Detailed information for compound 1424471

Basic information

Technical information
  • TDR Targets ID: 1424471
  • Name: [1-(2-methyl-1H-indol-3-yl)-1-oxopropan-2-yl] 6-chloropyridine-3-carboxylate
  • MW: 342.776 | Formula: C18H15ClN2O3
  • H donors: 1 H acceptors: 3 LogP: 4.01 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cn1)C(=O)OC(C(=O)c1c(C)[nH]c2c1cccc2)C
  • InChi: 1S/C18H15ClN2O3/c1-10-16(13-5-3-4-6-14(13)21-10)17(22)11(2)24-18(23)12-7-8-15(19)20-9-12/h3-9,11,21H,1-2H3
  • InChiKey: MXJQOQMOQWOZEA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [1-methyl-2-(2-methyl-1H-indol-3-yl)-2-oxo-ethyl] 6-chloropyridine-3-carboxylate
  • 6-chloro-3-pyridinecarboxylic acid [1-methyl-2-(2-methyl-1H-indol-3-yl)-2-oxoethyl] ester
  • 6-chloronicotinic acid [2-keto-1-methyl-2-(2-methyl-1H-indol-3-yl)ethyl] ester
  • [1-(2-methyl-1H-indol-3-yl)-1-oxo-propan-2-yl] 6-chloropyridine-3-carboxylate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei multidrug resistance protein E 0.0228 0.2026 0.4517
Brugia malayi ABC transporter transmembrane region family protein 0.0228 0.2026 0.1897
Entamoeba histolytica P-glycoprotein 5, putative 0.0719 0.8493 1
Brugia malayi ABC transporter transmembrane region family protein 0.0216 0.1861 0.1729
Leishmania major p-glycoprotein 0.0719 0.8493 1
Echinococcus multilocularis multidrug resistance protein 1 0.0503 0.5651 0.5484
Plasmodium vivax ABC transporter B family member 6, putative 0.0228 0.2026 0.161
Trypanosoma cruzi ABC transporter of the mitochondrion, putative 0.0228 0.2026 0.4517
Echinococcus granulosus ATP binding cassette sub family B 0.0216 0.1861 0.1547
Echinococcus granulosus ATP binding cassette sub family B 0.0228 0.2026 0.1719
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0719 0.8493 1
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0228 0.2026 0.2386
Loa Loa (eye worm) multidrug resistance protein 3 0.0719 0.8493 0.8435
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0228 0.2026 0.0249
Entamoeba histolytica P-glycoprotein-2, putative 0.0719 0.8493 1
Schistosoma mansoni smdr1 0.0228 0.2026 0.1719
Trypanosoma cruzi ATP-binding cassette protein, putative 0.0415 0.4486 1
Plasmodium vivax ABC transporter B family member 3, putative 0.0228 0.2026 0.161
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0719 0.8493 1
Schistosoma mansoni tar DNA-binding protein 0.0833 1 1
Entamoeba histolytica ABC transporter, putative 0.0228 0.2026 0.0249
Plasmodium falciparum multidrug resistance-associated protein 1 0.0228 0.2026 0.161
Leishmania major ATP-binding cassette protein subfamily B, member 1, putative 0.0228 0.2026 0.2386
Echinococcus granulosus multidrug resistance protein 1 0.0503 0.5651 0.5484
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0719 0.8493 0.8435
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0228 0.2026 0.5
Echinococcus multilocularis multidrug resistance protein 1 0.0719 0.8493 0.8435
Loa Loa (eye worm) RNA binding protein 0.0833 1 1
Entamoeba histolytica P-glycoprotein-2 0.0719 0.8493 1
Entamoeba histolytica multidrug resistance protein, putative 0.0228 0.2026 0.0249
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0719 0.8493 1
Trichomonas vaginalis ABC transporter, putative 0.0719 0.8493 1
Echinococcus granulosus multidrug resistance protein 1 0.0719 0.8493 0.8435
Schistosoma mansoni tar DNA-binding protein 0.0833 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0719 0.8493 1
Schistosoma mansoni multidrug resistance protein 0.0228 0.2026 0.1719
Echinococcus multilocularis ATP binding cassette sub family G 0.0415 0.4486 0.4273
Loa Loa (eye worm) hypothetical protein 0.0134 0.0786 0.043
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0324 0.3293 0.3184
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0706 0.8328 0.8263
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0719 0.8493 1
Plasmodium falciparum ABC transporter B family member 7, putative 0.0228 0.2026 0.161
Echinococcus multilocularis 0.0228 0.2026 0.1719
Trichomonas vaginalis abcb9, putative 0.0719 0.8493 1
Toxoplasma gondii ABC transporter family protein 0.0228 0.2026 0.2386
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0228 0.2026 0.4517
Entamoeba histolytica ATP-binding cassette protein, putative 0.0228 0.2026 0.0249
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0719 0.8493 0.8435
Echinococcus multilocularis ATP binding cassette sub family B 0.0228 0.2026 0.1719
Plasmodium vivax multidrug resistance-associated protein 2, putative 0.0228 0.2026 0.161
Schistosoma mansoni hypothetical protein 0.034 0.3505 0.3255
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0719 0.8493 0.5
Giardia lamblia Multidrug resistance-associated protein 1 0.0228 0.2026 0.0672
