Detailed information for compound 1424119

Basic information

Technical information
  • TDR Targets ID: 1424119
  • Name: [(amino-pyridin-4-ylmethylidene)amino] 1,3-be nzodioxole-5-carboxylate
  • MW: 285.255 | Formula: C14H11N3O4
  • H donors: 1 H acceptors: 2 LogP: 1.77 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc2c(c1)OCO2)ONC(=N)c1ccncc1
  • InChi: 1S/C14H11N3O4/c15-13(9-3-5-16-6-4-9)17-21-14(18)10-1-2-11-12(7-10)20-8-19-11/h1-7H,8H2,(H2,15,17)
  • InChiKey: JUYPIDRPNWEARC-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • [[amino-(4-pyridyl)methylene]amino] 1,3-benzodioxole-5-carboxylate
  • 1,3-benzodioxole-5-carboxylic acid [[amino-(4-pyridyl)methylene]amino] ester
  • [(amino-pyridin-4-yl-methylidene)amino] 1,3-benzodioxole-5-carboxylate
  • STK111875
  • MLS000765159
  • SMR000288564
  • BAS 06107819
  • ZINC04349990

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis isocitrate dehydrogenase 0.0482 0.169 0.4811
Brugia malayi CHE-14 protein 0.0051 0.0113 0.0113
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0009 0.0054
Loa Loa (eye worm) hypothetical protein 0.1573 0.5688 0.5688
Loa Loa (eye worm) TAR-binding protein 0.0861 0.3082 0.3082
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.0222 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.008 0.008
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0047 0.0098 0.0173
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0089 0.0252 0.0817
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0089 0.0252 0.2936
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0482 0.169 1
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.0058 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0031
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0031 0.1219
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0089 0.0252 0.0252
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0089 0.0252 0.0252
Schistosoma mansoni tar DNA-binding protein 0.0861 0.3082 0.5419
Schistosoma mansoni smad1 5 8 and 0.0187 0.0612 0.1077
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0089 0.0252 0.0252
Schistosoma mansoni peptidase Clp (S14 family) 0.0081 0.0222 0.0391
Loa Loa (eye worm) hypothetical protein 0.0089 0.0252 0.0252
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0023 0.0011 0.003
Schistosoma mansoni hypothetical protein 0.0049 0.0106 0.0187
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0023 0.0011 0.003
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0187 0.0612 0.1077
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0089 0.0252 0.0817
Loa Loa (eye worm) hypothetical protein 0.0042 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0042 0.008 0.008
Echinococcus multilocularis GPCR, family 2 0.0728 0.2593 0.7379
Schistosoma mansoni hypothetical protein 0.0049 0.0106 0.0187
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0031 0.0129
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0081 0.0222 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0482 0.169 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0081 0.0222 1
Echinococcus multilocularis expressed conserved protein 0.0112 0.0335 0.0954
Brugia malayi photoreceptor-specific nuclear receptor 0.0574 0.2028 0.2028
Loa Loa (eye worm) hypothetical protein 0.0042 0.008 0.008
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0053 0.012 0.0709
Schistosoma mansoni isocitrate dehydrogenase 0.0058 0.014 0.0247
Loa Loa (eye worm) nuclear receptor NHR-67 0.0042 0.008 0.008
Leishmania major hypothetical protein, conserved 0.022 0.0731 0.4291
Onchocerca volvulus 0.0089 0.0252 0.2936
Echinococcus granulosus tyrosine protein kinase Fyn 0.0023 0.0011 0.0034
Brugia malayi Probable ClpP-like protease 0.0081 0.0222 0.0222
Echinococcus granulosus tyrosine protein kinase Src64B 0.0023 0.0011 0.0034
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0023 0.0011 0.003
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0482 0.169 0.4811
Schistosoma mansoni hypothetical protein 0.1573 0.5688 1
Loa Loa (eye worm) pax transcription factor protein 2 0.0234 0.0784 0.0784
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0089 0.0252 0.0252
Toxoplasma gondii LsmAD domain-containing protein 0.022 0.0731 0.4291
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0053 0.012 0.0709
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0482 0.169 0.5485
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0031 0.0615
Brugia malayi Steroid receptor seven-up type 2 0.0587 0.2076 0.2076
Echinococcus multilocularis protein patched 0.0051 0.0113 0.0322
Echinococcus granulosus smad 0.0187 0.0612 0.1987
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0023 0.0011 0.003
Schistosoma mansoni ap endonuclease 0.0023 0.0009 0.0016
Loa Loa (eye worm) MH1 domain-containing protein 0.0187 0.0612 0.0612
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0031 0.1219
