TDR Targets

Basic information

Technical information

TDR Targets ID: 1424426
Name: [2-oxo-2-(phenylamino)ethyl] 4-methyl-3-piper idin-1-ylsulfonylbenzoate
MW: 416.491 | Formula: C21H24N2O5S
H donors: 1 H acceptors: 4 LogP: 3.04 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1ccccc1)COC(=O)c1ccc(c(c1)S(=O)(=O)N1CCCCC1)C
InChi: 1S/C21H24N2O5S/c1-16-10-11-17(14-19(16)29(26,27)23-12-6-3-7-13-23)21(25)28-15-20(24)22-18-8-4-2-5-9-18/h2,4-5,8-11,14H,3,6-7,12-13,15H2,1H3,(H,22,24)
InChiKey: ZFXDXZFSEXJSEK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

[2-oxo-2-(phenylamino)ethyl] 4-methyl-3-(1-piperidylsulfonyl)benzoate
4-methyl-3-(1-piperidylsulfonyl)benzoic acid [2-oxo-2-(phenylamino)ethyl] ester
4-methyl-3-piperidinosulfonyl-benzoic acid [2-keto-2-(phenylamino)ethyl] ester
[2-oxo-2-(phenylamino)ethyl] 4-methyl-3-piperidin-1-ylsulfonyl-benzoate
ZINC03448305
T5403444

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	chromobox homolog 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	heterochromatin protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Onchocerca volvulus	Heterochromatin protein 1 homolog	Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma japonicum	Chromobox protein homolog 5, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Echinococcus multilocularis	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	chromobox protein	Get druggable targets OG5_129545	All targets in OG5_129545
Echinococcus multilocularis	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Echinococcus granulosus	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Brugia malayi	Heterochromatin protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	chromobox protein	Get druggable targets OG5_129545	All targets in OG5_129545
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129545	All targets in OG5_129545
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Theileria parva	hypothetical protein	Get druggable targets OG5_129545	All targets in OG5_129545
Echinococcus granulosus	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Onchocerca volvulus		Get druggable targets OG5_129545	All targets in OG5_129545

