Detailed information for compound 1424870

Basic information

Technical information
  • TDR Targets ID: 1424870
  • Name: 7-hydroxy-8-methyl-4-[[4-(3-phenylprop-2-enyl )piperazin-1-yl]methyl]chromen-2-one
  • MW: 390.475 | Formula: C24H26N2O3
  • H donors: 1 H acceptors: 2 LogP: 3.25 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1cc(CN2CCN(CC2)C/C=C/c2ccccc2)c2c(o1)c(C)c(cc2)O
  • InChi: 1S/C24H26N2O3/c1-18-22(27)10-9-21-20(16-23(28)29-24(18)21)17-26-14-12-25(13-15-26)11-5-8-19-6-3-2-4-7-19/h2-10,16,27H,11-15,17H2,1H3/b8-5+
  • InChiKey: NFMZMZWHQXXIGM-VMPITWQZSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 7-hydroxy-8-methyl-4-[[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]methyl]chromen-2-one
  • 7-hydroxy-8-methyl-4-[[4-[(E)-3-phenylprop-2-enyl]-1-piperazinyl]methyl]-2-chromenone
  • 7-hydroxy-8-methyl-4-[[4-(3-phenylprop-2-enyl)-1-piperazinyl]methyl]-2-chromenone
  • 7-hydroxy-8-methyl-4-[[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]methyl]coumarin
  • 7-hydroxy-8-methyl-4-[[4-(3-phenylprop-2-enyl)piperazin-1-yl]methyl]coumarin
  • 7-Hydroxy-8-methyl-4-[4-((E)-3-phenyl-allyl)-piperazin-1-ylmethyl]-chromen-2-one
  • MLS000779059
  • SMR000415735

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens prolyl 4-hydroxylase, beta polypeptide Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense protein disulfide isomerase 2 Get druggable targets OG5_126843 All targets in OG5_126843
Leishmania braziliensis protein disulfide isomerase Get druggable targets OG5_126843 All targets in OG5_126843
Leishmania major protein disulfide isomerase Get druggable targets OG5_126843 All targets in OG5_126843
Trichomonas vaginalis protein disulfide isomerase, putative Get druggable targets OG5_126843 All targets in OG5_126843
Trypanosoma brucei gambiense protein disulfide isomerase,bloodstream- specific protein 2 precursor, putative Get druggable targets OG5_126843 All targets in OG5_126843
Echinococcus granulosus protein disulfide isomerase Get druggable targets OG5_126843 All targets in OG5_126843
Schistosoma mansoni Probable protein disulfide-isomerase ER-60 precursor (ERP60) Get druggable targets OG5_126843 All targets in OG5_126843
Toxoplasma gondii protein disulfide isomerase Get druggable targets OG5_126843 All targets in OG5_126843
Echinococcus granulosus protein disulfide isomerase A3 Get druggable targets OG5_126843 All targets in OG5_126843
Trypanosoma brucei protein disulfide isomerase Get druggable targets OG5_126843 All targets in OG5_126843
Schistosoma japonicum ko:K08056 protein disulfide isomerase family A, member 3, putative Get druggable targets OG5_126843 All targets in OG5_126843
Cryptosporidium parvum disulfide-isomerase, signal peptide plus ER retention motif, putative ER protein Get druggable targets OG5_126843 All targets in OG5_126843
Entamoeba histolytica thioredoxin, putative Get druggable targets OG5_126843 All targets in OG5_126843
Loa Loa (eye worm) transglutaminase Get druggable targets OG5_126843 All targets in OG5_126843
Brugia malayi protein disulphide isomerase Get druggable targets OG5_126843 All targets in OG5_126843
Schistosoma japonicum ko:K09580 prolyl 4-hydroxylase, beta polypeptide, putative Get druggable targets OG5_126843 All targets in OG5_126843
Theileria parva protein disulfide isomerase, putative Get druggable targets OG5_126843 All targets in OG5_126843
Babesia bovis protein disulfide-isomerase Get druggable targets OG5_126843 All targets in OG5_126843
Cryptosporidium hominis protein disulphide isomerase Get druggable targets OG5_126843 All targets in OG5_126843
Candida albicans hypothetical protein Get druggable targets OG5_126843 All targets in OG5_126843
Brugia malayi transglutaminase Get druggable targets OG5_126843 All targets in OG5_126843
Leishmania donovani protein disulfide isomerase 2 Get druggable targets OG5_126843 All targets in OG5_126843
Leishmania mexicana protein disulfide isomerase Get druggable targets OG5_126843 All targets in OG5_126843
Plasmodium yoelii protein disulfide isomerase Get druggable targets OG5_126843 All targets in OG5_126843
Echinococcus multilocularis protein disulfide isomerase A3 Get druggable targets OG5_126843 All targets in OG5_126843
Neospora caninum protein disulfide isomerase Get druggable targets OG5_126843 All targets in OG5_126843
Schistosoma mansoni protein disulfide-isomerase Get druggable targets OG5_126843 All targets in OG5_126843
Loa Loa (eye worm) protein disulfide isomerase Get druggable targets OG5_126843 All targets in OG5_126843
Candida albicans one of two genes similar to S. cerevisiae PDI1 (YCL043C) ER protein disulfide isomerase and foldase Get druggable targets OG5_126843 All targets in OG5_126843
Trichomonas vaginalis protein disulfide isomerase, putative Get druggable targets OG5_126843 All targets in OG5_126843
Brugia malayi probable protein disulfide-isomerase Get druggable targets OG5_126843 All targets in OG5_126843
