TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 237.253 | Formula: C15H11NO2
H donors: 1 H acceptors: 2 LogP: 3.64 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Oc1onc(c1c1ccccc1)c1ccccc1
InChi: 1S/C15H11NO2/c17-15-13(11-7-3-1-4-8-11)14(16-18-15)12-9-5-2-6-10-12/h1-10,17H
InChiKey: UUPSCULOIIVHCB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	v-ets avian erythroblastosis virus E26 oncogene homolog	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	ets-related	Get druggable targets OG5_131947	All targets in OG5_131947
Loa Loa (eye worm)	fli-1 protein	Get druggable targets OG5_131947	All targets in OG5_131947
Schistosoma japonicum	ko:K09435 transcriptional regulator ERG, putative	Get druggable targets OG5_131947	All targets in OG5_131947
Brugia malayi	Fli-1 protein	Get druggable targets OG5_131947	All targets in OG5_131947

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	ABC transporter	0.0276	0.4532	0.4532
Trichomonas vaginalis	taga, putative	0.0476	0.8868	1
Giardia lamblia	MRP-like ABC transporter	0.0152	0.1845	0.0514
Plasmodium vivax	multidrug resistance protein 2, putative	0.0152	0.1845	0.1275
Plasmodium vivax	multidrug resistance protein 1, putative	0.0476	0.8868	1
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0152	0.1845	0.1275
Trypanosoma cruzi	ABC transporter of the mitochondrion, putative	0.0152	0.1845	0.2156
Leishmania major	ATP-binding cassette protein subfamily G, member 6, putative	0.0324	0.5581	0.5916
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0476	0.8868	1
Echinococcus multilocularis	multidrug resistance protein 1	0.0476	0.8868	0.8868
Entamoeba histolytica	ABC transporter, putative	0.0152	0.1845	0.0266
Brugia malayi	ABC transporter family protein	0.0476	0.8868	0.8868
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0324	0.5581	1
Plasmodium falciparum	ABC transporter B family member 5, putative	0.0152	0.1845	0.1275
Trypanosoma brucei	multidrug resistance-associated protein, putative	0.0152	0.1845	0.2156
Leishmania major	ATP-binding cassette protein subfamily G, member 4, putative	0.0324	0.5581	0.5916
Schistosoma mansoni	multidrug resistance protein	0.0476	0.8868	0.8868
Trypanosoma cruzi	ABC transporter, putative	0.0324	0.5581	1
Brugia malayi	ABC transporter	0.0152	0.1845	0.1845
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0152	0.1845	0.1275
Trichomonas vaginalis	ABC transporter, putative	0.0476	0.8868	1
Entamoeba histolytica	P-glycoprotein-2, putative	0.0476	0.8868	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0138	0.1561	0.1561
Loa Loa (eye worm)	hypothetical protein	0.0476	0.8868	0.8868
Leishmania major	ATP-binding cassette protein subfamily C, member 5, putative	0.0152	0.1845	0.1275
Schistosoma mansoni	tar DNA-binding protein	0.0528	1	1
Echinococcus multilocularis	ATP binding cassette sub family B	0.0152	0.1845	0.1845
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.0476	0.8868	0.8868
Trypanosoma brucei	multidrug resistance protein E	0.0152	0.1845	0.2156
Onchocerca volvulus		0.0476	0.8868	1
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0476	0.8868	1
Brugia malayi	ABC transporter family protein	0.0152	0.1845	0.1845
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0476	0.8868	1
Echinococcus granulosus	multidrug resistance protein 1	0.0476	0.8868	0.8868
Echinococcus granulosus	multidrug resistance associated protein 7	0.0152	0.1845	0.1845
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0333	0.5782	0.5723
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0528	1	1
Brugia malayi	ABC transporter transmembrane region family protein	0.0143	0.1653	0.1653
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0476	0.8868	1
Echinococcus granulosus	ATP binding cassette sub family G	0.0324	0.5581	0.5581
Loa Loa (eye worm)	hypothetical protein	0.0143	0.1653	0.1653
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	0.0476	0.8868	1
Brugia malayi	ABC transporter family protein	0.0152	0.1845	0.1845
