Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Human immunodeficiency virus 1 | Aberrant vpr protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | isocitrate dehydrogenase | 0.0069 | 0.0954 | 0.0954 |
Schistosoma mansoni | hypothetical protein | 0.0122 | 0.2468 | 0.2722 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.1044 | 0.1573 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0122 | 0.2468 | 0.2229 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0385 | 1 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.0304 | 0.0304 |
Loa Loa (eye worm) | hypothetical protein | 0.0263 | 0.6514 | 0.6403 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0069 | 0.0954 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0122 | 0.2468 | 0.2722 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0069 | 0.0954 | 0.1402 |
Echinococcus multilocularis | tar DNA binding protein | 0.0226 | 0.5442 | 1 |
Brugia malayi | Isocitrate dehydrogenase | 0.0069 | 0.0954 | 0.0954 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0069 | 0.0954 | 1 |
Brugia malayi | TAR-binding protein | 0.0226 | 0.5442 | 0.5442 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0226 | 0.5442 | 0.5298 |
Schistosoma mansoni | tar DNA-binding protein | 0.0226 | 0.5442 | 0.8073 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0122 | 0.2468 | 0.4301 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0069 | 0.0954 | 0.1402 |
Schistosoma mansoni | hypothetical protein | 0.0122 | 0.2468 | 0.2722 |
Echinococcus granulosus | tar DNA binding protein | 0.0226 | 0.5442 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0069 | 0.0954 | 0.1402 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0389 | 0.0084 |
Brugia malayi | Bromodomain containing protein | 0.0091 | 0.1572 | 0.1572 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.1167 | 0.0383 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0069 | 0.0954 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0069 | 0.0954 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0263 | 0.6514 | 0.6514 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0069 | 0.0954 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0455 | 0.0152 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0122 | 0.2468 | 0.2468 |
Loa Loa (eye worm) | hypothetical protein | 0.0385 | 1 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0122 | 0.2468 | 0.4301 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0122 | 0.2468 | 0.4301 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.2468 | 0.2229 |
Brugia malayi | RNA binding protein | 0.0226 | 0.5442 | 0.5442 |
Schistosoma mansoni | tar DNA-binding protein | 0.0226 | 0.5442 | 0.8073 |
Schistosoma mansoni | tar DNA-binding protein | 0.0226 | 0.5442 | 0.8073 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0385 | 1 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0069 | 0.0954 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0069 | 0.0954 | 0.1402 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.1424 | 0.1153 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0069 | 0.0954 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0226 | 0.5442 | 0.5298 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0069 | 0.0954 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0226 | 0.5442 | 0.8073 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0069 | 0.0954 | 0.1402 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0069 | 0.0954 | 0.1402 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0069 | 0.0954 | 0.0668 |
Schistosoma mansoni | hypothetical protein | 0.0122 | 0.2468 | 0.2722 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0122 | 0.2468 | 0.2468 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0122 | 0.2468 | 0.4301 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0069 | 0.0954 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0226 | 0.5442 | 0.5298 |
Brugia malayi | hypothetical protein | 0.0055 | 0.0559 | 0.0559 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0122 | 0.2468 | 0.4301 |
Schistosoma mansoni | hypothetical protein | 0.0263 | 0.6514 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0226 | 0.5442 | 0.5442 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.1044 | 0.1573 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0559 | 0.0261 |
Schistosoma mansoni | tar DNA-binding protein | 0.0226 | 0.5442 | 0.8073 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0069 | 0.0954 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0122 | 0.2468 | 0.4301 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 195 um | PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Confirmation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1). (Class of assay: confirmatory) [Related pubchem assays: 2118 (Project Summary), 2098 (Primary HTS)] | ChEMBL. | No reference |
Potency (functional) | 3.5481 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 7.3753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5878 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (binding) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.