Detailed information for compound 1422900

Basic information

Technical information
  • TDR Targets ID: 1422900
  • Name: N-[(4-chlorophenyl)methyl]-N-(3-methylphenyl) methanesulfonamide
  • MW: 309.811 | Formula: C15H16ClNO2S
  • H donors: 0 H acceptors: 2 LogP: 3.56 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)CN(S(=O)(=O)C)c1cccc(c1)C
  • InChi: 1S/C15H16ClNO2S/c1-12-4-3-5-15(10-12)17(20(2,18)19)11-13-6-8-14(16)9-7-13/h3-10H,11H2,1-2H3
  • InChiKey: NGWJNKNPHSHBJZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(4-chlorobenzyl)-N-(3-methylphenyl)methanesulfonamide
  • MLS000862295
  • SMR000300731
  • ZINC00582700

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references
Homo sapiens Rap guanine nucleotide exchange factor (GEF) 4 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog Get druggable targets OG5_131726 All targets in OG5_131726
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131726 All targets in OG5_131726
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi N-terminal motif family protein Get druggable targets OG5_131726 All targets in OG5_131726
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0123 0.1347
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0032 0.0052
Brugia malayi Calcitonin receptor-like protein seb-1 0.0567 0.9331 0.9331
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0025 0.0123 0.0123
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.2636 0.4373
Leishmania major hypothetical protein, conserved 0.0025 0.0123 0.004
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.5901 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0575 0.0819
Echinococcus multilocularis lamin 0.0033 0.0257 0.0826
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.01 0.0284
Loa Loa (eye worm) DIX domain-containing protein 0.0019 0.0032 0.0032
Onchocerca volvulus 0.0033 0.0257 0.0377
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0179 0.275 0.275
Echinococcus granulosus mothers against decapentaplegic 5 0.0041 0.0405 0.1336
Echinococcus granulosus Pleckstrin G protein interacting region 0.0019 0.0032 0.0052
Brugia malayi RNA binding protein 0.0189 0.292 0.292
Schistosoma mansoni dishevelled 0.0019 0.0032 0.0024
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0233 0.0743
Schistosoma mansoni dep domain containing protein 0.0019 0.0032 0.0024
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.01 0.5
Echinococcus multilocularis smad 0.0041 0.0405 0.1336
Schistosoma mansoni smad1 5 8 and 0.0041 0.0405 0.0619
Mycobacterium ulcerans hypothetical protein 0.0192 0.2968 1
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0032 0.0024
Loa Loa (eye worm) hypothetical protein 0.0033 0.0257 0.0257
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0123 0.004
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.0233 0.023
Echinococcus granulosus lamin 0.0033 0.0257 0.0826
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.01 0.5
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0032 0.0024
Loa Loa (eye worm) MH2 domain-containing protein 0.0041 0.0405 0.0405
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.2636 0.4373
Brugia malayi Isocitrate dehydrogenase 0.0031 0.0233 0.0233
Loa Loa (eye worm) Smad1 0.0041 0.0405 0.0405
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.0233 0.0344
Schistosoma mansoni hypothetical protein 0.0179 0.275 0.436
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.2968 1
Brugia malayi MH2 domain containing protein 0.0041 0.0405 0.0405
Schistosoma mansoni hypothetical protein 0.0387 0.6285 1
Echinococcus multilocularis segment polarity protein dishevelled 0.0019 0.0032 0.0052
Echinococcus granulosus smad 0.0041 0.0405 0.1336
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0032 0.0032
Echinococcus granulosus tar DNA binding protein 0.0189 0.292 1
Schistosoma mansoni tar DNA-binding protein 0.0189 0.292 0.4632
Echinococcus multilocularis GPCR, family 2 0.0179 0.275 0.9413
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0387 0.6285 0.6285
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.0233 0.0464
Echinococcus multilocularis lamin dm0 0.0033 0.0257 0.0826
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0032 0.0052
Loa Loa (eye worm) TAR-binding protein 0.0189 0.292 0.292
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0017 0.0017
Loa Loa (eye worm) transcription factor SMAD2 0.0606 1 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0041 0.0405 0.1336
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.0233 0.0743
Schistosoma mansoni lamin 0.0033 0.0257 0.0383
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0233 0.2988
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0032
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.01 0.01
Echinococcus multilocularis tar DNA binding protein 0.0189 0.292 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.0233 0.023
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0032 0.0052
Loa Loa (eye worm) MH2 domain-containing protein 0.0606 1 1
Brugia malayi MH2 domain containing protein 0.0018 0.0017 0.0017
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.0233 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0123 0.004
Brugia malayi hypothetical protein 0.0025 0.0123 0.0123
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0567 0.9331 0.9331
Schistosoma mansoni smad1 5 8 and 0.0041 0.0405 0.0619
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.0233 1
Echinococcus multilocularis dna polymerase eta 0.0023 0.01 0.0284
Giardia lamblia DINP protein human, muc B family 0.0023 0.01 0.5
Echinococcus multilocularis dna polymerase kappa 0.0023 0.01 0.0284
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0032
Schistosoma mansoni smad 0.0041 0.0405 0.0619
Echinococcus granulosus intermediate filament protein 0.0033 0.0257 0.0826
Onchocerca volvulus 0.0033 0.0257 0.0377
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0179 0.275 0.9413
Loa Loa (eye worm) hypothetical protein 0.0393 0.6384 0.6384
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.5901 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0233 0.0743
