Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0777 | 1 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0246 | 0.2772 | 0.9503 |
Loa Loa (eye worm) | TAR-binding protein | 0.0257 | 0.2917 | 0.2917 |
Schistosoma mansoni | hypothetical protein | 0.0246 | 0.2772 | 0.4165 |
Brugia malayi | isocitrate dehydrogenase | 0.005 | 0.0112 | 0.0112 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.005 | 0.0112 | 0.0385 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.005 | 0.0112 | 0.0112 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.005 | 0.0112 | 0.0385 |
Schistosoma mansoni | tar DNA-binding protein | 0.0257 | 0.2917 | 0.4383 |
Schistosoma mansoni | hypothetical protein | 0.0246 | 0.2772 | 0.4165 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0257 | 0.2917 | 0.2917 |
Schistosoma mansoni | tar DNA-binding protein | 0.0257 | 0.2917 | 0.4383 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0246 | 0.2772 | 0.9503 |
Schistosoma mansoni | tar DNA-binding protein | 0.0257 | 0.2917 | 0.4383 |
Schistosoma mansoni | hypothetical protein | 0.0531 | 0.6654 | 1 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.005 | 0.0112 | 0.0169 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.005 | 0.0112 | 0.0385 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.062 | 0.7854 | 0.7854 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0531 | 0.6654 | 0.6654 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.062 | 0.7854 | 0.7854 |
Loa Loa (eye worm) | hypothetical protein | 0.0531 | 0.6654 | 0.6654 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.005 | 0.0112 | 0.0385 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.005 | 0.0112 | 0.5 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.005 | 0.0112 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0777 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.062 | 0.7854 | 0.7854 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.005 | 0.0112 | 0.5 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.005 | 0.0112 | 0.5 |
Brugia malayi | RNA binding protein | 0.0257 | 0.2917 | 0.2917 |
Brugia malayi | Isocitrate dehydrogenase | 0.005 | 0.0112 | 0.0112 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0246 | 0.2772 | 0.9503 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.005 | 0.0112 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.005 | 0.0112 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.005 | 0.0112 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0246 | 0.2772 | 0.4165 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0246 | 0.2772 | 0.2772 |
Schistosoma mansoni | tar DNA-binding protein | 0.0257 | 0.2917 | 0.4383 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0246 | 0.2772 | 0.2772 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0246 | 0.2772 | 0.9503 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0777 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0257 | 0.2917 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.005 | 0.0112 | 0.0385 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0246 | 0.2772 | 0.2772 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0246 | 0.2772 | 0.9503 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0257 | 0.2917 | 0.2917 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.005 | 0.0112 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.005 | 0.0112 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0257 | 0.2917 | 0.2917 |
Schistosoma mansoni | tar DNA-binding protein | 0.0257 | 0.2917 | 0.4383 |
Schistosoma mansoni | hypothetical protein | 0.0246 | 0.2772 | 0.4165 |
Echinococcus multilocularis | tar DNA binding protein | 0.0257 | 0.2917 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.005 | 0.0112 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.2772 | 0.2772 |
Brugia malayi | TAR-binding protein | 0.0257 | 0.2917 | 0.2917 |
Echinococcus multilocularis | GPCR, family 2 | 0.0246 | 0.2772 | 0.9503 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.005 | 0.0112 | 0.0385 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 um | PUBCHEM_BIOASSAY: GAPDH Dose Response Colorimetric Assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (binding) | > 100 uM | PUBCHEM_BIOASSAY: SAR analysis of an In Vitro TNAP Dose Response Luminescent Assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1548, AID1574, AID1577, AID1659, AID518] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.