.2855 0.2855
Plasmodium falciparum DNA-directed RNA polymerase subunit beta, putative 0.0066 0.0275 0.0856
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0061 0.0249 0.0749
Echinococcus granulosus dnaJ subfamily B 0.1243 0.631 0.631
Echinococcus multilocularis sodium:glucose cotransporter 2 0.004 0.014 0.014
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Toxoplasma gondii ABC1 family protein 0.0077 0.0335 0.6161
Leishmania major cathepsin L-like protease 0.0018 0.0027 0.0158
Echinococcus granulosus integrin beta 2 0.028 0.1374 0.1374
Echinococcus granulosus neuropeptide Y receptor 0.0013 0.0003 0.0003
Toxoplasma gondii ion channel protein 0.0118 0.0543 1
Leishmania major cathepsin L-like protease 0.0018 0.0027 0.0158
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0039 0.0136 0.0135
Loa Loa (eye worm) G-protein coupled receptor 0.0013 0.0003 0.0003
Brugia malayi nuclear hormone receptor 0.0039 0.0136 0.0136
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0105 0.0296
Plasmodium vivax replication factor C subunit 1, putative 0.003 0.0093 0.0285
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.005 0.0192 0.1166
Brugia malayi Latrophilin receptor protein 2 0.0098 0.0438 0.0438
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0137 0.0136
Brugia malayi acetyltransferase, GNAT family protein 0.0298 0.1465 0.1465
Brugia malayi GnHR receptor homolog 0.0013 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0041 0.0147 0.0145
Loa Loa (eye worm) melatonin receptor type 1A 0.0013 0.0003 0.0003
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.0444 0.0444
Brugia malayi hypothetical protein 0.0013 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Brugia malayi CXXC zinc finger family protein 0.0057 0.0229 0.0229
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0027 0.0026
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.005 0.0192 0.0192
Brugia malayi Frizzled/Smoothened family membrane region containing protein 0.0016 0.0021 0.0021
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0038 0.0038
Leishmania major hypothetical protein, conserved 0.0025 0.0064 0.038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.028 0.1704
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.004 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0118 0.0543 0.0543
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0137 0.0137
Loa Loa (eye worm) integrin beta-2 0.0378 0.1876 0.1876
Entamoeba histolytica fatty acid elongase, putative 0.0083 0.0361 0.3479
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0027 0.011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0003 0.0003
Onchocerca volvulus 0.0013 0.0003 0.0011
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0192 0.0568
Loa Loa (eye worm) G-protein coupled receptor 0.0013 0.0003 0.0003
Echinococcus granulosus neuropeptides capa receptor 0.0013 0.0003 0.0003
Plasmodium vivax acetyl-CoA synthetase, putative 0.005 0.0192 0.0596
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.001
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0058 0.0234 0.2249
Onchocerca volvulus 0.0064 0.0264 0.1063
Schistosoma mansoni twik family of potassium channels-related 0.0118 0.0543 0.0542
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0039 0.0136 0.0136
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.023 0.1117 0.6831
Echinococcus granulosus neuropeptide receptor A26 0.0013 0.0003 0.0003
Onchocerca volvulus 0.0118 0.0543 0.2186
Brugia malayi GH02984p 0.0359 0.1777 0.1777
Echinococcus multilocularis nuclear receptor nhr 48 0.0018 0.0031 0.0031
Echinococcus multilocularis neuropeptide FF receptor 2 0.0013 0.0003 0.0003
Brugia malayi sulfakinin receptor protein 0.0013 0.0003 0.0003
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0098 0.0438 0.0438
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0027 0.011
Mycobacterium ulcerans acyl-CoA synthetase 0.0169 0.0804 0.2489
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.028 0.1704
Brugia malayi regulator of G-protein signaling egl-10 0.0039 0.0137 0.0137
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0018 0.0031 0.0126
Schistosoma mansoni calcium-activated potassium channel 0.0118 0.0543 0.0542
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0039 0.0136 0.0136
Brugia malayi Pre-SET motif family protein 0.0064 0.0264 0.0264
Entamoeba histolytica acyl-coA synthetase, putative 0.0169 0.0804 0.777
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0093 0.0372
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0137 0.0136
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0173 0.1052
Trypanosoma cruzi cytochrome P450, putative 0.0014 0.0011 0.0057
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0003 0.0001
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0019 0.0019
Onchocerca volvulus 0.0013 0.0003 0.0011
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0037 0.0081
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0137 0.0136
Echinococcus granulosus g protein coupled receptor 0.0013 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0023
Schistosoma mansoni twik family of potassium channels-related 0.0118 0.0543 0.0542
Loa Loa (eye worm) hypothetical protein 0.0077 0.0335 0.0335
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0037 0.0216
Echinococcus multilocularis neuropeptide receptor A26 0.0013 0.0003 0.0003
Loa Loa (eye worm) AMP-binding enzyme family protein 0.005 0.0192 0.0192
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0003 0.0001
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0073 0.0073
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.028 0.1704
Schistosoma mansoni hypothetical protein 0.0014 0.001 0.0009
Echinococcus granulosus dna polymerase eta 0.0019 0.0037 0.0037
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0039 0.0136 0.0135
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0023 0.0057 0.034
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0118 0.0543 0.3318
Entamoeba histolytica acetyltransferase, GNAT family 0.008 0.0349 0.3368
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0037 0.0216
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0019 0.0026
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.005 0.0192 0.1549
Loa Loa (eye worm) hypothetical protein 0.0118 0.0543 0.0543
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.005 0.0192 0.3532
Brugia malayi hypothetical protein 0.0129 0.0599 0.0599
Schistosoma mansoni amine GPCR 0.0013 0.0003 0.0001
Brugia malayi Cathepsin L-like precursor 0.0018 0.0027 0.0027
Schistosoma mansoni hypothetical protein 0.0079 0.0344 0.0343
Brugia malayi regulator of G-protein signaling rgs-7 0.0039 0.0137 0.0137
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0039 0.0136 0.0136
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0335 0.1347
Echinococcus multilocularis nibrin 0.003 0.0093 0.0093
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0027 0.011
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0118 0.0543 0.3318
Mycobacterium ulcerans 6-phosphofructokinase 0.0214 0.1034 0.3211
Loa Loa (eye worm) hypothetical protein 0.0098 0.0438 0.0438
Echinococcus granulosus Smad4 0.0017 0.0025 0.0025
Schistosoma mansoni integrin alpha-ps 0.0166 0.0786 0.0785
Schistosoma mansoni tar DNA-binding protein 0.0265 0.1294 0.1292
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.0335 0.0335
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0013 0.0003 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.028 0.1704
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0031 0.0031
Schistosoma mansoni biogenic amine receptor 0.0013 0.0003 0.0001
Echinococcus multilocularis replication factor c subunit 1 0.003 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0043 0.0157 0.0457
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0027 0.011
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.005 0.0192 0.1166
Loa Loa (eye worm) 6-phosphofructokinase 0.0214 0.1034 0.1034
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0039 0.0136 0.0135
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0082 0.1517
Brugia malayi Integrin beta pat-3 precursor 0.0378 0.1876 0.1876
Onchocerca volvulus 0.0018 0.0027 0.011
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0107 0.0488 0.0488
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0042 0.0042
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0018 0.0031 0.0126
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0118 0.0543 0.2186
Echinococcus multilocularis dro:myosuppressin receptor 0.0013 0.0003 0.0003
Brugia malayi Serotonin receptor 0.0013 0.0003 0.0003
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0118 0.0543 0.2186
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog 0.0118 0.0543 0.0543
Onchocerca volvulus 0.0013 0.0003 0.0011
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0214 0.1034 0.6324
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0018 0.0031 0.0031
Echinococcus granulosus smoothened 0.0361 0.1788 0.1788
Trichomonas vaginalis phosphofructokinase, putative 0.0214 0.1034 0.4161
Echinococcus granulosus tm gpcr rhodopsin 0.0013 0.0003 0.0003
Brugia malayi RNA binding protein 0.0265 0.1294 0.1294
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0039 0.0136 0.0136
Loa Loa (eye worm) inositol-1 0.0037 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0118 0.0543 0.0543
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0234 0.0941
Echinococcus multilocularis Regulator of G protein signaling 20 0.0039 0.0137 0.0137
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.0335 0.1016
Schistosoma mansoni adenoreceptor 0.0013 0.0003 0.0001
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0039 0.0136 0.0135
Brugia malayi hypothetical protein 0.0013 0.0003 0.0003
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0031 0.003
Echinococcus granulosus 7TM GPCR rhodopsin 0.0013 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0004 0.0014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.028 0.1704
Loa Loa (eye worm) hypothetical protein 0.0025 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0118 0.0543 0.0543
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0058 0.0234 0.0727
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0037 0.0341
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0636 0.3197 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Schistosoma mansoni biogenic amine receptor 0.0013 0.0003 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0137 0.0552
Brugia malayi DNA-directed RNA polymerase III subunit 127.6 kDa polypeptide 0.0012 0.0002 0.0002
Echinococcus granulosus metabotropic glutamate receptor 2 0.0073 0.0312 0.0312
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0061 0.0249 0.1518
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0125 0.2298
Loa Loa (eye worm) hypothetical protein 0.0039 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0118 0.0543 0.0543
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Schistosoma mansoni amine GPCR 0.0013 0.0003 0.0001
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0019 0.0108
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0636 0.3197 1
Onchocerca volvulus 0.0023 0.0057 0.0229
