TDR Targets

Basic information

Technical information

TDR Targets ID: 1423418
Name: 4-(2,1,3-benzothiadiazol-7-ylsulfonylamino)-N -[(4-fluorophenyl)methyl]butanamide
MW: 408.47 | Formula: C17H17FN4O3S2
H donors: 2 H acceptors: 5 LogP: 1.96 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: O=C(NCc1ccc(cc1)F)CCCNS(=O)(=O)c1cccc2c1nsn2
InChi: 1S/C17H17FN4O3S2/c18-13-8-6-12(7-9-13)11-19-16(23)5-2-10-20-27(24,25)15-4-1-3-14-17(15)22-26-21-14/h1,3-4,6-9,20H,2,5,10-11H2,(H,19,23)
InChiKey: UFCGJFWKRVAAKF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(4-fluorobenzyl)-4-(piazthiol-4-ylsulfonylamino)butyramide
4-[(2,1,3-benzothiadiazol-4-ylsulfonyl)amino]-N-(4-fluorobenzyl)butanamide
MLS000047167
SMR000033178

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	muscleblind-like splicing regulator 1	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	Muscleblind-like protein	Get druggable targets OG5_132352	All targets in OG5_132352
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	muscleblind protein	Get druggable targets OG5_132352	All targets in OG5_132352
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	muscleblind protein 1	Get druggable targets OG5_132352	All targets in OG5_132352
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132352	All targets in OG5_132352
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132352	All targets in OG5_132352
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	muscleblind protein	Get druggable targets OG5_132352	All targets in OG5_132352

