Detailed information for compound 1424725

Basic information

Technical information
  • TDR Targets ID: 1424725
  • Name: 1-[[6-oxo-1-(phenylmethyl)pyridine-3-carbonyl ]amino]-3-prop-2-enylthiourea
  • MW: 342.415 | Formula: C17H18N4O2S
  • H donors: 3 H acceptors: 2 LogP: 1.46 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCNC(=S)NNC(=O)c1ccc(=O)n(c1)Cc1ccccc1
  • InChi: 1S/C17H18N4O2S/c1-2-10-18-17(24)20-19-16(23)14-8-9-15(22)21(12-14)11-13-6-4-3-5-7-13/h2-9,12H,1,10-11H2,(H,19,23)(H2,18,20,24)
  • InChiKey: HNKOWXNLSAPIPJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-allyl-1-[[6-oxo-1-(phenylmethyl)pyridine-3-carbonyl]amino]thiourea
  • 3-allyl-1-[[oxo-[6-oxo-1-(phenylmethyl)-3-pyridyl]methyl]amino]thiourea
  • 3-allyl-1-[[1-(benzyl)-6-keto-pyridine-3-carbonyl]amino]thiourea
  • 1-[[6-oxo-1-(phenylmethyl)pyridin-3-yl]carbonylamino]-3-prop-2-enyl-thiourea
  • 10E-386S
  • MLS000694623
  • N-allyl-2-[(1-benzyl-6-oxo-1,6-dihydro-3-pyridinyl)carbonyl]-1-hydrazinecarbothioamide
  • SMR000333301
  • ZINC03052131

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi latrophilin 2 splice variant baaae 0.0752 0.675 0.675
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0348 0.2978 0.3136
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.1564 0.1564
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0044 0.0141 1
Leishmania major DNA polymerase eta, putative 0.0051 0.0206 0.1517
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0479 0.4204 0.4204
Toxoplasma gondii LsmAD domain-containing protein 0.0136 0.1001 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.1032 0.9364 1
Loa Loa (eye worm) hypothetical protein 0.0348 0.2978 0.2978
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0044 0.0141 0.0088
Schistosoma mansoni GTP-binding protein alpha subunit 0.0044 0.0141 0.0088
Schistosoma mansoni alpha-glucosidase 0.0169 0.1309 0.1342
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.1032 0.9364 1
Brugia malayi TAR-binding protein 0.0479 0.4204 0.4204
Loa Loa (eye worm) MH1 domain-containing protein 0.0053 0.022 0.022
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0044 0.0141 0.0088
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0135 0.0135
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0044 0.0141 0.0088
Schistosoma mansoni hypothetical protein 0.0348 0.2978 0.3136
Loa Loa (eye worm) hypothetical protein 0.0149 0.1123 0.1123
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0348 0.2978 0.3136
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0044 0.0141 0.0088
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0044 0.0141 0.0141
Echinococcus granulosus mothers against decapentaplegic 5 0.0053 0.022 0.0173
Brugia malayi hypothetical protein 0.0136 0.1001 0.1001
Loa Loa (eye worm) hypothetical protein 0.0136 0.1001 0.1001
Echinococcus multilocularis smad 0.0053 0.022 0.0173
Echinococcus multilocularis dna polymerase eta 0.0051 0.0206 0.0157
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0135 0.0761
Loa Loa (eye worm) TAR-binding protein 0.0479 0.4204 0.4204
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0044 0.0141 1
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0044 0.0141 0.0088
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0044 0.0141 1
Schistosoma mansoni hypothetical protein 0.0752 0.675 0.719
Brugia malayi ImpB/MucB/SamB family protein 0.0051 0.0206 0.0206
Brugia malayi N-terminal motif family protein 0.019 0.1498 0.1498
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0044 0.0141 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.1032 0.9364 1
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0044 0.0141 0.0088
Echinococcus multilocularis mothers against decapentaplegic 5 0.0053 0.022 0.0173
Schistosoma mansoni tar DNA-binding protein 0.0479 0.4204 0.4454
Echinococcus granulosus geminin 0.0668 0.5962 0.6343
Brugia malayi MH2 domain containing protein 0.0053 0.022 0.022
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0044 0.0141 0.0141
Echinococcus granulosus dna polymerase eta 0.0051 0.0206 0.0157
Onchocerca volvulus 0.0114 0.079 0.478
Echinococcus multilocularis Smad4 0.0053 0.022 0.0173
Trypanosoma cruzi PAB1-binding protein , putative 0.0136 0.1001 1
