Detailed information for compound 1425738

Basic information

Technical information
  • TDR Targets ID: 1425738
  • Name: 5-[[(2-methylphenyl)amino]methyl]quinolin-8-o l
  • MW: 264.322 | Formula: C17H16N2O
  • H donors: 2 H acceptors: 2 LogP: 3.68 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccccc1NCc1ccc(c2c1cccn2)O
  • InChi: 1S/C17H16N2O/c1-12-5-2-3-7-15(12)19-11-13-8-9-16(20)17-14(13)6-4-10-18-17/h2-10,19-20H,11H2,1H3
  • InChiKey: KQYZVYHKUWPULP-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 5-[[(2-methylphenyl)amino]methyl]-8-quinolinol
  • MLS000123699
  • SMR000124308
  • 5-(o-Tolylamino-methyl)-quinolin-8-ol
  • BAS 07529531
  • ZINC00809943

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens mannose phosphate isomerase Starlite/ChEMBL No references
Homo sapiens arachidonate 12-lipoxygenase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Cryptosporidium parvum mannose-6-phosphate isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum mannose-6-phosphate isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei phosphomannose isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Leishmania major phosphomannose isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K01809 mannose-6-phosphate isomerase [EC5.3.1.8], putative Get druggable targets OG5_127555 All targets in OG5_127555
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium berghei mannose-6-phosphate isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi phosphomannose isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) mannose-6-phosphate isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Leishmania donovani phosphomannose isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_127555 All targets in OG5_127555
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis phosphomannose isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis mannose-6-phosphate isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Babesia bovis phosphomannose isomerase type I family protein Get druggable targets OG5_127555 All targets in OG5_127555
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Theileria parva mannose-6-phosphate isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana phosphomannose isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii phosphomannose isomerase type I protein Get druggable targets OG5_127555 All targets in OG5_127555
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi mannose-6-phosphate isomerase, class I family protein Get druggable targets OG5_127555 All targets in OG5_127555
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium vivax mannose-6-phosphate isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Neospora caninum hypothetical protein Get druggable targets OG5_127555 All targets in OG5_127555
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) mannose-6-phosphate isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Plasmodium yoelii Phosphomannose isomerase type I, putative Get druggable targets OG5_127555 All targets in OG5_127555
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium leprae probable mannose-6-phosphate isomerase ManA (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) (PHOSPHOHEXOISOMERASE) (PHO Get druggable targets OG5_127555 All targets in OG5_127555
Brugia malayi mannose-6-phosphate isomerase, class I family protein Get druggable targets OG5_127555 All targets in OG5_127555
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum phosphomannose isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans mannose-6-phosphate isomerase ManA Get druggable targets OG5_127555 All targets in OG5_127555
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi phosphomannose isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable mannose-6-phosphate isomerase ManA (phosphomannose isomerase) (phosphomannoisomerase) (PMI) (phosphohexoisomerase) (pho Get druggable targets OG5_127555 All targets in OG5_127555
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis mannose 6 phosphate isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Entamoeba histolytica phosphomannose isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus mannose 6 phosphate isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium knowlesi mannose-6-phosphate isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans mannose-6-phosphate isomerase capable of functionally substituting for S. cerevisiae PMI40 (YER003C) Get druggable targets OG5_127555 All targets in OG5_127555
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense phosphomannose isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni mannose-6-phosphate isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei gambiense phosphomannose isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Candida albicans mannose-6-phosphate isomerase capable of functionally substituting for S. cerevisiae PMI40 (YER003C) Get druggable targets OG5_127555 All targets in OG5_127555
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Echinococcus granulosus arachidonate 5 lipoxygenase arachidonate 12-lipoxygenase 663 aa 662 aa 22.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0082 0.0537
