Detailed information for compound 1425045

Basic information

Technical information
  • TDR Targets ID: 1425045
  • Name: methyl 3-[[4-(2,5-dimethylphenyl)piperazine-1 -carbothioyl]amino]thiophene-2-carboxylate
  • MW: 389.535 | Formula: C19H23N3O2S2
  • H donors: 0 H acceptors: 1 LogP: 4.33 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1sccc1N=C(N1CCN(CC1)c1cc(C)ccc1C)S
  • InChi: 1S/C19H23N3O2S2/c1-13-4-5-14(2)16(12-13)21-7-9-22(10-8-21)19(25)20-15-6-11-26-17(15)18(23)24-3/h4-6,11-12H,7-10H2,1-3H3,(H,20,25)
  • InChiKey: BRTJTTYVQVSSDC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-[[[4-(2,5-dimethylphenyl)-1-piperazinyl]-thioxomethyl]amino]-2-thiophenecarboxylic acid methyl ester
  • 3-[[4-(2,5-dimethylphenyl)piperazine-1-carbothioyl]amino]thiophene-2-carboxylic acid methyl ester
  • methyl 3-[[4-(2,5-dimethylphenyl)piperazin-1-yl]carbothioylamino]thiophene-2-carboxylate
  • methyl 3-({[4-(2,5-dimethylphenyl)piperazin-1-yl]carbonothioyl}amino)thiophene-2-carboxylate
  • MLS000580727
  • SMR000206113

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Papain family cysteine protease containing protein 0.0078 0.0295 0.0285
Brugia malayi Cathepsin L-like precursor 0.0039 0.0087 0.0077
Echinococcus granulosus heat shock protein 90 0.0038 0.0082 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.006 0.008
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0051 0.0038
Entamoeba histolytica cysteine protease, putative 0.0078 0.0295 0.2395
Echinococcus granulosus epidermal growth factor receptor 0.1901 1 1
Brugia malayi protein kinase C II. 0.0133 0.0589 0.058
Loa Loa (eye worm) raf kinase 0.0055 0.0173 0.0173
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0051 0.0038
Loa Loa (eye worm) hypothetical protein 0.006 0.0196 0.0196
Schistosoma mansoni protein kinase C mu 0.0055 0.0173 0.0173
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0087 0.013
Giardia lamblia PHD finger protein 15 0.006 0.0196 0.1239
Trypanosoma cruzi PB1 domain containing protein, putative 0.0055 0.0174 0.0537
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0052 0.0039
Trichomonas vaginalis glucosylceramidase, putative 0.1036 0.5392 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0039 0.0087 0.1005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0083 0.0321 0.0321
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0295 0.2853
Echinococcus multilocularis serine:threonine protein kinase N2 0.0078 0.0295 0.0283
Echinococcus multilocularis muscleblind protein 0.0145 0.0653 0.0641
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0295 0.2853
Loa Loa (eye worm) hypothetical protein 0.0055 0.0173 0.0173
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.1024 0.5327 0.5321
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0057 0.0182 0.0173
Onchocerca volvulus Glucosylceramidase homolog 0.068 0.3497 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0052 0.0039
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0018 0.0002
Echinococcus granulosus zinc finger protein 0.0068 0.0241 0.0228
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.1036 0.5392 0.5388
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0126 0.0114
Loa Loa (eye worm) hypothetical protein 0.0055 0.0173 0.0173
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0052 0.0052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0052 0.0052
Echinococcus granulosus cathepsin L 0.0039 0.0087 0.0074
Entamoeba histolytica cysteine protease, putative 0.0078 0.0295 0.2395
Leishmania major cysteine peptidase A (CPA) 0.0078 0.0295 0.2854
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0039 0.0087 0.1005
Entamoeba histolytica cysteine proteinase 1, putative 0.0078 0.0295 0.2395
Onchocerca volvulus 0.0032 0.0052 0.0121
Loa Loa (eye worm) hypothetical protein 0.0055 0.0173 0.0173
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0136 0.0136
Trichomonas vaginalis glucosylceramidase, putative 0.068 0.3497 0.6473
Loa Loa (eye worm) STE/STE11/MEKK2 protein kinase 0.0057 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0055 0.0173 0.0173
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0295 0.0516
Trichomonas vaginalis heat shock protein, putative 0.0045 0.0117 0.0185
Loa Loa (eye worm) hypothetical protein 0.0055 0.0173 0.0173
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0052 0.0039
Loa Loa (eye worm) hypothetical protein 0.0055 0.0173 0.0173
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0026 0.002 0.0008
Mycobacterium ulcerans beta-lactamase 0.0043 0.0111 1
Schistosoma mansoni cathepsin C 0.0039 0.0087 0.0087
Echinococcus granulosus muscleblind protein 0.0145 0.0653 0.0641
Schistosoma mansoni unc-13 (munc13) 0.0057 0.0184 0.0184
Trypanosoma cruzi cysteine peptidase, putative 0.0039 0.0087 0.0252
Onchocerca volvulus 0.0043 0.0111 0.029
Echinococcus multilocularis cathepsin L cysteine protease 0.0078 0.0295 0.0282
Plasmodium falciparum serine repeat antigen 9 0.0039 0.0087 0.1005
Echinococcus multilocularis heat shock protein 90 0.0045 0.0117 0.0104
Schistosoma mansoni hypothetical protein 0.0844 0.4374 0.4374
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0078 0.0295 0.0295
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0161 0.0148
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.0117 0.107
Plasmodium vivax serine-repeat antigen (SERA) 0.0039 0.0087 0.1005
Plasmodium falciparum phd finger protein, putative 0.006 0.0196 0.2426
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0295 0.0516
Plasmodium falciparum heat shock protein 90 0.0045 0.0117 0.1389
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0052 0.0042
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0078 0.0295 0.0283
Onchocerca volvulus 0.0078 0.0295 0.0817
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1399 0.1388
Schistosoma mansoni methyl-cpg binding protein mbd 0.005 0.0148 0.0148
Onchocerca volvulus 0.0048 0.0134 0.0355
Leishmania major heat shock protein 83-1 0.0045 0.0117 0.1071
Mycobacterium ulcerans hydrolase 0.0041 0.0098 0.8707
Onchocerca volvulus 0.0078 0.0295 0.0817
Trichomonas vaginalis endoplasmin, putative 0.0032 0.0052 0.0064
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0083 0.0321 0.0309
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0295 0.0516
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0248 0.1199 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.1011 0.1011
Schistosoma mansoni zinc finger protein 0.0045 0.012 0.012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0087 0.013
Loa Loa (eye worm) hypothetical protein 0.0039 0.0087 0.0087
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.0117 0.107
Giardia lamblia Cathepsin L-like protease 0.0039 0.0087 0.0059
Schistosoma mansoni rac gtpase activating protein 0.0055 0.0173 0.0173
Echinococcus multilocularis lysine specific demethylase 5A 0.0072 0.0263 0.0251
Echinococcus multilocularis cathepsin L 0.0039 0.0087 0.0074
Brugia malayi TAR-binding protein 0.0076 0.0287 0.0277
Schistosoma mansoni hypothetical protein 0.0032 0.0051 0.0051
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0126 0.0126
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0055 0.0173 0.0173
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0052 0.0039
Trichomonas vaginalis heat shock protein, putative 0.0038 0.0082 0.0121
Leishmania major heat shock protein 83-1 0.0045 0.0117 0.1071
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0039 0.0087 0.0253
Loa Loa (eye worm) TK/EGFR protein kinase 0.1901 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.068 0.3497 0.6473
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0039 0.0087 0.0077
Echinococcus granulosus cathepsin L 0.0078 0.0295 0.0282
Loa Loa (eye worm) hypothetical protein 0.0034 0.0059 0.0059
Toxoplasma gondii preprocathepsin c precursor, putative 0.0039 0.0087 0.0707
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.003 0.0037 0.0024
Echinococcus multilocularis Diacylglycerol kinase theta 0.0055 0.0173 0.0161
Loa Loa (eye worm) hypothetical protein 0.0136 0.0604 0.0604
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0034 0.0059 0.0059
Toxoplasma gondii cathepsin B 0.0212 0.1008 0.9132
Echinococcus granulosus NDR protein kinase 0.0078 0.0295 0.0283
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0039 0.0087 0.0059
Giardia lamblia Cathepsin B precursor 0.0212 0.1008 1
Echinococcus multilocularis heat shock protein 0.0045 0.0117 0.0104
Brugia malayi steroid hormone receptor 0.0032 0.0052 0.0042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0295 0.0516
