Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | microtubule-associated protein tau | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | microtubule associated protein 2 | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Schistosoma japonicum | ko:K04380 microtubule-associated protein tau, putative | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Schistosoma mansoni | microtubule-associated protein tau | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Echinococcus multilocularis | microtubule associated protein 2 | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0229 | 0.215 | 0.2501 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.017 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0181 | 0.1516 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0181 | 0.1516 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0725 | 0.8594 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0229 | 0.215 | 0.215 |
Echinococcus granulosus | tar DNA binding protein | 0.053 | 0.6062 | 0.6062 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0229 | 0.215 | 0.215 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.053 | 0.6062 | 0.7054 |
Brugia malayi | TAR-binding protein | 0.053 | 0.6062 | 0.7054 |
Brugia malayi | RNA recognition motif domain containing protein | 0.053 | 0.6062 | 0.7054 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0077 | 0.017 | 0.112 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0077 | 0.017 | 0.112 |
Leishmania major | hypothetical protein, conserved | 0.0181 | 0.1516 | 1 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0081 | 0.022 | 0.022 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0833 | 1 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.017 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0229 | 0.215 | 0.2501 |
Brugia malayi | hypothetical protein | 0.0181 | 0.1516 | 0.1764 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.022 | 0.022 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.017 | 0.0198 |
Loa Loa (eye worm) | hypothetical protein | 0.0725 | 0.8594 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0492 | 0.5562 | 0.6471 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0181 | 0.1516 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0229 | 0.215 | 0.2501 |
Loa Loa (eye worm) | TAR-binding protein | 0.053 | 0.6062 | 0.7054 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0229 | 0.215 | 0.215 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.1516 | 0.1764 |
Brugia malayi | hypothetical protein | 0.0117 | 0.0683 | 0.0795 |
Schistosoma mansoni | hypothetical protein | 0.0229 | 0.215 | 0.215 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0181 | 0.1516 | 1 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0077 | 0.017 | 0.017 |
Brugia malayi | Probable ClpP-like protease | 0.0077 | 0.017 | 0.0198 |
Schistosoma mansoni | tar DNA-binding protein | 0.053 | 0.6062 | 0.6062 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0064 | 0 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0492 | 0.5562 | 0.6471 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0181 | 0.1516 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.053 | 0.6062 | 0.7054 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0077 | 0.017 | 0.112 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0081 | 0.022 | 0.022 |
Schistosoma mansoni | hypothetical protein | 0.0229 | 0.215 | 0.215 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.017 | 0.112 |
Echinococcus granulosus | GPCR family 2 | 0.0229 | 0.215 | 0.215 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.017 | 0.5 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.017 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.053 | 0.6062 | 0.6062 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0181 | 0.1516 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0229 | 0.215 | 0.215 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.017 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.053 | 0.6062 | 0.6062 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0725 | 0.8594 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0725 | 0.8594 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.053 | 0.6062 | 0.6062 |
Schistosoma mansoni | tar DNA-binding protein | 0.053 | 0.6062 | 0.6062 |
Schistosoma mansoni | hypothetical protein | 0.0229 | 0.215 | 0.215 |
Loa Loa (eye worm) | hypothetical protein | 0.0496 | 0.5611 | 0.6529 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0492 | 0.5562 | 0.6471 |
Echinococcus multilocularis | GPCR, family 2 | 0.0229 | 0.215 | 0.215 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0077 | 0.017 | 0.017 |
Schistosoma mansoni | hypothetical protein | 0.0229 | 0.215 | 0.215 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0181 | 0.1516 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0229 | 0.215 | 0.2501 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0496 | 0.5611 | 0.6529 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0833 | 1 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0077 | 0.017 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.053 | 0.6062 | 0.6062 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0077 | 0.017 | 0.017 |
Brugia malayi | RNA binding protein | 0.053 | 0.6062 | 0.7054 |
Schistosoma mansoni | hypothetical protein | 0.0496 | 0.5611 | 0.5611 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.017 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (binding) | = 4.4668 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.