Loa Loa (eye worm) hypothetical protein 0.0042 0.0155 0.0155
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0192 0.0568
Schistosoma mansoni neuropeptide receptor 0.0013 0.0003 0.0001
Onchocerca volvulus 0.0013 0.0003 0.0011
Plasmodium falciparum histone acetyltransferase GCN5 0.008 0.0349 0.1088
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Echinococcus multilocularis 6 phosphofructokinase 0.0214 0.1034 0.1034
Loa Loa (eye worm) cytochrome P450 family protein 0.0053 0.0211 0.0211
Brugia malayi nuclear receptor NHR-88 0.0039 0.0136 0.0136
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0137 0.0136
Echinococcus multilocularis dna polymerase eta 0.0019 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0261 0.1277 0.1277
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0019 0.0354
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0216
Echinococcus granulosus GPCR family 2 0.0098 0.0438 0.0438
Brugia malayi hypothetical protein 0.0025 0.0064 0.0064
Brugia malayi Dopamine receptor protein 1 0.0013 0.0003 0.0003
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.005 0.0192 0.0568
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0027 0.011
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0137 0.0137
Echinococcus granulosus Two pore potassium channel protein sup 9 0.1963 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0013 0.0003 0.0003
Echinococcus granulosus biogenic amine 5HT receptor 0.0013 0.0003 0.0003
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0137 0.0137
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0335 0.1347
Trypanosoma brucei unspecified product 0.0013 0.0006 0.0027
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.005 0.0192 0.0192
Schistosoma mansoni cpg binding protein 0.0057 0.0229 0.0227
Schistosoma mansoni zinc finger protein 0.0018 0.0031 0.003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0019 0.0108
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0013 0.0003 0.0003
Brugia malayi beta-lactamase family protein 0.0077 0.0335 0.0335
Loa Loa (eye worm) hypothetical protein 0.0118 0.0543 0.0543
Echinococcus granulosus G protein coupled receptor 139 0.0013 0.0003 0.0003
Loa Loa (eye worm) cyclophilin-type peptidyl-prolyl cis-trans isomerase-2 0.0023 0.0057 0.0057
Schistosoma mansoni tar DNA-binding protein 0.0265 0.1294 0.1292
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0027 0.011
Loa Loa (eye worm) RGS-3 protein 0.0039 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0126 0.0585 0.0585
Brugia malayi Receptor family ligand binding region containing protein 0.0022 0.0052 0.0052
Brugia malayi hypothetical protein 0.0057 0.0232 0.0232
Echinococcus granulosus solute carrier family 5 0.004 0.014 0.014
Entamoeba histolytica phosphofructokinase, putative 0.0214 0.1034 1
Loa Loa (eye worm) hypothetical protein 0.0118 0.0543 0.0543
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.0335 0.1016
Echinococcus granulosus frizzled 0.0016 0.0021 0.0021
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0027 0.0081
Brugia malayi hypothetical protein 0.0118 0.0543 0.0543
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0058 0.0234 0.0675
Brugia malayi nuclear receptor RXR 0.002 0.0042 0.0042
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0013 0.0003 0.0003
Echinococcus multilocularis frizzled 0.0016 0.0021 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.0136 0.0136
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.0452 0.045
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0014 0.001 0.0027
Onchocerca volvulus 0.0055 0.0219 0.088
Echinococcus granulosus Regulator of G protein signaling 20 0.0039 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0118 0.0543 0.0543
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0146 0.0685 0.0685
Trypanosoma brucei unspecified product 0.0019 0.0037 0.0216
Loa Loa (eye worm) hypothetical protein 0.0118 0.0543 0.0543
Brugia malayi CHE-14 protein 0.0042 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0126 0.0585 0.0585
Echinococcus granulosus GPCR family 3 C terminal 0.0014 0.001 0.001
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0173 0.051
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0019 0.0055
Echinococcus multilocularis g protein coupled receptor 0.0013 0.0003 0.0003
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0004 0.0014
Echinococcus multilocularis lamin dm0 0.0055 0.0219 0.0219
Echinococcus multilocularis dnaJ subfamily B 0.1243 0.631 0.631
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0137 0.0137
Leishmania major hypothetical protein, conserved 0.0077 0.0335 0.204
Echinococcus granulosus DNA directed RNA polymerase II subunit RPB2 0.0012 0.0002 0.0002
Echinococcus granulosus regulator of G protein signaling 7 0.0039 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0039 0.0137 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0004 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0093 0.0372
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0192 0.0568
Echinococcus multilocularis thyroid hormone receptor alpha 0.0039 0.0136 0.0136
Mycobacterium ulcerans acyl-CoA synthetase 0.0169 0.0804 0.2489
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0019 0.0018
Plasmodium falciparum glutathione reductase 0.0016 0.0019 0.0055
Echinococcus multilocularis DNA directed RNA polymerase I subunit RPA2 0.0012 0.0002 0.0002
Trypanosoma brucei cytochrome P450, putative 0.0014 0.0011 0.0057
Onchocerca volvulus Neuropeptide F receptor homolog 0.0013 0.0003 0.0011
Brugia malayi hypothetical protein 0.0013 0.0003 0.0003
Mycobacterium ulcerans beta-lactamase 0.0077 0.0335 0.1016
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0058 0.0234 0.4303
Echinococcus granulosus survival motor neuron protein 1 0.0261 0.1277 0.1277
Loa Loa (eye worm) hypothetical protein 0.0118 0.0543 0.0543
Trichomonas vaginalis phosphofructokinase, putative 0.0214 0.1034 0.4161
Brugia malayi nuclear hormone receptor 0.0018 0.0031 0.0031
Schistosoma mansoni RAR-like nuclear receptor 0.0039 0.0136 0.0135
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Chlamydia trachomatis DNA-directed RNA polymerase subunit beta 0.0242 0.1179 0.3651
Loa Loa (eye worm) hypothetical protein 0.0118 0.0543 0.0543
Trichomonas vaginalis esterase, putative 0.0077 0.0335 0.1347
Echinococcus granulosus tachykinin peptides receptor 99D 0.0013 0.0003 0.0003
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.003 0.0093 0.0372
Leishmania major potassium channel subunit-like protein 0.0118 0.0543 0.3318
Echinococcus granulosus replication factor c subunit 1 0.003 0.0093 0.0093
Plasmodium falciparum phd finger protein, putative 0.0028 0.0082 0.0253
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Brugia malayi AMP-binding enzyme family protein 0.005 0.0192 0.0192
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0192 0.0568
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.023 0.1117 0.6831
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0004 0.0014
Trypanosoma brucei calcium-activated potassium channel, putative 0.0118 0.0543 0.3318
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.005 0.0192 0.0568
Toxoplasma gondii exonuclease III APE 0.0019 0.0035 0.064
Brugia malayi ecdysone receptor 0.0018 0.0031 0.0031
Brugia malayi Cytochrome P450 family protein 0.0053 0.0211 0.0211
Echinococcus granulosus TWiK family of potassium channels protein 7 0.0118 0.0543 0.0543
Onchocerca volvulus 0.0013 0.0003 0.0011
Echinococcus granulosus 7tm_1 domain containing protein 0.0013 0.0003 0.0003
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.0136 0.0136
Schistosoma mansoni biogenic amine (5HT) receptor 0.0013 0.0003 0.0001
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0025 0.0025
Brugia malayi Inositol-1 0.0037 0.0125 0.0125
Onchocerca volvulus 0.005 0.0192 0.0772
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.0335 0.1016
Plasmodium vivax potassium channel, putative 0.0118 0.0543 0.1695
Leishmania major trypanothione reductase 0.0046 0.0173 0.1052
Schistosoma mansoni thyroid hormone receptor 0.0039 0.0136 0.0135
Loa Loa (eye worm) hypothetical protein 0.0118 0.0543 0.0543
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.0475 0.3975
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0139 0.0139
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 21 0.0118 0.0543 0.0543
Giardia lamblia DNA-directed RNA polymerase RPB2 0.0012 0.0002 0.0029
Echinococcus granulosus peregrin 0.0036 0.012 0.012
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0003 0.0003
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0003 0.0003
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0013 0.0003 0.0001
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0035 0.0204
Brugia malayi AMP-binding enzyme family protein 0.0169 0.0804 0.0804
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.0335 0.0335
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0037 0.0216
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0093 0.0372
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.023 0.1117 0.6831
Toxoplasma gondii hypothetical protein 0.0043 0.0159 0.2934
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0058 0.0234 0.4303
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0039 0.0137 0.0137
Schistosoma mansoni nuclear hormone receptor 0.0039 0.0136 0.0135
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0169 0.0804 0.2489
Schistosoma mansoni hypothetical protein 0.002 0.0038 0.0037
Brugia malayi G-protein coupled receptor 0.0013 0.0003 0.0003
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0176 0.1069
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0019 0.0108
Echinococcus granulosus tumor protein p63 0.0339 0.1675 0.1675
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.0335 0.1016
Entamoeba histolytica hypothetical protein 0.0187 0.0898 0.8686
Mycobacterium tuberculosis Conserved protein 0.0077 0.0335 0.1016
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0019 0.0108
Brugia malayi Steroid receptor seven-up type 2 0.0039 0.0136 0.0136
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0082 0.0082
Brugia malayi hypothetical protein 0.002 0.0038 0.0038
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.0335 0.0335
Brugia malayi Serotonin receptor 0.0013 0.0003 0.0003
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Onchocerca volvulus 0.0018 0.0031 0.0126
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0126 0.0585 0.1801
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0636 0.3197 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0064 0.0064
Echinococcus multilocularis g-protein coupled receptor 0.0013 0.0003 0.0003
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0219 0.0219
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0039 0.0136 0.0548
Onchocerca volvulus UPF0528 protein homolog 0.0043 0.0159 0.0641
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.005 0.0192 0.0568
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0119 0.0549 0.169
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0039 0.0137 0.0136
Echinococcus multilocularis g protein coupled receptor 0.0013 0.0003 0.0003
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0064 0.038