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.003 0.0157
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0034 0.0082 0.0169
Loa Loa (eye worm) glutathione reductase 0.0057 0.0182 0.0177
Toxoplasma gondii NADPH-glutathione reductase 0.002 0.0022 0.001
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0887 0.3729 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0155 0.015
Trichomonas vaginalis glutathione reductase, putative 0.002 0.0022 0.0088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0346 0.0915
Schistosoma mansoni topbp1 0.0051 0.0155 0.0336
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0086 0.0081
Plasmodium vivax glutathione reductase, putative 0.0057 0.0182 0.044
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.002 0.0022 0.0031
Schistosoma mansoni smad 0.0072 0.0244 0.0535
Echinococcus multilocularis sentrin specific protease 1 0.0046 0.0136 0.035
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0887 0.3729 1
Schistosoma mansoni mannose-6-phosphate isomerase 0.0117 0.044 0.0973
Loa Loa (eye worm) hypothetical protein 0.0051 0.0155 0.015
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.0557 0.2225
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0887 0.3729 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.025 0.0548
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0022 0.0031
Trypanosoma brucei polo-like protein kinase 0.0114 0.0425 0.3478
Schistosoma mansoni tar DNA-binding protein 0.0725 0.3036 0.6785
Plasmodium falciparum ataxin-2 like protein, putative 0.0292 0.1188 0.3151
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0095 0.0206
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0139 0.05
Plasmodium falciparum thioredoxin reductase 0.002 0.0022 0.001
Loa Loa (eye worm) hypothetical protein 0.0047 0.0139 0.0134
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.004 0.0093
Schistosoma mansoni loxhd1 0.0024 0.004 0.0077
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.002 0.0022 0.001
Brugia malayi jmjC domain containing protein 0.0019 0.0019 0.0019
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0019 0.0031
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0067 0.0223 0.0584
Loa Loa (eye worm) transcription factor SMAD2 0.2354 1 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0491 0.2037 0.5455
Loa Loa (eye worm) Smad1 0.016 0.0623 0.0619
Schistosoma mansoni Smad4 0.0072 0.0244 0.0535
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0491 0.2037 0.5455
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0022 0.0031
Brugia malayi hypothetical protein 0.0024 0.004 0.004
Trypanosoma cruzi PAB1-binding protein , putative 0.0292 0.1188 1
Echinococcus granulosus lysine specific demethylase 5A 0.0073 0.025 0.0657
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.0425 0.1933
Brugia malayi mothers against decapentaplegic homolog 3 0.0072 0.0244 0.0244
Plasmodium falciparum glutathione reductase 0.0057 0.0182 0.044
Schistosoma mansoni rab6-interacting 0.0024 0.004 0.0077
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0887 0.3729 1
Plasmodium falciparum sentrin-specific protease 1 0.0046 0.0136 0.0315
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0034 0.0082 0.0169
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.1015 0.1011
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0117 0.044 0.044
Loa Loa (eye worm) MH1 domain-containing protein 0.0072 0.0244 0.0239
Loa Loa (eye worm) hypothetical protein 0.0024 0.004 0.0034
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.0557 0.1123
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.0425 0.0425
Plasmodium vivax SET domain protein, putative 0.0037 0.0095 0.0206
Schistosoma mansoni jumonji domain containing protein 0.0071 0.0241 0.0529
Brugia malayi MH1 domain containing protein 0.016 0.0623 0.0623
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.0495 0.1967
Chlamydia trachomatis DNA ligase 0.0051 0.0155 0.0359
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0019 0.0031
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0019 0.0014
Echinococcus granulosus replication factor c subunit 1 0.0051 0.0155 0.0403
Echinococcus granulosus smad 0.016 0.0623 0.166
Schistosoma mansoni hypothetical protein 0.0024 0.004 0.0077
Brugia malayi jmjC domain containing protein 0.0019 0.0019 0.0019
Plasmodium falciparum mannose-6-phosphate isomerase, putative 0.0117 0.044 0.1134
Trypanosoma cruzi hypothetical protein, conserved 0.0051 0.0155 0.1168
Brugia malayi Pre-SET motif family protein 0.0252 0.1015 0.1015
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0019 0.0037
Schistosoma mansoni hypothetical protein 0.0491 0.2037 0.4548
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0491 0.2037 0.5455
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0019 0.0014
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0297 0.2477
Brugia malayi Smad1 0.016 0.0623 0.0623
Onchocerca volvulus 0.0287 0.1164 0.5633
Mycobacterium leprae probable mannose-6-phosphate isomerase ManA (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) (PHOSPHOHEXOISOMERASE) (PHO 0.0064 0.021 0.0153
