Detailed information for compound 1423673

Basic information

Technical information
  • TDR Targets ID: 1423673
  • Name: benzimidazol-1-yl-(2-methyl-3-nitrophenyl)met hanone
  • MW: 281.266 | Formula: C15H11N3O3
  • H donors: 0 H acceptors: 4 LogP: 3.17 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1cccc(c1C)C(=O)n1cnc2c1cccc2
  • InChi: 1S/C15H11N3O3/c1-10-11(5-4-8-13(10)18(20)21)15(19)17-9-16-12-6-2-3-7-14(12)17/h2-9H,1H3
  • InChiKey: VDYJQQDNEQYZRB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • benzimidazol-1-yl-(2-methyl-3-nitro-phenyl)methanone
  • 1-benzimidazolyl-(2-methyl-3-nitrophenyl)methanone
  • AK-968/11367315
  • Oprea1_760969
  • Oprea1_733470
  • ZINC00138464
  • ST031093

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0028 0.0156 0.4994
Loa Loa (eye worm) TAR-binding protein 0.0397 0.3442 0.3433
Onchocerca volvulus 0.0027 0.0147 0.0138
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.0194 1
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0027 0.0147 0.5
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0017 0.0054 0.2076
Brugia malayi RNA binding protein 0.0397 0.3442 0.3406
Echinococcus multilocularis son of sevenless 1 0.0027 0.0147 0.0276
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0038 0.0245 0.0192
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.0017 0.0054 0.5
Brugia malayi MH2 domain containing protein 0.0253 0.2156 0.2113
Schistosoma mansoni dep domain containing protein 0.0038 0.0245 0.0283
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0038 0.0245 0.0564
Brugia malayi latrophilin 2 splice variant baaae 0.0775 0.6806 0.6788
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0019 0.0074 0.288
Echinococcus granulosus ras GTP exchange factor 0.0027 0.0147 0.0276
Loa Loa (eye worm) latrophilin receptor protein 2 0.0359 0.3099 0.309
Echinococcus multilocularis GPCR, family 2 0.0359 0.3099 0.8987
Brugia malayi MH1 domain containing protein 0.0017 0.0058 0.0004
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0027 0.0147 0.0138
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0058 0.0006
Schistosoma mansoni Smad4 0.0017 0.0058 0.0006
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0038 0.0245 0.0283
Mycobacterium tuberculosis Conserved hypothetical protein 0.0017 0.0054 0.2076
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.0017 0.0054 0.2076
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0027 0.0147 0.5
Mycobacterium ulcerans polyketide synthase Pks13 0.004 0.0258 1
Mycobacterium ulcerans polyketide synthase Pks9 0.0018 0.0061 0.0354
Treponema pallidum catabolite gene activator 0.0017 0.0054 0.5
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0015 0.0039 0.1505
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0027 0.0147 0.0138
Mycobacterium leprae Polyketide synthase Pks13 0.004 0.0258 1
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0027 0.0141 0.0088
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0038 0.0245 0.0192
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0027 0.0147 0.0138
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0028 0.0156 0.6033
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0021 0.0095 0.2013
Brugia malayi RNA recognition motif domain containing protein 0.0397 0.3442 0.3406
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0027 0.0141 0.5463
Echinococcus granulosus smad 0.0017 0.0058 0.0012
Schistosoma mansoni tar DNA-binding protein 0.0397 0.3442 0.5018
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0017 0.0054 0.1343
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.0194 0.0415
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0194 0.0415
Echinococcus granulosus segment polarity protein dishevelled 0.0038 0.0245 0.0564
Brugia malayi TAR-binding protein 0.0397 0.3442 0.3406
Schistosoma mansoni hypothetical protein 0.0775 0.6806 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0017 0.0054 0.2076
Echinococcus granulosus regulator of G protein signaling 7 0.0038 0.0245 0.0564
Brugia malayi Calcitonin receptor-like protein seb-1 0.1134 1 1
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0017 0.0058 0.1537
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0027 0.0141 0.5463
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0038 0.0245 0.0282
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.0017 0.0054 0.2076
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0033 0.0194 0.7524
Schistosoma mansoni ras GTP exchange factor 0.0027 0.0147 0.0138
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.0194 1
Mycobacterium ulcerans Type I modular polyketide synthase 0.0027 0.0141 0.4275
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.005 0.0353 0.0301
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.0027 0.0147 0.664
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0359 0.3099 0.8987
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0017 0.0054 0.1343
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.0194 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0028 0.0156 0.4994
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0194 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0027 0.0141 0.4275
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0038 0.0245 0.0232
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0025 0.0125 0.4861
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0058 0.0012
Schistosoma mansoni dishevelled 0.0038 0.0245 0.0283
Echinococcus multilocularis smad 0.0017 0.0058 0.0012
Mycobacterium leprae Probable polyketide synthase Pks1 0.0028 0.0156 0.4994
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0022 0.0102 0.2346