Trypanosoma brucei heat shock protein, putative 0.0045 0.0117 0.107
Trypanosoma cruzi cruzipain precursor, putative 0.0039 0.0087 0.0252
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0039 0.0087 0.0087
Schistosoma mansoni protein kinase C 0.0055 0.0173 0.0173
Schistosoma mansoni hypothetical protein 0.0058 0.0189 0.0189
Echinococcus granulosus methyl CpG binding domain protein 2 0.005 0.0148 0.0135
Brugia malayi Matrixin family protein 0.0081 0.0313 0.0303
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0052 0.0039
Mycobacterium tuberculosis Conserved protein 0.0043 0.0111 0.0749
Loa Loa (eye worm) TK/INSR protein kinase 0.061 0.3128 0.3128
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0031 0.0047 0.0034
Plasmodium falciparum cysteine proteinase falcipain 3 0.0078 0.0295 0.3702
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0052 0.0039
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.001
Echinococcus granulosus myotubularin protein 13 0.0055 0.0173 0.0161
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0042 0.0102 0.1796
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0052 0.0052
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0133 0.0589 0.0589
Schistosoma mansoni hypothetical protein 0.0036 0.0073 0.0073
Echinococcus multilocularis cathepsin b 0.0598 0.3063 0.3054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0295 0.0516
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0078 0.0295 0.0295
Schistosoma mansoni cathepsin F (C01 family) 0.0078 0.0295 0.0295
Schistosoma mansoni tyrosine kinase 0.1009 0.5248 0.5248
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0295 0.0516
Echinococcus granulosus twitchin 0.0027 0.0022 0.0009
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0041 0.0098 0.0652
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0189 0.018
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0111 0.0111
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.1036 0.5392 0.5392
Echinococcus granulosus insulin growth factor 1 receptor beta 0.061 0.3128 0.3119
Brugia malayi Variant SH3 domain containing protein 0.0055 0.0173 0.0164
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0039 0.0087 0.1005
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0039 0.0087 0.013
Mycobacterium leprae Probable lipase LipE 0.0043 0.0111 0.1965
Brugia malayi Bromodomain containing protein 0.0232 0.1112 0.1104
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0295 0.0516
Echinococcus multilocularis jumonji domain containing protein 0.0083 0.0321 0.0308
Brugia malayi Cathepsin L-like precursor 0.0078 0.0295 0.0285
Loa Loa (eye worm) hypothetical protein 0.0039 0.0087 0.0087
Echinococcus multilocularis N chimaerin 0.0055 0.0173 0.0161
Onchocerca volvulus 0.0115 0.0492 0.1384
Echinococcus multilocularis cysteine protease 0.0078 0.0295 0.0282
Schistosoma mansoni tyrosine kinase 0.1024 0.5327 0.5327
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0052 0.0052
Onchocerca volvulus Cathepsin F homolog 0.0078 0.0295 0.0817
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0078 0.0295 0.0283
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0052 0.0042
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0052 0.0052
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0052 0.0052
Brugia malayi Matrixin family protein 0.0034 0.0059 0.0049
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0126 0.0114
Leishmania major cathepsin L-like protease 0.0078 0.0295 0.2854
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0052 0.0039
Trichomonas vaginalis AGC family protein kinase 0.0078 0.0295 0.0517
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0052 0.0052
Brugia malayi Protein kinase domain containing protein 0.0078 0.0295 0.0286
Leishmania major heat shock protein, putative 0.003 0.0037 0.0273
Schistosoma mansoni hypothetical protein 0.007 0.025 0.025
Entamoeba histolytica cysteine protease, putative 0.0039 0.0087 0.0651
Entamoeba histolytica cysteine protease, putative 0.0078 0.0295 0.2395
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0212 0.1008 1
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0039 0.0087 0.1005
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0051 0.0051
Trypanosoma brucei cysteine peptidase C (CPC) 0.0212 0.1008 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0111 0.0174
Schistosoma mansoni cathepsin F (C01 family) 0.0039 0.0087 0.0087
Brugia malayi Cathepsin L-like precursor 0.0078 0.0295 0.0285
Onchocerca volvulus 0.0242 0.1165 0.3314
Loa Loa (eye worm) hypothetical protein 0.0039 0.0087 0.0087
Entamoeba histolytica 90 kDa heat shock protein, putative 0.003 0.0037 0.0229
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0052 0.0052
Echinococcus granulosus GPCR family 2 0.0032 0.0051 0.0038
Trypanosoma cruzi cysteine peptidase, putative 0.0078 0.0295 0.0932
Echinococcus multilocularis GPCR, family 2 0.0032 0.0051 0.0038
Giardia lamblia Cathepsin L precursor 0.0039 0.0087 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0052 0.0042
Echinococcus granulosus cathepsin L cysteine protease 0.0078 0.0295 0.0282
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0018 0.0002
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0498 0.0498
Loa Loa (eye worm) jmjC domain-containing protein 0.0084 0.0328 0.0328
Trypanosoma cruzi heat shock protein 90, putative 0.0045 0.0117 0.035
Trichomonas vaginalis glucosylceramidase, putative 0.0716 0.3691 0.6835
Brugia malayi Cathepsin L-like precursor 0.0039 0.0087 0.0077
Schistosoma mansoni hypothetical protein 0.0061 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.0039 0.0087 0.0087
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0042 0.0102 0.5
Schistosoma mansoni serine/threonine protein kinase 0.007 0.0252 0.0252
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0245 0.1186 0.1186
Loa Loa (eye worm) AGC/NDR protein kinase 0.0078 0.0295 0.0295
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0078 0.0295 0.0295
Trypanosoma brucei ISWI complex protein 0.0045 0.012 0.1104
Trypanosoma cruzi cysteine proteinase, putative 0.0078 0.0295 0.0932
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0082 0.0605
Echinococcus granulosus protein tyrosine kinase 0.0555 0.2835 0.2826
Plasmodium vivax serine-repeat antigen (SERA) 0.0039 0.0087 0.1005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0295 0.2853
Schistosoma mansoni tyrosine kinase 0.1024 0.5327 0.5327
Schistosoma mansoni protein kinase C mu 0.0057 0.0182 0.0182
Echinococcus granulosus Protein kinase C brain isozyme 0.0133 0.0589 0.0577
Loa Loa (eye worm) hypothetical protein 0.0078 0.0295 0.0295
Echinococcus granulosus N chimaerin 0.0055 0.0173 0.0161
Schistosoma mansoni coup transcription factor 0.0032 0.0052 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0052 0.0042
Loa Loa (eye worm) RNA binding protein 0.0076 0.0287 0.0287
Brugia malayi Protein kinase c protein 2 0.0057 0.0182 0.0173
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0052 0.0052
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0111 0.0749
Onchocerca volvulus Cathepsin L homolog 0.0078 0.0295 0.0817
Brugia malayi p70 ribosomal S6 kinase beta 0.0078 0.0295 0.0286
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0055 0.0173 0.0161
Trypanosoma cruzi cysteine peptidase, putative 0.0078 0.0295 0.0932
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.0117 0.0899
Brugia malayi Protein kinase domain containing protein 0.0078 0.0295 0.0286
Plasmodium falciparum serine repeat antigen 8 0.0039 0.0087 0.1005
Onchocerca volvulus 0.0055 0.0173 0.0469
Leishmania major heat shock protein 83-1 0.0045 0.0117 0.1071
Schistosoma mansoni tyrosine kinase 0.1901 1 1
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.006 0.0657
Schistosoma mansoni vav2 0.0055 0.0173 0.0173
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0055 0.0173 0.0173
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0111 0.0749
Echinococcus granulosus cathepsin l1 0.0039 0.0087 0.0074
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0037 0.0075 0.0062
Schistosoma mansoni cell polarity protein 0.0055 0.0174 0.0174
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0052 0.0042
Entamoeba histolytica cysteine protease, putative 0.0078 0.0295 0.2395
Leishmania major heat shock protein 83-1 0.0045 0.0117 0.1071
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0052 0.0039
Schistosoma mansoni serine/threonine kinase 0.0078 0.0295 0.0295
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0295 0.2853
Echinococcus multilocularis serine:threonine protein kinase N2 0.0078 0.0295 0.0283