Brugia malayi hypothetical protein 0.0292 0.1188 0.1188
Loa Loa (eye worm) latrophilin receptor protein 2 0.0491 0.2037 0.2033
Brugia malayi hypothetical protein 0.0024 0.004 0.004
Echinococcus multilocularis RUN 0.0024 0.004 0.0093
Toxoplasma gondii ATPase, AAA family protein 0.0051 0.0155 0.0368
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0182 0.0475
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.003 0.0157
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.0022 0.0031
Brugia malayi hypothetical protein 0.0051 0.0155 0.0155
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0051 0.0155 0.1168
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0887 0.3729 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0491 0.2037 0.2037
Echinococcus granulosus mothers against decapentaplegic 5 0.016 0.0623 0.166
Schistosoma mansoni hypothetical protein 0.1061 0.4473 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0034 0.0082 0.0171
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.0425 0.9529
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0346 0.0763
Onchocerca volvulus 0.0035 0.0086 0.0233
Brugia malayi MH2 domain containing protein 0.0072 0.0244 0.0244
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0095 0.0201
Brugia malayi hypothetical protein 0.0075 0.0256 0.0256
Plasmodium vivax sentrin-specific protease 1, putative 0.0046 0.0136 0.0315
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0014
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0022 0.0031
Brugia malayi topoisomerase 0.0051 0.0155 0.0155
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0425 0.3588
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.025 0.0245
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0051 0.0155 0.1168
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.1552 0.6571 0.6571
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0887 0.3729 1
Echinococcus granulosus peptidase Clp S14 family 0.0581 0.2423 0.6492
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0251 0.0551
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0887 0.3729 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.0346 0.0341
Echinococcus granulosus mothers against decapentaplegic 6 0.0072 0.0244 0.0642
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0046 0.0136 0.0136
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0034 0.0082 0.0205
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.003 0.0157
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0019 0.0037
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0241 0.0634
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0051 0.0155 0.0368
Schistosoma mansoni hypothetical protein 0.0491 0.2037 0.4548
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0015 0.0021
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.0425 0.3478
Echinococcus granulosus mannose 6 phosphate isomerase 0.0117 0.044 0.1167
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0022 0.0031
Echinococcus multilocularis peptidase Clp (S14 family) 0.0581 0.2423 0.6492
Schistosoma mansoni DNA ligase IV 0.0051 0.0155 0.0336
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0887 0.3729 1
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.0297 0.0292
Echinococcus granulosus nibrin 0.0051 0.0155 0.0403
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.0557 0.2225
Brugia malayi jmjC domain containing protein 0.0019 0.0019 0.0019
Loa Loa (eye worm) doublecortin family protein 0.0024 0.004 0.0034
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0491 0.2037 0.5455
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.0346 0.0346
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0179 0.145
Loa Loa (eye worm) hypothetical protein 0.0051 0.0155 0.015
Trypanosoma cruzi PAB1-binding protein , putative 0.0292 0.1188 1
Loa Loa (eye worm) hypothetical protein 0.0887 0.3729 0.3726
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0251 0.0551
Brugia malayi jmjC domain containing protein 0.0019 0.0019 0.0019
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.0557 0.2225
Brugia malayi Thioredoxin reductase 0.0057 0.0182 0.0182
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0095 0.0242
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0082 0.0169
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0034 0.0082 0.0205
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0425 0.3588
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0046 0.0136 0.1071
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0081 0.0593
Brugia malayi Pax transcription activation domain interacting protein 0.0051 0.0155 0.0155
Schistosoma mansoni smad1 5 8 and 0.016 0.0623 0.1384
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.002 0.0022 0.001
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.0241 0.0634
Schistosoma mansoni hypothetical protein 0.0491 0.2037 0.4548
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0082 0.0537
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0155 0.1237
Echinococcus multilocularis chromobox protein 1 0.0084 0.0297 0.0785
