TDR Targets

Basic information

Technical information

TDR Targets ID: 1425098
Name: 4-methoxy-N-(4-morpholin-4-ylphenyl)-3-pyrrol idin-1-ylsulfonylbenzamide
MW: 445.532 | Formula: C22H27N3O5S
H donors: 1 H acceptors: 3 LogP: 2.11 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1S(=O)(=O)N1CCCC1)C(=O)Nc1ccc(cc1)N1CCOCC1
InChi: 1S/C22H27N3O5S/c1-29-20-9-4-17(16-21(20)31(27,28)25-10-2-3-11-25)22(26)23-18-5-7-19(8-6-18)24-12-14-30-15-13-24/h4-9,16H,2-3,10-15H2,1H3,(H,23,26)
InChiKey: KMYMCLZUVQVIAN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-methoxy-N-(4-morpholinophenyl)-3-pyrrolidin-1-ylsulfonyl-benzamide
4-methoxy-N-(4-morpholinophenyl)-3-1-pyrrolidinylsulfonylbenzamide
4-methoxy-N-(4-morpholin-4-ylphenyl)-3-pyrrolidin-1-ylsulfonyl-benzamide
T5379640

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0308	0.8848	0.8848
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0815	0.1245
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.2419	0.2419
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0815	1
Echinococcus multilocularis	lamin	0.0027	0.0562	0.0562
Echinococcus multilocularis	musashi	0.0027	0.0562	0.0562
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0017	0.0247	0.1582
Trypanosoma brucei	PAB1-binding protein , putative	0.0051	0.1256	1
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0023	0.0426	0.0426
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0433	0.5314
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0562	0.0574
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0815	0.6021
Entamoeba histolytica	hypothetical protein	0.0037	0.0839	0.8874
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0815	1
Loa Loa (eye worm)	TAR-binding protein	0.0065	0.1661	0.1824
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.001	0.0058	0.0058
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0043	0.1033	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0815	0.0815
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.118	0.1675
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.001	0.0058	0.0058
Echinococcus multilocularis	tar DNA binding protein	0.0065	0.1661	0.1661
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0065	0.1661	0.1824
Echinococcus granulosus	tumor protein p63	0.0331	0.9533	0.9533
Echinococcus multilocularis	survival motor neuron protein 1	0.0237	0.6756	0.6756
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0233	0.0356
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0815	0.1245
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0815	0.1245
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.1661	0.1661
Echinococcus granulosus	importin subunit beta 1	0.0029	0.0603	0.0603
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0839	0.0839
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0815	0.789
Trichomonas vaginalis	DNA helicase recq, putative	0.0013	0.0148	0.1433
Brugia malayi	RNA, U transporter 1	0.0082	0.2174	0.316
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0562	0.0574
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0815	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0815	0.0862
Loa Loa (eye worm)	hypothetical protein	0.0051	0.1256	0.1363
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.0433	0.3663
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0023	0.0426	0.0426
Plasmodium falciparum	ataxin-2 like protein, putative	0.0051	0.1256	1
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0815	0.1245
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0433	0.5314
Mycobacterium ulcerans	lipase LipD	0.0036	0.0815	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0233	0.0356
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0603	0.0621
Schistosoma mansoni	lamin	0.0027	0.0562	0.0562
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0815	0.6021
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0128	0.008
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0839	0.0839
Echinococcus granulosus	bloom syndrome protein	0.0025	0.0494	0.0494
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0815	0.6021
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.1183	0.1183
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0433	0.5314
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0815	0.789
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0548	0.0557
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0043	0.1033	0.1033
Loa Loa (eye worm)	RNA binding protein	0.0065	0.1661	0.1824
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.0261	0.0398
Echinococcus multilocularis	importin subunit beta 1	0.0029	0.0603	0.0603
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0442	0.428
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0433	0.056
Loa Loa (eye worm)	acetyltransferase	0.0147	0.4111	0.4611
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0815	0.0862
Plasmodium falciparum	importin beta, putative	0.0029	0.0603	0.4553
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0017	0.0261	0.3199
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0433	0.5314
Brugia malayi	acetyltransferase, GNAT family protein	0.0147	0.4111	0.605
Brugia malayi	beta-lactamase family protein	0.0036	0.0815	0.1131
