Detailed information for compound 1425027

Basic information

Technical information
  • TDR Targets ID: 1425027
  • Name: 8-methoxy-5-methyl-3-(2-phenylethyl)-1-(pheny lmethyl)pyrimido[5,6-b]indole-2,4-dione
  • MW: 439.506 | Formula: C27H25N3O3
  • H donors: 0 H acceptors: 2 LogP: 4.64 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)c1c(n2C)c(=O)n(c(=O)n1Cc1ccccc1)CCc1ccccc1
  • InChi: 1S/C27H25N3O3/c1-28-23-14-13-21(33-2)17-22(23)24-25(28)26(31)29(16-15-19-9-5-3-6-10-19)27(32)30(24)18-20-11-7-4-8-12-20/h3-14,17H,15-16,18H2,1-2H3
  • InChiKey: WJFIWBJRHAFFHC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(benzyl)-8-methoxy-5-methyl-3-(2-phenylethyl)pyrimido[5,6-b]indole-2,4-quinone
  • E737-1255
  • NCGC00124979-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Equus caballus Ferritin light chain Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0043 0.0541 0.0513
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0211 0.0146
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0146 0.0119
Loa Loa (eye worm) hypothetical protein 0.002 0.0146 0.0117
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1771 0.1747
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.3236 0.3216
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0095 0.0067
Plasmodium falciparum phd finger protein, putative 0.0028 0.0293 0.1093
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0146 0.0117
Onchocerca volvulus 0.003 0.0315 0.0171
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0146 0.0081
Onchocerca volvulus 0.0604 1 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0074 0.0046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0146 0.0117
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0374 0.0345
Echinococcus granulosus GPCR family 2 0.0015 0.0074 0.0046
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0093 0.139 0.1366
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0286 0.0257
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0146 0.0117
Schistosoma mansoni hypothetical protein 0.0015 0.0074 0.0008
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0293 0.0264
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0046 0.0594 0.0568
Loa Loa (eye worm) hypothetical protein 0.0017 0.0105 0.0076
Schistosoma mansoni nuclear hormone receptor 0.002 0.0146 0.0081
Loa Loa (eye worm) X11 protein 0.0067 0.0941 0.0914
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0211 0.0184
Loa Loa (eye worm) voltage-dependent calcium channel 0.002 0.0145 0.0116
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0146 0.0119
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0388 0.0996
Brugia malayi Pre-SET motif family protein 0.0203 0.3236 0.3216
Brugia malayi ecdysteroid receptor 0.002 0.0146 0.0117
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0093 0.139 0.1366
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0146 0.0117
Brugia malayi nuclear hormone receptor 0.002 0.0146 0.0117
Mycobacterium leprae conserved hypothetical protein 0.017 0.268 0.5
Brugia malayi beta-NAC-like protein 0.0034 0.0388 0.036
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0146 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0146 0.0117
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0093 0.139 0.1366
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0293 0.0266
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0093 0.139 0.1366
Schistosoma mansoni bromodomain containing protein 0.0063 0.0879 0.0818
Leishmania major phosphopantetheinyl transferase-like protein 0.017 0.268 0.808
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.082 0.0795
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0452 0.0423
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0074 0.0046
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0074 0.0047
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0146 0.0119
Loa Loa (eye worm) hypothetical protein 0.002 0.0146 0.0117
Trypanosoma brucei hypothetical protein, conserved 0.0207 0.3301 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0634 0.0606
Giardia lamblia PHD finger protein 15 0.0028 0.0293 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0632 0.0604
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0632 0.0604
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0074 0.0045
Loa Loa (eye worm) hypothetical protein 0.0069 0.0974 0.0947
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.017 0.268 0.604
Loa Loa (eye worm) hypothetical protein 0.0048 0.0632 0.0604
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0146 0.0081
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0286 0.026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0146 0.0117
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0146 0.0119
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0146 0.0117
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0074 0.0045
Toxoplasma gondii hypothetical protein 0.0017 0.0105 0.0119
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0393 0.0367
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0146 0.0117
Echinococcus multilocularis cpg binding protein 0.0031 0.0344 0.0317
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.138 0.1356
Loa Loa (eye worm) hypothetical protein 0.0249 0.4014 0.3997
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0452 0.0425
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0293 0.1093
Brugia malayi jmjC domain containing protein 0.0093 0.138 0.1354
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0146 0.0081
Echinococcus granulosus peregrin 0.0031 0.0332 0.0305
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0093 0.139 0.1366
Brugia malayi isocitrate dehydrogenase 0.0015 0.0074 0.0045
Schistosoma mansoni hypothetical protein 0.0015 0.0074 0.0008
Loa Loa (eye worm) hypothetical protein 0.002 0.0146 0.0117
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0293 0.084
Loa Loa (eye worm) glutaminase 0.0266 0.4294 0.4277
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0024 0.0217 0.0547
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0074 0.0025
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0074 0.0047
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0105 0.0075
