Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | thioesterase TesA | 0.0043 | 0.0871 | 0.4682 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0062 | 0.1437 | 0.1437 |
Mycobacterium ulcerans | polyketide synthase | 0.0051 | 0.1114 | 0.6023 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein synthase | 0.0013 | 0.0024 | 0.0046 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0025 | 0.0384 | 1 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0029 | 0.0484 | 0.1378 |
Schistosoma mansoni | methyltransferase-related | 0.0015 | 0.0098 | 0.0183 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.3811 | 0.3811 |
Mycobacterium ulcerans | thioesterase | 0.0043 | 0.0871 | 0.4682 |
Loa Loa (eye worm) | RNA binding protein | 0.0199 | 0.5333 | 0.5333 |
Loa Loa (eye worm) | TAR-binding protein | 0.0199 | 0.5333 | 0.5333 |
Brugia malayi | RNA binding protein | 0.0199 | 0.5333 | 0.5333 |
Schistosoma mansoni | tar DNA-binding protein | 0.0199 | 0.5333 | 1 |
Plasmodium falciparum | 3-oxoacyl-acyl-carrier protein synthase I/II | 0.0013 | 0.0024 | 0.0637 |
Loa Loa (eye worm) | beta-ketoacyl synthase domain-containing protein | 0.0013 | 0.0024 | 0.0024 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0051 | 0.1114 | 0.6023 |
Brugia malayi | MH2 domain containing protein | 0.0025 | 0.0364 | 0.0364 |
Mycobacterium ulcerans | polyketide synthase MbtD | 0.0016 | 0.0107 | 0.0454 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0056 | 0.1266 | 0.4162 |
Echinococcus multilocularis | GPCR, family 2 | 0.0062 | 0.1437 | 0.2694 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0062 | 0.1437 | 0.1437 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0051 | 0.1114 | 0.581 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.1746 | 0.3273 |
Leishmania major | hypothetical protein, conserved | 0.0015 | 0.0098 | 0.0254 |
Schistosoma mansoni | smad1 5 8 and | 0.0025 | 0.0364 | 0.0683 |
Schistosoma mansoni | tar DNA-binding protein | 0.0199 | 0.5333 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.3499 | 0.3499 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0073 | 0.1746 | 0.3273 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0042 | 0.0849 | 0.4587 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0377 | 0.1224 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0377 | 0.9812 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0033 | 0.0603 | 0.3453 |
Loa Loa (eye worm) | RecQ helicase | 0.0029 | 0.0484 | 0.0484 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0114 | 0.2905 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0135 | 0.3499 | 0.3499 |
Schistosoma mansoni | hypothetical protein | 0.0062 | 0.1437 | 0.2694 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0021 | 0.0248 | 0.128 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0377 | 0.2159 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0114 | 0.2905 | 0.2905 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0377 | 0.1224 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0114 | 0.2905 | 0.5447 |
Mycobacterium ulcerans | polyketide synthase | 0.0054 | 0.1204 | 0.6522 |
Brugia malayi | MH1 domain containing protein | 0.0014 | 0.0049 | 0.0049 |
Echinococcus granulosus | smad | 0.0025 | 0.0364 | 0.0683 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0043 | 0.0871 | 0.4398 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0199 | 0.5333 | 0.5333 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.2905 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0034 | 0.0621 | 0.2941 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0076 | 0.1833 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.1746 | 0.9519 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.2905 | 1 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0025 | 0.0364 | 0.0683 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0076 | 0.1833 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0025 | 0.0364 | 0.0364 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0197 | 0.5276 | 0.5276 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0029 | 0.0484 | 0.0484 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0062 | 0.1437 | 0.2694 |
Schistosoma mansoni | tar DNA-binding protein | 0.0199 | 0.5333 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0474 | 0.0474 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0036 | 0.0695 | 0.3979 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0199 | 0.5333 | 0.5333 |
Schistosoma mansoni | tar DNA-binding protein | 0.0199 | 0.5333 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0025 | 0.0364 | 0.0364 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.2905 | 1 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0054 | 0.1204 | 0.6337 |