Loa Loa (eye worm) hypothetical protein 0.0118 0.0543 0.0543
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0058 0.0234 0.0675
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0035 0.0204
Schistosoma mansoni tar DNA-binding protein 0.0265 0.1294 0.1292
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.0535 0.4489
Echinococcus granulosus alpha 1A adrenergic receptor 0.0013 0.0003 0.0003
Schistosoma mansoni DNA polymerase eta 0.0019 0.0037 0.0035
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0246 0.0246
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0027 0.025
Echinococcus granulosus regulator of G protein signaling 7 0.0039 0.0137 0.0137
Onchocerca volvulus 0.0118 0.0543 0.2186
Toxoplasma gondii cyclophilin 1, putative 0.0023 0.0057 0.1049
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.003 0.0093 0.0557
Echinococcus granulosus 6 phosphofructokinase 0.0214 0.1034 0.1034
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0019 0.0108
Toxoplasma gondii hypothetical protein 0.0053 0.0211 0.3888
Giardia lamblia DINP protein human, muc B family 0.0019 0.0037 0.0677
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0137 0.0552
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0264 0.4863
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0031
Schistosoma mansoni ap endonuclease 0.0019 0.0035 0.0033
Echinococcus multilocularis high affinity choline transporter 1 0.0359 0.1777 0.1777
Trypanosoma cruzi ion transport protein, putative 0.0118 0.0543 0.3318
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0013 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0118 0.0543 0.2186
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0022 0.0052 0.0052
Entamoeba histolytica cysteine protease, putative 0.0018 0.0027 0.025
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0003 0.0001
Schistosoma mansoni transcription factor LCR-F1 0.0187 0.0898 0.0897
Loa Loa (eye worm) hypothetical protein 0.0048 0.0186 0.0186
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0192 0.0568
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.028 0.1704
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0035 0.0204
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0636 0.3197 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0013 0.0003 0.0003
Brugia malayi Dopamine receptor 0.0013 0.0003 0.0003
Brugia malayi jmjC domain containing protein 0.0093 0.0412 0.0412
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0118 0.0543 0.0543
Echinococcus multilocularis cysteine protease 0.0018 0.0027 0.0027
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0022 0.0022
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0013 0.0003 0.0003
Brugia malayi Calcitonin receptor-like protein seb-1 0.0309 0.152 0.152
Schistosoma mansoni opsin-like receptor 0.0013 0.0003 0.0001
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0013 0.0003 0.0001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0119 0.0549 0.169
Echinococcus granulosus g protein coupled receptor 0.0013 0.0003 0.0003
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0004 0.0014
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0027 0.011
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.005 0.0192 0.0568
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0216
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.005 0.0192 0.0568
Schistosoma mansoni smad1 5 8 and 0.0017 0.0025 0.0024
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Echinococcus granulosus twik family of potassium channels 0.0118 0.0543 0.0543
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0057 0.0232 0.0232
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0219 0.0219
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0146 0.0685 0.0685
Brugia malayi hypothetical protein 0.0013 0.0003 0.0003
Plasmodium falciparum potassium channel 0.0118 0.0543 0.1695
Brugia malayi MH2 domain containing protein 0.0017 0.0025 0.0025
Echinococcus multilocularis DNA directed RNA polymerase III subunit RPC2 0.0012 0.0002 0.0002
Toxoplasma gondii propionate-CoA ligase 0.005 0.0192 0.3532
Entamoeba histolytica fatty acid elongase, putative 0.0083 0.0361 0.3479
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0039 0.0137 0.0137
Brugia malayi hypothetical protein 0.003 0.0093 0.0093
Trypanosoma cruzi major cysteine proteinase, putative 0.0052 0.0206 0.1255
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0014 0.001 0.001
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.005 0.0192 0.0568
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.013 0.013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.028 0.1704
Brugia malayi orphan nuclear receptor NR2E1 0.0018 0.0031 0.0031
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0013 0.0003 0.0001
Schistosoma mansoni 6-phosphofructokinase 0.0214 0.1034 0.1033
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0027 0.011
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0037 0.0216
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0064 0.0194
Brugia malayi Cathepsin L-like precursor 0.0018 0.0027 0.0027
Schistosoma mansoni cyclophilin 0.0023 0.0057 0.0055
Loa Loa (eye worm) hypothetical protein 0.004 0.014 0.014
Echinococcus granulosus sodium:myo inositol cotransporter 0.004 0.014 0.014
Echinococcus granulosus metabotropic glutamate receptor 5 0.0107 0.0488 0.0488
Schistosoma mansoni hypothetical protein 0.0118 0.0543 0.0542
Trichomonas vaginalis DNA-directed RNA polymerase III subunit, putative 0.0012 0.0002 0.0006
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.005 0.0192 0.1166
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0234 0.0941
Echinococcus multilocularis twik family of potassium channels 0.0118 0.0543 0.0543
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0014 0.0011 0.0057
Loa Loa (eye worm) RecQ helicase 0.0021 0.0045 0.0045
Brugia malayi nuclear receptor RXR 0.0018 0.0031 0.0031
Plasmodium vivax vivapain-2 0.0018 0.0027 0.0081
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0013 0.0003 0.0003
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0192 0.0568
Schistosoma mansoni hypothetical protein 0.0098 0.0438 0.0437
Mycobacterium tuberculosis Possible transmembrane cation transporter 0.0118 0.0543 0.1671
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0216
Loa Loa (eye worm) hypothetical protein 0.0118 0.0543 0.0543
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.023 0.1117 0.6831
Schistosoma mansoni biogenic amine (5HT) receptor 0.0013 0.0003 0.0001
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 17 0.0118 0.0543 0.0543
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.005 0.0192 0.0568
Leishmania major ion transport protein-like protein 0.0118 0.0543 0.3318
Entamoeba histolytica hypothetical protein 0.0039 0.0137 0.1315
Echinococcus granulosus serotonin receptor 0.0013 0.0003 0.0003
Brugia malayi beta-lactamase family protein 0.0077 0.0335 0.0335
Brugia malayi RNA recognition motif domain containing protein 0.0265 0.1294 0.1294
Loa Loa (eye worm) PXA domain-containing protein 0.0039 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0337 0.1662 0.1662
Echinococcus granulosus twik family of potassium channels 0.0118 0.0543 0.0543
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0014 0.001 0.0041
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.003 0.0093 0.0256
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0027 0.0158
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0137 0.0136
Wolbachia endosymbiont of Brugia malayi DNA-directed RNA polymerase subunit beta/beta' 0.0242 0.1179 0.3651
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0013 0.0003 0.0011
Schistosoma mansoni hypothetical protein 0.0118 0.0543 0.0542
Brugia malayi jmjC domain containing protein 0.0037 0.013 0.013
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0027 0.0027
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0169 0.0804 0.2489
Echinococcus multilocularis serotonin receptor 0.0013 0.0003 0.0003
Schistosoma mansoni alpha-1 adrenergic receptor 0.0013 0.0003 0.0001
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0192 0.0568
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.003 0.0093 0.0093
Echinococcus multilocularis expressed protein 0.0023 0.0057 0.0057
Brugia malayi hypothetical protein 0.0018 0.0031 0.0031
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0058 0.0234 0.0727
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0013 0.0003 0.0003
Echinococcus multilocularis potassium channel subfamily K 0.0118 0.0543 0.0543
Loa Loa (eye worm) hypothetical protein 0.0118 0.0543 0.0543
Brugia malayi hypothetical protein 0.0261 0.1277 0.1277
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0155 0.0623
Trichomonas vaginalis DNA-directed RNA polymerase I subunit, putative 0.0012 0.0002 0.0006
Echinococcus granulosus histone acetyltransferase KAT2B 0.0088 0.0387 0.0387
Echinococcus multilocularis sex peptide receptor 0.0013 0.0003 0.0003
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0031
Entamoeba histolytica acyl-CoA synthetase, putative 0.0169 0.0804 0.777
Trichomonas vaginalis DNA-directed RNA polymerase I subunit, putative 0.0012 0.0002 0.0006
Echinococcus granulosus biogenic amine 5HT receptor 0.0013 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0077 0.0335 0.0335
Brugia malayi PHD-finger family protein 0.0028 0.0082 0.0082
Brugia malayi Melatonin receptor type 1A 0.0013 0.0003 0.0003
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.023 0.1117 0.6831
Loa Loa (eye worm) hypothetical protein 0.0309 0.152 0.152
Echinococcus granulosus Niemann Pick C1 protein 0.0141 0.0661 0.0661
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0019 0.0108
Loa Loa (eye worm) hypothetical protein 0.1845 0.9394 0.9394
Loa Loa (eye worm) TAR-binding protein 0.0265 0.1294 0.1294
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0039 0.0137 0.0137
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0146 0.0685 0.0685
Brugia malayi Cytochrome P450 family protein 0.0014 0.0011 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0039 0.0136 0.0136
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0636 0.3197 1
Echinococcus granulosus expressed protein 0.0759 0.3828 0.3828
Onchocerca volvulus 0.0077 0.0335 0.1347
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0039 0.0136 0.0136
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0082 0.0082
Echinococcus multilocularis regulator of G protein signaling 0.0039 0.0137 0.0137
Loa Loa (eye worm) RNA binding protein 0.0265 0.1294 0.1294
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0039 0.0136 0.0136
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0169 0.0804 0.6787
Brugia malayi Cathepsin L-like precursor 0.0018 0.0027 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0006 0.0027
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0013 0.0003 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0264 0.0263
Brugia malayi AMP-binding enzyme family protein 0.0169 0.0804 0.0804
Mycobacterium ulcerans hypothetical protein 0.0169 0.0804 0.2489
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0061 0.0249 0.0248
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0003 0.0003
