Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dopamine D2 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma japonicum | ko:K04145 dopamine receptor D2, putative | Dopamine D2 receptor | 444 aa | 432 aa | 30.8 % |
Echinococcus granulosus | biogenic amine 5HT receptor | Dopamine D2 receptor | 444 aa | 429 aa | 31.7 % |
Echinococcus multilocularis | serotonin receptor | Dopamine D2 receptor | 444 aa | 428 aa | 31.3 % |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | Dopamine D2 receptor | 444 aa | 487 aa | 23.8 % |
Schistosoma mansoni | biogenic amine receptor | Dopamine D2 receptor | 444 aa | 452 aa | 30.1 % |
Echinococcus granulosus | g protein coupled receptor | Dopamine D2 receptor | 444 aa | 457 aa | 21.0 % |
Schistosoma mansoni | biogenic amine (dopamine) receptor | Dopamine D2 receptor | 444 aa | 494 aa | 26.3 % |
Schistosoma japonicum | Octopamine receptor, putative | Dopamine D2 receptor | 444 aa | 456 aa | 29.4 % |
Schistosoma japonicum | ko:K04136 adrenergic receptor, alpha 1b, putative | Dopamine D2 receptor | 444 aa | 440 aa | 30.0 % |
Echinococcus multilocularis | g protein coupled receptor | Dopamine D2 receptor | 444 aa | 465 aa | 21.5 % |
Onchocerca volvulus | Dopamine D2 receptor | 444 aa | 418 aa | 23.0 % | |
Loa Loa (eye worm) | hypothetical protein | Dopamine D2 receptor | 444 aa | 433 aa | 21.2 % |
Schistosoma japonicum | ko:K04207 neuropeptide Y receptor Y5, putative | Dopamine D2 receptor | 444 aa | 386 aa | 19.7 % |
Onchocerca volvulus | RB1-inducible coiled-coil protein 1 homolog | Dopamine D2 receptor | 444 aa | 474 aa | 23.4 % |
Schistosoma mansoni | amine GPCR | Dopamine D2 receptor | 444 aa | 424 aa | 32.1 % |
Onchocerca volvulus | Glycoprotein hormone beta 5 homolog | Dopamine D2 receptor | 444 aa | 476 aa | 24.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0014 | 0.1841 | 0.55 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.002 | 0.3348 | 0.5 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.002 | 0.3348 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.3348 | 1 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.002 | 0.3348 | 0.3348 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.3348 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.3348 | 1 |
Trypanosoma brucei | unspecified product | 0.0014 | 0.1841 | 0.55 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.3348 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.3348 | 0.3348 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.3348 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.002 | 0.3348 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.3348 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.002 | 0.3348 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.3348 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.002 | 0.3348 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.002 | 0.3348 | 1 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.002 | 0.3348 | 1 |
Trypanosoma brucei | unspecified product | 0.0014 | 0.1841 | 0.55 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.3348 | 0.3348 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.3348 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.002 | 0.3348 | 1 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.002 | 0.3348 | 0.3348 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0014 | 0.1841 | 0.55 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.3348 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.3348 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.3348 | 1 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0006 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0014 | 0.1841 | 0.55 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.002 | 0.3348 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.3348 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.3348 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 1 | 1 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.002 | 0.3348 | 0.3348 |
Giardia lamblia | DINP protein human, muc B family | 0.002 | 0.3348 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.3348 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.002 | 0.3348 | 0.3348 |
Mycobacterium ulcerans | DNA polymerase IV | 0.002 | 0.3348 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.3348 | 1 |
Plasmodium vivax | DNA repair protein REV1, putative | 0.0006 | 0 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.002 | 0.3348 | 1 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0006 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 1 | 1 |
Toxoplasma gondii | BRCA1 C Terminus (BRCT) domain-containing protein | 0.0006 | 0 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.3348 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.3348 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.3348 | 0.3348 |
Trypanosoma brucei | unspecified product | 0.002 | 0.3348 | 1 |
Plasmodium falciparum | DNA repair protein REV1, putative | 0.0006 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.002 | 0.3348 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Compound behavior in rat; NT is Not Tested | ChEMBL. | 2573732 |
ED (functional) | > 20 mg kg-1 | Compound administered perorally was evaluated for the conditioned avoidance response in rats | ChEMBL. | 2573732 |
ED (functional) | = 25 mg kg-1 | Rotarod response in rat to assess muscular incoordination (following p.o. dosing) | ChEMBL. | 2573732 |
EDmin (functional) | = 50 mg kg-1 | Compound administered perorally was evaluated for the hypothermia (rectal temperature) in mice | ChEMBL. | 2573732 |
EDmin (functional) | = 50 mg kg-1 | Dose below which no catalepsy was observed at any time period (following p.o. dosing) | ChEMBL. | 2573732 |
EDmin (functional) | = 50 mg kg-1 | Compound administered perorally was evaluated for the hypothermia (rectal temperature) in mice | ChEMBL. | 2573732 |
EDmin (functional) | = 50 mg kg-1 | Dose below which no catalepsy was observed at any time period (following p.o. dosing) | ChEMBL. | 2573732 |
IC50 (binding) | uM | Compound was evaluated for the inhibition of [3H]-QNB binding to Muscarinic acetylcholine receptor from male Olac rat brain; NT is Not Tested | ChEMBL. | 2573732 |
IC50 (binding) | 0 uM | Compound was evaluated for the inhibition of [3H]-QNB binding to Muscarinic acetylcholine receptor from male Olac rat brain; NT is Not Tested | ChEMBL. | 2573732 |
IC50 (binding) | > 1 uM | Inhibition of [3H]-spiperone binding to Dopamine receptor D2 from striatum of the rat brain | ChEMBL. | 2573732 |
IC50 (binding) | > 1 uM | Inhibition of [3H]-spiperone binding to Dopamine receptor D2 from striatum of the rat brain | ChEMBL. | 2573732 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.