Loa Loa (eye worm) DR-78 0.0042 0.008 0.008
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.0058 0.014 0.014
Loa Loa (eye worm) pigment dispersing factor receptor c 0.23 0.8354 0.8354
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0081 0.0222 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0728 0.2593 0.7379
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0009 0.5
Schistosoma mansoni hypothetical protein 0.0098 0.0287 0.0505
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0031 0.0615
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.008 0.0227
Brugia malayi tailless protein 0.0042 0.008 0.008
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0482 0.169 0.4811
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0047 0.0098 0.0319
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0023 0.0011 0.003
Echinococcus multilocularis peptidase Clp (S14 family) 0.0053 0.012 0.0342
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0089 0.0252 0.0717
Plasmodium falciparum ataxin-2 like protein, putative 0.022 0.0731 0.4307
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0028 0.0882
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0089 0.0252 0.0252
Echinococcus multilocularis conserved hypothetical protein 0.0057 0.0135 0.0383
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0028 0.014
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0089 0.0252 0.0252
Brugia malayi Nuclear hormone receptor-like 1 0.0047 0.0098 0.0098
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0089 0.0252 0.0717
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0482 0.169 1
Brugia malayi hypothetical protein 0.0042 0.008 0.008
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0031 0.0182
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.0058 0.014 0.014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0089 0.0252 0.0252
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0713 0.2537 0.7219
Brugia malayi SRC-1 0.0023 0.0011 0.0011
Echinococcus multilocularis Glycosyl transferase, family 8 0.0077 0.0207 0.059
Schistosoma mansoni hypothetical protein 0.0728 0.2593 0.4559
Echinococcus granulosus mothers against decapentaplegic 5 0.0187 0.0612 0.1987
Entamoeba histolytica hypothetical protein 0.0043 0.0085 0.2156
Brugia malayi MH2 domain containing protein 0.0187 0.0612 0.0612
Loa Loa (eye worm) hypothetical protein 0.022 0.0731 0.0731
Schistosoma mansoni nuclear hormone receptor 0.0042 0.008 0.014
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0089 0.0252 0.0252
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0009 0.0009
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.0058 0.014 0.0247
Echinococcus multilocularis mothers against decapentaplegic 2 0.0084 0.0233 0.0663
Echinococcus granulosus tyrosine protein kinase Src42A 0.0023 0.0011 0.0034
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0023 0.0011 0.0034
Loa Loa (eye worm) glycosyl transferase family 8 protein 0.0077 0.0207 0.0207
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0861 0.3082 0.3082
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0089 0.0252 0.0252
Brugia malayi TAR-binding protein 0.0861 0.3082 0.3082
Loa Loa (eye worm) latrophilin receptor protein 2 0.0728 0.2593 0.2593
Brugia malayi Pax transcription factor protein 2 0.0234 0.0784 0.0784
Echinococcus granulosus mothers against decapentaplegic 2 0.0084 0.0233 0.0756
Echinococcus granulosus ecdysone induced protein 78C 0.0089 0.0252 0.0817
Echinococcus granulosus c src tyrosine kinase 0.0023 0.0011 0.0034
Onchocerca volvulus 0.0042 0.008 0.0648
Loa Loa (eye worm) hypothetical protein 0.0089 0.0252 0.0252
Brugia malayi nuclear hormone receptor 0.0042 0.008 0.008
Loa Loa (eye worm) RNA binding protein 0.0861 0.3082 0.3082
Loa Loa (eye worm) hypothetical protein 0.0084 0.0233 0.0233
Brugia malayi isocitrate dehydrogenase 0.0482 0.169 0.169
Brugia malayi nuclear receptor NHR-88 0.0089 0.0252 0.0252
Loa Loa (eye worm) MH1 domain-containing protein 0.0084 0.0233 0.0233
Brugia malayi Calcitonin receptor-like protein seb-1 0.23 0.8354 0.8354
Echinococcus granulosus Glycosyl transferase family 8 0.0077 0.0207 0.0672
Onchocerca volvulus 0.0234 0.0784 1
Brugia malayi conserved hypotetical protein 0.0042 0.008 0.008
Echinococcus granulosus Smad4 0.0187 0.0612 0.1987
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0368 0.0648
Schistosoma mansoni smad1 5 8 and 0.0187 0.0612 0.1077
Loa Loa (eye worm) hypothetical protein 0.0047 0.0098 0.0098
Echinococcus granulosus peptidase Clp S14 family 0.0053 0.012 0.039
Brugia malayi ecdysteroid receptor 0.0089 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0089 0.0252 0.0252
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0023 0.0011 0.003
Trichomonas vaginalis isocitrate dehydrogenase, putative 0.0058 0.014 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0081 0.0222 1
