TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 269.302 | Formula: C14H15N5O
H donors: 1 H acceptors: 5 LogP: 2.49 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCCc1nc(O)c2c(n1)n(nn2)Cc1ccccc1
InChi: 1S/C14H15N5O/c1-2-6-11-15-13-12(14(20)16-11)17-18-19(13)9-10-7-4-3-5-8-10/h3-5,7-8H,2,6,9H2,1H3,(H,15,16,20)
InChiKey: FXSGFGQPWZSMRU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	ABC transporter of the mitochondrion, putative	0.0146	0.2228	0.2771
Entamoeba histolytica	ABC transporter, putative	0.0146	0.2228	0.2228
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0065	0.0202	0.0202
Schistosoma mansoni	tar DNA-binding protein	0.0324	0.6664	0.6664
Schistosoma mansoni	ABC transporter	0.0323	0.6623	0.6623
Toxoplasma gondii	ATP-binding cassette G family transporter ABCG84	0.038	0.8042	0.7995
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0458	1	1
Plasmodium vivax	multidrug resistance protein 2, putative	0.0146	0.2228	0.1774
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0458	1	1
Schistosoma mansoni	ATP-binding cassette sub-family g2 (white protein) (abcg2)	0.038	0.8042	0.8042
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0146	0.2228	0.2043
Loa Loa (eye worm)	hypothetical protein	0.0146	0.2228	0.2228
Leishmania major	ATP-binding cassette protein subfamily C, member 6, putative	0.0146	0.2228	0.2043
Leishmania major	ATP-binding cassette protein subfamily C, member 5, putative	0.0146	0.2228	0.2043
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	0.0458	1	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0458	1	1
Trichomonas vaginalis	ABC transporter, putative	0.0458	1	1
Trypanosoma cruzi	ABC transporter, mitochondrial, putative	0.0146	0.2228	0.2771
Leishmania major	ATP-binding cassette protein subfamily C, member 1, putative	0.0146	0.2228	0.2043
Entamoeba histolytica	ABC transporter, putative	0.038	0.8042	0.8042
Trypanosoma cruzi	multidrug resistance-associated protein, putative	0.0146	0.2228	0.2771
Toxoplasma gondii	ABC transporter family protein	0.0146	0.2228	0.2043
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0458	1	1
Brugia malayi	P-glycoprotein-like protein	0.0146	0.2228	0.2228
Schistosoma mansoni	multidrug resistance protein	0.0458	1	1
Echinococcus multilocularis	ATP binding cassette sub family B	0.0146	0.2228	0.2068
Leishmania major	ATP-binding cassette protein subfamily B, member 3, putative	0.0146	0.2228	0.2043
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0458	1	1
Brugia malayi	ABC transporter family protein	0.0146	0.2228	0.2228
Loa Loa (eye worm)	MH2 domain-containing protein	0.0375	0.7921	0.7921
Mycobacterium tuberculosis	Iron-regulated transporter IrtA	0.0146	0.2228	0.2228
Wolbachia endosymbiont of Brugia malayi	ABC-type protease secretion system, ATPase and permease component, AprD	0.0146	0.2228	0.5
Mycobacterium tuberculosis	Probable drugs-transport transmembrane ATP-binding protein ABC transporter	0.0146	0.2228	0.2228
Trypanosoma brucei	ABC transporter of the mitochondrion, putative	0.0146	0.2228	0.2556
Echinococcus multilocularis	ATP binding cassette sub family B	0.0146	0.2228	0.2068
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0206	0.3706	0.3706
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.0458	1	0.5
Echinococcus granulosus	ATP binding cassette sub family G	0.038	0.8042	0.8001
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0458	1	1
Echinococcus multilocularis	ATP binding cassette sub family G	0.038	0.8042	0.8001
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0146	0.2228	0.2771
Trypanosoma brucei	ABC transporter, putative	0.038	0.8042	1
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0146	0.2228	0.2043
Echinococcus multilocularis	tar DNA binding protein	0.0324	0.6664	0.6595
Loa Loa (eye worm)	hypothetical protein	0.0137	0.1996	0.1996
