Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Probable isocitrate dehydrogenase | 0.0019 | 0.0015 | 0.0015 |
Schistosoma mansoni | hypothetical protein | 0.0383 | 0.4419 | 1 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0026 | 0.0091 | 0.0091 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.016 | 0.1715 | 0.593 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0177 | 0.1927 | 0.6667 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0207 | 0.0207 |
Echinococcus granulosus | Smad4 | 0.0058 | 0.0476 | 0.1608 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.016 | 0.1715 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.016 | 0.1715 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0032 | 0.0165 | 0.0165 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0177 | 0.1927 | 0.1927 |
Echinococcus multilocularis | mothers against decapentaplegic 6 | 0.0026 | 0.0091 | 0.0265 |
Schistosoma mansoni | smad | 0.0058 | 0.0476 | 0.1047 |
Schistosoma mansoni | Smad4 | 0.0058 | 0.0476 | 0.1047 |
Echinococcus multilocularis | Smad4 | 0.0058 | 0.0476 | 0.1608 |
Loa Loa (eye worm) | isocitrate dehydrogenase gamma subunit | 0.0019 | 0.0015 | 0.0015 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0845 | 1 | 1 |
Brugia malayi | Probable isocitrate dehydrogenase | 0.0019 | 0.0015 | 0.0015 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.016 | 0.1715 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.1927 | 0.4342 |
Echinococcus multilocularis | Glycosyl transferase, family 8 | 0.0071 | 0.0634 | 0.216 |
Loa Loa (eye worm) | RNA binding protein | 0.0256 | 0.2883 | 0.2883 |
Echinococcus multilocularis | glycosyltransferase protein LARGE2 | 0.0068 | 0.0607 | 0.2065 |
Loa Loa (eye worm) | TAR-binding protein | 0.0256 | 0.2883 | 0.2883 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0207 | 0.0671 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0207 | 1 |
Brugia malayi | mothers against decapentaplegic homolog 3 | 0.0026 | 0.0091 | 0.0091 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0052 | 0.0414 | 0.1391 |
Brugia malayi | Smad1 | 0.0058 | 0.0476 | 0.0476 |
Echinococcus granulosus | mothers against decapentaplegic 2 | 0.0026 | 0.0091 | 0.0265 |
Brugia malayi | MH2 domain containing protein | 0.0058 | 0.0476 | 0.0476 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0207 | 0.0437 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0207 | 0.0671 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0845 | 1 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.016 | 0.1715 | 0.593 |
Brugia malayi | isocitrate dehydrogenase | 0.016 | 0.1715 | 0.1715 |
Trichomonas vaginalis | isocitrate dehydrogenase, putative | 0.0019 | 0.0015 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0207 | 0.0437 |
Schistosoma mansoni | glycosyltransferase-related | 0.0071 | 0.0634 | 0.1406 |
Echinococcus multilocularis | smad | 0.0058 | 0.0476 | 0.1608 |
Brugia malayi | MH1 domain containing protein | 0.0032 | 0.0165 | 0.0165 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0207 | 1 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.016 | 0.1715 | 0.3862 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0207 | 1 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.016 | 0.1715 | 0.593 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0058 | 0.0476 | 0.0476 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 0.2349 | 0.2349 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0058 | 0.0476 | 0.1608 |
Mycobacterium leprae | PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) | 0.0019 | 0.0015 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0256 | 0.2883 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0026 | 0.0091 | 0.0091 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | 0.0019 | 0.0015 | 0.0015 |
Brugia malayi | Isocitrate dehydrogenase subunit gamma, mitochondrial precursor | 0.0019 | 0.0015 | 0.0015 |
Echinococcus granulosus | smad | 0.0058 | 0.0476 | 0.1608 |
Brugia malayi | Isocitrate dehydrogenase | 0.016 | 0.1715 | 0.1715 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.016 | 0.1715 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.016 | 0.1715 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0177 | 0.1927 | 0.6667 |
Echinococcus granulosus | Glycosyltransferase protein LARGE1 | 0.0052 | 0.0414 | 0.1391 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0026 | 0.0091 | 0.0091 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0238 | 0.2653 | 0.2653 |
Wolbachia endosymbiont of Brugia malayi | isocitrate dehydrogenase | 0.0019 | 0.0015 | 0.5 |
Onchocerca volvulus | 0.0238 | 0.2653 | 1 | |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.016 | 0.1715 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0177 | 0.1927 | 0.6667 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.1927 | 0.4342 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0561 | 0.6566 | 0.6566 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0383 | 0.4419 | 0.4419 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0561 | 0.6566 | 0.6566 |
