Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | RAB9A, member RAS oncogene family | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | Niemann-Pick disease, type C1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | ras-related protein Rab-5B | RAB9A, member RAS oncogene family | 201 aa | 165 aa | 30.9 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.1421 | 0.1421 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0205 | 0.2229 | 0.2229 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0047 | 0.0265 | 1 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0057 | 0.0378 | 0.0431 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0047 | 0.0265 | 1 |
Schistosoma mansoni | patched 1 | 0.0051 | 0.031 | 0.0171 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0287 | 0.0083 |
Brugia malayi | MH1 domain containing protein | 0.0031 | 0.0064 | 0.0064 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0287 | 0.0083 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0047 | 0.0265 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0057 | 0.0378 | 0.0431 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0047 | 0.0265 | 1 |
Brugia malayi | Smad1 | 0.0057 | 0.0378 | 0.0378 |
Schistosoma mansoni | tar DNA-binding protein | 0.0258 | 0.2883 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0031 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | Smad1 | 0.0057 | 0.0378 | 0.0378 |
Brugia malayi | MH2 domain containing protein | 0.0057 | 0.0378 | 0.0378 |
Brugia malayi | RNA binding protein | 0.0258 | 0.2883 | 0.2883 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0205 | 0.2229 | 0.2229 |
Echinococcus granulosus | geminin | 0.0205 | 0.2222 | 0.7477 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0116 | 0.1115 | 0.3245 |
Echinococcus granulosus | GPCR family 2 | 0.0065 | 0.0483 | 0.0832 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.1155 | 0.1155 |
Echinococcus granulosus | Smad4 | 0.0057 | 0.0378 | 0.0431 |
Schistosoma mansoni | smad | 0.0057 | 0.0378 | 0.0431 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0829 | 1 | 1 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0057 | 0.0378 | 0.0431 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0047 | 0.0265 | 0.0265 |
Brugia malayi | CHE-14 protein | 0.0051 | 0.031 | 0.031 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0121 | 0.1178 | 0.3486 |
Echinococcus multilocularis | protein patched | 0.0051 | 0.031 | 0.0171 |
Loa Loa (eye worm) | RNA binding protein | 0.0258 | 0.2883 | 0.2883 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0065 | 0.0483 | 0.0832 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0057 | 0.0378 | 0.0378 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.0483 | 0.0832 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0047 | 0.0265 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0057 | 0.0378 | 0.0431 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0057 | 0.0378 | 0.0431 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0051 | 0.031 | 0.0171 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0047 | 0.0265 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.2229 | 0.2229 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0119 | 0.1155 | 0.3399 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0287 | 0.0083 |
Schistosoma mansoni | smad1 5 8 and | 0.0057 | 0.0378 | 0.0431 |
Loa Loa (eye worm) | nuclear factor I | 0.0031 | 0.0064 | 0.0064 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0065 | 0.0483 | 0.0483 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0258 | 0.2883 | 0.2883 |
Schistosoma mansoni | tar DNA-binding protein | 0.0258 | 0.2883 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0258 | 0.2883 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0362 | 0.418 | 0.418 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0258 | 0.2883 | 0.2883 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.014 | 0.1421 | 0.1421 |
Schistosoma mansoni | tar DNA-binding protein | 0.0258 | 0.2883 | 1 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0119 | 0.1155 | 1 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0057 | 0.0378 | 0.0431 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0287 | 0.0083 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0065 | 0.0483 | 0.0832 |
Brugia malayi | hypothetical protein | 0.0116 | 0.1115 | 0.1115 |
Echinococcus multilocularis | GPCR, family 2 | 0.0065 | 0.0483 | 0.0832 |
Echinococcus multilocularis | geminin | 0.0205 | 0.2222 | 0.7477 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0065 | 0.0483 | 0.0832 |
Echinococcus multilocularis | smad | 0.0057 | 0.0378 | 0.0431 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0047 | 0.0265 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0057 | 0.0378 | 0.0378 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.2222 | 0.7477 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0051 | 0.031 | 0.031 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0065 | 0.0483 | 0.0483 |
Schistosoma mansoni | hypothetical protein | 0.014 | 0.1421 | 0.4415 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0119 | 0.1155 | 0.1155 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.2222 | 0.7477 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.0483 | 0.0832 |
Schistosoma mansoni | Smad4 | 0.0057 | 0.0378 | 0.0431 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0483 | 0.0483 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0051 | 0.031 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0453 | 0.0453 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.017 | 0.179 | 0.5825 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0116 | 0.1115 | 0.3245 |
Schistosoma mansoni | tar DNA-binding protein | 0.0258 | 0.2883 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0057 | 0.0378 | 0.0378 |
Brugia malayi | TAR-binding protein | 0.0258 | 0.2883 | 0.2883 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0057 | 0.0378 | 0.0431 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0205 | 0.2229 | 0.2229 |
Echinococcus granulosus | tar DNA binding protein | 0.0258 | 0.2883 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0057 | 0.0378 | 0.0378 |
Echinococcus granulosus | smad | 0.0057 | 0.0378 | 0.0431 |
Echinococcus multilocularis | tar DNA binding protein | 0.0258 | 0.2883 | 1 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0051 | 0.031 | 0.0171 |
Echinococcus multilocularis | expressed conserved protein | 0.0112 | 0.1065 | 0.3056 |
Echinococcus multilocularis | protein dispatched 1 | 0.0058 | 0.04 | 0.0513 |
Echinococcus granulosus | expressed conserved protein | 0.0112 | 0.1065 | 0.3056 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0119 | 0.1155 | 0.3399 |
Brugia malayi | isocitrate dehydrogenase | 0.0047 | 0.0265 | 0.0265 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0047 | 0.0265 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0258 | 0.2883 | 0.2883 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0051 | 0.031 | 0.0171 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.017 | 0.179 | 0.5825 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0362 | 0.418 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0065 | 0.0483 | 0.0832 |
Brugia malayi | Isocitrate dehydrogenase | 0.0047 | 0.0265 | 0.0265 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0116 | 0.1115 | 0.3245 |
Brugia malayi | MH1 domain containing protein | 0.0057 | 0.0378 | 0.0378 |
Brugia malayi | N-terminal motif family protein | 0.0362 | 0.418 | 0.418 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.031 | 0.031 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0829 | 1 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0047 | 0.0265 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.0483 | 0.0832 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0047 | 0.0265 | 1 |
Echinococcus multilocularis | Smad4 | 0.0057 | 0.0378 | 0.0431 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0065 | 0.0483 | 0.0483 |
Schistosoma mansoni | hypothetical protein | 0.0116 | 0.1115 | 0.3245 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.0483 | 0.0832 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 50 uM | Inhibition of human platelet-type N-terminally His6-tagged 12-lipoxygenase assessed as conjugated diene product formation using arachidonic acid by UV-vis spectrophotometer analysis | ChEMBL. | 21739938 |
Potency (functional) | 0.7308 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.7783 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 2.8184 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 3.1623 um | PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 5.6234 um | PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.8048 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 6.3096 um | PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 6.5733 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 9.285 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.8638 uM | PUBCHEM_BIOASSAY: Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E): 8HQs - Round 1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2147, AID2421, AID2677] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485366, AID485386, AID504448, AID504454, AID504459] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 32.6294 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 50 uM | PUBCHEM_BIOASSAY: Cuvette-Based Assay for Inhibitors of 12-hLO (12-human lipoxygenase): 8HQ Series - Round 1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1452, AID2162, AID2164, AID2584, AID493209, AID493216, AID493219, AID493220] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 | ||
Saccharomyces cerevisiae | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.