Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TAR-binding protein | 0.0486 | 0.3222 | 0.3021 |
Schistosoma mansoni | hypothetical protein | 0.0432 | 0.2805 | 0.3728 |
Schistosoma mansoni | tar DNA-binding protein | 0.0486 | 0.3222 | 0.4405 |
Loa Loa (eye worm) | hypothetical protein | 0.0432 | 0.2805 | 0.2592 |
Echinococcus granulosus | tar DNA binding protein | 0.0486 | 0.3222 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0486 | 0.3222 | 0.4405 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0432 | 0.2805 | 0.8464 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.1364 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0486 | 0.3222 | 0.4405 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0134 | 0.0508 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.0134 | 0.0508 | 0.0508 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0134 | 0.0508 | 1 |
Brugia malayi | hypothetical protein | 0.0105 | 0.0288 | 0.0288 |
Schistosoma mansoni | hypothetical protein | 0.0432 | 0.2805 | 0.3728 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.1159 | 0.8422 | 0.5 |
Brugia malayi | RNA binding protein | 0.0486 | 0.3222 | 0.3222 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0134 | 0.0508 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 0.1054 | 0.2013 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0134 | 0.0508 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0932 | 0.667 | 0.667 |
Loa Loa (eye worm) | hypothetical protein | 0.0932 | 0.667 | 0.6571 |
Loa Loa (eye worm) | hypothetical protein | 0.1159 | 0.8422 | 0.8376 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1054 | 0.0886 |
Brugia malayi | N-terminal motif family protein | 0.1159 | 0.8422 | 0.8422 |
Schistosoma mansoni | hypothetical protein | 0.0932 | 0.667 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.1364 | 1 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0134 | 0.0508 | 1 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0134 | 0.0508 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0134 | 0.0508 | 1 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0134 | 0.0508 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0432 | 0.2805 | 0.8464 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0432 | 0.2805 | 0.2805 |
Schistosoma mansoni | tar DNA-binding protein | 0.0486 | 0.3222 | 0.4405 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0432 | 0.2805 | 0.8464 |
Schistosoma mansoni | hypothetical protein | 0.0432 | 0.2805 | 0.3728 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0134 | 0.0508 | 0.0226 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0432 | 0.2805 | 0.8464 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0432 | 0.2805 | 0.8464 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0432 | 0.2805 | 0.2805 |
Brugia malayi | TAR-binding protein | 0.0486 | 0.3222 | 0.3222 |
Schistosoma mansoni | tar DNA-binding protein | 0.0486 | 0.3222 | 0.4405 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0134 | 0.0508 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0486 | 0.3222 | 0.3021 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0134 | 0.0508 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0432 | 0.2805 | 0.8464 |
Loa Loa (eye worm) | RNA binding protein | 0.0486 | 0.3222 | 0.3021 |
Echinococcus multilocularis | tar DNA binding protein | 0.0486 | 0.3222 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1364 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0205 | 0.1054 | 0.2013 |
Brugia malayi | Isocitrate dehydrogenase | 0.0134 | 0.0508 | 0.0508 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0486 | 0.3222 | 0.3222 |
Schistosoma mansoni | hypothetical protein | 0.0432 | 0.2805 | 0.3728 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1054 | 0.0886 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0432 | 0.2805 | 0.2592 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.6169 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 6.5733 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 9.2 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.