Schistosoma mansoni glutaminase 0.0266 0.4294 0.4256
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.004 0.0483 0.0457
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0095 0.0067
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.017 0.268 0.5
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0146 0.0119
Echinococcus multilocularis transcription factor btf3 0.0034 0.0388 0.0362
Schistosoma mansoni amyloid beta A4 protein related 0.0067 0.0941 0.0881
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0146 0.0081
Loa Loa (eye worm) hypothetical protein 0.0046 0.0594 0.0566
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0074 0.0047
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0074 0.0025
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0153 0.0124
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0093 0.139 0.1366
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0146 0.0119
Leishmania major hypothetical protein, conserved 0.0207 0.3301 1
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.017 0.268 0.604
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0146 0.0117
Loa Loa (eye worm) calcium channel 0.0093 0.139 0.1364
Echinococcus multilocularis zinc finger protein 0.0021 0.0163 0.0136
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0404 0.0377
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0095 0.0029
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0093 0.139 0.1333
Mycobacterium ulcerans glutaminase 0.0266 0.4294 1
Schistosoma mansoni hypothetical protein 0.002 0.0153 0.0088
Brugia malayi PHD-finger family protein 0.0026 0.025 0.0221
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0763 0.2646
Echinococcus granulosus voltage dependent calcium channel 0.002 0.0145 0.0118
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.017 0.268 1
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0057 0.0773 0.2186
Entamoeba histolytica hypothetical protein 0.017 0.268 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0146 0.0117
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0802 0.0774
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0074 0.0025
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0146 0.0119
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0093 0.139 0.1366
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0074 0.0025
Schistosoma mansoni transcription factor btf3 0.0034 0.0388 0.0324
Brugia malayi PHD-finger family protein 0.0028 0.0293 0.0264
Trichomonas vaginalis set domain proteins, putative 0.0231 0.3707 0.8559
Echinococcus granulosus jumonji domain containing protein 0.0039 0.048 0.0454
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0594 0.0532
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0217 0.0466
Brugia malayi hypothetical protein 0.0064 0.0897 0.087
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0074 0.0025
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.017 0.268 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0146 0.0117
Brugia malayi Pre-SET motif family protein 0.003 0.0315 0.0286
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0404 0.0377
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0146 0.0117
Echinococcus granulosus amyloid beta A4 protein 0.0067 0.0941 0.0916
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0388 0.0996
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0074 0.0008
Echinococcus multilocularis GPCR, family 2 0.0015 0.0074 0.0046
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0146 0.0081
Echinococcus multilocularis amyloid beta A4 protein 0.0067 0.0941 0.0916
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0315 0.0288
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0074 0.0047
Trichomonas vaginalis glutaminase, putative 0.0266 0.4294 1
Onchocerca volvulus 0.0231 0.3707 0.3613
Echinococcus multilocularis sodium channel protein 0.004 0.0483 0.0457
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0388 0.1205
Brugia malayi Bromodomain containing protein 0.0074 0.1071 0.1045
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0146 0.0081
Brugia malayi Bromodomain containing protein 0.0037 0.0443 0.0414
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0452 0.0388
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0146 0.0119
Echinococcus multilocularis L aminoadipate semialdehyde 0.0604 1 1
Schistosoma mansoni hypothetical protein 0.0033 0.0374 0.031
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0315 0.0923
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0146 0.0117
Schistosoma mansoni hypothetical protein 0.0015 0.0074 0.0008
Trypanosoma brucei hypothetical protein, conserved 0.017 0.268 0.808
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0388 0.0996
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.048 0.0454
Loa Loa (eye worm) hypothetical protein 0.0604 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0444 0.0416
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0146 0.0117
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0146 0.0119
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0293 0.0229
Brugia malayi CXXC zinc finger family protein 0.0028 0.0286 0.0257
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0146 0.0119
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0146 0.0117
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0146 0.0081
Echinococcus granulosus FTZ F1 alpha 0.002 0.0146 0.0119
Loa Loa (eye worm) hypothetical protein 0.0028 0.0293 0.0264
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.017 0.268 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0249 0.4014 0.3997
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0146 0.0081
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.0217 0.019
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0146 0.0081
Echinococcus multilocularis peregrin 0.0031 0.0332 0.0305
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0388 0.042
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0146 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0146 0.0117
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0831 0.0771
Trypanosoma cruzi hypothetical protein, conserved 0.0207 0.3301 1
Loa Loa (eye worm) glutaminase 2 0.0266 0.4294 0.4277