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0295 0.0516
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0039 0.0087 0.0059
Giardia lamblia Heat shock protein HSP 90-alpha 0.0038 0.0082 0.0007
Loa Loa (eye worm) hypothetical protein 0.0248 0.1199 0.1199
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0052 0.0064
Echinococcus granulosus mixed lineage leukemia protein mll 0.003 0.0038 0.0025
Loa Loa (eye worm) hypothetical protein 0.0032 0.0052 0.0052
Trichomonas vaginalis AGC family protein kinase 0.0078 0.0295 0.0517
Trichomonas vaginalis esterase, putative 0.0043 0.0111 0.0174
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0052 0.0052
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.0459 0.3331
Schistosoma mansoni cpg binding protein 0.0127 0.0557 0.0557
Echinococcus multilocularis protein kinase c epsilon type 0.0133 0.0589 0.0577
Echinococcus multilocularis cathepsin b 0.0598 0.3063 0.3054
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.0459 0.3331
Echinococcus granulosus histone lysine methyltransferase setb 0.0083 0.0321 0.0309
Leishmania major hypothetical protein, conserved 0.0045 0.012 0.1104
Loa Loa (eye worm) hypothetical protein 0.0102 0.0421 0.0421
Mycobacterium leprae PROBABLE HYDROLASE 0.0041 0.0098 0.1711
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0052 0.0039
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0018 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0087 0.013
Schistosoma mansoni heat shock protein 0.003 0.0037 0.0037
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0039 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0053 0.0161 0.0161
Leishmania major heat shock protein 83-1 0.0045 0.0117 0.1071
Trypanosoma brucei heat shock protein, putative 0.0045 0.0117 0.107
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0055 0.0173 0.0173
Schistosoma mansoni hypothetical protein 0.0032 0.0051 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.006 0.008
Giardia lamblia Grp94/Hsp90 0.0042 0.0102 0.022
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0018 0.0002
Brugia malayi Protein kinase domain containing protein 0.061 0.3128 0.3121
Entamoeba histolytica hypothetical protein 0.0036 0.0073 0.0528
Echinococcus multilocularis partitioning defective protein 6 0.0055 0.0174 0.0161
Giardia lamblia Hypothetical protein 0.0039 0.0087 0.0059
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0052 0.0052
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0161 0.0148
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0078 0.0295 0.0283
Brugia malayi cathepsin L-like cysteine proteinase 0.0039 0.0087 0.0077
Onchocerca volvulus 0.0043 0.0111 0.029
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0018 0.0002
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0052 0.0042
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.0421 0.0421
Brugia malayi RhoGAP domain containing protein 0.0055 0.0173 0.0164
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0078 0.0295 0.3702
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0052 0.0042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0087 0.013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0295 0.2853
Onchocerca volvulus 0.0078 0.0295 0.0817
Echinococcus granulosus cathepsin b 0.0598 0.3063 0.3054
Brugia malayi Bromodomain containing protein 0.007 0.0252 0.0242
Mycobacterium tuberculosis Conserved protein 0.0043 0.0111 0.0749
Brugia malayi Cathepsin L-like precursor 0.0078 0.0295 0.0285
Schistosoma mansoni nephrin 0.0025 0.0013 0.0013
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0039 0.0087 0.1005
Loa Loa (eye worm) hypothetical protein 0.0124 0.0539 0.0539
Leishmania major heat shock protein 83-1 0.0045 0.0117 0.1071
Brugia malayi Papain family cysteine protease containing protein 0.0078 0.0295 0.0285
Echinococcus multilocularis PHD finger protein rhinoceros 0.006 0.0196 0.0184
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0039 0.0087 0.1005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0018 0.0002
Toxoplasma gondii AGC kinase 0.0078 0.0295 0.2611
Schistosoma mansoni hypothetical protein 0.0032 0.0051 0.0051
Loa Loa (eye worm) AGC/PKN protein kinase 0.0078 0.0295 0.0295
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0039 0.0087 0.0087
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0039 0.0087 0.0087
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0287 0.0277
Plasmodium falciparum serine repeat antigen 5 0.0039 0.0087 0.1005
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0048 0.0137 0.1167
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0039 0.0087 0.0087
Brugia malayi beta-lactamase family protein 0.0043 0.0111 0.0101
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0078 0.0295 0.0516
Schistosoma mansoni tyrosine kinase 0.1009 0.5248 0.5248
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0055 0.0173 0.0161
Schistosoma mansoni cathepsin S (C01 family) 0.0039 0.0087 0.0087
Trypanosoma cruzi cysteine proteinase, putative 0.0078 0.0295 0.0932
Brugia malayi beta-lactamase family protein 0.0043 0.0111 0.0101
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0052 0.0039
Loa Loa (eye worm) cathepsin B 0.0212 0.1008 0.1008
Brugia malayi Partitioning defective-6 homolog alpha 0.0055 0.0174 0.0164
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0039 0.0087 0.013
Echinococcus multilocularis epidermal growth factor receptor 0.1024 0.5327 0.5321
Brugia malayi acetyltransferase, GNAT family protein 0.0148 0.0667 0.0658
Giardia lamblia Heat shock protein HSP 90-alpha 0.0045 0.0117 0.0377
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0295 0.0516
Echinococcus granulosus cathepsin l cysteine peptidase 0.0078 0.0295 0.0282
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0287 0.0287
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.0459 0.3331
Echinococcus multilocularis myotubularin protein 13 0.0055 0.0173 0.0161
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0126 0.0114
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0051 0.0041
Loa Loa (eye worm) heat shock protein 75 0.003 0.0037 0.0037
Trichomonas vaginalis AGC family protein kinase 0.0078 0.0295 0.0517
Onchocerca volvulus Cathepsin L homolog 0.0078 0.0295 0.0817
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0052 0.0039
Trypanosoma brucei heat shock protein, putative 0.0045 0.0117 0.107
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0052 0.0052
Schistosoma mansoni atypical protein kinase C 0.0942 0.4893 0.4893
Plasmodium falciparum cysteine proteinase falcipain 1 0.0078 0.0295 0.3702
Toxoplasma gondii Hsp90 domain-containing protein 0.0169 0.0779 0.7038
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0133 0.0589 0.0577
Trichomonas vaginalis glucosylceramidase, putative 0.1036 0.5392 1
Entamoeba histolytica cysteine protease, putative 0.0039 0.0087 0.0651
Schistosoma mansoni hypothetical protein 0.006 0.0196 0.0196
Echinococcus granulosus geminin 0.0844 0.4374 0.4367
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0338 0.1677 0.1677
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0076 0.0286 0.05
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0295 0.0295
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0055 0.0173 0.0173
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0048 0.0137 0.1658
Echinococcus multilocularis serine:threonine protein kinase 38 0.0078 0.0295 0.0283
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0039 0.0087 0.013
Leishmania major heat shock protein 83-1 0.0045 0.0117 0.1071
Loa Loa (eye worm) hypothetical protein 0.0034 0.0059 0.0059
Trypanosoma brucei rac serine-threonine kinase, putative 0.0078 0.0295 0.2859
Brugia malayi Protein kinase domain containing protein 0.0078 0.0295 0.0286
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.006 0.0196 0.0196
Trypanosoma cruzi heat shock protein, putative 0.003 0.0037 0.0089
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0195 0.0918 0.0906
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0039 0.0087 0.1005
Trichomonas vaginalis glucosylceramidase, putative 0.068 0.3497 0.6473
Schistosoma mansoni cpg binding protein 0.0115 0.0492 0.0492
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0182 0.0182
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0078 0.0295 0.0282
Echinococcus multilocularis methyl CpG binding domain protein 2 0.005 0.0148 0.0135
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0052 0.0042
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.006 0.0506
Giardia lamblia Cysteine protease 0.0039 0.0087 0.0059