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	LsmAD domain-containing protein	0.0051	0.0349	0.1881
Echinococcus multilocularis	guanine nucleotide binding protein (G protein)	0.0037	0.0178	0.0175
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0272	0.2988	0.302
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0092	0.0839	0.7749
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0112	0.108	1
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0037	0.0178	0.057
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0092	0.0839	0.0835
Echinococcus multilocularis	tar DNA binding protein	0.0318	0.3537	0.3576
Echinococcus granulosus	expressed protein	0.0037	0.0178	0.0175
Echinococcus granulosus	mothers against decapentaplegic 5	0.0049	0.0329	0.0329
Echinococcus multilocularis	smad	0.0049	0.0329	0.0329
Echinococcus granulosus	smad	0.0049	0.0329	0.0329
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0112	0.108	0.1093
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0023	0.0014	0.001
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0112	0.108	1
Onchocerca volvulus		0.015	0.1531	0.8364
Brugia malayi	ImpB/MucB/SamB family protein	0.0052	0.0364	0.036
Schistosoma mansoni	GTP-binding protein alpha subunit	0.0037	0.0178	0.018
Brugia malayi	guanine nucleotide-binding protein alpha-3 subunit, putative	0.0037	0.0178	0.0173
Trypanosoma cruzi	PAB1-binding protein , putative	0.0051	0.0349	0.3164
Brugia malayi	G-protein alpha subunit	0.0037	0.0178	0.0173
Schistosoma mansoni	Smad4	0.0022	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0364	0.036
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0049	0.0329	0.0329
Echinococcus granulosus	guanine nucleotide binding protein G protein	0.0037	0.0178	0.0175
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0272	0.2988	0.2985
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0037	0.0178	0.018
Loa Loa (eye worm)	RNA binding protein	0.0318	0.3537	0.3533
Schistosoma mansoni	smad	0.0049	0.0329	0.0333
Schistosoma mansoni	tar DNA-binding protein	0.0318	0.3537	0.3579
Echinococcus granulosus	guanine nucleotide binding protein subunit	0.0037	0.0178	0.0175
Schistosoma mansoni	smad1 5 8 and	0.0049	0.0329	0.0333
Leishmania major	hypothetical protein, conserved	0.0051	0.0349	0.3164
Echinococcus granulosus	guanine nucleotide binding protein subunit	0.0037	0.0178	0.0175
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.086	1	1
Schistosoma mansoni	tar DNA-binding protein	0.0318	0.3537	0.3579
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0272	0.2988	0.302
Loa Loa (eye worm)	guanine nucleotide-binding protein alpha-6 subunit	0.0037	0.0178	0.0173
Leishmania major	DNA polymerase eta, putative	0.0052	0.0364	0.3309
Loa Loa (eye worm)	glutaminase 2	0.0269	0.2948	0.2945
Echinococcus granulosus	Smad4	0.0049	0.0329	0.0329
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0049	0.0329	0.0329
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0049	0.0329	0.0329
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0349	0.0344
Brugia malayi	MH2 domain containing protein	0.0722	0.8357	0.8356
Schistosoma mansoni	GTP-binding protein (I) alpha-1subunit gnai1	0.0037	0.0178	0.018
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0037	0.0178	0.057
Schistosoma mansoni	kinase	0.0047	0.03	0.0303
Trichomonas vaginalis	GTP-binding protein (z) alpha subunit, gnaz, putative	0.0037	0.0178	0.057
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0092	0.0839	0.4573
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.085	0.9882	1
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0112	0.108	0.1076
Schistosoma mansoni	GTP-binding protein (I) alpha subunit gnai	0.0037	0.0178	0.018
Echinococcus multilocularis	muscleblind protein 1	0.018	0.1894	0.1913
Brugia malayi	glutaminase DH11.1	0.0269	0.2948	0.2945
Schistosoma mansoni	smad	0.0022	0.0005	0.0005
Brugia malayi	GTP-binding regulatory protein alpha chain - starfish, putative	0.0037	0.0178	0.0173
Schistosoma mansoni	tar DNA-binding protein	0.0318	0.3537	0.3579
Echinococcus granulosus	tar DNA binding protein	0.0318	0.3537	0.3576
Loa Loa (eye worm)	G protein alpha subunit 3	0.0037	0.0178	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0178	0.0173
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0112	0.108	1
Brugia malayi	guanine nucleotide-binding protein G-o protein alpha subunit	0.0037	0.0178	0.0173
Echinococcus multilocularis	dna polymerase eta	0.0052	0.0364	0.0364
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.085	0.9882	0.9882
Schistosoma mansoni	tar DNA-binding protein	0.0318	0.3537	0.3579
Trichomonas vaginalis	GTP-binding protein (q) alpha-11 subunit, gna11, putative	0.0037	0.0178	0.057
Schistosoma mansoni	GTP-binding protein (q) alpha-11 subunit gna11	0.0037	0.0178	0.018
Onchocerca volvulus		0.0037	0.0178	0.0949
Trichomonas vaginalis	G protein (olf) alpha subunit, gnal, putative	0.0037	0.0178	0.057
Echinococcus granulosus	GPCR family 2	0.0272	0.2988	0.302
Trypanosoma brucei	PAB1-binding protein , putative	0.0051	0.0349	0.3164
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0092	0.0839	0.0845
Brugia malayi	serine/threonine-protein kinase plk-2	0.0092	0.0839	0.0835
