Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | L aminoadipate semialdehyde | 0.1258 | 1 | 0.5 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0354 | 0.257 | 0.5 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0354 | 0.257 | 0.5 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.1258 | 1 | 0.5 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0354 | 0.257 | 0.5 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0354 | 0.257 | 1 |
Toxoplasma gondii | sterol carrier protein-2 HAD-2SCP-2 | 0.0073 | 0.0262 | 0.0777 |
Brugia malayi | maoC like domain containing protein | 0.0081 | 0.0331 | 0.0331 |
Entamoeba histolytica | hypothetical protein | 0.0354 | 0.257 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0331 | 0.0331 |
Mycobacterium tuberculosis | Probable dehydrogenase. Possible 2-enoyl acyl-CoA hydratase. | 0.0081 | 0.0331 | 0.1286 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0354 | 0.257 | 0.5 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.1258 | 1 | 0.5 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase domain-containing protein | 0.0354 | 0.257 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0081 | 0.0331 | 0.1286 |
Mycobacterium tuberculosis | Probable 3-hydroxyacyl-thioester dehydratase HtdY | 0.0081 | 0.0331 | 0.1286 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase superfamily protein | 0.0354 | 0.257 | 1 |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0354 | 0.257 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1258 | 1 | 1 |
Onchocerca volvulus | 0.1258 | 1 | 0.5 | |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0354 | 0.257 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0354 | 0.257 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0354 | 0.257 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0354 | 0.257 | 0.5 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0354 | 0.257 | 1 |
Mycobacterium ulcerans | dehydratase | 0.0081 | 0.0331 | 0.1286 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.