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	kinase	0.0047	0.2388	0.2388
Loa Loa (eye worm)	jmjC domain-containing protein	0.0034	0.1591	0.2288
Brugia malayi	Bromodomain containing protein	0.0028	0.1206	0.2249
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0014	0.0268	0.0167
Schistosoma mansoni	chromobox protein	0.0084	0.4811	0.4811
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0014	0.0268	0.0268
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.002	0.0701	0.581
Trichomonas vaginalis	chromobox protein, putative	0.0084	0.4811	0.9045
Entamoeba histolytica	hypothetical protein	0.0014	0.0268	0.0167
Echinococcus multilocularis	bloom syndrome protein	0.0023	0.0884	0.0884
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0268	0.0167
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0609	0.0609
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0014	0.0268	0.0167
Brugia malayi	Associated with TFs and helicases family protein	0.0014	0.0268	0.05
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0268	0.0385
Echinococcus multilocularis	chromodomain helicase DNA binding protein 1	0.0014	0.0268	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0268	0.0385
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.2945	0.4236
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.2945	0.2945
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2424	0.3486
Schistosoma mansoni	hypothetical protein	0.0019	0.0609	0.0609
Loa Loa (eye worm)	RecQ helicase	0.0023	0.0884	0.1271
Echinococcus multilocularis	chromobox protein 1	0.0084	0.4811	0.4811
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0016	0.0384	0.3185
Toxoplasma gondii	chromodomain helicase DNA binding protein CHD1/SWI2/SNF2	0.0014	0.0268	0.2221
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.3349	0.3349
Trichomonas vaginalis	Heterochromatin protein, putative	0.0014	0.0268	0.0167
Schistosoma mansoni	serine/threonine protein kinase	0.0092	0.53	0.53
Loa Loa (eye worm)	helicase	0.0014	0.0268	0.0385
Plasmodium falciparum	phd finger protein, putative	0.0028	0.1206	1
Brugia malayi	RNA binding protein	0.0061	0.3349	0.6244
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0268	0.0167
Schistosoma mansoni	hypothetical protein	0.0019	0.0609	0.0609
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0014	0.0268	0.0268
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0014	0.0268	0.0268
Trichomonas vaginalis	DNA helicase recq, putative	0.0023	0.0884	0.137
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0268	0.0167
Schistosoma mansoni	hypothetical protein	0.0165	1	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0609	0.0609
Echinococcus granulosus	GPCR family 2	0.0019	0.0609	0.0609
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0092	0.53	0.53
Schistosoma mansoni	jumonji domain containing protein	0.0074	0.4134	0.4134
Trypanosoma cruzi	polo-like protein kinase, putative	0.0092	0.53	1
Brugia malayi	Type III restriction enzyme, res subunit family protein	0.0014	0.0268	0.05
Trypanosoma brucei	polo-like protein kinase	0.0092	0.53	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0268	0.0167
Echinococcus granulosus	PHD finger protein rhinoceros	0.0028	0.1206	0.1206
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0014	0.0268	0.0167
Trichomonas vaginalis	CAMK family protein kinase	0.0045	0.231	0.4157
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0268	0.0167
Echinococcus granulosus	chromobox protein 1	0.0084	0.4811	0.4811
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.53	1
Brugia malayi	hypothetical protein	0.0014	0.0268	0.05
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.53	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0268	0.0167
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0093	0.5364	0.5364
Echinococcus granulosus	lysine specific demethylase 5A	0.0034	0.1591	0.1591
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.2424	0.438
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0268	0.0385
Loa Loa (eye worm)	CHromoDomain protein family member	0.0014	0.0268	0.0385
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.3266	0.4697
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0014	0.0268	0.0268
Loa Loa (eye worm)	hypothetical protein	0.006	0.3266	0.4697
Echinococcus multilocularis	peregrin	0.0028	0.1206	0.1206
Onchocerca volvulus	Alhambra homolog	0.0028	0.1206	0.1865
Echinococcus granulosus	bloom syndrome protein	0.0023	0.0884	0.0884
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0268	0.0167
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0014	0.0268	0.0167
Echinococcus granulosus	chromodomain helicase DNA binding protein 1	0.0014	0.0268	0.0268
Plasmodium falciparum	chromodomain-helicase-DNA-binding protein 1 homolog, putative	0.0014	0.0268	0.2221
Schistosoma mansoni	chromobox protein	0.0014	0.0268	0.0268
Echinococcus granulosus	chromobox protein 1	0.0084	0.4811	0.4811
Echinococcus multilocularis	chromobox protein 1	0.0084	0.4811	0.4811
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.53	1
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0093	0.5364	0.5364
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0609	0.0609
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.53	1
Schistosoma mansoni	chromobox protein	0.0084	0.4811	0.4811
Schistosoma mansoni	chromobox protein	0.0014	0.0268	0.0268
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.3349	0.3349
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0268	0.0385
Trichomonas vaginalis	DNA helicase recq1, putative	0.0023	0.0884	0.137
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0268	0.0167
Echinococcus multilocularis	jumonji domain containing protein	0.0039	0.1922	0.1922
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.2945	0.2945
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0609	0.0875
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.2945	0.2945
Echinococcus granulosus	jumonji domain containing protein	0.0039	0.1922	0.1922
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1766	0.254
Brugia malayi	Heterochromatin protein 1	0.0084	0.4811	0.8969
Schistosoma mansoni	blooms syndrome DNA helicase	0.0018	0.0567	0.0567
Schistosoma mansoni	hypothetical protein	0.0019	0.0609	0.0609
Brugia malayi	M-phase phosphoprotein, mpp8	0.0014	0.0268	0.05
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0609	0.0609
Schistosoma mansoni	hypothetical protein	0.0014	0.0268	0.0268
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.3349	0.3349
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0014	0.0268	0.0268
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0268	0.0167
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.53	1
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0014	0.0268	0.0167
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0268	0.0167
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0028	0.1206	0.1206
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0028	0.1206	0.1206
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.2945	0.2945
Loa Loa (eye worm)	hypothetical protein	0.0049	0.2512	0.3613
Brugia malayi	Valyl-tRNA synthetase	0.0014	0.0268	0.05
