Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | arginine vasopressin receptor 1B | Starlite/ChEMBL | No references |
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Homo sapiens | relaxin/insulin-like family peptide receptor 2 | Starlite/ChEMBL | No references |
Homo sapiens | relaxin/insulin-like family peptide receptor 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0.1209 | 0.5 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0175 | 0.0175 |
Echinococcus multilocularis | tar DNA binding protein | 0.0069 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.1209 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 1 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0027 | 0.1969 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0069 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.6681 | 0.6681 |
Brugia malayi | hypothetical protein | 0.0027 | 0.1969 | 0.1969 |
Loa Loa (eye worm) | TAR-binding protein | 0.0069 | 1 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0.1209 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.6681 | 0.6681 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0069 | 1 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.1209 | 0.1209 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0069 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0069 | 1 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0.1209 | 0.5 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0023 | 0.1209 | 0.1209 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.1969 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0027 | 0.1969 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.1969 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.1209 | 0.1209 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.6681 | 0.6681 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0.1209 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0023 | 0.1209 | 0.1209 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.1209 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0.1969 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.1209 | 0.1209 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0.1209 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.1969 | 0.1969 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0.1209 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0069 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.6681 | 0.6681 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.1969 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.3589 | 0.3589 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.3589 | 0.3589 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.3589 | 0.3589 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.1969 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0023 | 0.1209 | 0.1209 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0027 | 0.1969 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.2512 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.3245 uM | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1: RXFP2 Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2676, AID2703, AID489012] | ChEMBL. | No reference |
Potency (functional) | 17.3245 uM | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1: RXFP1 Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2676, AID2703, AID489043, AID492948] | ChEMBL. | No reference |
Potency (functional) | 19.4384 uM | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1: V1B Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2676, AID2703, AID489012] | ChEMBL. | No reference |
Potency (functional) | 19.4384 uM | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1: THP1 Hit Validation. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.