Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 4, group A, member 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | smad | 0.0016 | 0.0168 | 0.0168 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0047 | 0.1391 | 0.1391 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.015 | 0.5439 | 0.5439 |
Schistosoma mansoni | tar DNA-binding protein | 0.0265 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0265 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0265 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0265 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0265 | 1 | 1 |
Echinococcus granulosus | Smad4 | 0.0016 | 0.0168 | 0.0168 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0049 | 0.1471 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0016 | 0.0168 | 0.0168 |
Brugia malayi | Smad1 | 0.0016 | 0.0168 | 0.0168 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0016 | 0.0168 | 0.0168 |
Echinococcus multilocularis | tar DNA binding protein | 0.0265 | 1 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0047 | 0.1391 | 0.1391 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0179 | 0.6606 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.015 | 0.5439 | 0.5439 |
Brugia malayi | MH2 domain containing protein | 0.0016 | 0.0168 | 0.0168 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0016 | 0.0168 | 0.0168 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.6606 | 0.6606 |
Schistosoma mansoni | Smad4 | 0.0016 | 0.0168 | 0.0168 |
Schistosoma mansoni | tar DNA-binding protein | 0.0265 | 1 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0016 | 0.0168 | 0.0168 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.1391 | 0.1391 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0047 | 0.1391 | 0.1391 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.5439 | 0.5439 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.1391 | 0.1391 |
Schistosoma mansoni | smad1 5 8 and | 0.0016 | 0.0168 | 0.0168 |
Schistosoma mansoni | hypothetical protein | 0.0102 | 0.3565 | 0.3565 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1471 | 0.1471 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0265 | 1 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0016 | 0.0168 | 0.0168 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0047 | 0.1391 | 0.1391 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0393 | 0.0393 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0016 | 0.0168 | 0.0168 |
Echinococcus granulosus | GPCR family 2 | 0.0047 | 0.1391 | 0.1391 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0047 | 0.1391 | 0.1391 |
Brugia malayi | MH1 domain containing protein | 0.0016 | 0.0168 | 0.0168 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0022 | 0.0393 | 0.0393 |
Loa Loa (eye worm) | RNA binding protein | 0.0265 | 1 | 1 |
Brugia malayi | N-terminal motif family protein | 0.0179 | 0.6606 | 0.6606 |
Loa Loa (eye worm) | Smad1 | 0.0016 | 0.0168 | 0.0168 |
Brugia malayi | hypothetical protein | 0.0049 | 0.1471 | 0.1471 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0241 | 0.9069 | 0.9069 |
Echinococcus granulosus | tar DNA binding protein | 0.0265 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0265 | 1 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0049 | 0.1471 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0265 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0049 | 0.1471 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.1391 | 0.1391 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0016 | 0.0168 | 0.0168 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.1391 | 0.1391 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.015 | 0.5439 | 0.5439 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0016 | 0.0168 | 0.0168 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0022 | 0.0393 | 0.0393 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0049 | 0.1471 | 0.5 |
Echinococcus multilocularis | Smad4 | 0.0016 | 0.0168 | 0.0168 |
Leishmania major | hypothetical protein, conserved | 0.0049 | 0.1471 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.3565 | 0.3565 |
Schistosoma mansoni | smad1 5 8 and | 0.0016 | 0.0168 | 0.0168 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0016 | 0.0168 | 0.0168 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0047 | 0.1391 | 0.1391 |
Echinococcus granulosus | smad | 0.0016 | 0.0168 | 0.0168 |
Brugia malayi | MH2 domain containing protein | 0.0241 | 0.9069 | 0.9069 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0049 | 0.1471 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0047 | 0.1391 | 0.1391 |
Echinococcus multilocularis | smad | 0.0016 | 0.0168 | 0.0168 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0047 | 0.1391 | 0.1391 |
Brugia malayi | hypothetical protein | 0.0032 | 0.0778 | 0.0778 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0016 | 0.0168 | 0.0168 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0049 | 0.1471 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0241 | 0.9069 | 0.9069 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0049 | 0.1471 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0102 | 0.3565 | 0.3565 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.1391 | 0.1391 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 4.95 um | PUBCHEM_BIOASSAY: Fluorescence Polarization Dose Response Assay for TR3-Based Bcl-B Inhibitors. (Class of assay: confirmatory) [Related pubchem assays: 1240, 748, 432 ] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.