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.0549 0.178
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0098 0.0287 0.0817
Schistosoma mansoni hypothetical protein 0.0728 0.2593 0.4559
Schistosoma mansoni hypothetical protein 0.0728 0.2593 0.4559
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.008 0.0259
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0047 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0042 0.008 0.008
Brugia malayi hypothetical protein 0.022 0.0731 0.0731
Trypanosoma cruzi PAB1-binding protein , putative 0.022 0.0731 0.4291
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0113 0.0367
Brugia malayi Isocitrate dehydrogenase 0.0482 0.169 0.169
Trypanosoma cruzi PAB1-binding protein , putative 0.022 0.0731 0.4291
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0089 0.0252 0.0817
Loa Loa (eye worm) hypothetical protein 0.0047 0.0098 0.0098
Brugia malayi MH1 domain containing protein 0.0104 0.0306 0.0306
Echinococcus granulosus FTZ F1 alpha 0.0089 0.0252 0.0817
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0728 0.2593 0.8413
Brugia malayi nuclear receptor NHR-88 0.0042 0.008 0.008
Echinococcus granulosus nuclear receptor nhr 48 0.0042 0.008 0.0259
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0089 0.0252 0.0717
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0023 0.0011 0.0034
Brugia malayi steroid hormone receptor 0.0089 0.0252 0.0252
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0089 0.0252 0.0252
Brugia malayi hypothetical protein 0.0047 0.0098 0.0098
Schistosoma mansoni steroid hormone receptor ad4bp 0.0089 0.0252 0.0443
Schistosoma mansoni Smad4 0.0187 0.0612 0.1077
Echinococcus multilocularis c src tyrosine kinase 0.0023 0.0011 0.003
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0089 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.23 0.8354 0.8354
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0089 0.0252 0.0443
Echinococcus multilocularis nuclear receptor nhr 48 0.0042 0.008 0.0227
Mycobacterium ulcerans hypothetical protein 0.0029 0.0031 0.1219
Schistosoma mansoni thyroid hormone receptor 0.0089 0.0252 0.0443
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0089 0.0252 0.0252
Toxoplasma gondii isocitrate dehydrogenase 0.0482 0.169 1
Schistosoma mansoni patched 1 0.0051 0.0113 0.0199
Schistosoma mansoni glycosyltransferase-related 0.0077 0.0207 0.0364
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0042 0.008 0.0648
Loa Loa (eye worm) hypothetical protein 0.0728 0.2593 0.2593
Echinococcus granulosus tyrosine protein kinase Lyn 0.0023 0.0011 0.0034
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0053 0.012 0.4744
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0089 0.0252 0.0252
Echinococcus multilocularis thyroid hormone receptor alpha 0.0089 0.0252 0.0717
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0362 0.0362
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0089 0.0252 0.0252
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0728 0.2593 0.2593
Schistosoma mansoni unc-13 (munc13) 0.0058 0.014 0.0247
Brugia malayi hypothetical protein 0.0142 0.0446 0.0446
Schistosoma mansoni nuclear receptor nhr-48 0.0042 0.008 0.014
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0089 0.0252 0.0443
Loa Loa (eye worm) hypothetical protein 0.0089 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.027 0.0916 0.0916
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0009 0.0029
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0031 0.1219
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0482 0.169 1
Brugia malayi hypothetical protein 0.0043 0.0085 0.0085
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0728 0.2593 0.7379
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0089 0.0252 0.0443
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.0549 0.1561
Loa Loa (eye worm) nuclear factor I 0.0104 0.0306 0.0306
Schistosoma mansoni tar DNA-binding protein 0.0861 0.3082 0.5419
Brugia malayi mothers against decapentaplegic homolog 3 0.0084 0.0233 0.0233
Entamoeba histolytica hypothetical protein 0.0043 0.0085 0.2156
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0023 0.0011 0.003
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0023 0.0011 0.003
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0081 0.0222 0.0721
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.0058 0.014 0.0456
Loa Loa (eye worm) hypothetical protein 0.0042 0.008 0.008
Brugia malayi Nuclear hormone receptor-like 1 0.0047 0.0098 0.0098
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0047 0.0098 0.0173
Schistosoma mansoni retinoic acid receptor RXR 0.0089 0.0252 0.0443
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0089 0.0252 0.0252
Brugia malayi MH1 domain containing protein 0.0187 0.0612 0.0612
Onchocerca volvulus 0.0042 0.008 0.0648