Mycobacterium ulcerans acyl-CoA synthetase 0.0169 0.0804 0.2489
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0061 0.025 0.1522
Brugia malayi MH2 domain containing protein 0.0017 0.0025 0.0025
Leishmania major DNA polymerase kappa, putative 0.0019 0.0037 0.0216
Echinococcus multilocularis integrin alpha ps 0.0166 0.0786 0.0786
Loa Loa (eye worm) hypothetical protein 0.0118 0.0543 0.0543
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0027 0.011
Echinococcus granulosus sex peptide receptor 0.0013 0.0003 0.0003
Trypanosoma brucei cyclophilin a 0.0023 0.0057 0.034
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0019 0.0108
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0125 0.0502
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0013 0.0003 0.0003
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0279 0.1369 0.1369
Brugia malayi ecdysteroid receptor 0.0039 0.0136 0.0136
Loa Loa (eye worm) 6-phosphofructokinase 0.0214 0.1034 0.1034
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0003 0.0003
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0192 0.019
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0013 0.0003 0.0001
Mycobacterium leprae conserved hypothetical protein 0.0077 0.0335 0.2771
Trypanosoma cruzi hypothetical protein, conserved 0.0118 0.0543 0.3318
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0004 0.0014
Echinococcus granulosus tar DNA binding protein 0.0265 0.1294 0.1294
Entamoeba histolytica fatty acid elongase, putative 0.0083 0.0361 0.3479
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.0011 0.0057
Loa Loa (eye worm) hypothetical protein 0.0211 0.102 0.102
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0173 0.0173
Schistosoma mansoni smad 0.0017 0.0025 0.0024
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0045 0.0045
Schistosoma mansoni rab6-interacting 0.002 0.0038 0.0037
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.0335 0.1016
Echinococcus multilocularis smoothened 0.0361 0.1788 0.1788
Leishmania major cathepsin L-like protease 0.0067 0.028 0.1704
Echinococcus multilocularis RUN 0.002 0.0038 0.0038
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0037 0.0148
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0219 0.0219
Brugia malayi NC domain containing protein 0.0043 0.0159 0.0159
Brugia malayi Pre-SET motif family protein 0.0437 0.2177 0.2177
Loa Loa (eye worm) hypothetical protein 0.0064 0.0264 0.0264
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.0264 0.0263
Echinococcus multilocularis integrin alpha ps 0.0166 0.0786 0.0786
Echinococcus granulosus cathepsin l1 0.0018 0.0027 0.0027
Echinococcus multilocularis potassium channel subfamily K 8 0.0118 0.0543 0.0543
Loa Loa (eye worm) hypothetical protein 0.002 0.0038 0.0038
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0136 0.0136
Trypanosoma cruzi cyclophilin type peptidyl-prolyl cis-trans isomerase 0.0023 0.0057 0.034
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 45 0.0118 0.0543 0.0543
Leishmania major acetyl-CoA synthetase, putative 0.005 0.0192 0.1166
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Mycobacterium tuberculosis Conserved protein 0.0077 0.0335 0.1016
Loa Loa (eye worm) hypothetical protein 0.0126 0.0585 0.0585
Schistosoma mansoni twik family of potassium channels-related 0.1963 1 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 13 0.0118 0.0543 0.0543
Onchocerca volvulus 0.0055 0.0219 0.088
Brugia malayi hypothetical protein 0.0039 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0118 0.0543 0.0543
Schistosoma mansoni hypothetical protein 0.0187 0.0898 0.0897
Brugia malayi steroid hormone receptor 0.0039 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0118 0.0543 0.0543
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0013 0.0003 0.0003
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.0535 0.1646
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0125 0.0755
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.003 0.0093 0.1704
Leishmania major cyclophilin 11, putative 0.0023 0.0057 0.034
Onchocerca volvulus 0.0018 0.0027 0.011
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0047 0.0176 0.1069
Loa Loa (eye worm) S-phase kinase-associated protein 1A 0.0118 0.0543 0.0543
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.005 0.0192 0.0568
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0214 0.1034 0.3211
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0214 0.1034 0.8749
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0118 0.0543 0.0543
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0137 0.0137
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.013 0.013
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 5 0.0118 0.0543 0.0543
Brugia malayi putative neuropeptide receptor 0.0013 0.0003 0.0003
Trypanosoma brucei cyclophilin, putative 0.0023 0.0057 0.034
Echinococcus multilocularis FTZ F1 alpha 0.0039 0.0136 0.0136
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0042 0.0042
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0037 0.0081
Echinococcus granulosus neuropeptide s receptor 0.0013 0.0003 0.0003
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0061 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.0126 0.0585 0.0585
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.0685 0.0684
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0335 0.204
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0064 0.0194
Leishmania major acetyl-CoA synthetase, putative 0.005 0.0192 0.1166
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0039 0.0136 0.0136
Giardia lamblia Replication factor C, subunit 1 0.003 0.0093 0.1704
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0125 0.0755
Echinococcus granulosus integrin alpha 3 0.0283 0.1389 0.1389
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0031
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0118 0.0543 0.3318
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0014 0.0011 0.0057
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0027 0.0027
Leishmania major cathepsin L-like protease 0.0018 0.0027 0.0158
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0019 0.0019
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase 0.0023 0.0057 0.0174
Loa Loa (eye worm) latrophilin receptor protein 2 0.0098 0.0438 0.0438
Leishmania major cathepsin L-like protease 0.0067 0.028 0.1704
Loa Loa (eye worm) hypothetical protein 0.0118 0.0543 0.0543
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0137 0.0136
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.005 0.0192 0.0192
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0013 0.0003 0.0003
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0013 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Leishmania major cytochrome p450-like protein 0.0014 0.0011 0.0057
Echinococcus multilocularis cysteine protease 0.0018 0.0027 0.0027
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.004 0.014 0.2586
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.028 0.1704
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0019 0.0055
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0038 0.0114
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0216
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0335 0.1043
Loa Loa (eye worm) hypothetical protein 0.0204 0.0982 0.0982
Echinococcus granulosus RUN 0.002 0.0038 0.0038
Trypanosoma brucei calpain, putative 0.023 0.1117 0.6831
Schistosoma mansoni hypothetical protein 0.0014 0.0011 0.0009
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.005 0.0192 0.0568
Loa Loa (eye worm) AMP-binding enzyme family protein 0.005 0.0192 0.0192
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0035 0.0035
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0264 0.0263
Schistosoma mansoni inositol monophosphatase 0.0037 0.0125 0.0123
Loa Loa (eye worm) steroid hormone receptor 0.0039 0.0136 0.0136
Loa Loa (eye worm) nuclear receptor NHR-67 0.0018 0.0031 0.0031
Onchocerca volvulus 0.0118 0.0543 0.2186
Brugia malayi Twik (KCNK-like) family of potasium channels, alpha subunit 40 0.0118 0.0543 0.0543
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0013 0.0003 0.0003
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0014 0.0011 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0006 0.0027
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.0535 0.1646
Trypanosoma cruzi rotamase, putative 0.0023 0.0057 0.034
Echinococcus granulosus frizzled 5 0.0016 0.0021 0.0021
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0335 0.0333
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0157 0.0741 0.4526
Loa Loa (eye worm) hypothetical protein 0.0118 0.0543 0.0543
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0035 0.064
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.028 0.1704
Loa Loa (eye worm) uncoordinated protein 58 0.0118 0.0543 0.0543
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0004 0.0014
Schistosoma mansoni cytochrome P450 0.0014 0.0011 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0027 0.011
Leishmania major 4-coumarate:coa ligase-like protein 0.0169 0.0804 0.4914
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.1243 0.631 0.6309
Schistosoma mansoni lamin 0.0055 0.0219 0.0217
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Brugia malayi glutathione reductase 0.0046 0.0173 0.0173
Echinococcus multilocularis frizzled 4 0.0016 0.0021 0.0021
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0125 0.0755
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.002 0.0042 0.0042
Leishmania major mitochondrial DNA polymerase beta 0.0331 0.1634 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0009 0.017
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0118 0.0543 0.2186
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0125 0.1194
Schistosoma mansoni loxhd1 0.002 0.0038 0.0037
Echinococcus granulosus g protein coupled receptor 0.0013 0.0003 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0027 0.011
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0018 0.0031 0.0031
Brugia malayi Pax transcription activation domain interacting protein 0.003 0.0093 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0093 0.0372
Trypanosoma cruzi ion transport protein, putative 0.0118 0.0543 0.3318
Echinococcus multilocularis ecdysone induced protein 78C 0.0039 0.0136 0.0136
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0331 0.1634 1
Echinococcus multilocularis tar DNA binding protein 0.0265 0.1294 0.1294
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0082 0.1517
Echinococcus multilocularis fmrfamide receptor 0.0013 0.0003 0.0003
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0023 0.0057 0.034
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0058 0.0234 0.0941
Echinococcus granulosus DNA directed RNA polymerase I subunit RPA2 0.0012 0.0002 0.0002
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0035 0.0322
Onchocerca volvulus 0.002 0.0038 0.0153
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0038 0.0038
Schistosoma mansoni neuropeptide receptor 0.0013 0.0003 0.0001
Brugia malayi DKFZp564C0469 protein 0.003 0.0093 0.0093
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0037 0.0216