Loa Loa (eye worm) hypothetical protein 0.002 0.0145 0.0116
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0074 0.0276
Loa Loa (eye worm) hypothetical protein 0.002 0.0146 0.0117
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0146 0.0117
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0211 0.0184
Schistosoma mansoni jumonji domain containing protein 0.0074 0.1058 0.0999
Schistosoma mansoni hypothetical protein 0.0028 0.0293 0.0229
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0388 0.1448
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0388 0.042
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0106 0.0041
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0217 0.0466
Toxoplasma gondii transporter, cation channel family protein 0.002 0.0145 0.0272
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0074 0.0276
Schistosoma mansoni thyroid hormone receptor 0.002 0.0146 0.0081
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0074 0.0044
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0217 0.0466
Brugia malayi jmjC domain containing protein 0.0038 0.0452 0.0423
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.017 0.268 1
Brugia malayi steroid hormone receptor 0.002 0.0146 0.0117
Echinococcus granulosus transcription factor btf3 0.0034 0.0388 0.0362
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0146 0.0119
Schistosoma mansoni thyroid hormone receptor 0.002 0.0146 0.0081
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0604 1 1
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0093 0.139 0.1333
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0074 0.0047
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0146 0.0119
Brugia malayi nuclear receptor NHR-88 0.002 0.0146 0.0117
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0594 0.0532
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0315 0.025
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0388 0.1448
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0388 0.042
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0452 0.0388
Loa Loa (eye worm) hypothetical protein 0.002 0.0146 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0146 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0146 0.0117
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.138 0.1356
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0095 0.0029
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0164 0.0135
Loa Loa (eye worm) hypothetical protein 0.002 0.0146 0.0117
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0146 0.0117
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0455
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0315 0.025
Schistosoma mansoni voltage-gated cation channel 0.0093 0.139 0.1333
Echinococcus multilocularis voltage dependent calcium channel 0.0093 0.139 0.1366
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.017 0.268 0.5
Loa Loa (eye worm) hypothetical protein 0.002 0.0146 0.0117
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.082 0.0795
Schistosoma mansoni cpg binding protein 0.0031 0.0344 0.028
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0074 0.0044
Treponema pallidum 4'-phosphopantetheinyl transferase 0.017 0.268 0.5
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0074 0.0047
Onchocerca volvulus Alhambra homolog 0.0028 0.0293 0.0149
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0632 0.0604
Trypanosoma cruzi hypothetical protein, conserved 0.0207 0.3301 1
Leishmania major basic transcription factor 3a, putative 0.0034 0.0388 0.0996
Loa Loa (eye worm) hypothetical protein 0.0033 0.0374 0.0345
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0074 0.0046
Onchocerca volvulus 0.0028 0.0286 0.0141
Schistosoma mansoni zinc finger protein 0.0021 0.0163 0.0098
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0146 0.0119
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0293 0.084
Loa Loa (eye worm) hypothetical protein 0.0064 0.0897 0.087
Plasmodium vivax SET domain protein, putative 0.003 0.0315 0.1174
Brugia malayi glutaminase DH11.1 0.0266 0.4294 0.4277
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0146 0.0119
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0293 0.0266
Brugia malayi MH2 domain containing protein 0.0116 0.1771 0.1747
Schistosoma mansoni hypothetical protein 0.0015 0.0074 0.0008
Brugia malayi abnormal cell lineage protein 10 (Protein lin-10), putative 0.006 0.0822 0.0795
Echinococcus granulosus zinc finger protein 0.0021 0.0163 0.0136
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0146 0.0119
Echinococcus granulosus voltage dependent calcium channel 0.0093 0.139 0.1366
Schistosoma mansoni coup transcription factor 0.002 0.0146 0.0081
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0146 0.0117
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0146 0.0119
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.0217 0.019
Echinococcus granulosus L aminoadipate semialdehyde 0.0604 1 1
Mycobacterium tuberculosis Conserved protein 0.0024 0.0217 0.0547
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0057 0.0773 0.2186
Brugia malayi Bromodomain containing protein 0.0031 0.0332 0.0303
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1771 0.1747
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0044
Schistosoma mansoni cpg binding protein 0.0028 0.0286 0.0221
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0146 0.0119
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0074 0.0046
Loa Loa (eye worm) hypothetical protein 0.0017 0.0105 0.0076
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0074 0.0044
Echinococcus granulosus cpg binding protein 0.0031 0.0344 0.0317
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0388 0.036
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0093 0.139 0.1364
Echinococcus multilocularis voltage dependent calcium channel 0.0093 0.139 0.1366
Schistosoma mansoni cpg binding protein 0.0031 0.0344 0.028
Echinococcus granulosus histone lysine methyltransferase setb 0.0046 0.0594 0.0568
Loa Loa (eye worm) hypothetical protein 0.0093 0.139 0.1364
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.017 0.268 1

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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