Leishmania major	ATP-binding cassette protein subfamily B, member 3, putative	0.0152	0.1845	0.1275
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0476	0.8868	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0138	0.1561	0.1561
Loa Loa (eye worm)	multidrug resistance protein 3	0.0476	0.8868	0.8868
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0476	0.8868	1
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0324	0.5581	1
Entamoeba histolytica	P-glycoprotein 6, putative	0.0152	0.1845	0.0266
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0476	0.8868	0.8868
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0476	0.8868	0.8868
Brugia malayi	MH2 domain containing protein	0.0248	0.3931	0.3931
Schistosoma mansoni	multidrug resistance protein	0.0152	0.1845	0.1845
Schistosoma mansoni	tar DNA-binding protein	0.0528	1	1
Echinococcus multilocularis	ATP binding cassette sub family B	0.0152	0.1845	0.1845
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0152	0.1845	0.0266
Brugia malayi	Ets-domain containing protein	0.0087	0.0459	0.0459
Brugia malayi	hypothetical protein	0.0067	0.0021	0.0021
Brugia malayi	hypothetical protein	0.0104	0.0819	0.0819
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0138	0.1561	0.1561
Wolbachia endosymbiont of Brugia malayi	ABC-type protease secretion system, ATPase and permease component, AprD	0.0152	0.1845	0.5
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0476	0.8868	1
Schistosoma mansoni	multidrug resistance protein	0.0476	0.8868	0.8868
Loa Loa (eye worm)	ABC transporter transmembrane region family protein	0.0152	0.1845	0.1845
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0476	0.8868	0.8868
Mycobacterium leprae	PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER	0.0152	0.1845	0.5
Plasmodium falciparum	ABC transporter B family member 7, putative	0.0152	0.1845	0.1275
Schistosoma mansoni	ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6)	0.0143	0.1653	0.1653
Schistosoma mansoni	hypothetical protein	0.0143	0.1663	0.1663
Loa Loa (eye worm)	hypothetical protein	0.0143	0.1653	0.1653
Schistosoma mansoni	gabp alpha	0.0087	0.0459	0.0459
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0476	0.8868	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0476	0.8868	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0248	0.3931	0.3931
Plasmodium vivax	ABC transporter B family member 6, putative	0.0152	0.1845	0.1275
Brugia malayi	Fli-1 protein	0.0265	0.4311	0.4311
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0476	0.8868	1
Echinococcus multilocularis	ATP binding cassette sub family G	0.0324	0.5581	0.5581
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0476	0.8868	0.8868
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0476	0.8868	0.8868
Entamoeba histolytica	P-glycoprotein-5	0.0476	0.8868	1
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0819	0.0819
Brugia malayi	multidrug resistance protein 3	0.0476	0.8868	0.8868
Plasmodium falciparum	ABC transporter B family member 4, putative	0.0152	0.1845	0.1275
Schistosoma mansoni	smdr2	0.0476	0.8868	0.8868
Echinococcus multilocularis	ATP binding cassette sub family B	0.0152	0.1845	0.1845
Trypanosoma brucei	ABC transporter, mitochondrial, putative	0.0152	0.1845	0.2156
Echinococcus multilocularis	multidrug resistance protein 1	0.0476	0.8868	0.8868
Plasmodium falciparum	multidrug resistance protein 1	0.0476	0.8868	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0138	0.1561	0.1561
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0476	0.8868	1
Leishmania major	ATP-binding cassette protein subfamily C, member 1, putative	0.0152	0.1845	0.1275
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.0467	0.8676	0.8676
Loa Loa (eye worm)	ABC transporter	0.0152	0.1845	0.1845
Entamoeba histolytica	ABC transporter, putative	0.0324	0.5581	0.5444
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0476	0.8868	1
Schistosoma mansoni	multidrug resistance protein	0.0143	0.1653	0.1653
Trypanosoma cruzi	ABC transporter, mitochondrial, putative	0.0152	0.1845	0.2156