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.003 0.0093 0.0557
Loa Loa (eye worm) doublecortin family protein 0.002 0.0038 0.0038
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0335 0.1347
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0019 0.0108
Leishmania major cyclophilin 4, putative 0.0023 0.0057 0.034
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.023 0.1117 0.6831
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0037 0.0035
Brugia malayi hypothetical protein 0.0013 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0187 0.0898 0.0896
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0064 0.0194
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0137 0.0137
Brugia malayi cytochrome P450 0.0014 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0039 0.0136 0.0136
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0136 0.0136
Schistosoma mansoni neuropeptide receptor 0.0013 0.0003 0.0001
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0004 0.0014
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0035 0.0075
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0018 0.0031 0.0031
Brugia malayi larval opioid receptor 0.0013 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0107 0.0488 0.0488
Echinococcus granulosus tm gpcr rhodopsin 0.0013 0.0003 0.0003
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0019 0.0019
Schistosoma mansoni inositol transporter 0.004 0.014 0.0139
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0031
Trichomonas vaginalis replication factor C large subunit, putative 0.003 0.0093 0.0372
Leishmania major hypothetical protein, conserved 0.0118 0.0543 0.3318
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0219 0.0219
Toxoplasma gondii thioredoxin reductase 0.0046 0.0173 0.319
Mycobacterium ulcerans hypothetical protein 0.0174 0.0831 0.2575
Echinococcus multilocularis musashi 0.0055 0.0219 0.0219
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.0444 0.0444
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0004 0.0014
Loa Loa (eye worm) hypothetical protein 0.0077 0.0335 0.0335
Brugia malayi follicle stimulating hormone receptor 0.0489 0.2443 0.2443
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0126 0.0585 0.1801
Brugia malayi Bromodomain containing protein 0.0036 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0013 0.0003 0.0003
Plasmodium falciparum thioredoxin reductase 0.0046 0.0173 0.0537
Echinococcus granulosus histone acetyltransferase KAT2B 0.029 0.1422 0.1422
Schistosoma mansoni hypothetical protein 0.0098 0.0438 0.0437
Brugia malayi Cathepsin L-like precursor 0.0018 0.0027 0.0027
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.005 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0118 0.0543 0.0543
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0042
Schistosoma mansoni lamin 0.0055 0.0219 0.0217
Onchocerca volvulus 0.0013 0.0003 0.0011
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.004 0.014 0.014
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0192 0.0568
Loa Loa (eye worm) hypothetical protein 0.0039 0.0137 0.0137
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0035 0.0075
Onchocerca volvulus Poor gastrulation protein homolog 0.0014 0.001 0.0041
Brugia malayi AMP-binding enzyme family protein 0.005 0.0192 0.0192
Echinococcus granulosus smad 0.0017 0.0025 0.0025
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0061 0.0249 0.0249
Loa Loa (eye worm) frizzled/Smoothened family membrane region containing protein 0.0016 0.0021 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0039 0.0136 0.0136
Echinococcus granulosus potassium channel subfamily K 0.0118 0.0543 0.0543
Brugia malayi RE15519p 0.0013 0.0003 0.0003
Leishmania major calcium/potassium channel (CAKC), putative 0.0118 0.0543 0.3318
Schistosoma mansoni integrin alpha-ps 0.0086 0.0379 0.0378
Schistosoma mansoni inositol monophosphatase 0.0037 0.0125 0.0123
Onchocerca volvulus 0.0054 0.0213 0.0857
Loa Loa (eye worm) hypothetical protein 0.0118 0.0543 0.0543
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0037 0.0216
Mycobacterium ulcerans acetyl-CoA synthetase 0.005 0.0192 0.0568
Echinococcus multilocularis tumor protein p63 0.0339 0.1675 0.1675
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0013 0.0003 0.0001
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.1963 1 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.002 0.0042 0.0042
Giardia lamblia PHD finger protein 15 0.0028 0.0082 0.1517
Trypanosoma brucei unspecified product 0.0013 0.0006 0.0027
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0035 0.0204
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0018 0.0031 0.0031
Schistosoma mansoni hypothetical protein 0.0211 0.102 0.1018
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.0335 0.1016
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0025 0.0025
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0038 0.0114
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.005 0.0192 0.1166
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0137 0.0552
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0125 0.0332
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0035 0.0035
Plasmodium falciparum replication factor C subunit 1, putative 0.003 0.0093 0.0285
Onchocerca volvulus 0.0013 0.0003 0.0011
Schistosoma mansoni neuropeptide f receptor 76f 0.0013 0.0003 0.0001
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0047 0.0176 0.1069
Loa Loa (eye worm) hypothetical protein 0.0118 0.0543 0.0543
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0125 0.0358
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39B 0.0118 0.0543 0.0543
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0019 0.0108
Onchocerca volvulus 0.0013 0.0003 0.0011
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0019 0.0108
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0039 0.0136 0.0136
Entamoeba histolytica hypothetical protein 0.0039 0.0137 0.1315
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0118 0.0543 0.0543
Schistosoma mansoni frizzled-like receptor 0.0016 0.0021 0.0019
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.0335 0.0335
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0031
Trypanosoma cruzi cytochrome P450, putative 0.0014 0.0011 0.0057
Trichomonas vaginalis antibiotic synthetase, putative 0.005 0.0192 0.0772
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 12 0.0118 0.0543 0.0543
Brugia malayi G-protein coupled receptor 0.0013 0.0003 0.0003
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0025 0.0025
Onchocerca volvulus 0.0018 0.0027 0.011
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0019 0.0108
Echinococcus granulosus calcium activated potassium channel variant 0.0118 0.0543 0.0543
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.0011 0.0057
Schistosoma mansoni steroid hormone receptor ad4bp 0.0039 0.0136 0.0135
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0216
Echinococcus multilocularis allatostatin A receptor 0.0013 0.0003 0.0003
Brugia malayi tailless protein 0.0018 0.0031 0.0031
Schistosoma mansoni lipoxygenase 0.0055 0.0219 0.0218
Brugia malayi DNA-directed RNA polymerase, beta subunit family protein 0.0012 0.0002 0.0002
Echinococcus granulosus hypothetical protein 0.0013 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.003 0.0093 0.0093
Entamoeba histolytica fatty acid elongase, putative 0.0083 0.0361 0.3479
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0019 0.0077
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0073 0.0073
Brugia malayi hypothetical protein 0.0013 0.0003 0.0003
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0019 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0216
Loa Loa (eye worm) oxidoreductase 0.005 0.0192 0.0192
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0157 0.0741 0.4526
Schistosoma mansoni thyroid hormone receptor 0.0039 0.0136 0.0135
Echinococcus multilocularis regulator of G protein signaling 7 0.0039 0.0137 0.0137
Echinococcus granulosus expressed conserved protein 0.0093 0.0413 0.0413
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 7 0.0118 0.0543 0.0543
Entamoeba histolytica hypothetical protein 0.003 0.0093 0.0881
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0013 0.0003 0.0003
Onchocerca volvulus Alhambra homolog 0.0028 0.0082 0.0332
Trypanosoma cruzi 21 kDa cyclophilin, putative 0.0023 0.0057 0.034
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0031
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0113 0.0113
Plasmodium vivax 6-phosphofructokinase, putative 0.0058 0.0234 0.0727
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0298 0.1465 0.1465
Schistosoma mansoni survival motor neuron protein 0.0053 0.0211 0.0209
Brugia malayi ORL1-like opioid receptor 0.0013 0.0003 0.0003
Treponema pallidum DNA ligase (lig) 0.003 0.0093 0.0632
Echinococcus multilocularis frizzled 10 0.0016 0.0021 0.0021
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0003 0.0001
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.0249 0.0749
Loa Loa (eye worm) ctsf protein 0.0018 0.0027 0.0027
Brugia malayi Tachykinin-like peptides receptor 99D 0.0013 0.0003 0.0003
Echinococcus multilocularis integrin alpha ps 0.0079 0.0344 0.0344
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0039 0.0136 0.0136
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0475 0.1458
Schistosoma mansoni myosin xvIII 0.0013 0.0003 0.0001
Loa Loa (eye worm) histone methyltransferase 0.002 0.0039 0.0039
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.005 0.0192 0.1549
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0004 0.0014
Leishmania major cyclophilin a 0.0023 0.0057 0.034
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0118 0.0543 0.2186
Loa Loa (eye worm) hypothetical protein 0.0169 0.0804 0.0804
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0237 0.0237
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0057 0.0228 0.1389
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0031 0.0031
Schistosoma mansoni chromosome transmission fidelity factor 0.003 0.0093 0.0091
Onchocerca volvulus 0.002 0.0038 0.0153
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0022 0.0052 0.0052
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0155 0.0155
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0309 0.152 0.152
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0137 0.0136
Echinococcus multilocularis neuropeptide Y receptor 0.0013 0.0003 0.0003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0003 0.0003
Echinococcus multilocularis expressed conserved protein 0.0093 0.0413 0.0413
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0228 0.0228
Schistosoma mansoni amine GPCR 0.0013 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.1963 1 1
Leishmania major cytochrome p450-like protein 0.0014 0.0011 0.0057
Brugia malayi Cathepsin L-like precursor 0.0018 0.0027 0.0027
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0013 0.0003 0.0003
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0039 0.0137 0.0137
Loa Loa (eye worm) DR-78 0.0018 0.0031 0.0031
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0045 0.0045