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0053 0.0053
Entamoeba histolytica cysteine protease, putative 0.0039 0.0087 0.0651
Schistosoma mansoni hypothetical protein 0.0045 0.012 0.012
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.006 0.0165
Giardia lamblia Cathepsin B precursor 0.0212 0.1008 1
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.003 0.0037 0.0024
Trypanosoma cruzi cysteine peptidase, putative 0.0078 0.0295 0.0932
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0052 0.0039
Echinococcus multilocularis epidermal growth factor receptor 0.1901 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0295 0.0516
Entamoeba histolytica cysteine protease, putative 0.0039 0.0087 0.0651
Loa Loa (eye worm) jmjC domain-containing protein 0.0123 0.0534 0.0534
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0018 0.0002
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0057 0.0182 0.017
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0039 0.0087 0.0087
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0126 0.0334
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0287 0.0287
Echinococcus multilocularis dnaJ subfamily B 0.164 0.8611 0.8609
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0034 0.0021
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0209 0.0992 0.0992
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0248 0.1199 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0295 0.0516
Brugia malayi C1-like domain containing protein 0.0057 0.0182 0.0173
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0295 0.0516
Trichomonas vaginalis glucosylceramidase, putative 0.1036 0.5392 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.0137 0.0125
Schistosoma mansoni hypothetical protein 0.0282 0.1381 0.1381
Loa Loa (eye worm) matrixin family protein 0.0075 0.0277 0.0277
Loa Loa (eye worm) endoplasmin 0.0045 0.0117 0.0117
Plasmodium vivax heat shock protein 90, putative 0.003 0.0037 0.0353
Schistosoma mansoni unc-13 (munc13) 0.0055 0.0173 0.0173
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.0052 0.0039
Plasmodium falciparum serine repeat antigen 6 0.0039 0.0087 0.1005
Trichomonas vaginalis AGC family protein kinase 0.0078 0.0295 0.0517
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0287 0.0287
Echinococcus multilocularis peregrin 0.007 0.0252 0.0239
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0212 0.1008 0.3268
Trypanosoma brucei heat shock protein, putative 0.0045 0.0117 0.107
Brugia malayi PHD-finger family protein 0.0032 0.0048 0.0038
Loa Loa (eye worm) hypothetical protein 0.0046 0.0126 0.0126
Echinococcus granulosus raf serine:threonine protein kinase 0.007 0.0252 0.024
Echinococcus multilocularis mixed lineage leukemia protein mll 0.003 0.0038 0.0025
Trypanosoma brucei heat shock protein, putative 0.0045 0.0117 0.107
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.0459 0.8741
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0295 0.2853
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.003 0.0037 0.0078
Schistosoma mansoni tyrosine kinase 0.0026 0.002 0.002
Trypanosoma cruzi heat shock protein 85, putative 0.0038 0.0082 0.0237
Entamoeba histolytica cysteine proteinase, putative 0.0039 0.0087 0.0651
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0039 0.0087 0.0087
Giardia lamblia Cathepsin L precursor 0.0039 0.0087 0.0059
Leishmania major basic transcription factor 3a, putative 0.0034 0.006 0.0507
Schistosoma mansoni methyl-cpg binding protein mbd 0.005 0.0148 0.0148
Plasmodium falciparum thioredoxin reductase 0.0048 0.0133 0.1606
Giardia lamblia Cathepsin L-like protease 0.0039 0.0087 0.0059
Loa Loa (eye worm) hypothetical protein 0.0026 0.002 0.002
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0039 0.0087 0.1005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0295 0.0516
Loa Loa (eye worm) TK/FAK protein kinase 0.0562 0.2869 0.2869
Trichomonas vaginalis glucosylceramidase, putative 0.068 0.3497 0.6473
Loa Loa (eye worm) ctsf protein 0.0078 0.0295 0.0295
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0116 0.0116
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0287 0.0287
Echinococcus granulosus heat shock protein 0.0045 0.0117 0.0104
Brugia malayi Bromodomain containing protein 0.0117 0.05 0.0491
Mycobacterium ulcerans lipase LipD 0.0043 0.0111 1
Loa Loa (eye worm) AGC/AKT protein kinase 0.0078 0.0295 0.0295
Entamoeba histolytica cysteine proteinase, putative 0.0078 0.0295 0.2395
Brugia malayi mbt repeat family protein 0.0046 0.0126 0.0117
Entamoeba histolytica cysteine protease, putative 0.0039 0.0087 0.0651
Giardia lamblia Cathepsin L precursor 0.0039 0.0087 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0018 0.0002
Loa Loa (eye worm) hypothetical protein 0.0055 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0032 0.0052 0.0052
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0053 0.004
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.0523 0.381
Leishmania major hypothetical protein, conserved 0.0055 0.0174 0.1643
Loa Loa (eye worm) hypothetical protein 0.0113 0.0483 0.0483
Toxoplasma gondii thioredoxin reductase 0.0048 0.0133 0.113
Brugia malayi beta-NAC-like protein 0.0034 0.006 0.0051
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0126 0.0126
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0087 0.013
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0161 0.0148
Leishmania major cathepsin L-like protease 0.0078 0.0295 0.2854
Loa Loa (eye worm) hypothetical protein 0.0043 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0039 0.0087 0.0087
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0295 0.2853
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0052 0.0052
Entamoeba histolytica cysteine proteinase 2 0.0078 0.0295 0.2395
Giardia lamblia Hypothetical protein 0.0039 0.0087 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0039 0.0087 0.013
Trypanosoma cruzi cruzipain precursor, putative 0.0078 0.0295 0.0932
Giardia lamblia Cathepsin B precursor 0.0039 0.0087 0.0059
Toxoplasma gondii PHD-finger domain-containing protein 0.006 0.0196 0.1707
Plasmodium falciparum endoplasmin, putative 0.0032 0.0052 0.0542
Echinococcus granulosus insulin receptor 0.061 0.3128 0.3119
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0078 0.0295 0.0295
Echinococcus multilocularis protein TFG 0.0055 0.0174 0.0161
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0111 0.0749
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0052 0.0042
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0116 0.0116
Plasmodium falciparum serine repeat antigen 3 0.0039 0.0087 0.1005
Loa Loa (eye worm) RasGEF domain-containing protein 0.0055 0.0173 0.0173
Echinococcus granulosus lysine specific demethylase 5A 0.0084 0.0328 0.0316
Echinococcus granulosus transcription factor btf3 0.0034 0.006 0.0048
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0102 0.0158
Brugia malayi Immunoglobulin I-set domain containing protein 0.0338 0.1677 0.1669
Onchocerca volvulus Cathepsin L homolog 0.0039 0.0087 0.0222
Schistosoma mansoni transcription factor btf3 0.0034 0.006 0.006
Brugia malayi hypothetical protein 0.0036 0.0073 0.0063
Brugia malayi Protein kinase domain containing protein 0.0057 0.0182 0.0173
Trypanosoma brucei trypanothione reductase 0.0048 0.0133 0.1238
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0295 0.0516
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0295 0.2853
Echinococcus granulosus cathepsin L cysteine proteinase 0.0078 0.0295 0.0282
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.0117 0.0899
Brugia malayi Matrixin family protein 0.0034 0.0059 0.0049
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.0609 0.0597
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0057 0.0182 0.0182
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0111 0.0174
Loa Loa (eye worm) hypothetical protein 0.0055 0.0173 0.0173
Mycobacterium ulcerans hypothetical protein 0.0043 0.0111 1
Trichomonas vaginalis helicase, putative 0.0026 0.0018 0.0002
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.0523 0.381
Onchocerca volvulus 0.0039 0.0087 0.0222
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0212 0.1008 0.1842
Brugia malayi nuclear hormone receptor 0.0032 0.0052 0.0042
Onchocerca volvulus Matrilysin homolog 0.0034 0.0059 0.014
Echinococcus granulosus endoplasmin 0.0042 0.0102 0.0089
Loa Loa (eye worm) bromodomain containing protein 0.0056 0.0176 0.0176
Toxoplasma gondii PHD-finger domain-containing protein 0.006 0.0196 0.1707
Trichomonas vaginalis glucosylceramidase, putative 0.068 0.3497 0.6473