Brugia malayi	hypothetical protein	0.0037	0.0178	0.0173
Echinococcus multilocularis	Smad4	0.0049	0.0329	0.0329
Loa Loa (eye worm)	hypothetical protein	0.0175	0.1829	0.1826
Toxoplasma gondii	isocitrate dehydrogenase	0.0112	0.108	1
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0112	0.108	1
Loa Loa (eye worm)	hypothetical protein	0.015	0.1531	0.1527
Loa Loa (eye worm)	TAR-binding protein	0.0318	0.3537	0.3533
Brugia malayi	MH2 domain containing protein	0.0049	0.0329	0.0325
Schistosoma mansoni	GTP-binding protein alpha subunit gna	0.0037	0.0178	0.018
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0049	0.0329	0.0333
Loa Loa (eye worm)	MH1 domain-containing protein	0.0049	0.0329	0.0325
Brugia malayi	Latrophilin receptor protein 2	0.0272	0.2988	0.2985
Brugia malayi	Guanine nucleotide-binding protein alpha-12 subunit, putative	0.0037	0.0178	0.0173
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0272	0.2988	0.2985
Schistosoma mansoni	GTP-binding protein (I) alpha-1subunit gnai1	0.0037	0.0178	0.018
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.085	0.9882	0.9882
Brugia malayi	MH1 domain containing protein	0.0049	0.0329	0.0325
Echinococcus multilocularis	GPCR, family 2	0.0272	0.2988	0.302
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.085	0.9882	1
Loa Loa (eye worm)	hypothetical protein	0.0588	0.6754	0.6753
Brugia malayi	MH1 domain containing protein	0.0027	0.0067	0.0062
Trypanosoma cruzi	DNA polymerase eta, putative	0.0052	0.0364	0.3309
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0022	0.0011	0.0006
Brugia malayi	isocitrate dehydrogenase	0.0112	0.108	0.1076
Brugia malayi	ImpB/MucB/SamB family protein	0.0022	0.0011	0.0006
Echinococcus granulosus	muscleblind protein	0.018	0.1894	0.1913
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.0839	0.2821
Trypanosoma brucei	DNA polymerase eta, putative	0.0052	0.0364	0.3309
Brugia malayi	guanine nucleotide-binding protein alpha-7 subunit, putative	0.0037	0.0178	0.0173
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0112	0.108	0.1089
Schistosoma mansoni	trimeric G-protein alpha o subunit	0.0037	0.0178	0.018
Loa Loa (eye worm)	guanine nucleotide-binding protein alpha-12 subunit	0.0037	0.0178	0.0173
Brugia malayi	Calcitonin receptor-like protein seb-1	0.086	1	1
Brugia malayi	Guanine nucleotide-binding protein alpha-3 subunit, putative	0.0037	0.0178	0.0173
Loa Loa (eye worm)	Smad1	0.0049	0.0329	0.0325
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0112	0.108	1
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0037	0.0178	0.057
Schistosoma mansoni	hypothetical protein	0.0272	0.2988	0.3024
Brugia malayi	guanine nucleotide-binding protein G(o), alpha subunit, putative	0.0037	0.0178	0.0173
Echinococcus granulosus	guanine nucleotide binding protein G protein	0.0037	0.0178	0.0175
Echinococcus multilocularis	expressed protein	0.0037	0.0178	0.0175
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0037	0.0178	0.057
Brugia malayi	latrophilin 2 splice variant baaae	0.0588	0.6754	0.6753
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0272	0.2988	0.302
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.085	0.9882	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.085	0.9882	1
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0022	0.0011	0.0011
Trypanosoma cruzi	polo-like protein kinase, putative	0.0092	0.0839	0.7749
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0112	0.108	0.1089
Trypanosoma cruzi	polo-like protein kinase, putative	0.0092	0.0839	0.7749
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.0839	0.2821
Echinococcus multilocularis	isocitrate dehydrogenase	0.0112	0.108	0.1089
Schistosoma mansoni	hypothetical protein	0.0272	0.2988	0.3024
Giardia lamblia	Kinase, PLK	0.0092	0.0839	1
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0112	0.108	0.1089
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0272	0.2988	0.302
Echinococcus granulosus	gtp binding protein I alpha 1subunit	0.0037	0.0178	0.0175
Trichomonas vaginalis	GTP-binding protein (O) alpha subunit, gnao, putative	0.0037	0.0178	0.057
Onchocerca volvulus		0.0037	0.0178	0.0949
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.085	0.9882	1
Schistosoma mansoni	serine/threonine protein kinase	0.0092	0.0839	0.0849
Brugia malayi	TAR-binding protein	0.0318	0.3537	0.3533
Schistosoma mansoni	GTP-binding protein (q) alpha-11 subunit gna11	0.0037	0.0178	0.018
Schistosoma mansoni	GTP-binding protein alpha subunit	0.0037	0.0178	0.018
Schistosoma mansoni	smad1 5 8 and	0.0049	0.0329	0.0333
Loa Loa (eye worm)	heterotrimeric G protein alpha subunit	0.0037	0.0178	0.0173
Loa Loa (eye worm)	glutaminase	0.0269	0.2948	0.2945
Trypanosoma cruzi	PAB1-binding protein , putative	0.0051	0.0349	0.3164
Trypanosoma cruzi	DNA polymerase eta, putative	0.0037	0.018	0.158
Brugia malayi	hypothetical protein	0.015	0.1531	0.1527
Echinococcus multilocularis	guanine nucleotide binding protein subunit	0.0037	0.0178	0.0175
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.0839	0.2821
Brugia malayi	Smad1	0.0049	0.0329	0.0325
Echinococcus multilocularis	guanine nucleotide binding protein subunit	0.0037	0.0178	0.0175