Echinococcus granulosus orexin receptor type 2 0.0013 0.0003 0.0003
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0031 0.0031
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0077 0.0335 0.0335
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0031
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.013 0.0128
Mycobacterium tuberculosis DNA-directed RNA polymerase (beta chain) RpoB (transcriptase beta chain) (RNA polymerase beta subunit) 0.0059 0.0241 0.0723
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0155 0.0155
Schistosoma mansoni nuclear receptor nhr-48 0.0018 0.0031 0.003
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0088 0.0088
Mycobacterium leprae Probable lipase LipE 0.0077 0.0335 0.2771
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0027 0.0027
Plasmodium falciparum thioredoxin reductase 0.0016 0.0019 0.0055
Loa Loa (eye worm) hypothetical protein 0.0354 0.175 0.175
Plasmodium vivax potassium channel, putative 0.0118 0.0543 0.1695
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0187 0.0898 0.0898
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0073 0.0312 0.0312
Schistosoma mansoni hypothetical protein 0.0013 0.0003 0.0001
Schistosoma mansoni growth hormone secretagogue receptor 0.0013 0.0003 0.0001
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0155 0.0155
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0088 0.0387 0.1556
Schistosoma mansoni patched 1 0.0042 0.0155 0.0153
Echinococcus multilocularis cpg binding protein 0.006 0.0245 0.0245
Echinococcus multilocularis neuropeptide receptor 0.0013 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0187 0.0898 0.8686
Onchocerca volvulus 0.0169 0.0804 0.3234
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.003 0.0093 0.0372
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0093 0.0372
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0039 0.0136 0.0136
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0037 0.0216
Mycobacterium tuberculosis Conserved hypothetical protein 0.0174 0.0831 0.2575
Loa Loa (eye worm) TWK-7 protein 0.0118 0.0543 0.0543
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0022 0.0021
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0027 0.0027
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0035 0.014
Echinococcus multilocularis small conductance calcium activated potassium 0.0118 0.0543 0.0543
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0013 0.0003 0.0003
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0139 0.0139
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0004 0.0014
Trypanosoma brucei calpain-like protein, putative 0.023 0.1117 0.6831
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0214 0.1034 0.6324
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0126 0.0585 0.0585
Schistosoma mansoni hypothetical protein 0.0187 0.0898 0.0896
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0137 0.0137
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0018 0.0031 0.003
Trypanosoma cruzi FHA domain containing protein, putative 0.003 0.0093 0.0557
Loa Loa (eye worm) hypothetical protein 0.0118 0.0543 0.0543
Schistosoma mansoni neuropeptide F-like receptor 0.0013 0.0003 0.0001
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0037 0.0037
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0192 0.0568
Echinococcus granulosus g-protein coupled receptor 0.0013 0.0003 0.0003
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0437 0.2177 0.2177
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0031 0.0031
Echinococcus granulosus neuropeptide Y receptor 0.0013 0.0003 0.0003
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0013 0.0003 0.0003
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.0086 0.0086
Echinococcus granulosus dna polymerase kappa 0.0019 0.0037 0.0037
Brugia malayi nuclear receptor NHR-67 0.0018 0.0031 0.0031
Brugia malayi Nuclear hormone receptor-like 1 0.0039 0.0136 0.0136
Onchocerca volvulus 0.0013 0.0003 0.0011
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0013 0.0003 0.0001
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0023 0.0057 0.034
Loa Loa (eye worm) hypothetical protein 0.0026 0.0073 0.0073
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0027 0.0027
Onchocerca volvulus 0.004 0.014 0.0565
Echinococcus granulosus integrin alpha ps 0.0166 0.0786 0.0786
Loa Loa (eye worm) hypothetical protein 0.0169 0.0804 0.0804
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0146 0.0685 0.0685
Entamoeba histolytica phosphofructokinase, putative 0.0214 0.1034 1
Loa Loa (eye worm) hypothetical protein 0.0118 0.0543 0.0543
Brugia malayi hypothetical protein 0.0016 0.0019 0.0019
Leishmania major DNA polymerase eta, putative 0.0019 0.0037 0.0216
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0475 0.1458
Echinococcus multilocularis survival motor neuron protein 1 0.0261 0.1277 0.1277
Onchocerca volvulus 0.0118 0.0543 0.2186
Schistosoma mansoni high-affinity choline transporter 0.0359 0.1777 0.1776
Schistosoma mansoni hypothetical protein 0.0041 0.0147 0.0145
Schistosoma mansoni histamine h1 receptor 0.0013 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0001
Schistosoma mansoni coup transcription factor 0.0039 0.0136 0.0135
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0003 0.0003
Brugia malayi hypothetical protein 0.002 0.0042 0.0042
Brugia malayi putative neuropeptide receptor NPR1 0.0013 0.0003 0.0003
Echinococcus granulosus tm gpcr rhodopsin 0.0013 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0118 0.0543 0.0543
Echinococcus multilocularis neuropeptide receptor 0.0013 0.0003 0.0003
Brugia malayi intermediate filament protein 0.0055 0.0219 0.0219
Schistosoma mansoni hypothetical protein 0.0013 0.0003 0.0001
Toxoplasma gondii 6-phosphofructokinase 0.0058 0.0234 0.4303
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0027 0.011
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0169 0.0804 0.2489
Echinococcus multilocularis neuropeptide Y receptor 0.0013 0.0003 0.0003
Schistosoma mansoni Smad4 0.0017 0.0025 0.0024
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0039 0.0136 0.0136
Brugia malayi nuclear hormone receptor family member odr-7 0.0018 0.0031 0.0031
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.0335 0.1016
Trichomonas vaginalis peptidyl-prolyl cis-trans isomerase A, ppia, putative 0.0023 0.0057 0.0229
Schistosoma mansoni smad1 5 8 and 0.0017 0.0025 0.0024
Schistosoma mansoni twik family of potassium channels-related 0.0118 0.0543 0.0542
Brugia malayi Cytochrome P450 family protein 0.0014 0.0011 0.0011
Brugia malayi Dopamine receptor protein 2 0.0013 0.0003 0.0003
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0022 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0003 0.0003
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0039 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0042
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.0685 0.0684
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.0011 0.0011
Loa Loa (eye worm) frizzled/Smoothened family membrane region containing protein 0.0016 0.0021 0.0021
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.005 0.0192 0.0568
Brugia malayi Doublecortin family protein 0.002 0.0038 0.0038
Echinococcus multilocularis solute carrier family 5 0.004 0.014 0.014
Echinococcus multilocularis GPCR, family 2 0.0098 0.0438 0.0438
Onchocerca volvulus 0.0053 0.0211 0.0848
Schistosoma mansoni twik family of potassium channels-related 0.0118 0.0543 0.0542
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0137 0.0137
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0125 0.0755
Loa Loa (eye worm) RNA polymerase III 128kD subunit-PA 0.0012 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0027 0.011
Brugia malayi latrophilin 2 splice variant baaae 0.0211 0.102 0.102
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.028 0.1704
Schistosoma mansoni integrin beta subunit 0.0223 0.1079 0.1078
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0037 0.0037
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0019 0.0108
Trypanosoma brucei calcium/potassium channel (CAKC), putative 0.0118 0.0543 0.3318
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0137 0.0136
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.003 0.0093 0.0699
Echinococcus multilocularis Niemann Pick C1 protein 0.0141 0.0661 0.0661
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0019 0.0077
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.005 0.0192 0.3532
Loa Loa (eye worm) hypothetical protein 0.0019 0.0037 0.0037
Trypanosoma cruzi cruzipain precursor, putative 0.0067 0.028 0.1704
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0335 0.204
Onchocerca volvulus 0.0077 0.0335 0.1347
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0042
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.0249 0.0749
Echinococcus granulosus intermediate filament protein 0.0055 0.0219 0.0219
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0003 0.0001
Plasmodium vivax glutathione reductase, putative 0.0046 0.0173 0.0537
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0475 0.1458
Brugia malayi Smad1 0.0017 0.0025 0.0025
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0004 0.0014
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0636 0.3197 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0039 0.0136 0.0136
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0173 0.0537
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0013 0.0003 0.0003
Brugia malayi neuropeptide F receptor 0.0013 0.0003 0.0003
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0039 0.0136 0.0136
Echinococcus granulosus thyroid hormone receptor alpha 0.0018 0.0031 0.0031
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0412 0.0412
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.0011 0.0011
Brugia malayi TAR-binding protein 0.0265 0.1294 0.1294
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0331 0.1634 1
Onchocerca volvulus 0.003 0.0093 0.0372
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0264 0.0263
Trypanosoma brucei hypothetical protein 0.023 0.1117 0.6831
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0027 0.0027
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0123 0.0567 0.0566
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0013 0.0003 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0216
Brugia malayi AKH receptor 0.0013 0.0003 0.0003
Loa Loa (eye worm) beta-lactamase 0.0077 0.0335 0.0335
Schistosoma mansoni ap endonuclease 0.0019 0.0035 0.0033
Echinococcus granulosus integrin alpha ps 0.0079 0.0344 0.0344
Echinococcus multilocularis neuropeptide s receptor 0.0013 0.0003 0.0003
Onchocerca volvulus 0.0057 0.0229 0.0921
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0098 0.0438 0.0438
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.028 0.1704
Plasmodium vivax vivapain-2 0.0018 0.0027 0.0081
Schistosoma mansoni opsin-like receptor 0.0013 0.0003 0.0001
Echinococcus granulosus allatostatin A receptor 0.0013 0.0003 0.0003
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0037 0.0081
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0019 0.0354
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0039 0.0136 0.0136