Schistosoma mansoni serine/threonine protein kinase 0.0133 0.0589 0.0589
Plasmodium falciparum glutathione reductase 0.0048 0.0133 0.1606
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0039 0.0087 0.0087
Giardia lamblia Cathepsin B precursor 0.0039 0.0087 0.0059
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.0523 1
Schistosoma mansoni hypothetical protein 0.0032 0.0051 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0052 0.0052
Onchocerca volvulus 0.0055 0.0173 0.0469
Echinococcus granulosus tar DNA binding protein 0.0076 0.0287 0.0274
Entamoeba histolytica cysteine proteinase, putative 0.0078 0.0295 0.2395
Giardia lamblia Cysteine protease 0.0039 0.0087 0.0059
Entamoeba histolytica cysteine protease, putative 0.0078 0.0295 0.2395
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0053 0.0053
Loa Loa (eye worm) matrixin family protein 0.0081 0.0313 0.0313
Trypanosoma cruzi major cysteine proteinase, putative 0.0039 0.0087 0.0253
Entamoeba histolytica cysteine proteinase, putative 0.0078 0.0295 0.2395
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0078 0.0295 0.0295
Trichomonas vaginalis glucosylceramidase, putative 0.068 0.3497 0.6473
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0052 0.0042
Trypanosoma cruzi cysteine protease, putative 0.0078 0.0295 0.0932
Schistosoma mansoni heat shock protein 0.0045 0.0117 0.0117
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0295 0.0516
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0073 0.0269 0.0256
Leishmania major trypanothione reductase 0.0048 0.0133 0.1238
Plasmodium vivax vivapain-1 0.0078 0.0295 0.3702
Plasmodium vivax heat shock protein 86, putative 0.0045 0.0117 0.1389
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0161 0.0151
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0126 0.0114
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0598 0.3063 0.3063
Onchocerca volvulus 0.0055 0.0174 0.047
Entamoeba histolytica hypothetical protein 0.0036 0.0073 0.0528
Loa Loa (eye worm) hypothetical protein 0.0102 0.0423 0.0423
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.0459 0.3331
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0052 0.0121
Loa Loa (eye worm) ICD-1 protein 0.0034 0.006 0.006
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0183 0.0853 0.0841
Giardia lamblia Cysteine protease 0.0039 0.0087 0.0059
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0052 0.0039
Echinococcus granulosus Rac GTPase activating protein 1 0.0055 0.0173 0.0161
Plasmodium vivax hypothetical protein, conserved 0.006 0.0196 0.2426
Brugia malayi Cathepsin L-like precursor 0.0039 0.0087 0.0077
Loa Loa (eye worm) CXXC zinc finger family protein 0.0115 0.0492 0.0492
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0039 0.0087 0.0087
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0078 0.0295 0.0295
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0039 0.0087 0.1005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0116 0.0116
Entamoeba histolytica hypothetical protein 0.0039 0.0087 0.0651
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0039 0.0087 0.013
Loa Loa (eye worm) hypothetical protein 0.0043 0.0111 0.0111
Schistosoma mansoni diacylglycerol kinase theta 0.0055 0.0173 0.0173
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0052 0.0039
Loa Loa (eye worm) histone methyltransferase 0.0037 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0083 0.0321 0.0321
Loa Loa (eye worm) hypothetical protein 0.0055 0.0174 0.0174
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0073 0.006
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0287 0.0287
Entamoeba histolytica cysteine protease, putative 0.0078 0.0295 0.2395
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.006 0.0165
Brugia malayi cathepsin L-like precursor 0.0039 0.0087 0.0077
Trypanosoma brucei heat shock protein, putative 0.0045 0.0117 0.107
Echinococcus granulosus roundabout 2 0.0032 0.0048 0.0035
Echinococcus multilocularis raf serine:threonine protein kinase 0.007 0.0252 0.024
Brugia malayi RNA binding protein 0.0076 0.0287 0.0277
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0133 0.0404
Giardia lamblia Cathepsin L precursor 0.0039 0.0087 0.0059
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0133 0.0133
Giardia lamblia Cathepsin B precursor 0.0039 0.0087 0.0059
Leishmania major heat shock protein 83-1 0.0045 0.0117 0.1071
Loa Loa (eye worm) hypothetical protein 0.0055 0.0173 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0018 0.0002
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0111 0.1965
Brugia malayi mbt repeat family protein 0.0046 0.0126 0.0117
Leishmania major heat shock protein 83-1 0.0045 0.0117 0.1071
Leishmania major heat shock protein 83-1 0.0045 0.0117 0.1071
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0087 0.013
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0078 0.0295 0.0282
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0111 0.1312
Trypanosoma cruzi major cysteine proteinase, putative 0.0039 0.0087 0.0253
Echinococcus multilocularis protein kinase c eta type 0.0055 0.0173 0.0161
Loa Loa (eye worm) hypothetical protein 0.0039 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0039 0.0087 0.0087
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.0421 0.0412
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0295 0.0516
Onchocerca volvulus 0.0033 0.0053 0.0124
Schistosoma mansoni cathepsin F (C01 family) 0.0078 0.0295 0.0295
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.001
Echinococcus granulosus PHD finger protein rhinoceros 0.006 0.0196 0.0184
Trichomonas vaginalis glucosylceramidase, putative 0.068 0.3497 0.6473
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0018 0.0002
Plasmodium falciparum heat shock protein 90, putative 0.0026 0.0017 0.0096
Brugia malayi cathepsin F-like cysteine proteinase 0.0039 0.0087 0.0077
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0111 0.0749
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0052 0.0039
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0052 0.0042
Trichomonas vaginalis glucosylceramidase, putative 0.1036 0.5392 1
Loa Loa (eye worm) cysteine protease 0.0078 0.0295 0.0295
Loa Loa (eye worm) hypothetical protein 0.0039 0.0087 0.0087
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.0523 0.381
Echinococcus multilocularis cysteine protease 0.0078 0.0295 0.0282
Echinococcus granulosus protein kinase c eta type 0.0055 0.0173 0.0161
Loa Loa (eye worm) hypothetical protein 0.0043 0.0111 0.0111
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0111 0.033
Echinococcus granulosus protein kinase c iota type 0.0887 0.4599 0.4592
Loa Loa (eye worm) glutathione reductase 0.0048 0.0133 0.0133
Brugia malayi beta-lactamase 0.0043 0.0111 0.0101
Loa Loa (eye worm) matrix metalloproteinase 0.0034 0.0059 0.0059
Giardia lamblia Cathepsin B precursor 0.0039 0.0087 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0087 0.013
Brugia malayi CXXC zinc finger family protein 0.0115 0.0492 0.0483
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0052 0.0052
Entamoeba histolytica protein kinase, putative 0.0078 0.0295 0.24
Brugia malayi Protein kinase domain containing protein 0.0057 0.0183 0.0173
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0111 0.0098
Plasmodium falciparum heat shock protein 90, putative 0.0169 0.0779 1
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0126 0.0126
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0182 0.0182
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0111 0.0098
Echinococcus multilocularis muscleblind protein 1 0.0145 0.0653 0.0641
Echinococcus multilocularis heat shock protein 90 0.0038 0.0082 0.007
Loa Loa (eye worm) hypothetical protein 0.0032 0.0052 0.0052
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0111 0.0749
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0111 0.0101
Trypanosoma brucei PB1 domain containing protein, putative 0.0055 0.0174 0.1642
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0073 0.0073
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0039 0.0087 0.013
Trypanosoma cruzi ISWI complex protein 0.0045 0.012 0.0361
Schistosoma mansoni hypothetical protein 0.164 0.8611 0.8611
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.003 0.0038 0.0025
Entamoeba histolytica cysteine protease, putative 0.0078 0.0295 0.2395
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0018 0.0002
Brugia malayi cathepsin F-like cysteine proteinase 0.0039 0.0087 0.0077
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0052 0.0052