Plasmodium vivax replication factor C subunit 1, putative 0.0051 0.0155 0.0368
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0051 0.0155 0.1243
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0081 0.0593
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0251 0.0617
Brugia malayi jmjC domain containing protein 0.0073 0.025 0.025
Schistosoma mansoni tar DNA-binding protein 0.0725 0.3036 0.6785
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0182 0.0177
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0095 0.0201
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0346 0.0915
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0581 0.2423 0.6345
Entamoeba histolytica hypothetical protein 0.0075 0.0256 0.3973
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0155 0.1243
Brugia malayi Pre-SET motif family protein 0.0037 0.0095 0.0095
Brugia malayi hypothetical protein 0.0491 0.2035 0.2035
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0182 0.044
Trypanosoma cruzi phosphomannose isomerase, putative 0.0117 0.044 0.3601
Brugia malayi CXXC zinc finger family protein 0.0035 0.0086 0.0086
Plasmodium falciparum glutathione reductase 0.002 0.0022 0.001
Mycobacterium tuberculosis Probable reductase 0.013 0.0495 0.1967
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.003 0.0157
Trypanosoma cruzi phosphomannose isomerase, putative 0.0117 0.044 0.3601
Loa Loa (eye worm) hypothetical protein 0.0046 0.0136 0.0131
Brugia malayi glutathione reductase 0.0057 0.0182 0.0182
Echinococcus multilocularis isocitrate dehydrogenase 0.0034 0.0082 0.0205
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.004 0.0056
Brugia malayi TAR-binding protein 0.0725 0.3036 0.3036
Brugia malayi isocitrate dehydrogenase 0.0034 0.0082 0.0082
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0046 0.0136 0.0315
Toxoplasma gondii LsmAD domain-containing protein 0.0292 0.1188 0.3151
Schistosoma mansoni TGF-beta signal transducer Smad2 0.016 0.0623 0.1384
Echinococcus multilocularis smad 0.016 0.0623 0.166
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0182 0.1395
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0051 0.0155 0.065
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0139 0.1104
Loa Loa (eye worm) isocitrate dehydrogenase 0.0034 0.0082 0.0076
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0082 0.0169
Schistosoma mansoni cpg binding protein 0.0037 0.0095 0.02
Schistosoma mansoni polycystin 1-related 0.0024 0.004 0.0077
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.003 0.0157
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0182 0.0475
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0251 0.1988
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.0495 0.1967
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.0425 0.1128
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.0425 0.042
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0014
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0179 0.145
Mycobacterium ulcerans mannose-6-phosphate isomerase ManA 0.0117 0.044 0.1126
Schistosoma mansoni rab6-interacting 0.0024 0.004 0.0077
Echinococcus multilocularis mothers against decapentaplegic 2 0.0072 0.0244 0.0642
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0306 0.1244 0.3296
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0034 0.0082 0.0537
Brugia malayi MH1 domain containing protein 0.0089 0.0317 0.0317
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0155 0.0577
Schistosoma mansoni tar DNA-binding protein 0.0725 0.3036 0.6785
Brugia malayi Isocitrate dehydrogenase 0.0034 0.0082 0.0082
Brugia malayi jmjC domain containing protein 0.0071 0.0241 0.0241
Onchocerca volvulus 0.0491 0.2035 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.004 0.0093
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0082 0.0205
Trichomonas vaginalis replication factor C large subunit, putative 0.0051 0.0155 0.1243
Loa Loa (eye worm) hypothetical protein 0.0491 0.2035 0.2031
Toxoplasma gondii phosphomannose isomerase type I protein 0.0117 0.044 0.1134
Schistosoma mansoni Smad4 0.0072 0.0244 0.0535
Loa Loa (eye worm) MH2 domain-containing protein 0.016 0.0623 0.0619
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0034 0.0082 0.0246
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0155 0.1243
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.002 0.0022 0.0031
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0346 0.0763
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.0027 0.0059
Echinococcus multilocularis GPCR, family 2 0.0491 0.2037 0.5455
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0022 0.0031
Loa Loa (eye worm) MH2 domain-containing protein 0.0072 0.0244 0.0239
Entamoeba histolytica hypothetical protein 0.0075 0.0256 0.3973
Leishmania major hypothetical protein, conserved 0.0292 0.1188 1
Loa Loa (eye worm) hypothetical protein 0.1061 0.4473 0.447
Schistosoma mansoni topbp1 0.0051 0.0155 0.0336
Echinococcus granulosus GPCR family 2 0.0491 0.2037 0.5455
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0887 0.3729 1
Brugia malayi latrophilin 2 splice variant baaae 0.1061 0.4473 0.4473