Brugia malayi Cathepsin L-like precursor 0.0018 0.0027 0.0027
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0013 0.0003 0.0003
Echinococcus multilocularis frizzled 0.0016 0.0021 0.0021
Trichomonas vaginalis set domain proteins, putative 0.0497 0.2485 1
Brugia malayi Sodium:solute symporter family protein 0.004 0.014 0.014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0039 0.0136 0.0136
Echinococcus multilocularis regulator of G protein signaling 7 0.0039 0.0137 0.0137
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0025 0.0024
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0192 0.1549
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0057 0.0232 0.0232
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0039 0.0136 0.0136
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0137 0.0137
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0027 0.011
Mycobacterium tuberculosis Conserved protein 0.0077 0.0335 0.1016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0039 0.0136 0.0136
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0137 0.0136
Loa Loa (eye worm) hypothetical protein 0.0052 0.0204 0.0204
Loa Loa (eye worm) glutamate receptor 0.0034 0.0114 0.0114
Giardia lamblia Histone acetyltransferase GCN5 0.008 0.0349 0.643
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.013 0.0128
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0003 0.0003
Toxoplasma gondii cathepsin CPL 0.0018 0.0027 0.0503
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0137 0.0136
Loa Loa (eye worm) Smad1 0.0017 0.0025 0.0025
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.003 0.0093 0.0093
Mycobacterium ulcerans lipase LipD 0.0077 0.0335 0.1016
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0039 0.0136 0.0136
Schistosoma mansoni metabotropic glutamate receptor 0.0073 0.0312 0.0311
Loa Loa (eye worm) hypothetical protein 0.0022 0.0052 0.0052
Onchocerca volvulus 0.0018 0.0027 0.011
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0035 0.014
Brugia malayi Metabotropic glutamate receptor precursor. 0.0087 0.0385 0.0385
Onchocerca volvulus 0.0013 0.0003 0.0011
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0027 0.0026
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0098 0.0438 0.0438
Onchocerca volvulus 0.0013 0.0003 0.0011
Echinococcus multilocularis g protein coupled receptor 0.0013 0.0003 0.0003
Echinococcus multilocularis GPCR, family 3, C terminal 0.0014 0.001 0.001
Schistosoma mansoni tar DNA-binding protein 0.0265 0.1294 0.1292
Toxoplasma gondii cyclophilin precursor 0.0023 0.0057 0.1049
Echinococcus granulosus nuclear receptor nhr 48 0.0018 0.0031 0.0031
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0019 0.0354
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0298 0.1465 0.1464
Brugia malayi Thioredoxin reductase 0.0046 0.0173 0.0173
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0035 0.0104
Echinococcus granulosus dro:myosuppressin receptor 0.0013 0.0003 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0216
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0045 0.018
Brugia malayi cyclophilin-type peptidyl-prolyl cis-trans isomerase-3, Bmcyp-3 0.0023 0.0057 0.0057
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0039 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Echinococcus granulosus neuropeptide FF receptor 2 0.0013 0.0003 0.0003
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0019 0.0026
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0234 0.0941
Schistosoma mansoni hypothetical protein 0.0041 0.0147 0.0145
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0019 0.0026
Brugia malayi A-kinase anchor protein 10, precursor 0.0039 0.0137 0.0137
Brugia malayi 6-phosphofructokinase 0.0214 0.1034 0.1034
Schistosoma mansoni neuropeptide receptor 0.0013 0.0003 0.0001
Loa Loa (eye worm) nuclear hormone receptor 0.0018 0.0031 0.0031
Entamoeba histolytica phosphofructokinase, putative 0.0214 0.1034 1
Brugia malayi Kelch motif family protein 0.0057 0.0232 0.0232
Loa Loa (eye worm) hypothetical protein 0.0099 0.0444 0.0444
Plasmodium falciparum acetyl-CoA synthetase, putative 0.005 0.0192 0.0596
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0088 0.0088
Echinococcus multilocularis G protein coupled receptor 139 0.0013 0.0003 0.0003
Schistosoma mansoni calcium-activated potassium channel 0.0118 0.0543 0.0542
Treponema pallidum DNA-directed RNA polymerase subunit beta 0.0242 0.1179 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0039 0.0136 0.0135
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0038 0.0038
Echinococcus multilocularis sodium:myo inositol cotransporter 0.004 0.014 0.014
Echinococcus multilocularis protein patched 0.0042 0.0155 0.0155
Echinococcus multilocularis neuropeptides capa receptor 0.0013 0.0003 0.0003
Echinococcus multilocularis calcium activated potassium channel variant 0.0118 0.0543 0.0543
Loa Loa (eye worm) hypothetical protein 0.002 0.0038 0.0038
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0031 0.0031
Schistosoma mansoni tar DNA-binding protein 0.0265 0.1294 0.1292
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0192 0.0568
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 28 0.0118 0.0543 0.0543
Loa Loa (eye worm) hypothetical protein 0.003 0.0093 0.0093
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0082 0.0253
Schistosoma mansoni lipoxygenase 0.002 0.0038 0.0037
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.005 0.0192 0.1843
Echinococcus multilocularis orexin receptor type 2 0.0013 0.0003 0.0003
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0636 0.3197 1
Onchocerca volvulus 0.0013 0.0003 0.0011
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0064 0.038
Echinococcus granulosus frizzled 0.0016 0.0021 0.0021
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.005 0.0192 0.0568
Loa Loa (eye worm) hypothetical protein 0.003 0.0093 0.0093
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0176 0.1069
Onchocerca volvulus 0.0023 0.0057 0.0229
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0475 0.1458
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0019 0.0055
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0042 0.0041
Echinococcus multilocularis expressed protein 0.0759 0.3828 0.3828
Echinococcus granulosus lamin dm0 0.0055 0.0219 0.0219
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0027 0.011
Schistosoma mansoni amine GPCR 0.0013 0.0003 0.0001
Echinococcus multilocularis integrin beta 2 0.028 0.1374 0.1374
Chlamydia trachomatis DNA ligase 0.003 0.0093 0.0231
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.028 0.1704
Echinococcus granulosus beta-adrenergic receptor kinase 0.0039 0.0137 0.0137
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 24 0.0118 0.0543 0.0543
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0088 0.0387 0.7119
Echinococcus multilocularis geminin 0.0187 0.0898 0.0898
Brugia malayi nuclear hormone receptor family member nhr-6 0.0018 0.0031 0.0031
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0214 0.1034 0.8758
Plasmodium falciparum acyl-CoA synthetase 0.0126 0.0585 0.1826
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0019 0.0108
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0234 0.0941
Echinococcus granulosus fmrfamide receptor 0.0013 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0042
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0099 0.0446 0.0445
Leishmania major cathepsin L-like protease 0.0067 0.028 0.1704
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.0136 0.0136
Brugia malayi hypothetical protein 0.002 0.0042 0.0042
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0013 0.0003 0.0003
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0058 0.0234 0.185
Mycobacterium ulcerans DNA-directed RNA polymerase subunit beta 0.0242 0.1179 0.3667
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Loa Loa (eye worm) cytochrome P450 0.0014 0.0011 0.0011
Onchocerca volvulus 0.0018 0.0027 0.011
Echinococcus granulosus high affinity choline transporter 1 0.0359 0.1777 0.1777
Mycobacterium tuberculosis Probable reductase 0.0105 0.0475 0.1458
Schistosoma mansoni hypothetical protein 0.0098 0.0438 0.0437
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0013 0.0003 0.0003
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0118 0.0543 0.0543
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0031
Loa Loa (eye worm) glutamate receptor 0.0087 0.0385 0.0385
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0013 0.0003 0.0003
Brugia malayi Cytochrome P450 family protein 0.0014 0.0011 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.0136 0.0136
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.005 0.0192 0.0568
Schistosoma mansoni cpg binding protein 0.006 0.0245 0.0244
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0027 0.0081
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0027 0.011
Mycobacterium ulcerans ion transport protein 0.0118 0.0543 0.1671
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0039 0.0137 0.0552
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0025 0.0025
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0012 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0027 0.011
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0157 0.0741 0.4526
Schistosoma mansoni topbp1 0.003 0.0093 0.0091
Brugia malayi acetyl-Coenzyme A synthetase 2 0.005 0.0192 0.0192
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.003 0.0093 0.0882
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0003 0.0003
Mycobacterium ulcerans hypothetical protein 0.0077 0.0335 0.1016
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.023 0.1117 0.6831
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0335 0.204
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0082 0.0081
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0119 0.0549 0.169
Onchocerca volvulus Bile acid receptor homolog 0.0039 0.0136 0.0548
Plasmodium vivax unspecified product 0.0023 0.0057 0.0174
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.023 0.1117 0.6831
Echinococcus granulosus cytochrome P450 2K1 0.0014 0.0011 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0003 0.0001
Brugia malayi hypothetical protein 0.0013 0.0003 0.0003
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0264 0.0264
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0013 0.0003 0.0001
Giardia lamblia DNA-directed RNA polymerase subunit B 0.0012 0.0002 0.0029
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0027 0.011
Entamoeba histolytica acyl-CoA synthetase, putative 0.0169 0.0804 0.777
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0027 0.011
Echinococcus granulosus peptide allatostatin:somatostatin 0.0013 0.0003 0.0003
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0187 0.0898 0.0898
Trypanosoma brucei trypanothione reductase 0.0046 0.0173 0.1052
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0042
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1651 0.8401 0.8401
Loa Loa (eye worm) hypothetical protein 0.0077 0.0335 0.0335
Schistosoma mansoni biogenic amine receptor 0.0013 0.0003 0.0001
Schistosoma mansoni nuclear receptor 0.0018 0.0031 0.003