Plasmodium falciparum	multidrug resistance-associated protein 2	0.0152	0.1845	0.1275
Plasmodium vivax	ABC transporter B family member 5, putative	0.0152	0.1845	0.1275
Brugia malayi	hypothetical protein	0.0152	0.1845	0.1845
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0476	0.8868	1
Loa Loa (eye worm)	hypothetical protein	0.0147	0.1757	0.1757
Schistosoma mansoni	multidrug resistance protein	0.0152	0.1845	0.1845
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0324	0.5581	1
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0476	0.8868	0.8868
Loa Loa (eye worm)	hypothetical protein	0.0152	0.1845	0.1845
Trypanosoma brucei	ABC transporter of the mitochondrion, putative	0.0152	0.1845	0.2156
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0476	0.8868	1
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0476	0.8868	0.8868
Trypanosoma cruzi	multidrug resistance-associated protein, putative	0.0152	0.1845	0.2156
Echinococcus granulosus	multidrug resistance protein 1	0.0333	0.5782	0.5782
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0152	0.1845	0.1275
Leishmania major	ATP-binding cassette protein subfamily C, member 6, putative	0.0152	0.1845	0.1275
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0138	0.1561	0.1561
Giardia lamblia	Multidrug resistance-associated protein 1	0.0152	0.1845	0.0514
Plasmodium falciparum	ABC transporter B family member 3, putative	0.0152	0.1845	0.1275
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0209	0.3097	0.3097
Plasmodium vivax	multidrug resistance-associated protein 2, putative	0.0152	0.1845	0.1275
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0476	0.8868	1
Schistosoma mansoni	ets-related	0.0265	0.4311	0.4311
Brugia malayi	latrophilin 2 splice variant baaae	0.0143	0.1663	0.1663
Brugia malayi	Ets-domain containing protein	0.0087	0.0459	0.0459
Loa Loa (eye worm)	RNA binding protein	0.0528	1	1
Loa Loa (eye worm)	hypothetical protein	0.0152	0.1845	0.1845
Plasmodium vivax	ABC transporter B family member 4, putative	0.0152	0.1845	0.1275
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0476	0.8868	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0152	0.1845	0.0266
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0152	0.1845	0.0266
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0138	0.1561	0.1561
Echinococcus multilocularis	ATP binding cassette sub family B	0.0467	0.8676	0.8676
Onchocerca volvulus		0.0235	0.3648	0.2659
Entamoeba histolytica	P-glycoprotein-2	0.0476	0.8868	1
Echinococcus granulosus	multidrug resistance protein 1	0.0476	0.8868	0.8868
Loa Loa (eye worm)	pax transcription factor protein 2	0.0235	0.3648	0.3648
Plasmodium falciparum	ABC transporter G family member 2	0.0324	0.5581	0.5916
Trichomonas vaginalis	ABC transporter, putative	0.0476	0.8868	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0476	0.8868	1
Echinococcus multilocularis		0.0152	0.1845	0.1845
Schistosoma mansoni	multidrug resistance protein	0.0476	0.8868	0.8868
Brugia malayi	TAR-binding protein	0.0528	1	1
Leishmania major	ABC-thiol transporter	0.0152	0.1845	0.1275
Loa Loa (eye worm)	ABC transporter	0.0152	0.1845	0.1845
Plasmodium vivax	ABC transporter B family member 7, putative	0.0152	0.1845	0.1275
Entamoeba histolytica	P-glycoprotein-2	0.0476	0.8868	1
Entamoeba histolytica	P-glycoprotein-1	0.0476	0.8868	1
Schistosoma mansoni	multidrug resistance protein	0.0152	0.1845	0.1845
Loa Loa (eye worm)	hypothetical protein	0.0476	0.8868	0.8868
Leishmania major	pentamidine resistance protein 1	0.0152	0.1845	0.1275
Schistosoma mansoni	tar DNA-binding protein	0.0528	1	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0476	0.8868	0.8868
Wolbachia endosymbiont of Brugia malayi	ABC-type multidrug transport system, ATPase and permease component	0.0152	0.1845	0.5
Plasmodium falciparum	multidrug resistance protein 2	0.0152	0.1845	0.1275
Brugia malayi	hypothetical protein	0.0147	0.1757	0.1757
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0152	0.1845	0.1275
