Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0194 | 0.2837 | 0.4678 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0031 | 0 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0175 | 0.2512 | 0.8857 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0194 | 0.2837 | 0.2837 |
Loa Loa (eye worm) | RNA binding protein | 0.0194 | 0.2837 | 0.2837 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.2512 | 0.4143 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0554 | 0.9123 | 0.9123 |
Brugia malayi | TAR-binding protein | 0.0194 | 0.2837 | 0.2837 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0031 | 0 | 0.5 |
Brugia malayi | Smad1 | 0.0041 | 0.0171 | 0.0171 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0175 | 0.2512 | 0.2512 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0041 | 0.0171 | 0.0171 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0554 | 0.9123 | 0.9123 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0031 | 0 | 0.5 |
Echinococcus multilocularis | Smad4 | 0.0041 | 0.0171 | 0.0603 |
Schistosoma mansoni | smad1 5 8 and | 0.0041 | 0.0171 | 0.0282 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0041 | 0.0171 | 0.0603 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0041 | 0.0171 | 0.0603 |
Schistosoma mansoni | smad1 5 8 and | 0.0041 | 0.0171 | 0.0282 |
Echinococcus granulosus | smad | 0.0041 | 0.0171 | 0.0603 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0604 | 1 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0041 | 0.0171 | 0.0171 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0041 | 0.0171 | 0.0603 |
Schistosoma mansoni | tar DNA-binding protein | 0.0194 | 0.2837 | 0.4678 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0175 | 0.2512 | 0.8857 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.2512 | 0.2512 |
Brugia malayi | MH2 domain containing protein | 0.0041 | 0.0171 | 0.0171 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.2512 | 0.4143 |
Schistosoma mansoni | Smad4 | 0.0041 | 0.0171 | 0.0282 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0175 | 0.2512 | 0.2512 |
Brugia malayi | RNA binding protein | 0.0194 | 0.2837 | 0.2837 |
Schistosoma mansoni | smad | 0.0041 | 0.0171 | 0.0282 |
Echinococcus multilocularis | GPCR, family 2 | 0.0175 | 0.2512 | 0.8857 |
Schistosoma mansoni | smad1 5 8 and | 0.0041 | 0.0171 | 0.0282 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0175 | 0.2512 | 0.8857 |
Brugia malayi | MH2 domain containing protein | 0.0041 | 0.0171 | 0.0171 |
Echinococcus multilocularis | tar DNA binding protein | 0.0194 | 0.2837 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0031 | 0 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | Smad1 | 0.0041 | 0.0171 | 0.0171 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.2512 | 0.4143 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0175 | 0.2512 | 0.2512 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0031 | 0 | 0.5 |
Echinococcus granulosus | Smad4 | 0.0041 | 0.0171 | 0.0603 |
Schistosoma mansoni | tar DNA-binding protein | 0.0194 | 0.2837 | 0.4678 |
Brugia malayi | MH1 domain containing protein | 0.0041 | 0.0171 | 0.0171 |
Loa Loa (eye worm) | TAR-binding protein | 0.0194 | 0.2837 | 0.2837 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0041 | 0.0171 | 0.0171 |
Loa Loa (eye worm) | hypothetical protein | 0.0379 | 0.6063 | 0.6063 |
Loa Loa (eye worm) | hypothetical protein | 0.0554 | 0.9123 | 0.9123 |
Schistosoma mansoni | hypothetical protein | 0.0379 | 0.6063 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0379 | 0.6063 | 0.6063 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0554 | 0.9123 | 0.9123 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0041 | 0.0171 | 0.0282 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0031 | 0 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0175 | 0.2512 | 0.8857 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0175 | 0.2512 | 0.8857 |
Schistosoma mansoni | tar DNA-binding protein | 0.0194 | 0.2837 | 0.4678 |
Schistosoma mansoni | tar DNA-binding protein | 0.0194 | 0.2837 | 0.4678 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0031 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0194 | 0.2837 | 1 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0604 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.2512 | 0.4143 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0194 | 0.2837 | 0.2837 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0041 | 0.0171 | 0.0603 |
Echinococcus multilocularis | smad | 0.0041 | 0.0171 | 0.0603 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.