Echinococcus multilocularis ras GTP exchange factor 0.0027 0.0147 0.0276
Brugia malayi hypothetical protein 0.0038 0.0245 0.0192
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0017 0.0054 0.0041
Toxoplasma gondii type I fatty acid synthase, putative 0.0028 0.0156 0.597
Trypanosoma cruzi hypothetical protein 0.0027 0.0147 0.664
Brugia malayi N-terminal motif family protein 0.0027 0.0147 0.0094
Echinococcus granulosus son of sevenless 1 0.0027 0.0147 0.0276
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0027 0.0147 0.5
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0194 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0025 0.0125 0.0113
Loa Loa (eye worm) DIX domain-containing protein 0.0038 0.0245 0.0232
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0027 0.0147 0.0138
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0027 0.0147 0.0276
Mycobacterium ulcerans polyketide synthase 0.0027 0.0141 0.4275
Schistosoma mansoni hypothetical protein 0.0359 0.3099 0.451
Brugia malayi Isocitrate dehydrogenase 0.0033 0.0194 0.0141
Loa Loa (eye worm) hypothetical protein 0.0775 0.6806 0.6801
Schistosoma mansoni dishevelled 0.0038 0.0245 0.0283
Treponema pallidum cyclic nucleotide binding protein 0.0017 0.0054 0.5
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0021 0.0095 0.2013
Brugia malayi RasGEF domain containing protein 0.0027 0.0147 0.0094
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0058 0.0012
Echinococcus multilocularis regulator of G protein signaling 7 0.0038 0.0245 0.0564
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.004 0.0258 1
Schistosoma mansoni smad1 5 8 and 0.0017 0.0058 0.0006
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0028 0.0156 0.6033
Echinococcus multilocularis segment polarity protein dishevelled 0.0038 0.0245 0.0564
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.0194 0.0415
Loa Loa (eye worm) hypothetical protein 0.0045 0.0302 0.0289
Loa Loa (eye worm) Smad1 0.0017 0.0058 0.0045
Toxoplasma gondii hypothetical protein 0.0038 0.0245 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0194 0.0415
Brugia malayi MH2 domain containing protein 0.0017 0.0058 0.0004
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0194 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.0041
Echinococcus multilocularis tar DNA binding protein 0.0397 0.3442 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0777 0.6823 1
Mycobacterium tuberculosis Polyketide synthase Pks13 0.004 0.0258 1
Onchocerca volvulus Fatty acid synthase homolog 0.0048 0.0331 0.041
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0018 0.0061 0.0354
Schistosoma mansoni tar DNA-binding protein 0.0397 0.3442 0.5018
Mycobacterium ulcerans thioesterase 0.0022 0.0102 0.2346
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0026 0.0134 0.5182
Mycobacterium tuberculosis Probable thioesterase TesA 0.0022 0.0102 0.3934
Echinococcus granulosus Protein son of sevenless 0.0027 0.0147 0.0276
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0028 0.0156 0.4994
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0194 0.7713
Echinococcus granulosus segment polarity protein dishevelled 0.0038 0.0245 0.0564
Brugia malayi regulator of G-protein signaling egl-10 0.0038 0.0245 0.0192
Loa Loa (eye worm) RasGEF domain-containing protein 0.0027 0.0147 0.0134
Loa Loa (eye worm) hypothetical protein 0.1134 1 1
Onchocerca volvulus 0.0025 0.0125 0.0106
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0027 0.0147 0.5
Mycobacterium ulcerans thioesterase TesA 0.0022 0.0102 0.2346
Brugia malayi hypothetical protein 0.0038 0.0245 0.0192
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0026 0.0135 0.0121
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0027 0.0147 0.5
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0017 0.0054 0.1343
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0017 0.0054 0.0041
Treponema pallidum cyclic nucleotide binding protein 0.0017 0.0054 0.5
Loa Loa (eye worm) hypothetical protein 0.0777 0.6823 0.6819
Schistosoma mansoni hypothetical protein 0.0359 0.3099 0.451
Schistosoma mansoni tar DNA-binding protein 0.0397 0.3442 0.5018
Entamoeba histolytica hypothetical protein 0.0027 0.0147 0.5
Onchocerca volvulus 0.0046 0.0316 0.0388
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0017 0.0054 0.0041
Mycobacterium ulcerans Type I modular polyketide synthase 0.0027 0.0141 0.4275
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0397 0.3442 0.3433
Echinococcus granulosus GPCR family 2 0.0359 0.3099 0.8987
Schistosoma mansoni smad1 5 8 and 0.0017 0.0058 0.0006
Brugia malayi isocitrate dehydrogenase 0.0033 0.0194 0.0141
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.0194 0.0415
Schistosoma mansoni z-protein (S1r protein) 0.0038 0.0245 0.0283
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.0194 0.0208
Loa Loa (eye worm) hypothetical protein 0.0038 0.0245 0.0232
Loa Loa (eye worm) hypothetical protein 0.0027 0.0147 0.0134
Loa Loa (eye worm) RasGEF domain-containing protein 0.0027 0.0147 0.0134
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0027 0.0147 0.0276
Echinococcus multilocularis Protein son of sevenless 0.0027 0.0147 0.0276
Brugia malayi RasGEF domain containing protein 0.0027 0.0147 0.0094
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0359 0.3099 0.3061
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.0194 0.0181
Trichomonas vaginalis ras GTP exchange factor, putative 0.0027 0.0147 1
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0194 0.7713
Loa Loa (eye worm) fatty acid synthase 0.0026 0.0138 0.0125
Mycobacterium tuberculosis Conserved protein 0.0017 0.0054 0.2076