Plasmodium falciparum multidrug resistance-associated protein 2 0.0228 0.2026 0.161
Trichomonas vaginalis taga, putative 0.0719 0.8493 1
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.0228 0.2026 0.5
Echinococcus granulosus multidrug resistance protein 1 0.0719 0.8493 0.8435
Schistosoma mansoni multidrug resistance protein 0.0228 0.2026 0.1719
Echinococcus granulosus multidrug resistance associated protein 1 0.0228 0.2026 0.1719
Leishmania major pentamidine resistance protein 1 0.0228 0.2026 0.2386
Schistosoma mansoni multidrug resistance protein 0.0719 0.8493 0.8435
Trypanosoma brucei ABC transporter, mitochondrial, putative 0.0228 0.2026 0.4517
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.029 0.2846 0.257
Loa Loa (eye worm) ABC transporter 0.0228 0.2026 0.1719
Schistosoma mansoni tar DNA-binding protein 0.0833 1 1
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.0415 0.4486 0.5282
Loa Loa (eye worm) hypothetical protein 0.0719 0.8493 0.8435
Plasmodium vivax multidrug resistance protein 2, putative 0.0228 0.2026 0.161
Echinococcus granulosus multidrug resistance protein 1 0.0503 0.5651 0.5484
Brugia malayi latrophilin 2 splice variant baaae 0.0222 0.1941 0.181
Schistosoma mansoni tar DNA-binding protein 0.0833 1 1
Trichomonas vaginalis abcb9, putative 0.0719 0.8493 1
Schistosoma mansoni tar DNA-binding protein 0.0833 1 1
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0228 0.2026 0.1897
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0719 0.8493 1
Trichomonas vaginalis abcb9, putative 0.0719 0.8493 1
Brugia malayi P-glycoprotein-like protein 0.0228 0.2026 0.1897
Brugia malayi ABC transporter family protein 0.0719 0.8493 0.8469
Loa Loa (eye worm) hypothetical protein 0.0706 0.8328 0.8263
Trypanosoma brucei ATP-binding cassette protein, putative 0.0415 0.4486 1
Trichomonas vaginalis ABC transporter, putative 0.0719 0.8493 1
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0228 0.2026 0.4517
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0719 0.8493 1
Brugia malayi hypothetical protein 0.0157 0.1088 0.0944
Echinococcus granulosus ATP binding cassette sub family G 0.0415 0.4486 0.4273
Echinococcus granulosus ATP binding cassette sub family G 0.0415 0.4486 0.4273
Echinococcus multilocularis ATP binding cassette sub family B 0.0706 0.8328 0.8263
Echinococcus multilocularis multidrug resistance associated protein 1 0.0228 0.2026 0.1719
Echinococcus multilocularis ATP binding cassette sub family B 0.0228 0.2026 0.1719
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0719 0.8493 1
Toxoplasma gondii LsmAD domain-containing protein 0.0134 0.0786 0.0925
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0719 0.8493 0.8435
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0228 0.2026 0.2386
Brugia malayi multidrug resistance protein 3 0.0719 0.8493 0.8469
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.029 0.2846 0.257
Trypanosoma brucei PAB1-binding protein , putative 0.0134 0.0786 0.1751
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0719 0.8493 1
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0228 0.2026 0.2386
Plasmodium vivax ABC transporter B family member 7, putative 0.0228 0.2026 0.161
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0719 0.8493 0.8435
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0415 0.4486 1
Brugia malayi Latrophilin receptor protein 2 0.0103 0.0372 0.0215
Leishmania major hypothetical protein, conserved 0.0134 0.0786 0.0925
Plasmodium falciparum multidrug resistance protein 2 0.0228 0.2026 0.161
Giardia lamblia ABC transporter 0.0402 0.4321 1
Loa Loa (eye worm) hypothetical protein 0.0228 0.2026 0.1719
Loa Loa (eye worm) transcription factor SMAD2 0.0514 0.5793 0.5631
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0719 0.8493 1
Echinococcus granulosus ATP binding cassette sub family G 0.0415 0.4486 0.4273
Giardia lamblia Multidrug resistance-associated protein 1 0.0228 0.2026 0.0672
Plasmodium falciparum ABC transporter B family member 4, putative 0.0228 0.2026 0.161
Brugia malayi Calcitonin receptor-like protein seb-1 0.0324 0.3293 0.3184
Entamoeba histolytica ABC transporter, putative 0.0415 0.4486 0.3958
Giardia lamblia MRP-like ABC transporter 0.0228 0.2026 0.0672
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0719 0.8493 1
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0228 0.2026 0.4517
Trypanosoma cruzi ABC transporter, mitochondrial, putative 0.0228 0.2026 0.4517
Echinococcus granulosus multidrug resistance associated protein 7 0.0228 0.2026 0.1719
Brugia malayi ABC transporter family protein 0.0228 0.2026 0.1897
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0228 0.2026 0.2386
