Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli O157:H7 | Shiga toxin | Starlite/ChEMBL | No references |
Homo sapiens | l(3)mbt-like 1 (Drosophila) | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | endonuclease exonuclease phosphatase | Get druggable targets OG5_130415 | All targets in OG5_130415 |
Schistosoma japonicum | Lethal(3)malignant brain tumor-like 4 protein, putative | Get druggable targets OG5_130415 | All targets in OG5_130415 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | Get druggable targets OG5_130415 | All targets in OG5_130415 |
Schistosoma japonicum | Lethal(3)malignant brain tumor-like 3 protein, putative | Get druggable targets OG5_130415 | All targets in OG5_130415 |
Schistosoma mansoni | hypothetical protein | Get druggable targets OG5_130415 | All targets in OG5_130415 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | katanin P80 subunit | Shiga toxin | 89 aa | 72 aa | 23.6 % |
Echinococcus granulosus | imidazolonepropionase | Shiga toxin | 89 aa | 94 aa | 25.5 % |
Echinococcus multilocularis | imidazolonepropionase | Shiga toxin | 89 aa | 94 aa | 26.6 % |
Schistosoma japonicum | Katanin p80 WD40-containing subunit B1, putative | Shiga toxin | 89 aa | 72 aa | 23.6 % |
Trichomonas vaginalis | coatomer beta subunit, putative | Shiga toxin | 89 aa | 87 aa | 27.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0227 | 0.579 | 0.6335 |
Schistosoma mansoni | tar DNA-binding protein | 0.0325 | 0.914 | 0.914 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0103 | 0.1536 | 0.168 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0066 | 0.0273 | 0.0298 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0273 | 0.0298 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.3158 | 0.3455 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.015 | 0.3158 | 0.3455 |
Schistosoma mansoni | hypothetical protein | 0.0103 | 0.1536 | 0.1536 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0066 | 0.0273 | 0.0273 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.015 | 0.3158 | 0.3455 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0066 | 0.0273 | 0.0298 |
Onchocerca volvulus | 0.0058 | 0 | 0.5 | |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0066 | 0.0273 | 0.0298 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0066 | 0.0273 | 0.0298 |
Schistosoma mansoni | tar DNA-binding protein | 0.0325 | 0.914 | 0.914 |
Schistosoma mansoni | tar DNA-binding protein | 0.0325 | 0.914 | 0.914 |
Brugia malayi | TAR-binding protein | 0.0325 | 0.914 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0325 | 0.914 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0325 | 0.914 | 0.914 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0325 | 0.914 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0325 | 0.914 | 0.914 |
Echinococcus multilocularis | tar DNA binding protein | 0.0325 | 0.914 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.1536 | 0.168 |
Loa Loa (eye worm) | TAR-binding protein | 0.0325 | 0.914 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0325 | 0.914 | 1 |
Loa Loa (eye worm) | MBCTL1 | 0.0066 | 0.0273 | 0.0298 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0325 | 0.914 | 1 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0058 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.015 | 0.3158 | 0.3455 |
Brugia malayi | RNA binding protein | 0.0325 | 0.914 | 1 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0227 | 0.579 | 0.6335 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0066 | 0.0273 | 0.0298 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.7981 um | PUBCHEM_BIOASSAY: A qHTS for Small Molecule Inhibitors of Shiga Toxin (Confirmatory). (Class of assay: confirmatory) [Related pubchem assays: 2314, 2318, 2315 ] | ChEMBL. | No reference |
Potency (functional) | 4.6535 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 75.6863 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.