Loa Loa (eye worm) | hypothetical protein | 0.0383 | 0.4419 | 0.4419 |
Echinococcus multilocularis | Glycosyltransferase protein LARGE1 | 0.0052 | 0.0414 | 0.1391 |
Echinococcus granulosus | mothers against decapentaplegic 6 | 0.0026 | 0.0091 | 0.0265 |
Brugia malayi | MH1 domain containing protein | 0.0058 | 0.0476 | 0.0476 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit beta, mitochondrial | 0.0019 | 0.0015 | 0.0015 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0015 | 0.0015 |
Brugia malayi | TAR-binding protein | 0.0256 | 0.2883 | 0.2883 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0165 | 0.0165 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0207 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0058 | 0.0476 | 0.1047 |
Brugia malayi | MH2 domain containing protein | 0.0058 | 0.0476 | 0.0476 |
Schistosoma mansoni | tar DNA-binding protein | 0.0256 | 0.2883 | 0.6512 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.016 | 0.1715 | 0.593 |
Schistosoma mansoni | smad1 5 8 and | 0.0058 | 0.0476 | 0.1047 |
Brugia malayi | MH1 domain containing protein | 0.0058 | 0.0476 | 0.0476 |
Schistosoma mansoni | Smad4 | 0.0026 | 0.0091 | 0.0173 |
Schistosoma mansoni | tar DNA-binding protein | 0.0256 | 0.2883 | 0.6512 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0081 | 0.0081 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0177 | 0.1927 | 0.1927 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0256 | 0.2883 | 0.2883 |
Loa Loa (eye worm) | glycosyl transferase family 8 protein | 0.0071 | 0.0634 | 0.0634 |
Echinococcus multilocularis | mothers against decapentaplegic 2 | 0.0026 | 0.0091 | 0.0265 |
Schistosoma mansoni | smad1 5 8 and | 0.0058 | 0.0476 | 0.1047 |
Loa Loa (eye worm) | nuclear factor I | 0.0032 | 0.0165 | 0.0165 |
Echinococcus granulosus | glycosyltransferase protein LARGE2 | 0.0068 | 0.0607 | 0.2065 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.1927 | 0.1927 |
Brugia malayi | Pax transcription factor protein 2 | 0.0238 | 0.2653 | 0.2653 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.1927 | 0.4342 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.016 | 0.1715 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.016 | 0.1715 | 0.593 |
Loa Loa (eye worm) | hypothetical protein | 0.0561 | 0.6566 | 0.6566 |
Schistosoma mansoni | smad | 0.0026 | 0.0091 | 0.0173 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.016 | 0.1715 | 0.593 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0177 | 0.1927 | 0.6667 |
Schistosoma mansoni | tar DNA-binding protein | 0.0256 | 0.2883 | 0.6512 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0561 | 0.6566 | 0.6566 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0212 | 0.2349 | 0.8811 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0058 | 0.0476 | 0.1608 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0058 | 0.0476 | 0.1047 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.1927 | 0.4342 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.016 | 0.1715 | 0.1715 |
Brugia malayi | Glycosyl transferase family 8 protein | 0.0071 | 0.0634 | 0.0634 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0081 | 0.0081 |
Schistosoma mansoni | tar DNA-binding protein | 0.0256 | 0.2883 | 0.6512 |
Schistosoma mansoni | tar DNA-binding protein | 0.0256 | 0.2883 | 0.6512 |
Brugia malayi | RNA binding protein | 0.0256 | 0.2883 | 0.2883 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0091 | 0.0091 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0081 | 0.0387 |
Echinococcus granulosus | Glycosyl transferase family 8 | 0.0071 | 0.0634 | 0.216 |
Brugia malayi | N-terminal motif family protein | 0.0212 | 0.2349 | 0.2349 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0177 | 0.1927 | 0.1927 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0177 | 0.1927 | 0.6667 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.016 | 0.1715 | 1 |
Schistosoma mansoni | Smad4 | 0.0026 | 0.0091 | 0.0173 |
Loa Loa (eye worm) | Smad1 | 0.0058 | 0.0476 | 0.0476 |
Echinococcus multilocularis | tar DNA binding protein | 0.0256 | 0.2883 | 1 |
Echinococcus multilocularis | glycosyltransferase protein LARGE2 | 0.0068 | 0.0607 | 0.2065 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.016 | 0.1715 | 1 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0058 | 0.0476 | 0.1608 |
Echinococcus multilocularis | glycosyltransferase protein LARGE2 | 0.0068 | 0.0607 | 0.2065 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.016 | 0.1715 | 1 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0058 | 0.0476 | 0.0476 |
Mycobacterium ulcerans | 3-isopropylmalate dehydrogenase | 0.0019 | 0.0015 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0177 | 0.1927 | 0.6667 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0058 | 0.0476 | 0.1608 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0256 | 0.2883 | 0.2883 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 44.6684 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.