Echinococcus granulosus | tar DNA binding protein | 0.0199 | 0.5333 | 1 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0114 | 0.2905 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 0.1746 | 0.5976 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0054 | 0.1204 | 0.6337 |
Mycobacterium tuberculosis | Conserved protein | 0.0015 | 0.0098 | 0.0455 |
Schistosoma mansoni | kinase | 0.0058 | 0.1309 | 0.2454 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.5276 | 0.5276 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 0.1746 | 0.9522 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0041 | 0.083 | 0.4452 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.2905 | 1 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0015 | 0.01 | 0.0009 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0054 | 0.1204 | 0.6337 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0062 | 0.1437 | 0.1437 |
Schistosoma mansoni | hypothetical protein | 0.0062 | 0.1437 | 0.2694 |
Onchocerca volvulus | 0.0089 | 0.219 | 0.6213 | |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0016 | 0.0116 | 0.0508 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0062 | 0.1437 | 0.2694 |
Schistosoma mansoni | 3-oxoacyl-[ACP] synthase | 0.0013 | 0.0024 | 0.0046 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0025 | 0.0364 | 0.0364 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0114 | 0.2905 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.2905 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0025 | 0.0364 | 0.0683 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0025 | 0.0364 | 0.0364 |
Trypanosoma brucei | polo-like protein kinase | 0.0114 | 0.2905 | 1 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0023 | 0.0311 | 0.0583 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0051 | 0.1114 | 0.6023 |
Schistosoma mansoni | hypothetical protein | 0.0062 | 0.1437 | 0.2694 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0026 | 0.0394 | 0.2259 |
Schistosoma mansoni | tar DNA-binding protein | 0.0199 | 0.5333 | 1 |
Schistosoma mansoni | smad | 0.0025 | 0.0364 | 0.0683 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2102 | 0.2102 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.002 | 0.0217 | 0.5469 |
Echinococcus multilocularis | 3 oxoacyl (acyl carrier protein) synthase | 0.0013 | 0.0024 | 0.0046 |
Brugia malayi | MH1 domain containing protein | 0.0014 | 0.0049 | 0.0049 |
Toxoplasma gondii | 3-oxoacyl-acyl-carrier protein synthase I/II, putative | 0.0013 | 0.0024 | 0.014 |
Mycobacterium tuberculosis | Polyketide synthetase MbtD (polyketide synthase) | 0.0016 | 0.0107 | 0.0505 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0377 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0049 | 0.0049 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.2905 | 1 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0029 | 0.0484 | 0.1378 |
Loa Loa (eye worm) | acyl carrier protein | 0.0023 | 0.0328 | 0.0328 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0037 | 0.0704 | 0.3791 |
Brugia malayi | TAR-binding protein | 0.0199 | 0.5333 | 0.5333 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 0.1746 | 1 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0018 | 0.0159 | 0.0795 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.2905 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0041 | 0.083 | 0.4452 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0054 | 0.1204 | 0.6522 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0025 | 0.0364 | 0.0683 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0025 | 0.0364 | 0.0683 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0048 | 0.1018 | 0.5519 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0123 | 0.0123 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0054 | 0.1204 | 0.6896 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0051 | 0.1114 | 0.6044 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 0.1746 | 0.3273 |
Echinococcus multilocularis | Smad4 | 0.0025 | 0.0364 | 0.0683 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0092 | 0.2281 | 0.6691 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0197 | 0.5276 | 0.5276 |
Schistosoma mansoni | hypothetical protein | 0.0062 | 0.1437 | 0.2694 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0197 | 0.5276 | 0.5276 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0015 | 0.0098 | 0.0455 |
Schistosoma mansoni | Smad4 | 0.0025 | 0.0364 | 0.0683 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0062 | 0.1437 | 0.2694 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0363 | 1 | 1 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0054 | 0.1204 | 0.6541 |
Echinococcus granulosus | bloom syndrome protein | 0.0029 | 0.0484 | 0.0908 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0062 | 0.1437 | 0.2694 |
