Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | transient receptor potential cation channel, subfamily C, member 4 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | short transient receptor potential channel 6 | transient receptor potential cation channel, subfamily C, member 4 | 890 aa | 799 aa | 31.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.3315 | 0.3315 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0369 | 1 | 1 |
Echinococcus granulosus | TRP transient receptor potential channel | 0.0044 | 0.0784 | 0.0784 |
Onchocerca volvulus | 0.0016 | 0 | 0.5 | |
Brugia malayi | TAR-binding protein | 0.0133 | 0.3315 | 0.3315 |
Echinococcus multilocularis | TRP (transient receptor potential) channel | 0.0044 | 0.0784 | 0.0784 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0078 | 0.1744 | 0.1744 |
Echinococcus granulosus | transient receptor potential gamma protein | 0.0117 | 0.2867 | 0.2867 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.0117 | 0.2867 | 0.2867 |
Schistosoma mansoni | transient receptor potential channel | 0.0078 | 0.1744 | 0.1744 |
Trichomonas vaginalis | GTP-binding protein (q) alpha-11 subunit, gna11, putative | 0.0016 | 0 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.2868 | 0.2868 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.3315 | 0.3315 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.3315 | 0.3315 |
Entamoeba histolytica | G protein alpha subunit, putative | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 0.2868 | 0.2868 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0133 | 0.3315 | 0.3315 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.2868 | 0.2868 |
Trichomonas vaginalis | GTP-binding protein alpha subunit, gna, putative | 0.0016 | 0 | 0.5 |
Brugia malayi | Transient-receptor-potential like protein | 0.0044 | 0.0784 | 0.0784 |
Trichomonas vaginalis | GTP-binding protein (O) alpha subunit, gnao, putative | 0.0016 | 0 | 0.5 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0113 | 0.2756 | 0.2756 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0113 | 0.2756 | 0.2756 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0078 | 0.1744 | 0.1744 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.2867 | 0.2867 |
Echinococcus multilocularis | tar DNA binding protein | 0.0133 | 0.3315 | 0.3315 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1634 | 0.1634 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0369 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0369 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0369 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0369 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0133 | 0.3315 | 0.3315 |
Onchocerca volvulus | 0.0016 | 0 | 0.5 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0369 | 1 | 1 |
Onchocerca volvulus | 0.0016 | 0 | 0.5 | |
Trichomonas vaginalis | GTP-binding protein (z) alpha subunit, gnaz, putative | 0.0016 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0369 | 1 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.0078 | 0.1744 | 0.1744 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.3315 | 0.3315 |
Trichomonas vaginalis | GTP-binding protein alpha subunit, gna, putative | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0784 | 0.0784 |
Loa Loa (eye worm) | RNA binding protein | 0.0133 | 0.3315 | 0.3315 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0369 | 1 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.0117 | 0.2867 | 0.2867 |
Trichomonas vaginalis | G protein (olf) alpha subunit, gnal, putative | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0674 | 0.0674 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.3315 | 0.3315 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0078 | 0.1744 | 0.1744 |
Trichomonas vaginalis | GTP-binding protein alpha subunit, gna, putative | 0.0016 | 0 | 0.5 |
Trichomonas vaginalis | GTP-binding protein alpha subunit, gna, putative | 0.0016 | 0 | 0.5 |
Brugia malayi | RNA binding protein | 0.0133 | 0.3315 | 0.3315 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0078 | 0.1744 | 0.1744 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0133 | 0.3315 | 0.3315 |
Loa Loa (eye worm) | TAR-binding protein | 0.0133 | 0.3315 | 0.3315 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.0117 | 0.2867 | 0.2867 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | 5.308 uM | PUBCHEM_BIOASSAY: Confirmation dose response assay for compounds that inhibit transient receptor potential cation channel C4 (TRPC4). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2247, AID2256] | ChEMBL. | No reference |
Potency (functional) | 2.6169 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 2.8184 um | PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Saccharomyces cerevisiae | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.