Echinococcus multilocularis ATP binding cassette sub family B 0.0228 0.2026 0.1719
Schistosoma mansoni multidrug resistance protein 0.0719 0.8493 0.8435
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0103 0.0372 0.0215
Echinococcus multilocularis ATP binding cassette sub family G 0.0415 0.4486 0.4273
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0503 0.5651 0.5715
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0415 0.4486 1
Trypanosoma brucei p-glycoprotein 0.0228 0.2026 0.4517
Echinococcus granulosus ATP binding cassette sub family B 0.0228 0.2026 0.1719
Leishmania major ATP-binding cassette protein subfamily C, member 8, putative 0.0228 0.2026 0.2386
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0719 0.8493 0.8435
Toxoplasma gondii ABC transporter, putative 0.0228 0.2026 0.2386
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0719 0.8493 0.8435
Entamoeba histolytica ATP-binding cassette protein, putative 0.0228 0.2026 0.0249
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0719 0.8493 0.8435
Schistosoma mansoni multidrug resistance protein 0.0228 0.2026 0.1719
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0228 0.2026 0.4517
Trichomonas vaginalis ABC transporter, putative 0.0719 0.8493 1
Brugia malayi ABC transporter family protein 0.0228 0.2026 0.1897
Brugia malayi hypothetical protein 0.0134 0.0786 0.0636
Loa Loa (eye worm) MH2 domain-containing protein 0.0514 0.5793 0.5631
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0833 1 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0719 0.8493 0.8435
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0228 0.2026 0.5
Entamoeba histolytica P-glycoprotein-1 0.0719 0.8493 1
Brugia malayi ABC transporter 0.0228 0.2026 0.1897
Loa Loa (eye worm) hypothetical protein 0.0228 0.2026 0.1719
Brugia malayi TAR-binding protein 0.0833 1 1
Plasmodium vivax multidrug resistance protein 1, putative 0.0719 0.8493 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0228 0.2026 0.2386
Echinococcus multilocularis multidrug resistance protein 1 0.0719 0.8493 0.8435
Loa Loa (eye worm) hypothetical protein 0.0222 0.1941 0.163
Plasmodium falciparum ABC transporter B family member 5, putative 0.0228 0.2026 0.161
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.0415 0.4486 0.4273
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0719 0.8493 0.8435
Trypanosoma cruzi ABC transporter, putative 0.0415 0.4486 1
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0415 0.4486 1
Echinococcus granulosus tar DNA binding protein 0.0833 1 1
Echinococcus multilocularis multidrug resistance associated protein 7 0.0228 0.2026 0.1719
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.029 0.2846 0.273
Trichomonas vaginalis ABC transporter, putative 0.0719 0.8493 1
Loa Loa (eye worm) ABC transporter 0.0228 0.2026 0.1719
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0216 0.1861 0.1547
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0228 0.2026 0.2386
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0719 0.8493 1
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0228 0.2026 0.1719
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0719 0.8493 1
Brugia malayi ABC transporter family protein 0.0228 0.2026 0.1897
Schistosoma mansoni multidrug resistance protein 0.0228 0.2026 0.1719
Trypanosoma brucei ABC transporter of the mitochondrion, putative 0.0228 0.2026 0.4517
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0719 0.8493 1
Brugia malayi hypothetical protein 0.0228 0.2026 0.1897
Plasmodium falciparum ABC transporter B family member 6, putative 0.0228 0.2026 0.161
Onchocerca volvulus 0.0719 0.8493 1
Plasmodium falciparum multidrug resistance protein 1 0.0719 0.8493 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0719 0.8493 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0719 0.8493 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.029 0.2846 0.257
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.029 0.2846 0.257
Leishmania major p-glycoprotein e 0.0228 0.2026 0.2386
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0324 0.3293 0.3034
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.029 0.2846 0.257
Schistosoma mansoni smdr2 0.0719 0.8493 0.8435
Schistosoma mansoni hypothetical protein 0.0222 0.1941 0.163
Plasmodium vivax ABC transporter B family member 5, putative 0.0228 0.2026 0.161
Echinococcus multilocularis ATP binding cassette sub family G 0.0415 0.4486 0.4273
Giardia lamblia ABC transporter, putative 0.0228 0.2026 0.0672
Schistosoma mansoni multidrug resistance protein 0.0719 0.8493 0.8435
Echinococcus multilocularis tar DNA binding protein 0.0833 1 1
Loa Loa (eye worm) hypothetical protein 0.0228 0.2026 0.1719
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0228 0.2026 0.2386