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0027 0.0141 0.5463
Brugia malayi RasGEF domain containing protein 0.0027 0.0147 0.0094
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.0017 0.0054 0.2076
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0359 0.3099 0.8987
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0359 0.3099 0.8987
Brugia malayi Smad1 0.0017 0.0058 0.0004
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.0017 0.0054 0.1343
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0027 0.0147 0.5
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0359 0.3099 0.8987
Schistosoma mansoni hypothetical protein 0.0359 0.3099 0.451
Schistosoma mansoni tar DNA-binding protein 0.0397 0.3442 0.5018
Schistosoma mansoni smad 0.0017 0.0058 0.0006
Mycobacterium ulcerans polyketide synthase 0.0028 0.0156 0.4994
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0027 0.0147 0.5
Onchocerca volvulus 0.0038 0.0245 0.0282
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0058 0.0012
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.0017 0.0054 0.5
Loa Loa (eye worm) RNA binding protein 0.0397 0.3442 0.3433
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0027 0.0141 0.4275
Loa Loa (eye worm) hypothetical protein 0.0038 0.0245 0.0232
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.0041
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0058 0.0012
Echinococcus granulosus regulator of G protein signaling 7 0.0038 0.0245 0.0564
Brugia malayi N-terminal motif family protein 0.0777 0.6823 0.6806
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.0194 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0038 0.0245 0.0564
Loa Loa (eye worm) AGC/PKG protein kinase 0.0017 0.0054 0.0041
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0027 0.0147 0.0276
Echinococcus granulosus Smad4 0.0017 0.0058 0.0012
Loa Loa (eye worm) RasGEF domain-containing protein 0.0027 0.0147 0.0134
Trichomonas vaginalis ras GTP exchange factor, putative 0.0027 0.0147 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0245 0.0232
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0028 0.0156 0.4994
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0018 0.0061 0.0354
Brugia malayi MH2 domain containing protein 0.0017 0.0058 0.0004
Mycobacterium ulcerans Type I modular polyketide synthase 0.0027 0.0141 0.4275
Trypanosoma cruzi hypothetical protein 0.0027 0.0147 0.664
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0027 0.0147 0.5
Brugia malayi MH1 domain containing protein 0.0017 0.0058 0.0004
Loa Loa (eye worm) hypothetical protein 0.0027 0.0147 0.0134
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1134 1 1
Loa Loa (eye worm) transcription factor SMAD2 0.0253 0.2156 0.2145
Echinococcus multilocularis Smad4 0.0017 0.0058 0.0012
Schistosoma mansoni tar DNA-binding protein 0.0397 0.3442 0.5018
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0027 0.0147 0.5
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0027 0.0147 0.0276
Loa Loa (eye worm) hypothetical protein 0.0359 0.3099 0.309
Loa Loa (eye worm) MH2 domain-containing protein 0.0253 0.2156 0.2145
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0021 0.0095 0.2013
Schistosoma mansoni smad1 5 8 and 0.0017 0.0058 0.0006
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0027 0.0147 0.5
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0027 0.0147 0.5
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0058 0.0045
Echinococcus granulosus tar DNA binding protein 0.0397 0.3442 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0024
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0017 0.0054 0.1343
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0058 0.0045
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0027 0.0147 0.5
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.0027 0.0147 1
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0026 0.0134 0.5182
Brugia malayi N-terminal motif family protein 0.0027 0.0147 0.0094
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0017 0.0054 0.0041
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0027 0.0141 0.4275
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0027 0.0147 0.5
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0027 0.0147 0.0138
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0245 0.0283
Brugia malayi DIX domain containing protein 0.0038 0.0245 0.0192
Treponema pallidum catabolite gene activator (Crp) 0.0017 0.0054 0.5
Echinococcus granulosus Pleckstrin G protein interacting region 0.0038 0.0245 0.0564
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0017 0.0054 0.1343
Echinococcus multilocularis segment polarity protein dishevelled 0.0038 0.0245 0.0564
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0194 0.0415
Brugia malayi Latrophilin receptor protein 2 0.0359 0.3099 0.3061
Toxoplasma gondii type I fatty acid synthase, putative 0.0019 0.0073 0.2214
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0028 0.0156 0.6033
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.0041
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0022 0.0098 0.3792
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0027 0.0147 1
Schistosoma mansoni hypothetical protein 0.0359 0.3099 0.451
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0125 0.0072

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.2213 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 32.6427 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Saccharomyces cerevisiae ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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