Loa Loa (eye worm) | nuclear factor I | 0.0014 | 0.0049 | 0.0049 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0114 | 0.2905 | 0.5447 |
Schistosoma mansoni | smad1 5 8 and | 0.0025 | 0.0364 | 0.0683 |
Brugia malayi | Smad1 | 0.0025 | 0.0364 | 0.0364 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0097 | 0.2416 | 0.2416 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.005 | 0.1069 | 0.5799 |
Loa Loa (eye worm) | Smad1 | 0.0025 | 0.0364 | 0.0364 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0377 | 0.1224 |
Loa Loa (eye worm) | fatty acid synthase | 0.005 | 0.1094 | 0.1094 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0015 | 0.01 | 0.0263 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0051 | 0.1114 | 0.1114 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0051 | 0.1114 | 0.6023 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0051 | 0.1114 | 0.6023 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0043 | 0.0871 | 0.4711 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0054 | 0.1204 | 0.6522 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0041 | 0.083 | 0.4155 |
Echinococcus granulosus | GPCR family 2 | 0.0062 | 0.1437 | 0.2694 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0054 | 0.1204 | 0.6541 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0015 | 0.01 | 0.0263 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0048 | 0.1018 | 0.1018 |
Brugia malayi | Methyltransferase-like protein 4 | 0.0015 | 0.0098 | 0.0098 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0015 | 0.01 | 0.0263 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0016 | 0.0116 | 0.0558 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.2497 | 0.2497 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.1746 | 0.9519 |
Echinococcus multilocularis | bloom syndrome protein | 0.0029 | 0.0484 | 0.0908 |
Brugia malayi | AMP-binding enzyme family protein | 0.0048 | 0.1018 | 0.1018 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0051 | 0.1114 | 0.6044 |
Giardia lamblia | Methyltransferase like 2 | 0.0015 | 0.0098 | 0.0336 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0363 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0056 | 0.1266 | 0.4162 |
Brugia malayi | AMP-binding enzyme family protein | 0.0016 | 0.0107 | 0.0107 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.2905 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1437 | 0.1437 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0377 | 0.9812 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0051 | 0.1114 | 0.6044 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.005 | 0.1069 | 0.5799 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.01 | 0.2497 | 0.8546 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.01 | 0.2497 | 0.8546 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0076 | 0.1833 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.2905 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.1746 | 0.9519 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0114 | 0.2905 | 0.2905 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0034 | 0.0621 | 0.3299 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0051 | 0.1114 | 0.581 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0013 | 0.0024 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0199 | 0.5333 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0377 | 0.1224 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.1746 | 0.3273 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0377 | 0.0377 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0025 | 0.0364 | 0.0683 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0034 | 0.0621 | 0.3299 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0054 | 0.1204 | 0.6541 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0377 | 0.0377 |
Chlamydia trachomatis | 3-oxoacyl-ACP synthase | 0.0013 | 0.0024 | 0.5 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0076 | 0.1833 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0019 | 0.0211 | 0.1206 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0013 | 0.0024 | 0.0024 |
Giardia lamblia | Kinase, PLK | 0.0114 | 0.2905 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0025 | 0.0364 | 0.0364 |
Echinococcus multilocularis | smad | 0.0025 | 0.0364 | 0.0683 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0114 | 0.2905 | 0.5447 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0025 | 0.0364 | 0.0683 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0029 | 0.0486 | 0.2593 |
Schistosoma mansoni | hypothetical protein | 0.0135 | 0.3499 | 0.656 |
Echinococcus granulosus | Smad4 | 0.0025 | 0.0364 | 0.0683 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 25.1189 uM | PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.