Leishmania major	ATP-binding cassette protein subfamily C, member 2, putative	0.0152	0.1845	0.1275
Trichomonas vaginalis	ABC transporter, putative	0.0476	0.8868	1
Loa Loa (eye worm)	hypothetical protein	0.0209	0.3097	0.3097
Mycobacterium leprae	PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER	0.0152	0.1845	0.5
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0476	0.8868	0.8868
Brugia malayi	Pax transcription factor protein 2	0.0235	0.3648	0.3648
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0476	0.8868	1
Trichomonas vaginalis	abcb9, putative	0.0476	0.8868	1
Echinococcus granulosus	multidrug resistance protein 1	0.0476	0.8868	0.8868
Echinococcus multilocularis	multidrug resistance associated protein 1	0.0152	0.1845	0.1845
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0087	0.0459	0.0459
Echinococcus multilocularis	GA binding protein alpha chain	0.0087	0.0459	0.0459
Trichomonas vaginalis	abcb9, putative	0.0476	0.8868	1
Trichomonas vaginalis	abcb9, putative	0.0476	0.8868	1
Plasmodium vivax	ABC transporter G family member 2, putative	0.0324	0.5581	0.5916
Loa Loa (eye worm)	ABC transporter	0.0152	0.1845	0.1845
Leishmania major	p-glycoprotein	0.0476	0.8868	1
Leishmania major	ATP-binding cassette protein subfamily B, member 1, putative	0.0152	0.1845	0.1275
Loa Loa (eye worm)	fli-1 protein	0.0265	0.4311	0.4311
Brugia malayi	multidrug Resistance Protein family member (mrp-5), putative	0.0152	0.1845	0.1845
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0184	0.0184
Giardia lamblia	Multidrug resistance-associated protein 1	0.0152	0.1845	0.0514
Loa Loa (eye worm)	ABC transporter	0.0276	0.4532	0.4532
Echinococcus multilocularis	ATP binding cassette sub family B	0.0152	0.1845	0.1845
Giardia lamblia	ABC transporter	0.0315	0.5389	1
Plasmodium falciparum	ABC transporter B family member 6, putative	0.0152	0.1845	0.1275
Brugia malayi	P-glycoprotein-like protein	0.0152	0.1845	0.1845
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0138	0.1561	0.1561
Entamoeba histolytica	P-glyco protein 6, putative	0.0476	0.8868	1
Trypanosoma brucei	ABC transporter, putative	0.0324	0.5581	1
Echinococcus granulosus	ATP binding cassette sub family B	0.0152	0.1845	0.1845
Toxoplasma gondii	ABC transporter, putative	0.0152	0.1845	0.1275
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0152	0.1845	0.1275
Toxoplasma gondii	ABC transporter family protein	0.0152	0.1845	0.1275
Echinococcus granulosus	multidrug resistance protein 1	0.0333	0.5782	0.5782
Entamoeba histolytica	multidrug resistance protein, putative	0.0152	0.1845	0.0266
Plasmodium falciparum	multidrug resistance-associated protein 1	0.0152	0.1845	0.1275
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0138	0.1561	0.1561
Brugia malayi	ABC transporter transmembrane region family protein	0.0152	0.1845	0.1845
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	0.0476	0.8868	1
Echinococcus granulosus	ATP binding cassette sub family G	0.0324	0.5581	0.5581
Schistosoma mansoni	multidrug resistance protein	0.0152	0.1845	0.1845
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0138	0.1561	0.1561
Brugia malayi	RNA recognition motif domain containing protein	0.0528	1	1
Leishmania major	p-glycoprotein e	0.0152	0.1845	0.1275
Schistosoma mansoni	hypothetical protein	0.0267	0.434	0.434
Brugia malayi	multidrug resistance related protein 1	0.0152	0.1845	0.1845
Plasmodium vivax	ABC transporter B family member 3, putative	0.0152	0.1845	0.1275
Brugia malayi	ABC transporter	0.0143	0.1653	0.1653
Loa Loa (eye worm)	hypothetical protein	0.0143	0.1663	0.1663
Loa Loa (eye worm)	hypothetical protein	0.0467	0.8676	0.8676
Entamoeba histolytica	P-glycoprotein 5, putative	0.0476	0.8868	1
Brugia malayi	ABC transporter family protein	0.0276	0.4532	0.4532
Leishmania major	ATP-binding cassette protein subfamily C, member 8, putative	0.0152	0.1845	0.1275
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0209	0.3097	0.3097
Trypanosoma cruzi	multidrug resistance protein E, putative	0.0152	0.1845	0.2156