Leishmania major isocitrate dehydrogenase, putative 0.0058 0.014 0.078
Entamoeba histolytica hypothetical protein 0.0043 0.0085 0.2156
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0089 0.0252 0.0717
Schistosoma mansoni ap endonuclease 0.0023 0.0009 0.0016
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0031 0.0129
Mycobacterium tuberculosis Probable 3-isopropylmalate dehydrogenase LeuB (beta-IPM dehydrogenase) (IMDH) (3-IPM-DH) 0.0058 0.014 0.0829
Loa Loa (eye worm) MH2 domain-containing protein 0.2749 1 1
Schistosoma mansoni Smad4 0.0084 0.0233 0.0409
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0362 0.1174
Echinococcus granulosus isocitrate dehydrogenase NAD 0.0058 0.014 0.0456
Brugia malayi hypothetical protein 0.0042 0.008 0.008
Brugia malayi nuclear receptor RXR 0.0042 0.008 0.008
Entamoeba histolytica tartrate dehydrogenase, putative 0.0058 0.014 0.372
Schistosoma mansoni tar DNA-binding protein 0.0861 0.3082 0.5419
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0031 0.0615
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0023 0.0011 0.003
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0004
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0004 0.0025
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0482 0.169 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0081 0.0222 0.1291
Loa Loa (eye worm) transcription factor SMAD2 0.2749 1 1
Schistosoma mansoni smad1 5 8 and 0.0187 0.0612 0.1077
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.0222 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0084 0.0233 0.0233
Brugia malayi nuclear hormone receptor 0.0089 0.0252 0.0252
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0089 0.0252 0.0252
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0031 0.1219
Toxoplasma gondii isocitrate dehydrogenase 0.0482 0.169 1
Loa Loa (eye worm) hypothetical protein 0.0545 0.1922 0.1922
Schistosoma mansoni tyrosine kinase 0.0023 0.0011 0.0018
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0031 0.0129
Echinococcus granulosus tar DNA binding protein 0.0861 0.3082 1
Mycobacterium leprae PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) 0.0058 0.014 0.5789
Plasmodium falciparum ataxin-2 like protein, putative 0.022 0.0731 0.4307
Loa Loa (eye worm) hypothetical protein 0.0042 0.008 0.008
Brugia malayi Nuclear hormone receptor E75 0.0042 0.008 0.008
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0028 0.014
Loa Loa (eye worm) hypothetical protein 0.0042 0.008 0.008
Schistosoma mansoni hypothetical protein 0.0728 0.2593 0.4559
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0023 0.0011 0.0034
Brugia malayi Probable isocitrate dehydrogenase 0.0058 0.014 0.014
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0042 0.008 0.008
Loa Loa (eye worm) SRC-1 0.0023 0.0011 0.0011
Echinococcus multilocularis glycosyltransferase protein LARGE2 0.0074 0.0198 0.0564
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0042 0.008 0.0227
Echinococcus granulosus Glycosyltransferase protein LARGE1 0.0057 0.0135 0.0437
Loa Loa (eye worm) hypothetical protein 0.0089 0.0252 0.0252
Schistosoma mansoni hypothetical protein 0.0049 0.0106 0.0187
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0009 0.0222
Schistosoma mansoni zinc finger protein 0.0042 0.008 0.014
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.0222 0.1266
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0187 0.0612 0.1743
Schistosoma mansoni hypothetical protein 0.0043 0.0085 0.015
Brugia malayi MH1 domain containing protein 0.0104 0.0306 0.0306
Brugia malayi RNA binding protein 0.0861 0.3082 0.3082
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0009 0.0009
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0089 0.0252 0.0443
Schistosoma mansoni smad 0.0084 0.0233 0.0409
Schistosoma mansoni tar DNA-binding protein 0.0861 0.3082 0.5419
Brugia malayi ecdysone receptor 0.0042 0.008 0.008
Brugia malayi Tyrosine-protein kinase abl-1 0.029 0.099 0.099
Loa Loa (eye worm) TK/ABL protein kinase 0.0713 0.2537 0.2537
Schistosoma mansoni nuclear receptor 0.0042 0.008 0.014
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0009 0.0029
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0085 0.0243
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0031
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0031 0.0031
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0482 0.169 0.2972
Brugia malayi Glycosyl transferase family 8 protein 0.0077 0.0207 0.0207
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0587 0.2076 0.6734
Trypanosoma brucei PAB1-binding protein , putative 0.022 0.0731 0.4291
Loa Loa (eye worm) Smad1 0.0187 0.0612 0.0612
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0009 0.0026
Echinococcus granulosus glycosyltransferase protein LARGE2 0.0074 0.0198 0.0643
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.0058 0.014 0.04
