Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.252 | 0.3768 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.089 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.089 | 0.133 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0043 | 0.089 | 0.133 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0043 | 0.089 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.089 | 0.133 |
Onchocerca volvulus | 0.0043 | 0.089 | 0.5 | |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.154 | 0.2303 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0.089 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.089 | 0.5 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0021 | 0.0029 | 0.0043 |
Mycobacterium leprae | conserved hypothetical protein | 0.0043 | 0.089 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0.089 | 0.5 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0258 | 0.0385 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.0258 | 0.0385 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.0998 | 0.0995 |
Toxoplasma gondii | ABC1 family protein | 0.0043 | 0.089 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1202 | 0.1797 |
Echinococcus multilocularis | zinc finger protein | 0.0024 | 0.0118 | 0.0177 |
Mycobacterium leprae | Probable lipase LipE | 0.0043 | 0.089 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.0886 | 0.1325 |
Onchocerca volvulus | 0.0043 | 0.089 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.56 | 0.8374 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0.089 | 0.133 |
Mycobacterium ulcerans | beta-lactamase | 0.0043 | 0.089 | 0.5 |
Brugia malayi | beta-lactamase | 0.0043 | 0.089 | 0.0824 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0193 | 0.6688 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.089 | 0.0824 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.089 | 0.133 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.089 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.0886 | 0.1325 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0193 | 0.6688 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.089 | 0.0824 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.089 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.56 | 0.8374 |
Onchocerca volvulus | 0.0043 | 0.089 | 0.5 | |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0193 | 0.6688 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.089 | 0.133 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.089 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.089 | 0.133 |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0.089 | 0.133 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0799 | 0.0681 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.2171 | 0.3245 |
Echinococcus granulosus | geminin | 0.0165 | 0.56 | 0.8374 |
Echinococcus granulosus | zinc finger protein | 0.0024 | 0.0118 | 0.0177 |
Brugia malayi | Bromodomain containing protein | 0.0091 | 0.2721 | 0.3722 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1001 | 0.1497 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0025 | 0.0168 | 0.0251 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0193 | 0.6688 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0043 | 0.089 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.154 | 0.2303 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.089 | 0.133 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0043 | 0.089 | 0.5 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0043 | 0.089 | 0.133 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.2002 | 0.2994 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.154 | 0.1853 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0799 | 0.1195 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.2002 | 0.2994 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.089 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0799 | 0.1195 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.089 | 0.133 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1112 | 0.1663 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0193 | 0.6688 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0193 | 0.6688 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0193 | 0.6688 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0193 | 0.6688 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0193 | 0.6688 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.089 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0168 | 0.0251 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.154 | 0.1853 |
Mycobacterium ulcerans | lipase LipD | 0.0043 | 0.089 | 0.5 |
Schistosoma mansoni | zinc finger protein | 0.0024 | 0.0118 | 0.0177 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.0258 | 0.0385 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0.089 | 0.5 |
Echinococcus multilocularis | geminin | 0.0165 | 0.56 | 0.8374 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.089 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.089 | 0.0824 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.089 | 0.133 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.5623 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 0.7079 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 7.9433 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.