Entamoeba histolytica	hypothetical protein	0.0014	0.0268	0.0167
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0014	0.0268	0.0167
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0047	0.2424	0.4285
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0016	0.0396	0.1368
Trichomonas vaginalis	chromobox protein, putative	0.0014	0.0268	0.0167
Schistosoma mansoni	hypothetical protein	0.0165	1	1
Echinococcus granulosus	peregrin	0.0028	0.1206	0.1206
Trichomonas vaginalis	CAMK family protein kinase	0.0045	0.231	0.4157
Brugia malayi	jmjC domain containing protein	0.0034	0.1591	0.2966
Trichomonas vaginalis	chromobox protein, putative	0.0051	0.2655	0.4832
Echinococcus granulosus	tar DNA binding protein	0.0061	0.3349	0.3349
Loa Loa (eye worm)	PHD-finger family protein	0.0028	0.1206	0.1735
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.3349	0.3349
Trichomonas vaginalis	chromobox protein, putative	0.0051	0.2655	0.4832
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0092	0.53	1
Echinococcus multilocularis	tar DNA binding protein	0.0061	0.3349	0.3349
Loa Loa (eye worm)	hypothetical protein	0.0117	0.6953	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0034	0.1591	0.1591
Loa Loa (eye worm)	hypothetical protein	0.0028	0.1206	0.1735
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0092	0.53	0.7622
Brugia malayi	Protein cec-1.	0.0014	0.0268	0.05
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0609	0.1135
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0268	0.0385
Trichomonas vaginalis	chromobox protein, putative	0.0084	0.4811	0.9045
Trichomonas vaginalis	chromobox protein, putative	0.0014	0.0268	0.0167
Loa Loa (eye worm)	RNA binding protein	0.0061	0.3349	0.4817
Echinococcus granulosus	Chromo domain	0.0014	0.0268	0.0268
Toxoplasma gondii	'chromo' (CHRromatin Organization MOdifier) domain-containing protein	0.0014	0.0268	0.2221
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0268	0.0167
Entamoeba histolytica	hypothetical protein	0.0014	0.0268	0.0167
Schistosoma mansoni	hypothetical protein	0.0019	0.0609	0.0609
Toxoplasma gondii	PHD-finger domain-containing protein	0.0028	0.1206	1
Plasmodium falciparum	heterochromatin protein 1	0.0014	0.0268	0.2221
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0268	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0041	0.2036	0.2928
Schistosoma mansoni	hypothetical protein	0.0028	0.1206	0.1206
Brugia malayi	Bloom's syndrome protein homolog	0.0023	0.0884	0.1647
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0268	0.0167
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.2945	0.2945
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0034	0.1591	0.1591
Trichomonas vaginalis	hypothetical protein	0.0014	0.0268	0.0167
Brugia malayi	TAR-binding protein	0.0061	0.3349	0.6244
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0609	0.1135
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0014	0.0268	0.2221
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.2036	0.3796
Giardia lamblia	PHD finger protein 15	0.0028	0.1206	0.2276
Loa Loa (eye worm)	heterochromatin protein 1	0.0084	0.4811	0.6919
Echinococcus multilocularis	Chromobox protein 3	0.0014	0.0268	0.0268
Echinococcus multilocularis	lysine specific demethylase 5A	0.0034	0.1591	0.1591
Toxoplasma gondii	PHD-finger domain-containing protein	0.0028	0.1206	1
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0014	0.0268	0.0268
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.3266	0.6088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.2945	0.2945
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0014	0.0268	0.0167
Loa Loa (eye worm)	jmjC domain-containing protein	0.0058	0.3152	0.4533
Brugia malayi	serine/threonine-protein kinase plk-2	0.0092	0.53	0.988
Brugia malayi	jmjC domain containing protein	0.0093	0.5364	1
Echinococcus multilocularis	geminin	0.0165	1	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.2945	0.5491
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0014	0.0268	0.0268
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0268	0.0167
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.3349	0.3349
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.1535	0.2642
Echinococcus multilocularis	chromobox protein 2	0.0014	0.0268	0.0268
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0268	0.0167
Brugia malayi	RNA recognition motif domain containing protein	0.0061	0.3349	0.6244
Echinococcus multilocularis	Chromo domain	0.0014	0.0268	0.0268
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0051	0.2655	0.4744
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0268	0.0167
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0268	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0268	0.0385
Brugia malayi	PHD-finger family protein	0.0028	0.1206	0.2249
Echinococcus granulosus	Chromobox protein 3	0.0014	0.0268	0.0268
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.53	1
Brugia malayi	SET domain containing protein	0.0014	0.0268	0.05
Trichomonas vaginalis	chromobox protein, putative	0.0014	0.0268	0.0167
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0092	0.53	0.53
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.1535	0.2642
Schistosoma mansoni	hypothetical protein	0.0041	0.2036	0.2036
Echinococcus granulosus	chromobox protein 2	0.0014	0.0268	0.0268
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0092	0.53	1
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0092	0.53	1
Brugia malayi	CHD4 protein	0.0014	0.0268	0.05
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.3266	0.6088
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0609	0.0609
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0061	0.3349	0.4817
Trypanosoma cruzi	polo-like protein kinase, putative	0.0092	0.53	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0609	0.0875
Onchocerca volvulus		0.0037	0.1766	0.2977
Plasmodium vivax	hypothetical protein, conserved	0.0028	0.1206	1
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.53	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0268	0.0167
Plasmodium vivax	hypothetical protein, conserved	0.0014	0.0268	0.0000000027296
Toxoplasma gondii	'chromo' (CHRromatin Organization MOdifier) domain-containing protein	0.0014	0.0268	0.2221
Loa Loa (eye worm)	TAR-binding protein	0.0061	0.3349	0.4817
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.2945	0.2945
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.2424	0.438
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0014	0.0268	0.0167
Brugia malayi	chromobox protein homolog 3	0.0047	0.2424	0.4519
Giardia lamblia	Kinase, PLK	0.0092	0.53	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	6.3096 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	10 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	10.4179 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	14.1254 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	25.9185 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (binding)	= 50.1187 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	56.2341 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1555402

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1424426