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0039 0.0087 0.0651
Brugia malayi Papain family cysteine protease containing protein 0.0039 0.0087 0.0077
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0052 0.0039
Brugia malayi Hr1 repeat family protein 0.0078 0.0295 0.0286
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0117 0.035
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0039 0.0087 0.013
Brugia malayi Cathepsin L-like precursor 0.0078 0.0295 0.0285
Schistosoma mansoni endoplasmin 0.0045 0.0117 0.0117
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0053 0.0396
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0055 0.0173 0.0161
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0039 0.0087 0.1005
Entamoeba histolytica cysteine protease, putative 0.0078 0.0295 0.2395
Trypanosoma brucei heat shock protein 84, putative 0.003 0.0037 0.0272
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0078 0.0295 0.3702
Trypanosoma brucei Heat shock protein 83, putative 0.0045 0.0117 0.107
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.0459 0.3331
Loa Loa (eye worm) hypothetical protein 0.0039 0.0087 0.0087
Giardia lamblia Cathepsin B precursor 0.0212 0.1008 1
Brugia malayi cathepsin B-like cysteine proteinase 0.0598 0.3063 0.3056
Loa Loa (eye worm) fibroinase 0.0078 0.0295 0.0295
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0078 0.0295 0.0932
Entamoeba histolytica protein kinase, putative 0.0078 0.0295 0.24
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0212 0.1008 0.1008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0295 0.0516
Schistosoma mansoni jumonji domain containing protein 0.0155 0.0704 0.0704
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0598 0.3063 0.3063
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0057 0.0182 0.017
Plasmodium vivax vivapain-2 0.0078 0.0295 0.3702
Toxoplasma gondii heat shock protein 90, putative 0.0045 0.0117 0.0977
Mycobacterium ulcerans heat shock protein 90 0.0042 0.0102 0.9139
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0052 0.0042
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0073 0.0269 0.0269
Onchocerca volvulus Protein TFG homolog 0.0055 0.0174 0.047
Loa Loa (eye worm) zinc finger protein 0.0055 0.0174 0.0174
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0039 0.0087 0.0087
Trichomonas vaginalis AGC family protein kinase 0.0078 0.0295 0.0517
Onchocerca volvulus 0.0296 0.1457 0.415
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0055 0.0173 0.0161
Echinococcus multilocularis zinc finger protein 0.0068 0.0241 0.0228
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.0082 0.0237
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0111 0.0174
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0295 0.0516
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.006 0.008
Brugia malayi PHD-finger family protein 0.006 0.0196 0.0187
Schistosoma mansoni zinc finger protein 0.0068 0.0241 0.0241
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0041 0.0098 0.0088
Loa Loa (eye worm) MBCTL1 0.0053 0.0161 0.0161
Echinococcus multilocularis serine threonine protein kinase 0.0078 0.0295 0.0283
Loa Loa (eye worm) hypothetical protein 0.0286 0.1399 0.1399
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0051 0.0038
Trypanosoma cruzi PB1 domain containing protein, putative 0.0055 0.0174 0.0537
Trichomonas vaginalis bromodomain-containing protein, putative 0.0048 0.0137 0.0223
Entamoeba histolytica hypothetical protein 0.0055 0.0173 0.1375
Loa Loa (eye worm) hypothetical protein 0.0032 0.0052 0.0052
Entamoeba histolytica cysteine proteinase, putative 0.0078 0.0295 0.2395
Plasmodium falciparum serine repeat antigen 4 0.0039 0.0087 0.1005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0116 0.0116
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0042 0.0102 0.0684
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0866 0.4486 0.4486
Loa Loa (eye worm) PHD-finger family protein 0.0061 0.0204 0.0204
Onchocerca volvulus 0.0078 0.0295 0.0817
Loa Loa (eye worm) hypothetical protein 0.0039 0.0087 0.0087
Entamoeba histolytica cysteine protease, putative 0.0078 0.0295 0.2395
Echinococcus granulosus cysteine protease 0.0078 0.0295 0.0282
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0031 0.0047 0.0034
Loa Loa (eye worm) hypothetical protein 0.0041 0.0098 0.0098
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0052 0.0039
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0051 0.0038
Onchocerca volvulus Tyrosine kinase homolog 0.0316 0.1563 0.4455
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0083 0.0321 0.0321
Onchocerca volvulus Alhambra homolog 0.006 0.0196 0.0535
Onchocerca volvulus 0.0039 0.0087 0.0222
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0039 0.0087 0.1005
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0116 0.0107
Toxoplasma gondii diacylglycerol kinase, putative 0.0055 0.0173 0.1496
Echinococcus multilocularis insulin receptor 0.061 0.3128 0.3119
Onchocerca volvulus Matrilysin homolog 0.0075 0.0277 0.0766
Trypanosoma cruzi Heat shock protein 83, putative 0.0045 0.0117 0.035
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.025 0.024
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0052 0.0052
Brugia malayi nuclear receptor NHR-88 0.0032 0.0052 0.0042
Loa Loa (eye worm) hypothetical protein 0.0043 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0032 0.0048 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0018 0.0002
Echinococcus granulosus epidermal growth factor receptor 0.1024 0.5327 0.5321
Schistosoma mansoni diacylglycerol kinase theta 0.0055 0.0173 0.0173
Schistosoma mansoni jumonji/arid domain-containing protein 0.0084 0.0328 0.0328
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0039 0.0087 0.0077
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0052 0.0052
Onchocerca volvulus 0.0048 0.0136 0.036
Echinococcus granulosus heat shock protein 90 0.0045 0.0117 0.0104
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0148 0.0667 0.0667
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1399 0.1388
Echinococcus granulosus tumor protein p63 0.0329 0.1629 0.1619
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0052 0.0052
Brugia malayi RhoGAP domain containing protein 0.0055 0.0173 0.0164
Entamoeba histolytica cysteine proteinase, putative 0.0078 0.0295 0.2395
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0116 0.0104
Brugia malayi protein kinase C3,putative 0.081 0.4192 0.4186
Toxoplasma gondii NAC domain-containing protein 0.0034 0.006 0.0463
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0082 0.0934
Plasmodium vivax SET domain protein, putative 0.0033 0.0053 0.0562
Trypanosoma brucei heat shock protein, putative 0.0045 0.0117 0.107
Trichomonas vaginalis glucosylceramidase, putative 0.0716 0.3691 0.6835
Echinococcus multilocularis geminin 0.0844 0.4374 0.4367
Loa Loa (eye worm) hypothetical protein 0.0032 0.0052 0.0052
Schistosoma mansoni cpg binding protein 0.0127 0.0557 0.0557
Brugia malayi Cathepsin L-like precursor 0.0078 0.0295 0.0285
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0052 0.0042
Brugia malayi Ras association domain family 1 isoform A 0.0055 0.0173 0.0164
Brugia malayi diacylglycerol kinase 0.0055 0.0173 0.0164
Brugia malayi Cathepsin L-like precursor 0.0078 0.0295 0.0285
Leishmania major heat shock protein 83-1 0.0045 0.0117 0.1071
Loa Loa (eye worm) hypothetical protein 0.0032 0.0051 0.0051
Entamoeba histolytica cysteine protease, putative 0.0039 0.0087 0.0651
Brugia malayi Protein kinase domain containing protein 0.0562 0.2869 0.2862
Loa Loa (eye worm) hypothetical protein 0.0048 0.0136 0.0136
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0122 0.0531 0.0519
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0161 0.0148
Onchocerca volvulus 0.0078 0.0295 0.0817
Toxoplasma gondii cathepsin CPL 0.0078 0.0295 0.2606
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0133 0.0121
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0111 0.0111
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0039 0.0087 0.0087
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.006 0.0657
Brugia malayi diacylglycerol kinase 0.0055 0.0173 0.0164
Brugia malayi Papain family cysteine protease containing protein 0.0039 0.0087 0.0077
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0048 0.0137 0.0223
Leishmania major cathepsin L-like protease 0.0078 0.0295 0.2854
Treponema pallidum heat shock protein 90 0.0042 0.0102 0.5
Mycobacterium tuberculosis Probable reductase 0.0109 0.0459 0.3331
