Detailed information for compound 1423749

Basic information

Technical information
  • TDR Targets ID: 1423749
  • Name: N-[2-(3,4-dimethoxyphenyl)ethyl]-N'-(5-ethyl- 1,3,4-thiadiazol-2-yl)butanediamide
  • MW: 392.473 | Formula: C18H24N4O4S
  • H donors: 2 H acceptors: 4 LogP: 1.79 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(CCNC(=O)CCC(=O)Nc2nnc(s2)CC)ccc1OC
  • InChi: 1S/C18H24N4O4S/c1-4-17-21-22-18(27-17)20-16(24)8-7-15(23)19-10-9-12-5-6-13(25-2)14(11-12)26-3/h5-6,11H,4,7-10H2,1-3H3,(H,19,23)(H,20,22,24)
  • InChiKey: GTKUVNUTYOCJFK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(3,4-dimethoxyphenyl)ethyl]-N'-(5-ethyl-1,3,4-thiadiazol-2-yl)succinamide
  • ZINC02425688
  • MLS000331684
  • N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-N'-(5-ethyl-[1,3,4]thiadiazol-2-yl)-succinamide
  • SMR000220788

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus importin subunit beta 1 0.0035 0.0266 0.0266
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0014 0.0279
Echinococcus multilocularis snurportin 1 0.0372 1 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0856 0.0856
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0516 0.0516
Schistosoma mansoni tar DNA-binding protein 0.0195 0.4897 0.4897
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0516 1
Plasmodium falciparum importin beta, putative 0.0035 0.0266 1
Brugia malayi beta-lactamase family protein 0.0043 0.0516 0.0687
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0856 0.0856
Onchocerca volvulus 0.0058 0.0942 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0 0.5
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0075 0.1461
Loa Loa (eye worm) hypothetical protein 0.0043 0.0516 0.0516
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1378 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0856 0.0856
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0266 0.1927
Schistosoma mansoni tar DNA-binding protein 0.0195 0.4897 0.4897
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0014 0.0104
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0516 0.0516
Brugia malayi beta-lactamase family protein 0.0043 0.0516 0.0687
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0516 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1378 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0014 0.0541
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.7286 1
Trichomonas vaginalis esterase, putative 0.0043 0.0516 1
Schistosoma mansoni survival motor neuron protein 0.0058 0.0942 0.0942
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0075 0.1461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0195 0.4897 0.4897
Brugia malayi hypothetical protein 0.0286 0.751 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0856 0.0856
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0856 0.1139
Toxoplasma gondii ABC1 family protein 0.0043 0.0516 0.3743
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0516 0.0516
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0075 0.1461
Leishmania major hypothetical protein, conserved 0.0026 0.0014 0.0104
Plasmodium vivax importin-beta 2, putative 0.0035 0.0266 0.515
Schistosoma mansoni importin beta-1 0.0035 0.0266 0.0266
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0856 0.0856
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.1378 0.1274
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0516 1
Brugia malayi hypothetical protein 0.0026 0.0014 0.0019
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0014 0.0279
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0014 0.0541
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0516 0.5
Loa Loa (eye worm) hypothetical protein 0.0043 0.0516 0.0516
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0856 0.0856
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0516 1
Mycobacterium leprae Probable lipase LipE 0.0043 0.0516 0.5
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0516 0.0516
Schistosoma mansoni hypothetical protein 0.0372 1 1
Loa Loa (eye worm) TAR-binding protein 0.0195 0.4897 0.4897
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0516 0.0516
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0856 0.0856
Brugia malayi RNA, U transporter 1 0.0099 0.2121 0.2823
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0266 0.0266
Brugia malayi RNA binding protein 0.0195 0.4897 0.652
Brugia malayi RNA recognition motif domain containing protein 0.0195 0.4897 0.652
Loa Loa (eye worm) hypothetical protein 0.0043 0.0516 0.0516
Brugia malayi Importin beta-1 subunit 0.0035 0.0266 0.0354
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0266 0.515
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0516 1
Leishmania major hypothetical protein, conserved 0.0043 0.0516 0.3743
Loa Loa (eye worm) hypothetical protein 0.0043 0.0516 0.0516
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.1378 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0942 0.1255
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.751 0.751
Schistosoma mansoni tar DNA-binding protein 0.0195 0.4897 0.4897
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0856 0.0856
Schistosoma mansoni hypothetical protein 0.0058 0.0942 0.0942
Echinococcus granulosus tar DNA binding protein 0.0195 0.4897 0.4897
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1378 0.1378
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.1378 0.1378
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0266 0.515
Brugia malayi TAR-binding protein 0.0195 0.4897 0.652
Loa Loa (eye worm) hypothetical protein 0.0035 0.0266 0.0266
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1378 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0075 0.1461
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.0014
Loa Loa (eye worm) beta-lactamase 0.0043 0.0516 0.0516
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0014 0.0279
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0516 1
Echinococcus multilocularis tar DNA binding protein 0.0195 0.4897 0.4897
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0014 0.0279
Schistosoma mansoni tar DNA-binding protein 0.0195 0.4897 0.4897
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 1 1
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0516 1
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0516 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0516 0.0516
Leishmania major importin beta-1 subunit, putative 0.0028 0.0075 0.0547
Loa Loa (eye worm) hypothetical protein 0.0043 0.0516 0.0516
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0516 0.0687
Entamoeba histolytica hypothetical protein 0.0028 0.0075 1
Loa Loa (eye worm) hypothetical protein 0.0286 0.751 0.751
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.1378 1
Brugia malayi beta-lactamase 0.0043 0.0516 0.0687
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1378 0.1378
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.1378 0.1378
Loa Loa (eye worm) RNA binding protein 0.0195 0.4897 0.4897
Schistosoma mansoni tar DNA-binding protein 0.0195 0.4897 0.4897
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0516 1
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.751 0.751

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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