Brugia malayi TAR-binding protein 0.0189 0.292 0.292
Loa Loa (eye worm) hypothetical protein 0.0023 0.01 0.01
Echinococcus multilocularis Smad4 0.0041 0.0405 0.1336
Echinococcus multilocularis segment polarity protein dishevelled 0.0019 0.0032 0.0052
Brugia malayi MH1 domain containing protein 0.0023 0.0092 0.0092
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0233 0.0743
Brugia malayi RNA recognition motif domain containing protein 0.0189 0.292 0.292
Schistosoma mansoni dishevelled 0.0019 0.0032 0.0024
Schistosoma mansoni Smad4 0.0041 0.0405 0.0619
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0257 0.0257
Schistosoma mansoni intermediate filament proteins 0.0033 0.0257 0.0383
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.01 0.0132
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.01 0.01
Echinococcus multilocularis musashi 0.0033 0.0257 0.0826
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.2636 0.4373
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0179 0.275 0.9413
Schistosoma mansoni smad1 5 8 and 0.0041 0.0405 0.0619
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0575 0.0819
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0233 0.2988
Schistosoma mansoni tar DNA-binding protein 0.0189 0.292 0.4632
Brugia malayi isocitrate dehydrogenase 0.0031 0.0233 0.0233
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.01 0.01
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0019 0.0032 0.0024
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.0233 0.0743
Toxoplasma gondii hypothetical protein 0.0059 0.0703 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.5901 1
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0019 0.0032 0.0024
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0032 0.0052
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0393 0.6384 1
Brugia malayi MH2 domain containing protein 0.0041 0.0405 0.0405
Brugia malayi MH1 domain containing protein 0.0041 0.0405 0.0405
Echinococcus granulosus segment polarity protein dishevelled 0.0019 0.0032 0.0052
Loa Loa (eye worm) hypothetical protein 0.0567 0.9331 0.9331
Schistosoma mansoni tar DNA-binding protein 0.0189 0.292 0.4632
Brugia malayi MH1 domain containing protein 0.0023 0.0092 0.0092
Loa Loa (eye worm) MH1 domain-containing protein 0.0041 0.0405 0.0405
Loa Loa (eye worm) latrophilin receptor protein 2 0.0179 0.275 0.275
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0017 0.0017
Brugia malayi Smad1 0.0041 0.0405 0.0405
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0179 0.275 0.9413
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0041 0.0405 0.0619
Echinococcus granulosus Smad4 0.0041 0.0405 0.1336
Onchocerca volvulus 0.0019 0.0032 0.0024
Loa Loa (eye worm) hypothetical protein 0.0179 0.275 0.275
Brugia malayi latrophilin 2 splice variant baaae 0.0387 0.6285 0.6285
Brugia malayi hypothetical protein 0.0019 0.0032 0.0032
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0233 0.023
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.01 0.0284
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0019 0.0032 0.0032
Brugia malayi Latrophilin receptor protein 2 0.0179 0.275 0.275
Brugia malayi hypothetical protein 0.0019 0.0032 0.0032
Echinococcus multilocularis mothers against decapentaplegic 5 0.0041 0.0405 0.1336
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0766 0.1148
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0575 0.0819
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0257 0.0257
Brugia malayi mothers against decapentaplegic homolog 3 0.0018 0.0017 0.0017
Loa Loa (eye worm) nuclear factor I 0.0023 0.0092 0.0092
Brugia malayi intermediate filament protein 0.0033 0.0257 0.0257
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0189 0.292 0.292
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.0233 0.0233
Schistosoma mansoni hypothetical protein 0.0179 0.275 0.436
Brugia malayi DIX domain containing protein 0.0019 0.0032 0.0032
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0019 0.0032 0.0052
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0123 0.004
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.5901 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0575 0.0819
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0179 0.275 0.9413
Schistosoma mansoni lamin 0.0033 0.0257 0.0383
Brugia malayi N-terminal motif family protein 0.0393 0.6384 0.6384
Echinococcus granulosus dna polymerase kappa 0.0023 0.01 0.0284
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0019 0.0032 0.0032
Brugia malayi MH1 domain containing protein 0.0041 0.0405 0.0405
Loa Loa (eye worm) hypothetical protein 0.0023 0.0092 0.0092
Schistosoma mansoni tar DNA-binding protein 0.0189 0.292 0.4632
Schistosoma mansoni tar DNA-binding protein 0.0189 0.292 0.4632
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0041 0.0405 0.1336
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0233 0.023
Loa Loa (eye worm) RNA binding protein 0.0189 0.292 0.292
Schistosoma mansoni DNA polymerase eta 0.0023 0.01 0.0132
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0567 0.9331 0.9331
Echinococcus granulosus lamin dm0 0.0033 0.0257 0.0826
Echinococcus granulosus segment polarity protein dishevelled 0.0019 0.0032 0.0052
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.0233 0.0743
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.01 0.0132
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0233 0.023
Schistosoma mansoni hypothetical protein 0.0179 0.275 0.436
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.01 0.5
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.0032 0.0247 0.0247
Schistosoma mansoni hypothetical protein 0.0179 0.275 0.436
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0032
Echinococcus granulosus dna polymerase eta 0.0023 0.01 0.0284
Echinococcus granulosus GPCR family 2 0.0179 0.275 0.9413

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0794 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.7079 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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