Schistosoma mansoni neuropeptide F-like receptor 0.0013 0.0003 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0027 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.0137 0.0137
Toxoplasma gondii DNA-directed RNA polymerase II RPB2 0.0012 0.0002 0.0029
Schistosoma mansoni hypothetical protein 0.0013 0.0003 0.0001
Brugia malayi neuropeptide F receptor 0.0013 0.0003 0.0003
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0265 0.1294 0.1294
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0031 0.0031
Leishmania major 4-coumarate:coa ligase-like protein 0.0169 0.0804 0.4914
Loa Loa (eye worm) cyclophilin Ovcyp-2 0.0023 0.0057 0.0057
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0013 0.0003 0.0003
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.0535 0.1646
Loa Loa (eye worm) transcription factor SMAD2 0.0252 0.1228 0.1228
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0027 0.025
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0119 0.0549 0.169
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0331 0.1634 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0137 0.0137
Schistosoma mansoni calcium-activated potassium channel 0.0118 0.0543 0.0542
Trypanosoma brucei acetyl-CoA synthetase, putative 0.005 0.0192 0.1166
Leishmania major hypothetical protein, conserved 0.0118 0.0543 0.3318
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0013 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0028 0.0082 0.0082
Brugia malayi metabotropic glutamate receptor type 2 0.0043 0.0156 0.0156
Echinococcus multilocularis G-protein coupled receptor, putative 0.0013 0.0003 0.0003
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.003 0.0093 0.0372
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0037 0.0035
Loa Loa (eye worm) hypothetical protein 0.0039 0.0136 0.0136
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0489 0.2443 0.2443
Brugia malayi cyclophilin-type peptidyl-prolyl cis-trans isomerase-2, Bmcyp-2 0.0023 0.0057 0.0057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0039 0.0136 0.0136
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0031 0.0031
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0037 0.0037
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.0335 0.1016
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0027 0.011
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.0335 0.1016
Loa Loa (eye worm) hypothetical protein 0.005 0.0192 0.0192
Trichomonas vaginalis phosphofructokinase, putative 0.0214 0.1034 0.4161
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0027 0.0027
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0027 0.011
Leishmania major cathepsin L-like protease 0.0018 0.0027 0.0158
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0026 0.0069 0.0067
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0335 0.0333
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0031 0.003
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0019 0.0108
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0412 0.0412
Brugia malayi topoisomerase 0.003 0.0093 0.0093
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.023 0.1117 0.6831
Echinococcus granulosus sodium:glucose cotransporter 2 0.004 0.014 0.014
Echinococcus granulosus neuropeptides capa receptor 0.0013 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0013 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0126 0.0585 0.178
Mycobacterium leprae DNA-DIRECTED RNA POLYMERASE (BETA CHAIN) RPOB (TRANSCRIPTASE BETA CHAIN) (RNA POLYMERASE BETA SUBUNIT) 0.0242 0.1179 1
Brugia malayi MH1 domain containing protein 0.0017 0.0025 0.0025
Onchocerca volvulus 0.0018 0.0031 0.0126
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0118 0.0543 0.3318
Schistosoma mansoni z-protein (S1r protein) 0.0039 0.0137 0.0136
Brugia malayi beta-lactamase 0.0077 0.0335 0.0335
Toxoplasma gondii phosphofructokinase PFKII 0.0058 0.0234 0.4303
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.023 0.1117 0.6831
Schistosoma mansoni cpg binding protein 0.006 0.0245 0.0244
Loa Loa (eye worm) hypothetical protein 0.0118 0.0543 0.0543
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0035 0.0049
Schistosoma mansoni DNA ligase IV 0.003 0.0093 0.0091
Loa Loa (eye worm) hypothetical protein 0.0279 0.1369 0.1369
Echinococcus granulosus DNA directed RNA polymerase III subunit RPC2 0.0012 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0064 0.1171
Echinococcus granulosus nibrin 0.003 0.0093 0.0093
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.002 0.0042 0.0041
Loa Loa (eye worm) hypothetical protein 0.0055 0.0219 0.0219
Brugia malayi PHD-finger family protein 0.0012 0.0001 0.0001
Loa Loa (eye worm) DNA-directed RNA polymerase II second largest subunit 0.0012 0.0002 0.0002
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0037 0.0216
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0037 0.0216
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0137 0.0136
Plasmodium falciparum glutathione reductase 0.0046 0.0173 0.0537
Toxoplasma gondii DNA-directed RNA polymerase III RPC2 0.0012 0.0002 0.0029
Onchocerca volvulus 0.0013 0.0003 0.0011
Onchocerca volvulus 0.0077 0.0335 0.1347
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Echinococcus multilocularis protein dispatched 1 0.0048 0.0186 0.0186
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0137 0.0137
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0039 0.0039
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0027 0.011
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0039 0.0137 0.0137
Trichomonas vaginalis helicase, putative 0.0013 0.0004 0.0014
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0013 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0137 0.0552
Echinococcus granulosus ecdysone induced protein 78C 0.0039 0.0136 0.0136
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0027 0.011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0027 0.011
Schistosoma mansoni inositol transporter 0.004 0.014 0.0139
Onchocerca volvulus 0.0497 0.2485 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0019 0.0108
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0061 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.1963 1 1
Onchocerca volvulus 0.0118 0.0543 0.2186
Trypanosoma cruzi cyclophilin, putative 0.0023 0.0057 0.034
Entamoeba histolytica hypothetical protein 0.0039 0.0137 0.1315
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0264 0.0264
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.023 0.1117 0.6831
Loa Loa (eye worm) hypothetical protein 0.0079 0.0344 0.0344
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0192 0.0568
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0079 0.0343 0.0343
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0045 0.018
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0229 0.0229
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0216
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0136 0.0136
Echinococcus multilocularis smad 0.0017 0.0025 0.0025
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0082 0.0082
Loa Loa (eye worm) MH2 domain-containing protein 0.0252 0.1228 0.1228
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0004 0.0014
Brugia malayi MH2 domain containing protein 0.0252 0.1228 0.1228
Entamoeba histolytica calcium-gated potassium channel protein, putative 0.0118 0.0543 0.5246
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0125 0.0502
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0064 0.038
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0093 0.0557
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Echinococcus multilocularis frizzled 5 0.0016 0.0021 0.0021
Onchocerca volvulus 0.0013 0.0003 0.0011
Echinococcus multilocularis lamin 0.0055 0.0219 0.0219
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0098 0.0438 0.0438
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0031 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0004 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0006 0.0027
Echinococcus multilocularis DNA directed RNA polymerase II subunit RPB2 0.0012 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Brugia malayi AMP-binding enzyme family protein 0.005 0.0192 0.0192
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0013 0.0003 0.0001
Brugia malayi G protein-coupled receptor 0.0013 0.0003 0.0003
Leishmania major ATP-dependent phosphofructokinase 0.0214 0.1034 0.6324
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0169 0.0804 0.2489
Schistosoma mansoni nuclear receptor 0.0018 0.0031 0.003
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0137 0.0136
Brugia malayi 6-phosphofructokinase 0.0214 0.1034 0.1034
Loa Loa (eye worm) hypothetical protein 0.0086 0.0379 0.0379
Schistosoma mansoni twik family of potassium channels-related 0.0118 0.0543 0.0542
Schistosoma mansoni smad1 5 8 and 0.0017 0.0025 0.0024
Echinococcus granulosus potassium channel subfamily K 8 0.0118 0.0543 0.0543
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.003 0.0093 0.0372
Trypanosoma cruzi hypothetical protein, conserved 0.0118 0.0543 0.3318
Schistosoma mansoni 6-phosphofructokinase 0.0214 0.1034 0.1033
Onchocerca volvulus 0.0118 0.0543 0.2186
Toxoplasma gondii ion channel protein 0.0118 0.0543 1
Echinococcus granulosus somatostatin receptor 0.0013 0.0003 0.0003
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0118 0.0543 0.0543
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.0685 0.0684
Schistosoma mansoni retinoic acid receptor RXR 0.0039 0.0136 0.0135
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0003 0.0003
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0118 0.0543 0.0543
Onchocerca volvulus 0.005 0.0192 0.0772
Loa Loa (eye worm) hypothetical protein 0.0039 0.0137 0.0137
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0004 0.0014
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.028 0.1704
Loa Loa (eye worm) hypothetical protein 0.0077 0.0335 0.0335
Loa Loa (eye worm) hypothetical protein 0.0039 0.0136 0.0136
Brugia malayi Integrin alpha pat-2 precursor 0.0369 0.183 0.183
Onchocerca volvulus 0.0018 0.0027 0.011
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0019 0.0055
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0136 0.0136

Activities

Activity type Activity value Assay description Source Reference
Clearance (ADMET) = 16 ml min-1 kg-1 Plasma clearance of the compound in rat ChEMBL. 10633035
F (ADMET) = 34 % Oral bioavailability in rat ChEMBL. 10633035
IC50 (functional) = 12 nM HEK cell adhesion mediated by alpha v beta 3 integrin ChEMBL. 10633035
IC50 (functional) = 12 nM HEK cell adhesion mediated by alpha v beta 3 integrin ChEMBL. 10633035
Ki (binding) = 0.9 nM Binding affinity for Vitronectin receptor (alpha V beta 3) ChEMBL. 10633035
Ki (binding) = 0.9 nM Binding affinity for Vitronectin receptor (alpha V beta 3) ChEMBL. 10633035
Ki (binding) = 3300 nM Binding affinity for alpha IIb beta3 integrin ChEMBL. 10633035
Ki (binding) = 3300 nM Binding affinity for alpha IIb beta3 integrin ChEMBL. 10633035
T1/2 (ADMET) = 360 min Half life period of the compound in rat ChEMBL. 10633035

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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