Schistosoma mansoni	hypothetical protein	0.0037	0.0839	0.0839
Brugia malayi	hypothetical protein	0.0051	0.1256	0.1789
Echinococcus multilocularis	snurportin 1	0.0308	0.8848	0.8848
Loa Loa (eye worm)	hypothetical protein	0.0122	0.3345	0.3739
Schistosoma mansoni	hypothetical protein	0.0347	1	1
Leishmania major	hypothetical protein, conserved	0.0051	0.1256	1
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0143	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0261	0.0231
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0562	0.0574
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0815	0.0862
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0261	0.0231
Toxoplasma gondii	LsmAD domain-containing protein	0.0051	0.1256	1
Trichomonas vaginalis	DNA helicase recq1, putative	0.0025	0.0494	0.478
Brugia malayi	hypothetical protein	0.0037	0.0839	0.1166
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0815	0.0815
Onchocerca volvulus	Huntingtin homolog	0.0122	0.3345	1
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0815	1
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0603	0.411
Brugia malayi	hypothetical protein	0.0237	0.6756	1
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0022	0.0404	0.2886
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0562	0.0753
Onchocerca volvulus		0.0048	0.1183	0.2576
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.1661	0.1661
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0261	0.0231
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0043	0.1033	0.814
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0433	0.3663
Echinococcus granulosus	snurportin 1	0.0308	0.8848	0.8848
Giardia lamblia	Histone acetyltransferase GCN5	0.004	0.0926	1
Echinococcus multilocularis	bloom syndrome protein	0.0025	0.0494	0.0494
Treponema pallidum	bacterioferrin (TpF1)	0.0008	0	0.5
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.009	0.2419	0.3524
Loa Loa (eye worm)	hypothetical protein	0.0122	0.3345	0.3739
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0186	0.0146
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0058	0.000000001165
Trypanosoma cruzi	PAB1-binding protein , putative	0.0051	0.1256	1
Echinococcus multilocularis	lamin dm0	0.0027	0.0562	0.0562
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0815	0.1245
Brugia malayi	RNA recognition motif domain containing protein	0.0065	0.1661	0.2393
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0017	0.0261	0.5
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0261	0.0231
Trichomonas vaginalis	esterase, putative	0.0036	0.0815	0.789
Wolbachia endosymbiont of Brugia malayi	bacterioferritin/cytochrome b1	0.0008	0	0.5
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0433	0.2574
Onchocerca volvulus		0.0027	0.0562	0.0444
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0433	0.0662
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0815	0.1131
Schistosoma mansoni	importin beta-1	0.0029	0.0603	0.0603
Brugia malayi	Importin beta-1 subunit	0.0029	0.0603	0.0814
Plasmodium vivax	importin-beta 2, putative	0.0029	0.0603	0.349
Schistosoma mansoni	survival motor neuron protein	0.0048	0.118	0.118
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0261	0.0231
Entamoeba histolytica	acetyltransferase, GNAT family	0.004	0.0926	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.1183	0.128
Brugia malayi	beta-lactamase	0.0036	0.0815	0.1131
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0043	0.1033	0.7778
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0143	0.0143
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0433	0.5314
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0815	0.0862
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.009	0.2419	0.2419
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0433	0.3663
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0815	0.1245
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0433	0.5314
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.009	0.2419	0.2419
Entamoeba histolytica	hypothetical protein	0.0023	0.0442	0.378
Schistosoma mansoni	DNA helicase recq1	0.001	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0815	0.0862
Brugia malayi	RNA binding protein	0.0065	0.1661	0.2393
Brugia malayi	hypothetical protein	0.0033	0.0723	0.0993
Toxoplasma gondii	ABC1 family protein	0.0036	0.0815	0.6321
Toxoplasma gondii	HEAT repeat-containing protein	0.0029	0.0603	0.4553
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0815	0.789
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0815	1
Schistosoma mansoni	hypothetical protein	0.0347	1	1
Plasmodium vivax	acyl-CoA synthetase, putative	0.0017	0.0261	0.0074
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0815	0.0815
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0143	0.3988	0.3988
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.001	0.0058	0.0058
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.1661	0.1661
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0815	0.1245
Schistosoma mansoni	DNA helicase recq5	0.001	0.0058	0.0058
Brugia malayi	beta-lactamase family protein	0.0036	0.0815	0.1131
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0433	0.056
Brugia malayi	TAR-binding protein	0.0065	0.1661	0.2393