Echinococcus granulosus phd:f box containing protein 0.0019 0.0019 0.0037
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.0027 0.0059
Schistosoma mansoni cpg binding protein 0.0035 0.0086 0.0181
Echinococcus multilocularis mothers against decapentaplegic 6 0.0072 0.0244 0.0642
Brugia malayi Latrophilin receptor protein 2 0.0491 0.2037 0.2037
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0425 0.3588
Brugia malayi MH1 domain containing protein 0.0089 0.0317 0.0317
Onchocerca volvulus 0.0051 0.0155 0.058
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0425 0.3588
Brugia malayi Doublecortin family protein 0.0024 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0024 0.004 0.0034
Trypanosoma brucei trypanothione reductase 0.0057 0.0182 0.1395
Brugia malayi Probable ClpP-like protease 0.0887 0.3729 0.3729
Entamoeba histolytica hypothetical protein 0.0075 0.0256 0.3973
Echinococcus multilocularis mothers against decapentaplegic 5 0.016 0.0623 0.166
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.0425 0.1128
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.002 0.0022 0.001
Schistosoma mansoni chromobox protein 0.0084 0.0297 0.0654
Echinococcus granulosus mothers against decapentaplegic 2 0.0072 0.0244 0.0642
Echinococcus granulosus TGF beta signal transducer SmadC 0.016 0.0623 0.166
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.002 0.0022 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0051 0.0155 0.1168
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0019 0.0037
Schistosoma mansoni chromobox protein 0.0084 0.0297 0.0654
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.003 0.0157
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0425 0.0941
Trichomonas vaginalis set domain proteins, putative 0.0287 0.1164 1
Trypanosoma cruzi FHA domain containing protein, putative 0.0051 0.0155 0.1168
Loa Loa (eye worm) nuclear factor I 0.0089 0.0317 0.0312
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.003 0.0157
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0155 0.1237
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0095 0.0242
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0306 0.1244 0.3302
Echinococcus granulosus chromobox protein 1 0.0084 0.0297 0.0785
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0425 0.3588
Brugia malayi DKFZp564C0469 protein 0.0051 0.0155 0.0155
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0581 0.2423 1
Echinococcus granulosus RUN 0.0024 0.004 0.0093
Loa Loa (eye worm) MH1 domain-containing protein 0.016 0.0623 0.0619
Loa Loa (eye worm) hypothetical protein 0.0051 0.0155 0.015
Brugia malayi RNA binding protein 0.0725 0.3036 0.3036
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0022 0.0031
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0224 0.0554
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0022 0.0039
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.0425 0.3478
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0086 0.0218
Brugia malayi MH2 domain containing protein 0.016 0.0623 0.0623
Echinococcus multilocularis TGF beta signal transducer SmadC 0.016 0.0623 0.166
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0251 0.0661
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0014
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0051 0.0155 0.0359
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0051 0.0155 0.1243
Schistosoma mansoni Smad4 0.016 0.0623 0.1384
Brugia malayi MH2 domain containing protein 0.016 0.0623 0.0623
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0051 0.0155 0.1243
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.004 0.0093
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0581 0.2423 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0306 0.1244 0.3302
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0022 0.0046
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0022 0.0022
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.0241 0.0634
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1552 0.6571 0.657
Toxoplasma gondii thioredoxin reductase 0.0057 0.0182 0.044
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.004 0.0093
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0046 0.0136 0.0292
Schistosoma mansoni smad 0.016 0.0623 0.1384
Echinococcus multilocularis cpg binding protein 0.0037 0.0095 0.024
Schistosoma mansoni lipoxygenase 0.0024 0.004 0.0077
Leishmania major acetoin dehydrogenase e3 component-like protein 0.002 0.0022 0.0031
Trichomonas vaginalis mannose-6-phosphate isomerase, putative 0.0117 0.044 0.3712
Loa Loa (eye worm) TAR-binding protein 0.0725 0.3036 0.3033
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0022 0.0031
Plasmodium falciparum replication factor C subunit 1, putative 0.0051 0.0155 0.0368
Loa Loa (eye worm) hypothetical protein 0.0491 0.2037 0.2033
Echinococcus granulosus cpg binding protein 0.0037 0.0095 0.024
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0019 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0155 0.1243
Schistosoma mansoni tar DNA-binding protein 0.0725 0.3036 0.6785