Schistosoma mansoni hypothetical protein 0.0049 0.0106 0.0187
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0113 0.7912
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0023 0.0011 0.0018
Loa Loa (eye worm) hypothetical protein 0.0574 0.2028 0.2028
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.3514 1
Brugia malayi nuclear receptor NHR-67 0.0042 0.008 0.008
Onchocerca volvulus Protein ultraspiracle homolog 0.0089 0.0252 0.2936
Onchocerca volvulus Bile acid receptor homolog 0.0089 0.0252 0.2936
Brugia malayi latrophilin 2 splice variant baaae 0.1573 0.5688 0.5688
Loa Loa (eye worm) hypothetical protein 0.0042 0.008 0.008
Schistosoma mansoni smad 0.0187 0.0612 0.1077
Brugia malayi nuclear hormone receptor family member odr-7 0.0042 0.008 0.008
Schistosoma mansoni Smad4 0.0084 0.0233 0.0409
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0085 0.015
Schistosoma mansoni tyrosine kinase 0.0023 0.0011 0.0018
Echinococcus multilocularis ecdysone induced protein 78C 0.0089 0.0252 0.0717
Schistosoma mansoni nuclear hormone receptor 0.0042 0.008 0.014
Loa Loa (eye worm) hypothetical protein 0.0047 0.0098 0.0098
Brugia malayi Nuclear hormone receptor-like 1 0.0089 0.0252 0.0252
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0089 0.0252 0.0817
Brugia malayi MH2 domain containing protein 0.0187 0.0612 0.0612
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0031 0.0182
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0081 0.0222 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0306 0.0306
Echinococcus multilocularis mothers against decapentaplegic 5 0.0187 0.0612 0.1743
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0081 0.0222 0.0632
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0042 0.008 0.0227
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0089 0.0252 0.0443
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0004
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.0058 0.014 0.04
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0362 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0031
Loa Loa (eye worm) MH2 domain-containing protein 0.0187 0.0612 0.0612
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0047 0.0098 0.028
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0047 0.0098 0.0098
Plasmodium vivax ataxin-2 like protein, putative 0.022 0.0731 0.4307
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0089 0.0252 0.0817
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0004
Schistosoma mansoni RAR-like nuclear receptor 0.0089 0.0252 0.0443
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0482 0.169 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0482 0.169 0.169
Brugia malayi Latrophilin receptor protein 2 0.0728 0.2593 0.2593
Echinococcus granulosus mothers against decapentaplegic 6 0.0084 0.0233 0.0756
Loa Loa (eye worm) hypothetical protein 0.0042 0.008 0.008
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0042 0.008 0.0227
Wolbachia endosymbiont of Brugia malayi isocitrate dehydrogenase 0.0058 0.014 0.6161
Brugia malayi Smad1 0.0187 0.0612 0.0612
Schistosoma mansoni nuclear receptor 0.0042 0.008 0.014
Echinococcus granulosus thyroid hormone receptor alpha 0.0042 0.008 0.0259
Loa Loa (eye worm) hypothetical protein 0.0089 0.0252 0.0252
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0482 0.169 0.4811
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.0222 0.1266
Echinococcus multilocularis protein dispatched 1 0.0058 0.0139 0.0397
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0031 0.1219
Echinococcus multilocularis smad 0.0187 0.0612 0.1743
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0009 0.003
Echinococcus multilocularis Glycosyltransferase protein LARGE1 0.0057 0.0135 0.0383
Loa Loa (eye worm) hypothetical protein 0.0042 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0051 0.0113 0.0113
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0089 0.0252 0.0252
Schistosoma mansoni nuclear hormone receptor 0.0089 0.0252 0.0443
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0089 0.0252 0.0443
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0031 0.015
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0728 0.2593 0.8413
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0084 0.0233 0.2682
Echinococcus multilocularis mothers against decapentaplegic 6 0.0084 0.0233 0.0663
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0089 0.0252 0.0717
Brugia malayi RNA recognition motif domain containing protein 0.0861 0.3082 0.3082
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0587 0.2076 0.5906
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.23 0.8354 0.8354
Echinococcus multilocularis tar DNA binding protein 0.0861 0.3082 0.8771
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0081 0.0222 0.1291
Echinococcus granulosus tyrosine protein kinase Fyn 0.0023 0.0011 0.0034
