Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.007 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.007 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.007 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.6045 | 0.6045 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.007 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.3247 | 0.3247 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.3247 | 0.3247 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.3247 | 0.3247 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.007 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.007 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.007 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.6045 | 0.6045 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.6045 | 0.6045 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.6045 | 0.6045 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.