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0458	1	1
Loa Loa (eye worm)	multidrug resistance protein 3	0.0458	1	1
Mycobacterium ulcerans	component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD	0.0146	0.2228	0.2771
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.0449	0.9768	0.9763
Echinococcus multilocularis	multidrug resistance protein 1	0.0458	1	1
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0146	0.2228	0.2228
Brugia malayi	ABC transporter transmembrane region family protein	0.0146	0.2228	0.2228
Trypanosoma cruzi	ABC transporter, putative	0.0066	0.0232	0.0289
Brugia malayi	ABC transporter family protein	0.0323	0.6623	0.6623
Schistosoma mansoni	smdr2	0.0458	1	1
Trypanosoma brucei	p-glycoprotein	0.0146	0.2228	0.2556
Echinococcus granulosus	multidrug resistance protein 1	0.0321	0.6585	0.6514
Plasmodium falciparum	ABC transporter B family member 6, putative	0.0146	0.2228	0.1774
Schistosoma mansoni	hypothetical protein	0.0065	0.0202	0.0202
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0458	1	1
Plasmodium falciparum	multidrug resistance-associated protein 2	0.0146	0.2228	0.1774
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0146	0.2228	0.2043
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0553	0.0553
Trichomonas vaginalis	abcb9, putative	0.0458	1	1
Schistosoma mansoni	multidrug resistance protein	0.0137	0.1996	0.1996
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0458	1	1
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0321	0.6585	0.5733
Plasmodium vivax	multidrug resistance-associated protein 2, putative	0.0146	0.2228	0.1774
Trypanosoma cruzi	hypothetical protein, conserved	0.0066	0.0232	0.0289
Brugia malayi	hypothetical protein	0.0079	0.0553	0.0553
Plasmodium vivax	ABC transporter B family member 7, putative	0.0146	0.2228	0.1774
Echinococcus multilocularis		0.0146	0.2228	0.2068
Brugia malayi	TAR-binding protein	0.0324	0.6664	0.6664
Trypanosoma brucei	multidrug resistance-associated protein, putative	0.0146	0.2228	0.2556
Loa Loa (eye worm)	hypothetical protein	0.0137	0.1996	0.1996
Toxoplasma gondii	ABC transporter, putative	0.0146	0.2228	0.2043
Leishmania major	ABC-thiol transporter	0.0146	0.2228	0.2043
Brugia malayi	ABC transporter family protein	0.0458	1	1
Entamoeba histolytica	P-glycoprotein-2	0.0458	1	1
Echinococcus multilocularis	multidrug resistance associated protein 1	0.0146	0.2228	0.2068
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0206	0.3706	0.3706
Schistosoma mansoni	tar DNA-binding protein	0.0324	0.6664	0.6664
Trypanosoma cruzi	ATP-binding cassette protein, putative	0.038	0.8042	1
Schistosoma mansoni	multidrug resistance protein	0.0146	0.2228	0.2228
Brugia malayi	multidrug Resistance Protein family member (mrp-5), putative	0.0146	0.2228	0.2228
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0146	0.2228	0.2771
Plasmodium falciparum	ABC transporter B family member 4, putative	0.0146	0.2228	0.1774
Schistosoma mansoni	tar DNA-binding protein	0.0324	0.6664	0.6664
Entamoeba histolytica	P-glyco protein 6, putative	0.0458	1	1
Brugia malayi	ABC transporter transmembrane region family protein	0.0137	0.1996	0.1996
Loa Loa (eye worm)	ABC transporter transmembrane region family protein	0.0146	0.2228	0.2228
Plasmodium falciparum	ABC transporter B family member 3, putative	0.0146	0.2228	0.1774
Entamoeba histolytica	P-glycoprotein 5, putative	0.0458	1	1
Loa Loa (eye worm)	hypothetical protein	0.0146	0.2228	0.2228
Schistosoma mansoni	multidrug resistance protein	0.0146	0.2228	0.2228
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0458	1	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0458	1	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0458	1	1
Plasmodium vivax	ABC transporter G family member 2, putative	0.038	0.8042	0.7927
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0458	1	1