Plasmodium berghei protein disulfide isomerase Get druggable targets OG5_126843 All targets in OG5_126843
Plasmodium vivax protein disulfide isomerase, putative Get druggable targets OG5_126843 All targets in OG5_126843
Schistosoma mansoni protein disulfide-isomerase er-60 precursor (erp60) Get druggable targets OG5_126843 All targets in OG5_126843
Plasmodium knowlesi protein disulfide isomerase, putative Get druggable targets OG5_126843 All targets in OG5_126843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126843 All targets in OG5_126843
Trypanosoma cruzi bloodstream- specific protein 2 precursor Get druggable targets OG5_126843 All targets in OG5_126843
Giardia lamblia Protein disulfide isomerase PDI2 Get druggable targets OG5_126843 All targets in OG5_126843
Loa Loa (eye worm) Pdia4 protein Get druggable targets OG5_126843 All targets in OG5_126843
Trichomonas vaginalis protein disulfide isomerase, putative Get druggable targets OG5_126843 All targets in OG5_126843
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Echinococcus multilocularis protein disulfide isomerase Get druggable targets OG5_126843 All targets in OG5_126843
Plasmodium falciparum protein disulfide isomerase Get druggable targets OG5_126843 All targets in OG5_126843
Candida albicans one of two genes similar to S. cerevisiae PDI1 (YCL043C) ER protein disulfide isomerase and foldase Get druggable targets OG5_126843 All targets in OG5_126843
Leishmania infantum protein disulfide isomerase Get druggable targets OG5_126843 All targets in OG5_126843
Trichomonas vaginalis protein disulfide isomerase, putative Get druggable targets OG5_126843 All targets in OG5_126843
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Plasmodium falciparum protein disulfide-isomerase prolyl 4-hydroxylase, beta polypeptide 508 aa 478 aa 21.6 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0064 0.0558 0.1769
Loa Loa (eye worm) TAR-binding protein 0.0444 0.4481 0.7245
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0064 0.0558 1
Schistosoma mansoni tar DNA-binding protein 0.0444 0.4481 0.9315
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0064 0.0558 1
Giardia lamblia Protein disulfide isomerase PDI2 0.0009 0 0.5
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0064 0.0558 1
Echinococcus granulosus peptidase Clp S14 family 0.0312 0.312 0.6485
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0476 0.4811 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0064 0.0558 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0064 0.0558 0.1161
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0064 0.0558 0.1161
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0164 0.1593 0.3312
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0476 0.4811 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0609 0.6185 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0193 0.189 0.3929
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0476 0.4811 1
Brugia malayi isocitrate dehydrogenase 0.0064 0.0558 0.0903
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0064 0.0558 0.1161
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0193 0.189 0.3056
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0476 0.4811 1
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0164 0.1593 0.3301
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0064 0.0558 0.0558
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0064 0.0558 0.0558
Schistosoma mansoni hypothetical protein 0.0193 0.189 0.3929
Schistosoma mansoni ferritin light chain 0.001 0.0008 0.0016
Brugia malayi latrophilin 2 splice variant baaae 0.0417 0.4197 0.6786
Toxoplasma gondii isocitrate dehydrogenase 0.0064 0.0558 0.1161
Brugia malayi Probable ClpP-like protease 0.0476 0.4811 0.7778
Echinococcus granulosus tar DNA binding protein 0.0444 0.4481 0.9315
Echinococcus multilocularis expressed protein 0.001 0.0008 0.0008
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0064 0.0558 0.0558
Echinococcus granulosus GPCR family 2 0.0193 0.189 0.3929
Schistosoma mansoni hypothetical protein 0.0193 0.189 0.3929
Schistosoma mansoni ferritin 0.001 0.0008 0.0016
Schistosoma mansoni peptidase Clp (S14 family) 0.0476 0.4811 1
Schistosoma mansoni tar DNA-binding protein 0.0444 0.4481 0.9315
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0216 0.3871
Echinococcus multilocularis GPCR, family 2 0.0193 0.189 0.189
Schistosoma mansoni ferritin 0.001 0.0008 0.0016
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0444 0.4481 0.7245
Schistosoma mansoni ferritin light chain 0.001 0.0008 0.0016
Loa Loa (eye worm) isocitrate dehydrogenase 0.0064 0.0558 0.0903
Brugia malayi hypothetical protein 0.003 0.0216 0.0349
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0216 0.0449
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0476 0.4811 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0312 0.312 1