Schistosoma mansoni	tar DNA-binding protein	0.0528	1	1
Echinococcus granulosus	ATP binding cassette sub family B	0.0152	0.1845	0.1845
Echinococcus granulosus	GA binding protein alpha chain	0.0087	0.0459	0.0459
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0152	0.1845	0.1275
Leishmania major	ATP-binding cassette protein subfamily B, member 2, putative	0.0476	0.8868	1
Entamoeba histolytica	hypothetical protein	0.0152	0.1845	0.0266
Trypanosoma brucei	p-glycoprotein	0.0152	0.1845	0.2156
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0476	0.8868	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0476	0.8868	1
Trypanosoma cruzi	multidrug resistance-associated protein, putative	0.0152	0.1845	0.2156
Loa Loa (eye worm)	hypothetical protein	0.0152	0.1845	0.1845
Echinococcus granulosus	ATP binding cassette sub family B	0.0143	0.1653	0.1653
Echinococcus granulosus	ATP binding cassette sub family G	0.0324	0.5581	0.5581
Mycobacterium tuberculosis	Probable conserved transmembrane ATP-binding protein ABC transporter	0.0267	0.434	0.3552
Echinococcus multilocularis	tar DNA binding protein	0.0528	1	1
Echinococcus multilocularis	ATP binding cassette sub family G	0.0324	0.5581	0.5581
Trypanosoma cruzi	ATP-binding cassette protein, putative	0.0324	0.5581	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0476	0.8868	1
Brugia malayi	ABC transporter family protein	0.0152	0.1845	0.1845
Giardia lamblia	ABC transporter, putative	0.0152	0.1845	0.0514
Toxoplasma gondii	ATP-binding cassette sub-family B member 5	0.0152	0.1845	0.1275
Entamoeba histolytica	P-glycoprotein 6, putative	0.0152	0.1845	0.0266
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0152	0.1845	0.0266
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0152	0.1845	0.0266
Echinococcus multilocularis	ATP binding cassette sub family G	0.0324	0.5581	0.5581
Trypanosoma brucei	multidrug resistance-associated protein, putative	0.0152	0.1845	0.2156
Schistosoma mansoni	multidrug resistance protein	0.0152	0.1845	0.1845
Echinococcus granulosus	multidrug resistance associated protein 1	0.0152	0.1845	0.1845
Plasmodium vivax	multidrug resistance-associated protein 1, putative	0.0152	0.1845	0.1275
Schistosoma mansoni	ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7)	0.0152	0.1845	0.1845
Loa Loa (eye worm)	TAR-binding protein	0.0528	1	1
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.0476	0.8868	0.5
Trichomonas vaginalis	ABC transporter, putative	0.0476	0.8868	1
Schistosoma mansoni	tar DNA-binding protein	0.0528	1	1
Echinococcus multilocularis	multidrug resistance protein 1	0.0333	0.5782	0.5782
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0476	0.8868	1
Echinococcus multilocularis	multidrug resistance associated protein 7	0.0152	0.1845	0.1845
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0476	0.8868	1
Schistosoma mansoni	ATP-binding cassette sub-family g2 (white protein) (abcg2)	0.0324	0.5581	0.5581
Trypanosoma brucei	ATP-binding cassette protein, putative	0.0324	0.5581	1
Brugia malayi	ABC transporter transmembrane region family protein	0.0152	0.1845	0.1845
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0209	0.3097	0.3097
Schistosoma mansoni	smdr1	0.0152	0.1845	0.1845
Toxoplasma gondii	ATP-binding cassette G family transporter ABCG84	0.0324	0.5581	0.5916
Echinococcus granulosus	tar DNA binding protein	0.0528	1	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0248	0.3931	0.3931

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	> 195 um	PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Confirmation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1). (Class of assay: confirmatory) [Related pubchem assays: 2118 (Project Summary), 2098 (Primary HTS)]	ChEMBL.	No reference
Potency (functional)	0.7079 uM	PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	3.1623 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	32.6427 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1555398

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1424401