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0042 0.008 0.0259
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0042 0.008 0.0227
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0113 0.0322
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0482 0.169 0.4811
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0089 0.0252 0.0252
Echinococcus multilocularis FTZ F1 alpha 0.0089 0.0252 0.0717
Schistosoma mansoni tyrosine kinase 0.0702 0.2499 0.4394
Schistosoma mansoni tyrosine kinase 0.0023 0.0011 0.0018
Brugia malayi hypothetical protein 0.0047 0.0098 0.0098
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0089 0.0252 0.0252
Schistosoma mansoni tar DNA-binding protein 0.0861 0.3082 0.5419
Brugia malayi nuclear receptor RXR 0.0047 0.0098 0.0098
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0482 0.169 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0031 0.0031
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0023 0.0011 0.003
Brugia malayi MH1 domain containing protein 0.0187 0.0612 0.0612
Brugia malayi Tyrosine-protein kinase abl-1 0.0432 0.1509 0.1509
Entamoeba histolytica hypothetical protein 0.0043 0.0085 0.2156
Brugia malayi Probable isocitrate dehydrogenase 0.0058 0.014 0.014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0089 0.0252 0.0252
Echinococcus granulosus TGF beta signal transducer SmadC 0.0187 0.0612 0.1987
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0042 0.008 0.0648
Echinococcus multilocularis tyrosine protein kinase Abl 0.029 0.099 0.2818
Echinococcus granulosus Nuclear hormone receptor HR96 0.0042 0.008 0.0259
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0085 0.0277
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.0058 0.014 0.014
Echinococcus multilocularis Smad4 0.0187 0.0612 0.1743
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0042 0.008 0.014
Loa Loa (eye worm) hypothetical protein 0.0042 0.008 0.008
Brugia malayi nuclear hormone receptor family member nhr-6 0.0042 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0058 0.014 0.014
Toxoplasma gondii hypothetical protein 0.0028 0.0028 0.0112
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0031 0.015
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0042 0.008 0.008
Loa Loa (eye worm) steroid hormone receptor 0.0089 0.0252 0.0252
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0362 0.1029
Brugia malayi MH2 domain containing protein 0.0084 0.0233 0.0233
Mycobacterium ulcerans 3-isopropylmalate dehydrogenase 0.0058 0.014 0.6246
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0031 0.1219
Schistosoma mansoni coup transcription factor 0.0089 0.0252 0.0443
Schistosoma mansoni thyroid hormone receptor 0.0089 0.0252 0.0443
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0482 0.169 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0222 0.0222
Echinococcus granulosus tyrosine protein kinase ABL1 0.0713 0.2537 0.8231
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0089 0.0252 0.0252
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0089 0.0252 0.0817
Brugia malayi orphan nuclear receptor NR2E1 0.0042 0.008 0.008
Echinococcus multilocularis glycosyltransferase protein LARGE2 0.0074 0.0198 0.0564
Brugia malayi Nuclear hormone receptor E75 0.0042 0.008 0.008
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0113 0.0367
Echinococcus granulosus expressed conserved protein 0.0112 0.0335 0.1088
Echinococcus multilocularis glycosyltransferase protein LARGE2 0.0074 0.0198 0.0564
Loa Loa (eye worm) nuclear hormone receptor 0.054 0.1903 0.1903
Schistosoma mansoni tyrosine kinase 0.0023 0.0011 0.0018
Loa Loa (eye worm) hypothetical protein 0.0119 0.0362 0.0362
Echinococcus granulosus tyrosine protein kinase Fyn 0.0023 0.0011 0.0034
Loa Loa (eye worm) hypothetical protein 0.0042 0.008 0.008
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0042 0.008 0.014
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0098 0.0287 0.0931
Echinococcus granulosus GPCR family 2 0.0728 0.2593 0.8413
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0031 0.1219
Echinococcus granulosus Nuclear hormone receptor HR96 0.0042 0.008 0.0259
Loa Loa (eye worm) hypothetical protein 0.0062 0.0155 0.0155

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0794 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.4716 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 1.5101 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.4668 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.8048 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.3183 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 11.5774 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK). (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Leishmania Mexicana Pyruvate Kinase (LmPK). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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