Plasmodium vivax mannose-6-phosphate isomerase, putative 0.0117 0.044 0.1134
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0725 0.3036 0.3033
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0067 0.0223 0.0584
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0131 0.0499 0.1325
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0022 0.0031
Leishmania major trypanothione reductase 0.0057 0.0182 0.1395
Brugia malayi hypothetical protein 0.0189 0.0745 0.0745
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0082 0.0537
Echinococcus multilocularis nibrin 0.0051 0.0155 0.0403
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0082 0.0205
Trypanosoma brucei phosphomannose isomerase 0.0117 0.044 0.3601
Echinococcus multilocularis replication factor c subunit 1 0.0051 0.0155 0.0403
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0306 0.1244 0.3046
Schistosoma mansoni smad1 5 8 and 0.016 0.0623 0.1384
Entamoeba histolytica hypothetical protein 0.0051 0.0155 0.065
Schistosoma mansoni smad1 5 8 and 0.016 0.0623 0.1384
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0034 0.0082 0.0537
Brugia malayi chromobox protein homolog 3 0.0047 0.0139 0.0139
Brugia malayi RNA recognition motif domain containing protein 0.0725 0.3036 0.3036
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0117 0.044 0.044
Echinococcus multilocularis mannose 6 phosphate isomerase 0.0117 0.044 0.1167
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0251 0.0953
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0256 0.0562
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0051 0.0155 0.0359
Loa Loa (eye worm) hypothetical protein 0.0089 0.0317 0.0312
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0256 0.0675
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.002 0.0022 0.001
Trichomonas vaginalis mercuric reductase, putative 0.002 0.0022 0.0088
Brugia malayi MH1 domain containing protein 0.016 0.0623 0.0623
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0019 0.0037
Loa Loa (eye worm) hypothetical protein 0.0292 0.1188 0.1183
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.0258 0.0566
Echinococcus granulosus chromobox protein 1 0.0084 0.0297 0.0785
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.004 0.0093
Onchocerca volvulus 0.0037 0.0096 0.0282
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0117 0.044 0.0435
Brugia malayi Heterochromatin protein 1 0.0084 0.0297 0.0297
Brugia malayi Calcitonin receptor-like protein seb-1 0.1552 0.6571 0.6571
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0887 0.3729 1
Schistosoma mansoni kinase 0.0058 0.0186 0.0404
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0346 0.0915
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0019 0.0031
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0022 0.0031
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0346 0.0915
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0251 0.0626
Plasmodium falciparum ataxin-2 like protein, putative 0.0292 0.1188 0.3151
Echinococcus multilocularis tar DNA binding protein 0.0725 0.3036 0.8139
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0887 0.3729 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0887 0.3729 1
Schistosoma mansoni cpg binding protein 0.0037 0.0095 0.02
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.025 0.0548
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0095 0.0201
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0022 0.0031
Mycobacterium tuberculosis Probable mannose-6-phosphate isomerase ManA (phosphomannose isomerase) (phosphomannoisomerase) (PMI) (phosphohexoisomerase) (pho 0.0064 0.021 0.0781
Loa Loa (eye worm) hypothetical protein 0.1552 0.6571 0.657
Plasmodium vivax ataxin-2 like protein, putative 0.0292 0.1188 0.3151
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0251 0.0617
Giardia lamblia Kinase, PLK 0.0114 0.0425 1
Schistosoma mansoni hypothetical protein 0.0491 0.2037 0.4548
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0251 0.0661
Echinococcus multilocularis Smad4 0.016 0.0623 0.166
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.0495 0.0949
Echinococcus granulosus Smad4 0.016 0.0623 0.166
Loa Loa (eye worm) hypothetical protein 0.0037 0.0095 0.009
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0019 0.0037
Onchocerca volvulus 0.0051 0.0154 0.0573
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0019 0.0037
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0425 0.3588
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0346 0.0763
Brugia malayi CHD4 protein 0.0016 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0155 0.1243
Entamoeba histolytica phosphomannose isomerase, putative 0.0117 0.044 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0131 0.0499 0.1325
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0117 0.044 0.0435
Schistosoma mansoni tar DNA-binding protein 0.0725 0.3036 0.6785
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0019 0.0037
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0022 0.0046
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.002 0.0022 0.0031