Entamoeba histolytica G protein alpha subunit, putative 0.0044 0.0141 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.1032 0.9364 0.9364
Plasmodium falciparum ataxin-2 like protein, putative 0.0136 0.1001 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.0775 0.6959 0.6959
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0044 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0044 0.0141 0.0141
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0044 0.0141 0.0141
Loa Loa (eye worm) RNA binding protein 0.0479 0.4204 0.4204
Echinococcus multilocularis geminin 0.0668 0.5962 0.6343
Brugia malayi Calcitonin receptor-like protein seb-1 0.11 1 1
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0044 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0752 0.675 0.675
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.1032 0.9364 1
Onchocerca volvulus 0.0149 0.1123 0.7232
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0044 0.0141 0.0141
Loa Loa (eye worm) latrophilin receptor protein 2 0.0348 0.2978 0.2978
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0135 0.0081
Brugia malayi MH2 domain containing protein 0.0775 0.6959 0.6959
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0348 0.2978 0.3136
Loa Loa (eye worm) Smad1 0.0053 0.022 0.022
Schistosoma mansoni hypothetical protein 0.0348 0.2978 0.3136
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0348 0.2978 0.2978
Schistosoma mansoni smad1 5 8 and 0.0053 0.022 0.0173
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0044 0.0141 0.0141
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0044 0.0141 0.0088
Loa Loa (eye worm) hypothetical protein 0.0044 0.0141 0.0141
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0811 0.7296 0.7777
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0044 0.0141 0.0141
Schistosoma mansoni smad 0.0053 0.022 0.0173
Trypanosoma brucei PAB1-binding protein , putative 0.0136 0.1001 1
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0044 0.0141 0.0088
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.1564 0.1617
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0135 0.9225
Brugia malayi RNA binding protein 0.0479 0.4204 0.4204
Loa Loa (eye worm) pigment dispersing factor receptor c 0.11 1 1
Loa Loa (eye worm) G protein alpha subunit 3 0.0044 0.0141 0.0141
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0044 0.0141 0.0088
Schistosoma mansoni smad1 5 8 and 0.0053 0.022 0.0173
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.1032 0.9364 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.1564 0.1564
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0348 0.2978 0.3136
Loa Loa (eye worm) hypothetical protein 0.0044 0.0141 0.0141
Schistosoma mansoni alpha glucosidase 0.0044 0.0135 0.0081
Schistosoma mansoni hypothetical protein 0.0668 0.5962 0.6343
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.1564 0.1617
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0044 0.0141 0.0141
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0044 0.0141 0.0088
Echinococcus granulosus Smad4 0.0053 0.022 0.0173
Leishmania major hypothetical protein, conserved 0.0136 0.1001 1
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0044 0.0141 1
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0044 0.0141 0.0088
Brugia malayi Latrophilin receptor protein 2 0.0348 0.2978 0.2978
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0044 0.0141 1
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0044 0.0141 0.0141
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0135 0.0761
Trypanosoma cruzi DNA polymerase eta, putative 0.0051 0.0206 0.1517
Brugia malayi RNA recognition motif domain containing protein 0.0479 0.4204 0.4204
Brugia malayi hypothetical protein 0.0088 0.055 0.055
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.1032 0.9364 0.9364
Loa Loa (eye worm) hypothetical protein 0.11 1 1
Schistosoma mansoni hypothetical protein 0.0348 0.2978 0.3136
Brugia malayi MH1 domain containing protein 0.0053 0.022 0.022
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0135 0.0761
Brugia malayi MH1 domain containing protein 0.0053 0.022 0.022
