Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sphingomyelin phosphodiesterase 1, acid lysosomal | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | lipase LipD | 0.0041 | 0.0287 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0136 | 0.3198 | 0.3198 |
Toxoplasma gondii | kringle domain-containing protein | 0.0035 | 0.0079 | 0.2762 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0287 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0342 | 0.9562 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0264 | 0.7162 | 1 |
Echinococcus granulosus | snurportin 1 | 0.0342 | 0.9562 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0194 | 0.5016 | 0.5245 |
Schistosoma mansoni | hypothetical protein | 0.0194 | 0.5016 | 0.5245 |
Onchocerca volvulus | 0.0041 | 0.0287 | 0.021 | |
Trypanosoma brucei | hypothetical protein, conserved | 0.0041 | 0.0287 | 1 |
Echinococcus multilocularis | geminin | 0.0194 | 0.5016 | 0.5245 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0287 | 0.5 |
Brugia malayi | beta-lactamase | 0.0041 | 0.0287 | 0.0287 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0035 | 0.0079 | 0.0083 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0035 | 0.0079 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0.0287 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0136 | 0.3198 | 0.3344 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0041 | 0.0287 | 0.0301 |
Brugia malayi | RNA binding protein | 0.0136 | 0.3198 | 0.3198 |
Echinococcus granulosus | tar DNA binding protein | 0.0136 | 0.3198 | 0.3344 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0136 | 0.3198 | 0.3198 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0287 | 0.5 |
Mycobacterium ulcerans | beta-lactamase | 0.0041 | 0.0287 | 0.5 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0041 | 0.0287 | 0.0287 |
Brugia malayi | Kringle domain containing protein | 0.0035 | 0.0079 | 0.0079 |
Loa Loa (eye worm) | hypothetical protein | 0.0356 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0287 | 0.0287 |
Brugia malayi | TAR-binding protein | 0.0136 | 0.3198 | 0.3198 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0035 | 0.0079 | 0.0079 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0041 | 0.0287 | 0.0287 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0287 | 0.0287 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0342 | 0.9562 | 0.9562 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0041 | 0.0287 | 0.0301 |
Onchocerca volvulus | 0.0356 | 1 | 1 | |
Trichomonas vaginalis | esterase, putative | 0.0041 | 0.0287 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0287 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0041 | 0.0287 | 0.0287 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0041 | 0.0287 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0287 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0136 | 0.3198 | 0.3344 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.2091 | 0.2091 |
Schistosoma mansoni | tar DNA-binding protein | 0.0136 | 0.3198 | 0.3344 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0035 | 0.0079 | 0.2762 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0035 | 0.0079 | 0.0083 |
Loa Loa (eye worm) | TAR-binding protein | 0.0136 | 0.3198 | 0.3198 |
Onchocerca volvulus | 0.0041 | 0.0287 | 0.021 | |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0287 | 0.0287 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0.0287 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0287 | 0.0287 |
Echinococcus granulosus | geminin | 0.0194 | 0.5016 | 0.5245 |
Echinococcus multilocularis | snurportin 1 | 0.0342 | 0.9562 | 1 |
Brugia malayi | RNA, U transporter 1 | 0.0091 | 0.1822 | 0.1822 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0079 | 0.0083 |
Toxoplasma gondii | ABC1 family protein | 0.0041 | 0.0287 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0035 | 0.0079 | 0.0079 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.01 | 0.2091 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0041 | 0.0287 | 1 |
Onchocerca volvulus | 0.0041 | 0.0287 | 0.021 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0136 | 0.3198 | 0.3344 |
Leishmania major | hypothetical protein, conserved | 0.0041 | 0.0287 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0041 | 0.0287 | 0.0287 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0287 | 0.0287 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.01 | 0.2091 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0041 | 0.0287 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0041 | 0.0287 | 0.0301 |
Loa Loa (eye worm) | beta-lactamase | 0.0041 | 0.0287 | 0.0287 |
Loa Loa (eye worm) | RNA binding protein | 0.0136 | 0.3198 | 0.3198 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0287 | 0.0287 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0041 | 0.0287 | 0.0301 |
Schistosoma mansoni | tar DNA-binding protein | 0.0136 | 0.3198 | 0.3344 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0079 | 0.0079 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0041 | 0.0287 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0041 | 0.0287 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0136 | 0.3198 | 0.3344 |
Mycobacterium leprae | Probable lipase LipE | 0.0041 | 0.0287 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.