Plasmodium falciparum	multidrug resistance protein 2	0.0146	0.2228	0.1774
Plasmodium vivax	multidrug resistance-associated protein 1, putative	0.0146	0.2228	0.1774
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0458	1	1
Brugia malayi	hypothetical protein	0.0146	0.2228	0.2228
Leishmania major	hypothetical protein, conserved	0.0079	0.0553	0.0328
Echinococcus multilocularis	ATP binding cassette sub family G	0.038	0.8042	0.8001
Schistosoma mansoni	multidrug resistance protein	0.0146	0.2228	0.2228
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0065	0.0202	0.0202
Schistosoma mansoni	hypothetical protein	0.0313	0.639	0.639
Entamoeba histolytica	P-glycoprotein-2, putative	0.0458	1	1
Toxoplasma gondii	ATP-binding cassette sub-family B member 5	0.0146	0.2228	0.2043
Echinococcus multilocularis	multidrug resistance protein 1	0.0458	1	1
Trichomonas vaginalis	abcb9, putative	0.0458	1	1
Brugia malayi	ABC transporter transmembrane region family protein	0.0146	0.2228	0.2228
Schistosoma mansoni	hypothetical protein	0.0065	0.0202	0.0202
Entamoeba histolytica	P-glycoprotein-5	0.0458	1	1
Echinococcus multilocularis	ATP binding cassette sub family B	0.0146	0.2228	0.2068
Schistosoma mansoni	multidrug resistance protein	0.0458	1	1
Entamoeba histolytica	P-glycoprotein-2, putative	0.0137	0.1996	0.1996
Echinococcus granulosus	ATP binding cassette sub family G	0.038	0.8042	0.8001
Echinococcus granulosus	multidrug resistance associated protein 1	0.0146	0.2228	0.2068
Loa Loa (eye worm)	hypothetical protein	0.0458	1	1
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0458	1	1
Echinococcus granulosus	multidrug resistance protein 1	0.0458	1	1
Giardia lamblia	ABC transporter	0.037	0.7809	1
Schistosoma mansoni	hypothetical protein	0.0065	0.0202	0.0202
Echinococcus multilocularis	ATP binding cassette sub family G	0.038	0.8042	0.8001
Schistosoma mansoni	multidrug resistance protein	0.0146	0.2228	0.2228
Trypanosoma cruzi	hypothetical protein, conserved	0.0066	0.0232	0.0289
Loa Loa (eye worm)	TAR-binding protein	0.0324	0.6664	0.6664
Plasmodium falciparum	ABC transporter G family member 2	0.038	0.8042	0.7927
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0146	0.2228	0.2771
Plasmodium vivax	multidrug resistance protein 1, putative	0.0458	1	1
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0146	0.2228	0.2228
Brugia malayi	MH2 domain containing protein	0.0375	0.7921	0.7921
Giardia lamblia	Multidrug resistance-associated protein 1	0.0146	0.2228	0.04
Trypanosoma brucei	PAB1-binding protein , putative	0.0079	0.0553	0.041
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0458	1	1
Brugia malayi	ABC transporter family protein	0.0146	0.2228	0.2228
Trichomonas vaginalis	abcb9, putative	0.0458	1	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0202	0.0202
Leishmania major	pentamidine resistance protein 1	0.0146	0.2228	0.2043
Leishmania major	ATP-binding cassette protein subfamily G, member 4, putative	0.038	0.8042	0.7995
Loa Loa (eye worm)	ABC transporter	0.0146	0.2228	0.2228
Leishmania major	p-glycoprotein e	0.0146	0.2228	0.2043
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0458	1	1
Leishmania major	ATP-binding cassette protein subfamily C, member 2, putative	0.0146	0.2228	0.2043
Leishmania major	ATP-binding cassette protein subfamily B, member 1, putative	0.0146	0.2228	0.2043
Brugia malayi	multidrug resistance related protein 1	0.0146	0.2228	0.2228
Brugia malayi	Latrophilin receptor protein 2	0.0065	0.0202	0.0202
Echinococcus granulosus	multidrug resistance associated protein 7	0.0146	0.2228	0.2068
Trichomonas vaginalis	ABC transporter, putative	0.0458	1	1
Trypanosoma cruzi	ATP-binding cassette protein subfamily G	0.0066	0.0232	0.0289
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.038	0.8042	1
Loa Loa (eye worm)	hypothetical protein	0.0146	0.2228	0.2228