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.029 0.2846 0.257
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0719 0.8493 1
Loa Loa (eye worm) TAR-binding protein 0.0833 1 1
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0719 0.8493 1
Entamoeba histolytica P-glycoprotein-5 0.0719 0.8493 1
Entamoeba histolytica hypothetical protein 0.0228 0.2026 0.0249
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0719 0.8493 1
Onchocerca volvulus 0.025 0.2315 0.1656
Loa Loa (eye worm) pax transcription factor protein 2 0.025 0.2315 0.2018
Brugia malayi ABC transporter 0.0216 0.1861 0.1729
Leishmania major ABC-thiol transporter 0.0228 0.2026 0.2386
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0719 0.8493 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0719 0.8493 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0719 0.8493 1
Plasmodium vivax multidrug resistance-associated protein 1, putative 0.0228 0.2026 0.161
Brugia malayi ABC transporter transmembrane region family protein 0.0228 0.2026 0.1897
Trypanosoma cruzi PAB1-binding protein , putative 0.0134 0.0786 0.1751
Plasmodium falciparum ABC transporter G family member 2 0.0415 0.4486 0.4801
Leishmania major ATP-binding cassette protein subfamily B, member 3, putative 0.0228 0.2026 0.2386
Loa Loa (eye worm) ABC transporter 0.0353 0.3671 0.3427
Echinococcus multilocularis ATP binding cassette sub family B 0.0228 0.2026 0.1719
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0228 0.2026 0.2386
Schistosoma mansoni ABC transporter 0.0353 0.3671 0.3427
Loa Loa (eye worm) ABC transporter 0.0228 0.2026 0.1719
Entamoeba histolytica P-glyco protein 6, putative 0.0719 0.8493 1
Brugia malayi MH2 domain containing protein 0.0514 0.5793 0.5725
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0719 0.8493 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.0228 0.2026 0.0249
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0228 0.2026 0.2386
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0719 0.8493 1
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0228 0.2026 0.1719
Entamoeba histolytica P-glycoprotein 6, putative 0.0228 0.2026 0.0249
Trypanosoma brucei ABC transporter, putative 0.0415 0.4486 1
Brugia malayi ABC transporter family protein 0.0353 0.3671 0.3568
Plasmodium vivax ABC transporter B family member 4, putative 0.0228 0.2026 0.161
Brugia malayi RNA recognition motif domain containing protein 0.0833 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0134 0.0786 0.1751
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.029 0.2846 0.257
Loa Loa (eye worm) hypothetical protein 0.0216 0.1861 0.1547
Schistosoma mansoni multidrug resistance protein 0.0216 0.1861 0.1547
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0719 0.8493 0.8435
Entamoeba histolytica P-glycoprotein-2 0.0719 0.8493 1
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.0228 0.2026 0.5
Mycobacterium tuberculosis Probable conserved transmembrane ATP-binding protein ABC transporter 0.034 0.3505 0.2287
Brugia malayi Pax transcription factor protein 2 0.025 0.2315 0.219
Trypanosoma cruzi multidrug resistance protein E, putative 0.0228 0.2026 0.4517
Brugia malayi multidrug resistance related protein 1 0.0228 0.2026 0.1897
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.0415 0.4486 0.5282
Loa Loa (eye worm) hypothetical protein 0.0719 0.8493 0.8435
Loa Loa (eye worm) hypothetical protein 0.0157 0.1088 0.0744
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.0415 0.4486 0.5282
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0228 0.2026 0.2386
Entamoeba histolytica ATP-binding cassette protein, putative 0.0228 0.2026 0.0249
Loa Loa (eye worm) hypothetical protein 0.0216 0.1861 0.1547
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0719 0.8493 1
Schistosoma mansoni multidrug resistance protein 0.0228 0.2026 0.1719
Plasmodium falciparum ABC transporter B family member 3, putative 0.0228 0.2026 0.161
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.029 0.2846 0.257
Echinococcus granulosus multidrug resistance protein 1 0.0719 0.8493 0.8435
Plasmodium vivax ABC transporter G family member 2, putative 0.0415 0.4486 0.4801
Entamoeba histolytica P-glycoprotein 6, putative 0.0228 0.2026 0.0249
Loa Loa (eye worm) hypothetical protein 0.0324 0.3293 0.3034
Toxoplasma gondii ATP-binding cassette sub-family B member 5 0.0228 0.2026 0.2386
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0719 0.8493 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 60.1198 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 125.8925 uM PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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