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0216 0.0449
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0193 0.189 0.189
Brugia malayi RNA recognition motif domain containing protein 0.0444 0.4481 0.7245
Trichomonas vaginalis ferritin, putative 0.001 0.0008 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0476 0.4811 0.4811
Toxoplasma gondii isocitrate dehydrogenase 0.0064 0.0558 0.1161
Schistosoma mansoni hypothetical protein 0.0417 0.4197 0.8724
Toxoplasma gondii hypothetical protein 0.0164 0.1593 0.3312
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0193 0.189 0.189
Leishmania major hypothetical protein, conserved 0.003 0.0216 0.3871
Loa Loa (eye worm) hypothetical protein 0.0609 0.6185 1
Brugia malayi Latrophilin receptor protein 2 0.0193 0.189 0.3056
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0043 0.0089
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0609 0.6185 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0476 0.4811 1
Echinococcus granulosus expressed protein 0.001 0.0008 0.0016
Entamoeba histolytica thioredoxin, putative 0.0009 0 0.5
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0476 0.4811 1
Schistosoma mansoni hypothetical protein 0.0014 0.0043 0.0089
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0312 0.312 0.6479
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0193 0.189 0.3929
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0164 0.1593 0.3301
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0064 0.0558 0.0558
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0216 0.3871
Loa Loa (eye worm) hypothetical protein 0.003 0.0216 0.0349
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0312 0.312 1
Schistosoma mansoni hypothetical protein 0.0193 0.189 0.3929
Loa Loa (eye worm) hypothetical protein 0.0476 0.4811 0.7778
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0476 0.4811 0.5
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0417 0.4197 0.6786
Echinococcus multilocularis tar DNA binding protein 0.0444 0.4481 0.4481
Schistosoma mansoni tar DNA-binding protein 0.0444 0.4481 0.9315
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0476 0.4811 1
Schistosoma mansoni hypothetical protein 0.0193 0.189 0.3929
Echinococcus granulosus ferritin 0.001 0.0008 0.0016
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0476 0.4811 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0193 0.189 0.3056
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0064 0.0558 1
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0216 0.0449
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0164 0.1593 0.3312
Schistosoma mansoni apoferritin-2 0.001 0.0008 0.0016
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0476 0.4811 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0064 0.0558 0.0558
Schistosoma mansoni apoferritin-2 0.001 0.0008 0.0016
Schistosoma mansoni ferritin 0.001 0.0008 0.0016
Schistosoma mansoni tar DNA-binding protein 0.0444 0.4481 0.9315
Schistosoma mansoni tar DNA-binding protein 0.0444 0.4481 0.9315
Schistosoma mansoni ferritin 0.001 0.0008 0.0016
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0216 0.3871
Loa Loa (eye worm) hypothetical protein 0.0193 0.189 0.3056
Loa Loa (eye worm) RNA binding protein 0.0444 0.4481 0.7245
Echinococcus multilocularis peptidase Clp (S14 family) 0.0312 0.312 0.312
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0476 0.4811 0.5
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0216 0.0449
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0064 0.0558 0.1161
Brugia malayi Isocitrate dehydrogenase 0.0064 0.0558 0.0903
Brugia malayi Calcitonin receptor-like protein seb-1 0.0609 0.6185 1
Brugia malayi hypothetical protein 0.002 0.0105 0.017
Echinococcus multilocularis ferritin 0.001 0.0008 0.0008
Brugia malayi RNA binding protein 0.0444 0.4481 0.7245
Brugia malayi TAR-binding protein 0.0444 0.4481 0.7245

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 19.5 uM PUBCHEM_BIOASSAY: Turbidimetric Biochemical Primary HTS to identify inhibitors of Protein Disulfide Isomerase Measured in Biochemical System Using Plate Reader - 2137-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
AC50 (functional) 19.5 uM PubChem BioAssay. Turbidimetric Biochemical Primary HTS to identify inhibitors of Protein Disulfide Isomerase Measured in Biochemical System Using Plate Reader - 2137-01_Inhibitor_Dose_CherryPick_Activity_Set2. (Class of assay: confirmatory) ChEMBL. No reference
AC50 (functional) 70 uM PubChem BioAssay. Cytotoxicity (24 hours) Measured in Cell-Based System Using Plate Reader - 2137-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.6169 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.6169 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (binding) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3489 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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