Schistosoma mansoni	ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6)	0.0137	0.1996	0.1996
Brugia malayi	RNA recognition motif domain containing protein	0.0324	0.6664	0.6664
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0458	1	1
Plasmodium falciparum	ABC transporter B family member 5, putative	0.0146	0.2228	0.1774
Leishmania major	p-glycoprotein	0.0458	1	1
Wolbachia endosymbiont of Brugia malayi	ABC-type multidrug transport system, ATPase and permease component	0.0146	0.2228	0.5
Trypanosoma cruzi	PAB1-binding protein , putative	0.0079	0.0553	0.0687
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0324	0.6664	0.6664
Echinococcus granulosus	multidrug resistance protein 1	0.0458	1	1
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0458	1	1
Brugia malayi	ABC transporter family protein	0.0146	0.2228	0.2228
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0458	1	1
Entamoeba histolytica	multidrug resistance protein, putative	0.0146	0.2228	0.2228
Loa Loa (eye worm)	ABC transporter	0.0146	0.2228	0.2228
Trichomonas vaginalis	ABC transporter, putative	0.0458	1	1
Echinococcus granulosus	ATP binding cassette sub family B	0.0146	0.2228	0.2068
Plasmodium vivax	ABC transporter B family member 3, putative	0.0146	0.2228	0.1774
Schistosoma mansoni	multidrug resistance protein	0.0458	1	1
Trichomonas vaginalis	taga, putative	0.0458	1	1
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0458	1	1
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0458	1	1
Trypanosoma cruzi	multidrug resistance-associated protein, putative	0.0146	0.2228	0.2771
Mycobacterium leprae	PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER	0.0146	0.2228	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0458	1	1
Schistosoma mansoni	smdr1	0.0146	0.2228	0.2228
Mycobacterium ulcerans	drugs-transport transmembrane ATP-binding protein ABC transporter	0.0146	0.2228	0.2771
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0146	0.2228	0.2228
Trypanosoma cruzi	PAB1-binding protein , putative	0.0079	0.0553	0.0687
Echinococcus granulosus	multidrug resistance protein 1	0.0321	0.6585	0.6514
Giardia lamblia	ABC transporter, putative	0.0146	0.2228	0.04
Trypanosoma brucei	ABC transporter, mitochondrial, putative	0.0146	0.2228	0.2556
Echinococcus granulosus	ATP binding cassette sub family B	0.0137	0.1996	0.1831
Echinococcus granulosus	tar DNA binding protein	0.0324	0.6664	0.6595
Entamoeba histolytica	P-glycoprotein 5, putative	0.0137	0.1996	0.1996
Echinococcus multilocularis	ATP binding cassette sub family B	0.0449	0.9768	0.9763
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.038	0.8042	1
Entamoeba histolytica	P-glycoprotein-1	0.0458	1	1
Loa Loa (eye worm)	hypothetical protein	0.0141	0.2084	0.2084
Echinococcus multilocularis	ATP binding cassette sub family B	0.0146	0.2228	0.2068
Loa Loa (eye worm)	ABC transporter	0.0323	0.6623	0.6623
Mycobacterium tuberculosis	Probable conserved transmembrane ATP-binding protein ABC transporter	0.0313	0.639	0.639
Entamoeba histolytica	P-glycoprotein-2	0.0458	1	1
Schistosoma mansoni	hypothetical protein	0.0141	0.2084	0.2084
Trypanosoma cruzi	multidrug resistance protein E, putative	0.0146	0.2228	0.2771
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0458	1	1
Plasmodium falciparum	ABC transporter B family member 7, putative	0.0146	0.2228	0.1774
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0146	0.2228	0.2228
Trypanosoma brucei	ATP-binding cassette protein, putative	0.038	0.8042	1
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0458	1	1
Brugia malayi	ABC transporter	0.0137	0.1996	0.1996
Trypanosoma brucei	multidrug resistance protein E	0.0146	0.2228	0.2556
Giardia lamblia	Multidrug resistance-associated protein 1	0.0146	0.2228	0.04
Plasmodium vivax	ABC transporter B family member 5, putative	0.0146	0.2228	0.1774
Plasmodium falciparum	multidrug resistance protein 1	0.0458	1	1