Echinococcus granulosus	dna polymerase eta	0.0052	0.0364	0.0364
Schistosoma mansoni	Smad4	0.0022	0.0005	0.0005
Brugia malayi	MH1 domain containing protein	0.0049	0.0329	0.0325
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0037	0.0178	0.018
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0092	0.0839	1
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0022	0.0011	0.0006
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0112	0.108	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0178	0.0173
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0092	0.0839	0.0845
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.0839	0.2821
Loa Loa (eye worm)	hypothetical protein	0.018	0.1894	0.189
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0178	0.0173
Brugia malayi	Guanine nucleotide-binding protein alpha-6 subunit, putative	0.0037	0.0178	0.0173
Loa Loa (eye worm)	hypothetical protein	0.018	0.1894	0.189
Loa Loa (eye worm)	MH2 domain-containing protein	0.0049	0.0329	0.0325
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0285	0.0936
Loa Loa (eye worm)	hypothetical protein	0.0272	0.2988	0.2985
Brugia malayi	Isocitrate dehydrogenase	0.0112	0.108	0.1076
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.0839	0.2821
Echinococcus multilocularis	dna polymerase kappa	0.0022	0.0011	0.0006
Schistosoma mansoni	hypothetical protein	0.0272	0.2988	0.3024
Echinococcus granulosus	dna polymerase kappa	0.0022	0.0011	0.0006
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0175	0.1829	1
Loa Loa (eye worm)	hypothetical protein	0.086	1	1
Loa Loa (eye worm)	nuclear factor I	0.0027	0.0067	0.0062
Brugia malayi	Guanine nucleotide-binding protein alpha-3 subunit, putative	0.0037	0.0178	0.0173
Mycobacterium ulcerans	glutaminase	0.0269	0.2948	1
Brugia malayi	MH1 domain containing protein	0.0027	0.0067	0.0062
Trypanosoma brucei	polo-like protein kinase	0.0092	0.0839	0.7749
Leishmania major	DNA polymerase eta, putative	0.0037	0.018	0.158
Brugia malayi	Muscleblind-like protein	0.018	0.1894	0.189
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.085	0.9882	1
Brugia malayi	RNA binding protein	0.0318	0.3537	0.3533
Schistosoma mansoni	hypothetical protein	0.0588	0.6754	0.6835
Echinococcus multilocularis	gtp binding protein (I) alpha 1subunit	0.0037	0.0178	0.0175
Schistosoma mansoni	hypothetical protein	0.0023	0.0014	0.0015
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.0839	0.2821
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0112	0.108	0.1089
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0112	0.108	0.1089
Onchocerca volvulus		0.0037	0.0178	0.0949
Schistosoma mansoni	glutaminase	0.0269	0.2948	0.2983
Brugia malayi	hypothetical protein	0.0033	0.0134	0.0129
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0285	0.0936
Entamoeba histolytica	G protein alpha subunit, putative	0.0037	0.0178	0.202
Loa Loa (eye worm)	transcription factor SMAD2	0.0722	0.8357	0.8356
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0178	0.0173
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.0839	0.2821
Schistosoma mansoni	smad1 5 8 and	0.0049	0.0329	0.0333
Echinococcus multilocularis	muscleblind protein	0.018	0.1894	0.1913
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0022	0.0011	0.0006
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0037	0.0178	0.018
Brugia malayi	hypothetical protein	0.0051	0.0349	0.0344
Trichomonas vaginalis	glutaminase, putative	0.0269	0.2948	1
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0022	0.0011	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0067	0.0062
Echinococcus multilocularis	guanine nucleotide binding protein (G protein)	0.0037	0.0178	0.0175
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0318	0.3537	0.3533
Schistosoma mansoni	tar DNA-binding protein	0.0318	0.3537	0.3579
Brugia malayi	N-terminal motif family protein	0.0175	0.1829	0.1826
Schistosoma mansoni	hypothetical protein	0.0272	0.2988	0.3024
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0023	0.0014	0.001
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0112	0.108	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0178	0.0173
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.085	0.9882	1
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0112	0.108	1
Toxoplasma gondii	isocitrate dehydrogenase	0.0112	0.108	1
Schistosoma mansoni	Smad4	0.0049	0.0329	0.0333
Brugia malayi	RNA recognition motif domain containing protein	0.0318	0.3537	0.3533
Schistosoma mansoni	DNA polymerase eta	0.0052	0.0364	0.0369
Brugia malayi	MH2 domain containing protein	0.0049	0.0329	0.0325
Loa Loa (eye worm)	GTP-binding regulatory protein alpha chain	0.0037	0.0178	0.0173
Loa Loa (eye worm)	MH2 domain-containing protein	0.0722	0.8357	0.8356
Schistosoma mansoni	GTP-binding protein alpha subunit gna	0.0037	0.0178	0.018

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	2.2387 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (binding)	19.9526 uM	PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	20.7865 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 28.1838 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1555582

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1423418