Trichomonas vaginalis AGC family protein kinase 0.0078 0.0295 0.0517
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0026 0.002 0.0136
Echinococcus multilocularis protein kinase c iota type 0.0887 0.4599 0.4592
Echinococcus granulosus serine:threonine protein kinase N2 0.0078 0.0295 0.0283
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0049 0.0141 0.0141
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.0421 0.0412
Leishmania major cathepsin L-like protease 0.0078 0.0295 0.2854
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0598 0.3063 0.3063
Brugia malayi Hsp90 protein 0.003 0.0037 0.0027
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0078 0.0295 0.0283
Brugia malayi heat shock protein 90 0.0045 0.0117 0.0107
Entamoeba histolytica diacylglycerol kinase, putative 0.0055 0.0173 0.1375
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0126 0.0126
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0133 0.0917
Trichomonas vaginalis glucosylceramidase, putative 0.1036 0.5392 1
Schistosoma mansoni hypothetical protein 0.0844 0.4374 0.4374
Entamoeba histolytica cysteine protease, putative 0.0078 0.0295 0.2395
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.001
Entamoeba histolytica hypothetical protein 0.0036 0.0073 0.0528
Echinococcus multilocularis roundabout 2 0.0032 0.0048 0.0035
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0111 1
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0039 0.0087 0.1005
Plasmodium vivax endoplasmin, putative 0.0045 0.0117 0.1389
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0111 0.0111
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0111 0.0749
Echinococcus multilocularis cpg binding protein 0.0127 0.0557 0.0545
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0598 0.3063 0.3063
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0133 0.0121
Trypanosoma cruzi ISWI complex protein 0.0045 0.012 0.0361
Brugia malayi ecdysteroid receptor 0.0032 0.0052 0.0042
Brugia malayi MH2 domain containing protein 0.0116 0.0498 0.0488
Brugia malayi Pleckstrin Homology Domain 0.0055 0.0173 0.0164
Onchocerca volvulus Matrix metalloproteinase homolog 0.0075 0.0277 0.0766
Loa Loa (eye worm) hypothetical protein 0.0032 0.0052 0.0052
Onchocerca volvulus 0.0057 0.0183 0.0496
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0038 0.0082 0.007
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0052 0.0042
Giardia lamblia Cysteine protease 0.0039 0.0087 0.0059
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0039 0.0087 0.0087
Trichomonas vaginalis AGC family protein kinase 0.0078 0.0295 0.0517
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0037 0.0075 0.0062
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0148 0.0667 0.0655
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0287 0.0274
Brugia malayi Cathepsin L-like cysteine proteinase 0.0039 0.0087 0.0077
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0295 0.2853
Loa Loa (eye worm) hypothetical protein 0.0043 0.0111 0.0111
Echinococcus granulosus fetal alzheimer antigen falz 0.0073 0.0269 0.0256
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0117 0.035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0295 0.0516
Loa Loa (eye worm) hypothetical protein 0.0039 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0039 0.0087 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0018 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0295 0.2853
Loa Loa (eye worm) hypothetical protein 0.0055 0.0173 0.0173
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0116 0.0104
Echinococcus granulosus protein TFG 0.0055 0.0174 0.0161
Entamoeba histolytica cysteine proteinase, putative 0.0078 0.0295 0.2395
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0295 0.2853
Loa Loa (eye worm) hypothetical protein 0.0055 0.0173 0.0173
Onchocerca volvulus 0.0034 0.0059 0.014
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0078 0.0295 0.0295
Loa Loa (eye worm) hypothetical protein 0.0598 0.3063 0.3063
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0122 0.0531 0.0519
Plasmodium vivax unspecified product 0.0039 0.0087 0.1005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0087 0.013
Loa Loa (eye worm) hypothetical protein 0.0043 0.0111 0.0111
Entamoeba histolytica hypothetical protein 0.0036 0.0073 0.0528
Brugia malayi cathepsin Z-like cysteine proteinase 0.0039 0.0087 0.0077
Schistosoma mansoni serine/threonine protein kinase 0.0133 0.0589 0.0589
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0295 0.0516
Schistosoma mansoni jumonji/arid domain-containing protein 0.0084 0.0328 0.0328
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0295 0.0516
Brugia malayi RhoGEF domain containing protein 0.0055 0.0173 0.0164
Echinococcus multilocularis Rac GTPase activating protein 1 0.0055 0.0173 0.0161
Giardia lamblia Cathepsin L precursor 0.0039 0.0087 0.0059
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0116 0.0104
Echinococcus granulosus Diacylglycerol kinase theta 0.0055 0.0173 0.0161
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0295 0.0516
Trypanosoma brucei heat shock protein, putative 0.0045 0.0117 0.107
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0295 0.0516
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0116 0.0104
Leishmania major cathepsin L-like protease 0.0078 0.0295 0.2854
Mycobacterium tuberculosis Conserved protein 0.0043 0.0111 0.0749
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0078 0.0295 0.0295
Loa Loa (eye worm) hypothetical protein 0.0034 0.0059 0.0059
Onchocerca volvulus 0.0058 0.0189 0.0515
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0078 0.0295 0.0283
Loa Loa (eye worm) hypothetical protein 0.0145 0.0653 0.0653
Leishmania major hypothetical protein, conserved 0.0043 0.0111 0.1012
Brugia malayi Muscleblind-like protein 0.0145 0.0653 0.0644
Schistosoma mansoni tyrosine kinase 0.061 0.3128 0.3128
Schistosoma mansoni bromodomain containing protein 0.0197 0.0928 0.0928
Echinococcus granulosus protein kinase C gamma type 0.0078 0.0295 0.0283
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0039 0.0087 0.0059
Echinococcus granulosus cathepsin b 0.0598 0.3063 0.3054
Onchocerca volvulus 0.0055 0.0173 0.0469
Trypanosoma cruzi cysteine peptidase, putative 0.0078 0.0295 0.0932
Entamoeba histolytica protein kinase, putative 0.0078 0.0295 0.24
Brugia malayi hypothetical protein 0.0286 0.1399 0.1391
Plasmodium vivax unspecified product 0.0039 0.0087 0.1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0039 0.0087 0.0087
Leishmania major heat shock protein 83-1 0.0045 0.0117 0.1071
Plasmodium vivax hypothetical protein, conserved 0.0026 0.002 0.0136
Giardia lamblia Cathepsin B precursor 0.0039 0.0087 0.0059
Onchocerca volvulus 0.0078 0.0295 0.0817
Trichomonas vaginalis AGC family protein kinase 0.0078 0.0295 0.0517
Echinococcus multilocularis protein tyrosine kinase 0.0555 0.2835 0.2826
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.061 0.3128 0.3119
Echinococcus granulosus cathepsin l1 0.0078 0.0295 0.0282
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.1358 1
Giardia lamblia Cathepsin L precursor 0.0039 0.0087 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0018 0.0002
Trichomonas vaginalis set domain proteins, putative 0.0242 0.1165 0.2136
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0195 0.0918 0.0906
Brugia malayi glutathione reductase 0.0048 0.0133 0.0124
Brugia malayi Hemopexin family protein 0.0048 0.0134 0.0124
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0078 0.0295 0.0295
Schistosoma mansoni hypothetical protein 0.0048 0.0134 0.0134
Echinococcus multilocularis 0.0587 0.3005 0.2996
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0039 0.0087 0.013
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0052 0.0121
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0183 0.0853 0.0841
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0073 0.006
Echinococcus multilocularis unc 13 (munc13) 0.0055 0.0173 0.0161
Entamoeba histolytica diacylglycerol kinase, putative 0.0055 0.0173 0.1375
Toxoplasma gondii heat shock protein HSP90 0.0045 0.0117 0.0977
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0111 0.1011
Schistosoma mansoni endoplasmin 0.0045 0.0117 0.0117
Toxoplasma gondii heat shock protein 75, putative 0.003 0.0037 0.0248
Brugia malayi Matrixin family protein 0.0034 0.0059 0.0049
Echinococcus granulosus cpg binding protein 0.0127 0.0557 0.0545
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0111 1
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0498 0.0498