Brugia malayi SET domain containing protein 0.0016 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0051 0.0155 0.015
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0251 0.0617
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0887 0.3729 1
Plasmodium falciparum thioredoxin reductase 0.0057 0.0182 0.044
Loa Loa (eye worm) hypothetical protein 0.0072 0.0244 0.0239
Schistosoma mansoni chromosome transmission fidelity factor 0.0051 0.0155 0.0336
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0082 0.0205
Schistosoma mansoni hypothetical protein 0.0131 0.0499 0.1104
Echinococcus granulosus sentrin specific protease 1 0.0046 0.0136 0.035
Schistosoma mansoni hypothetical protein 0.0075 0.0256 0.0562
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0051 0.0154 0.0333
Leishmania major phosphomannose isomerase 0.0117 0.044 0.3601
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.0425 0.3478
Treponema pallidum DNA ligase (lig) 0.0051 0.0155 0.0359
Loa Loa (eye worm) hypothetical protein 0.0051 0.0155 0.015
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0095 0.0242
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0182 0.0664
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0072 0.0244 0.1026
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.0495 0.1967
Loa Loa (eye worm) MH2 domain-containing protein 0.2354 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0155 0.1243
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.004 0.0056
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0022 0.0031
Schistosoma mansoni peptidase Clp (S14 family) 0.0887 0.3729 0.8337
Entamoeba histolytica mannose-6-phosphate isomerase, putative 0.0054 0.0168 0.1054
Loa Loa (eye worm) hypothetical protein 0.0037 0.0096 0.0091
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0046 0.0136 0.0292
Schistosoma mansoni lipoxygenase 0.0067 0.0223 0.0487
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0051 0.0155 0.0155
Entamoeba histolytica hypothetical protein 0.0075 0.0256 0.3973
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0256 0.0675
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.003 0.0157
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0051 0.0155 0.1243
Loa Loa (eye worm) RNA binding protein 0.0725 0.3036 0.3033
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.0495 0.1967
Echinococcus granulosus tar DNA binding protein 0.0725 0.3036 0.8139
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0297 0.2477
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.0495 0.1967
Giardia lamblia Replication factor C, subunit 1 0.0051 0.0155 0.3299
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0019 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0015 0.0021
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0019 0.0031
Echinococcus multilocularis chromobox protein 1 0.0084 0.0297 0.0785
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0139 0.1104
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0425 0.3588
Brugia malayi hypothetical protein 0.0051 0.0155 0.0155
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.004 0.0093
Toxoplasma gondii hypothetical protein 0.0306 0.1244 0.3302
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0022 0.0031
Trypanosoma brucei PAB1-binding protein , putative 0.0292 0.1188 1

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) = 0 % Cytotoxicity against human LNCAP cells assessed as growth inhibition at 10 uM after 72 hrs by MTT assay ChEMBL. 23445471
IC50 (binding) = 11.502 um PUBCHEM_BIOASSAY: HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay using a high concentration of mannose 6-phosphate. (Class of assay: confirmatory) [Related pubchem assays: 1209 ] ChEMBL. No reference
IC50 (binding) = 12.547 um PUBCHEM_BIOASSAY: HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay. (Class of assay: confirmatory) [Related pubchem assays: 1220 ] ChEMBL. No reference
IC50 (binding) > 20 uM Inhibition of HIV-1 integrase strand transfer activity ChEMBL. 23445471
IC50 (binding) > 20 uM Inhibition of HIV-1 integrase 3'-processing activity ChEMBL. 23445471
Potency (functional) 0.631 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 1.122 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 1.2589 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) = 1.4125 um PUBCHEM_BIOASSAY: Confirmation qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) [Related pubchem assays: 2147 (qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E)), 2421 (Probe Summary for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E))] ChEMBL. No reference
Potency (functional) 2.9935 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 5.8048 uM PubChem BioAssay. qHTS for Inhibitors of TGF-b: CCL64 Cells Orthogonal Assay for Cherry Picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 12-hLO (12-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. qHTS for Inhibitors of TGF-b: Confirmation of Cherry Picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (binding) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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