Echinococcus granulosus	multidrug resistance protein 1	0.0458	1	1
Trypanosoma cruzi	ABC transporter, putative	0.038	0.8042	1
Echinococcus granulosus	ATP binding cassette sub family B	0.0146	0.2228	0.2068
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0146	0.2228	0.2043
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0458	1	1
Onchocerca volvulus		0.0458	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0449	0.9768	0.9768
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0458	1	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0458	1	1
Plasmodium vivax	ABC transporter B family member 4, putative	0.0146	0.2228	0.1774
Entamoeba histolytica	P-glycoprotein 6, putative	0.0146	0.2228	0.2228
Loa Loa (eye worm)	RNA binding protein	0.0324	0.6664	0.6664
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0458	1	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0206	0.3706	0.3706
Schistosoma mansoni	multidrug resistance protein	0.0146	0.2228	0.2228
Trypanosoma brucei	multidrug resistance-associated protein, putative	0.0146	0.2228	0.2556
Schistosoma mansoni	hypothetical protein	0.0065	0.0202	0.0202
Entamoeba histolytica	P-glycoprotein 6, putative	0.0146	0.2228	0.2228
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0458	1	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0141	0.2084	0.2084
Giardia lamblia	MRP-like ABC transporter	0.0146	0.2228	0.04
Leishmania major	ATP-binding cassette protein subfamily C, member 8, putative	0.0146	0.2228	0.2043
Plasmodium falciparum	multidrug resistance-associated protein 1	0.0146	0.2228	0.1774
Plasmodium vivax	ABC transporter B family member 6, putative	0.0146	0.2228	0.1774
Entamoeba histolytica	hypothetical protein	0.0146	0.2228	0.2228
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0146	0.2228	0.029
Loa Loa (eye worm)	transcription factor SMAD2	0.0375	0.7921	0.7921
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.0458	1	1
Loa Loa (eye worm)	hypothetical protein	0.0458	1	1
Trichomonas vaginalis	ABC transporter, putative	0.0458	1	1
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0146	0.2228	0.2043
Toxoplasma gondii	LsmAD domain-containing protein	0.0079	0.0553	0.0328
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	0.0458	1	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0458	1	1
Mycobacterium leprae	PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER	0.0146	0.2228	1
Schistosoma mansoni	tar DNA-binding protein	0.0324	0.6664	0.6664
Echinococcus granulosus	ATP binding cassette sub family G	0.038	0.8042	0.8001
Leishmania major	ATP-binding cassette protein subfamily B, member 2, putative	0.0458	1	1
Brugia malayi	ABC transporter	0.0146	0.2228	0.2228
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0458	1	1
Leishmania major	ATP-binding cassette protein subfamily G, member 6, putative	0.038	0.8042	0.7995
Echinococcus multilocularis	multidrug resistance associated protein 7	0.0146	0.2228	0.2068
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.038	0.8042	1
Trypanosoma cruzi	ATP-binding cassette protein subfamily G	0.0066	0.0232	0.0289
Echinococcus multilocularis	multidrug resistance protein 1	0.0321	0.6585	0.6514
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0146	0.2228	0.2043
Schistosoma mansoni	tar DNA-binding protein	0.0324	0.6664	0.6664
Loa Loa (eye worm)	ABC transporter	0.0146	0.2228	0.2228
Schistosoma mansoni	ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7)	0.0146	0.2228	0.2228
Brugia malayi	RNA binding protein	0.0324	0.6664	0.6664
Loa Loa (eye worm)	hypothetical protein	0.0206	0.3706	0.3706

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	56.2341 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	63.0957 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1559520

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1422970