Loa Loa (eye worm) hypothetical protein 0.0044 0.0141 0.0141
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0044 0.0141 0.0088
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0135 0.0761
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0053 0.022 0.0173
Echinococcus multilocularis tar DNA binding protein 0.0479 0.4204 0.4454
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0135 0.0081
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0061 0.0299 0.0257
Loa Loa (eye worm) MH2 domain-containing protein 0.0053 0.022 0.022
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.1032 0.9364 1
Schistosoma mansoni tar DNA-binding protein 0.0479 0.4204 0.4454
Brugia malayi hypothetical protein 0.0036 0.006 0.006
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0044 0.0141 0.0088
Schistosoma mansoni Smad4 0.0053 0.022 0.0173
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0044 0.0141 0.0088
Schistosoma mansoni tar DNA-binding protein 0.0479 0.4204 0.4454
Brugia malayi Smad1 0.0053 0.022 0.022
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0135 0.0135
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0044 0.0141 0.0088
Schistosoma mansoni alpha-glucosidase 0.0169 0.1309 0.1342
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0044 0.0141 0.0088
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0044 0.0141 1
Schistosoma mansoni hypothetical protein 0.0668 0.5962 0.6343
Loa Loa (eye worm) hypothetical protein 0.0051 0.0206 0.0206
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0044 0.0141 0.0088
Echinococcus granulosus tar DNA binding protein 0.0479 0.4204 0.4454
Schistosoma mansoni DNA polymerase eta 0.0051 0.0206 0.0157
Echinococcus granulosus expressed protein 0.0044 0.0141 0.0088
Echinococcus multilocularis GPCR, family 2 0.0348 0.2978 0.3136
Schistosoma mansoni smad1 5 8 and 0.0053 0.022 0.0173
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0053 0.022 0.0173
Loa Loa (eye worm) hypothetical protein 0.019 0.1498 0.1498
Brugia malayi hypothetical protein 0.0044 0.0141 0.0141
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.1032 0.9364 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0135 0.9225
Trypanosoma cruzi PAB1-binding protein , putative 0.0136 0.1001 1
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0044 0.0141 0.0088
Schistosoma mansoni hypothetical protein 0.0348 0.2978 0.3136
Loa Loa (eye worm) hypothetical protein 0.0044 0.0141 0.0141
Schistosoma mansoni GTP-binding protein alpha subunit 0.0044 0.0141 0.0088
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0044 0.0141 1
Schistosoma mansoni tar DNA-binding protein 0.0479 0.4204 0.4454
Plasmodium falciparum ataxin-2 like protein, putative 0.0136 0.1001 0.5
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0044 0.0141 0.0088
Echinococcus granulosus GPCR family 2 0.0348 0.2978 0.3136
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0044 0.0141 0.0141
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0044 0.0141 0.0088
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0044 0.0141 0.0088
Echinococcus multilocularis expressed protein 0.0044 0.0141 0.0088
Schistosoma mansoni tar DNA-binding protein 0.0479 0.4204 0.4454
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0044 0.0141 0.0141
Brugia malayi hypothetical protein 0.0149 0.1123 0.1123
Brugia malayi G-protein alpha subunit 0.0044 0.0141 0.0141
Echinococcus granulosus TGF beta signal transducer SmadC 0.0053 0.022 0.0173
Schistosoma mansoni hypothetical protein 0.0061 0.0299 0.0257
Brugia malayi MH2 domain containing protein 0.0053 0.022 0.022
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.1564 0.1617
Echinococcus granulosus smad 0.0053 0.022 0.0173
Loa Loa (eye worm) transcription factor SMAD2 0.0775 0.6959 0.6959
Plasmodium vivax ataxin-2 like protein, putative 0.0136 0.1001 0.5
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0061 0.0299 0.0257
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0044 0.0141 0.0141
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.019 0.1498 1
Trypanosoma brucei DNA polymerase eta, putative 0.0051 0.0206 0.0818

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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