Leishmania major hypothetical protein, conserved 0.0025 0.001 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0039 0.0087 0.013
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0042 0.0102 0.0925
Plasmodium falciparum serine repeat antigen 1 0.0039 0.0087 0.1005
Plasmodium vivax glutathione reductase, putative 0.0048 0.0133 0.1606
Trypanosoma cruzi cysteine peptidase, putative 0.0078 0.0295 0.0932
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0039 0.0087 0.1005
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0018 0.0002
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0039 0.0087 0.0651
Loa Loa (eye worm) hypothetical protein 0.0145 0.0653 0.0653
Schistosoma mansoni cathepsin s 0.0039 0.0087 0.0087
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0039 0.0087 0.0059
Plasmodium vivax vivapain-3 0.0078 0.0295 0.3702
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0161 0.0161
Schistosoma mansoni serine/threonine protein kinase 0.0133 0.0589 0.0589
Brugia malayi Pre-SET motif family protein 0.0033 0.0053 0.0043
Leishmania major heat shock protein 83-1 0.0045 0.0117 0.1071
Brugia malayi F/Y-rich N-terminus family protein 0.0061 0.0206 0.0197
Leishmania major heat shock protein 83-1 0.0045 0.0117 0.1071
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.003 0.0038 0.0025
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0186 0.0872 0.086
Plasmodium vivax heat shock protein, putative 0.0169 0.0779 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0052 0.0042
Entamoeba histolytica cysteine protease, putative 0.0078 0.0295 0.2395
Schistosoma mansoni tyrosine kinase 0.0555 0.2835 0.2835
Loa Loa (eye worm) hypothetical protein 0.0055 0.0173 0.0173
Plasmodium vivax unspecified product 0.0078 0.0295 0.3702
Plasmodium vivax vivapain-2 0.0078 0.0295 0.3702
Echinococcus granulosus peregrin 0.007 0.0252 0.0239
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0295 0.2853
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0052 0.0042
Onchocerca volvulus 0.0078 0.0295 0.0817
Loa Loa (eye worm) hypothetical protein 0.0032 0.0048 0.0048
Echinococcus multilocularis tumor protein p63 0.0329 0.1629 0.1619
Echinococcus multilocularis endoplasmin 0.0042 0.0102 0.0089
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0295 0.0295
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0087 0.013
Echinococcus multilocularis cathepsin L cysteine protease 0.0078 0.0295 0.0282
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.008 0.0305 0.0305
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0039 0.0087 0.013
Brugia malayi fibroinase precursor 0.0039 0.0087 0.0077
Onchocerca volvulus 0.0043 0.0111 0.029
Echinococcus multilocularis transcription factor btf3 0.0034 0.006 0.0048
Schistosoma mansoni tyrosine kinase 0.061 0.3128 0.3128
Brugia malayi jmjC domain containing protein 0.0195 0.0918 0.0909
Brugia malayi PHD-finger family protein 0.0084 0.0325 0.0315
Schistosoma mansoni survival motor neuron protein 0.0058 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.001
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0048 0.0137 0.1167
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0055 0.0173 0.0173
Toxoplasma gondii cathepsin CPC2 0.0039 0.0087 0.0707
Echinococcus granulosus dnaJ subfamily B 0.164 0.8611 0.8609
Echinococcus multilocularis cathepsin L 0.0078 0.0295 0.0282
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0039 0.0087 0.013
Brugia malayi cathepsin Z-like cysteine proteinase 0.0039 0.0087 0.0077
Leishmania major cathepsin L-like protease 0.0078 0.0295 0.2854
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0186 0.0872 0.086
Schistosoma mansoni tyrosine kinase 0.1009 0.5248 0.5248
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0106 0.0445 0.0432
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0087 0.013
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0117 0.035
Leishmania major heat shock protein 83-1 0.0045 0.0117 0.1071
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.006 0.0426
Loa Loa (eye worm) beta-lactamase 0.0043 0.0111 0.0111
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0295 0.0295
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0295 0.2853
Trichomonas vaginalis AGC family protein kinase 0.0078 0.0295 0.0517
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0133 0.1606
Brugia malayi jmjC domain containing protein 0.0084 0.0328 0.0319
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0287 0.0287
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0018 0.0002
Entamoeba histolytica cysteine protease, putative 0.0078 0.0295 0.2395
Toxoplasma gondii cathepsin CPC1 0.0039 0.0087 0.0707
Plasmodium falciparum serine repeat antigen 2 0.0039 0.0087 0.1005
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0052 0.0121
Schistosoma mansoni cathepsin B (C01 family) 0.0039 0.0087 0.0087
Brugia malayi cathepsin L precursor 0.0039 0.0087 0.0077
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0111 0.0174
Brugia malayi Endoplasmin precursor 0.0045 0.0117 0.0107
Brugia malayi Papain family cysteine protease containing protein 0.0078 0.0295 0.0285
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0295 0.0516
Schistosoma mansoni heat shock protein 0.0045 0.0117 0.0117
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0295 0.0516
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0111 0.0174
Loa Loa (eye worm) acetyltransferase 0.0148 0.0667 0.0667
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0598 0.3063 1
Leishmania major cathepsin L-like protease 0.0078 0.0295 0.2854
Trichomonas vaginalis AGC family protein kinase 0.0078 0.0295 0.0517
Brugia malayi Papain family cysteine protease containing protein 0.0039 0.0087 0.0077
Entamoeba histolytica cysteine protease, putative 0.0078 0.0295 0.2395
Trichomonas vaginalis AGC family protein kinase 0.0078 0.0295 0.0517
Entamoeba histolytica protein kinase, putative 0.0078 0.0295 0.24
Entamoeba histolytica hypothetical protein, conserved 0.0055 0.0174 0.1379
Loa Loa (eye worm) PAR-6 protein 0.0055 0.0174 0.0174
Schistosoma mansoni cell adhesion molecule 0.0026 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.007 0.025 0.025
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0295 0.0295
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0287 0.0287
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0051 0.0041
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0102 0.0158
Loa Loa (eye worm) hypothetical protein 0.0032 0.0052 0.0052
Loa Loa (eye worm) PHD-finger family protein 0.006 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0032 0.0048 0.0048
Leishmania major cathepsin L-like protease 0.0078 0.0295 0.2854
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0078 0.0295 0.0516
Loa Loa (eye worm) hypothetical protein 0.0078 0.0295 0.0295
Brugia malayi hypothetical protein 0.0025 0.001 0.0000082998
Trichomonas vaginalis glucosylceramidase, putative 0.1036 0.5392 1
Echinococcus granulosus jumonji domain containing protein 0.0083 0.0321 0.0308
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0078 0.0295 0.0283
Brugia malayi Matrixin family protein 0.0034 0.0059 0.0049
Toxoplasma gondii histone lysine methyltransferase SET1 0.023 0.1102 1
Brugia malayi Thioredoxin reductase 0.0048 0.0133 0.0124
Echinococcus granulosus protein kinase c epsilon type 0.0133 0.0589 0.0577
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0111 0.0749
Onchocerca volvulus 0.0046 0.0126 0.0334
Leishmania major heat shock protein 83-1 0.0045 0.0117 0.1071
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0018 0.0002
Echinococcus granulosus unc 13 munc13 0.0055 0.0173 0.0161
Toxoplasma gondii ABC1 family protein 0.0043 0.0111 0.0923
Giardia lamblia Encystation-specific protease 0.0039 0.0087 0.0059
Entamoeba histolytica cysteine protease, putative 0.0078 0.0295 0.2395
Leishmania major heat shock protein 83-1 0.0045 0.0117 0.1071
Entamoeba histolytica hypothetical protein 0.0034 0.006 0.0426
Loa Loa (eye worm) heat shock protein 90 0.0045 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0032 0.0052 0.0052
Brugia malayi Pre-SET motif family protein 0.0213 0.1011 0.1002
Plasmodium falciparum serine repeat antigen 7 0.0039 0.0087 0.1005
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0111 0.033
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0106 0.0445 0.0432
Schistosoma mansoni hypothetical protein 0.0055 0.0173 0.0173

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 4.1095 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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