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.2419	0.2419
Echinococcus granulosus	lamin	0.0027	0.0562	0.0562
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0815	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0433	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0126	0.3489	0.3904
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0233	0.0356
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0815	0.1245
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0815	0.1245
Leishmania major	hypothetical protein, conserved	0.0036	0.0815	0.6021
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0433	0.5314
Schistosoma mansoni	hypothetical protein	0.0023	0.0426	0.0426
Brugia malayi	Bloom's syndrome protein homolog	0.0025	0.0494	0.0651
Schistosoma mansoni	lamin	0.0027	0.0562	0.0562
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0442	0.2655
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.009	0.2419	0.2419
Brugia malayi	intermediate filament protein	0.0027	0.0562	0.0753
Brugia malayi	hypothetical protein	0.0122	0.3345	0.4907
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.001	0.0058	0.0058
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0433	0.2574
Onchocerca volvulus	Huntingtin homolog	0.0122	0.3345	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0839	0.0839
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0442	0.2655
Trichomonas vaginalis	DNA helicase recq, putative	0.0025	0.0494	0.478
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0815	1
Echinococcus granulosus	survival motor neuron protein 1	0.0237	0.6756	0.6756
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.009	0.2419	0.2419
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.023	0.6549	1
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0562	0.0562
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0442	0.428
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0433	0.2574
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0603	0.411
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0143	0.0097
Plasmodium falciparum	histone acetyltransferase GCN5	0.004	0.0926	0.7249
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0815	0.789
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0308	0.8848	1
Plasmodium vivax	ataxin-2 like protein, putative	0.0051	0.1256	1
Schistosoma mansoni	blooms syndrome DNA helicase	0.002	0.0338	0.0338
Trypanosoma cruzi	PAB1-binding protein , putative	0.0051	0.1256	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0233	0.0356
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0442	0.428
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.1661	0.1661
Loa Loa (eye worm)	RecQ helicase	0.0025	0.0494	0.0496
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0433	0.056
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0433	0.5314
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0433	0.0427
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0147	0.4111	0.4111
Plasmodium falciparum	ataxin-2 like protein, putative	0.0051	0.1256	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0815	0.789
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0815	0.0862
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0433	0.5314
Echinococcus granulosus	lamin dm0	0.0027	0.0562	0.0562
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0433	0.5314
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0043	0.1033	0.814
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0433	0.0662
Echinococcus multilocularis	geminin	0.0347	1	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0815	0.0815
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0043	0.1033	1
Echinococcus granulosus	intermediate filament protein	0.0027	0.0562	0.0562
Onchocerca volvulus		0.0036	0.0815	0.1312
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.2419	0.2419
Loa Loa (eye worm)	hypothetical protein	0.0237	0.6756	0.7621
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0433	0.0427
Echinococcus granulosus	tar DNA binding protein	0.0065	0.1661	0.1661
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.1661	0.1661
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0147	0.4111	0.4111
Echinococcus multilocularis	tumor protein p63	0.0331	0.9533	0.9533
Plasmodium falciparum	acyl-CoA synthetase	0.0017	0.0261	0.1694
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0128	0.008
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0815	0.0862
Entamoeba histolytica	hypothetical protein	0.0037	0.0839	0.8874
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0186	0.0191
Onchocerca volvulus		0.0036	0.0815	0.1312
Onchocerca volvulus		0.0048	0.118	0.2566
Entamoeba histolytica	hypothetical protein	0.0037	0.0839	0.8874
Entamoeba histolytica	hypothetical protein	0.0037	0.0839	0.8874
Schistosoma mansoni	hypothetical protein	0.0048	0.118	0.118
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.009	0.2419	0.2686
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0815	0.0862
Onchocerca volvulus		0.0027	0.0562	0.0444
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0815	0.5603
Onchocerca volvulus		0.0036	0.0815	0.1312

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1556268

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1425098