Detailed information for compound 1425763

Basic information

Technical information
  • TDR Targets ID: 1425763
  • Name: N-[[3-(2-chlorophenyl)-1-(4-methoxyphenyl)pyr azol-4-yl]methyl]-3-imidazol-1-ylpropan-1-ami ne
  • MW: 421.923 | Formula: C23H24ClN5O
  • H donors: 1 H acceptors: 2 LogP: 3.6 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)n1cc(c(n1)c1ccccc1Cl)CNCCCn1ccnc1
  • InChi: 1S/C23H24ClN5O/c1-30-20-9-7-19(8-10-20)29-16-18(15-25-11-4-13-28-14-12-26-17-28)23(27-29)21-5-2-3-6-22(21)24/h2-3,5-10,12,14,16-17,25H,4,11,13,15H2,1H3
  • InChiKey: XQPZUGBRDVZFDJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[[3-(2-chlorophenyl)-1-(4-methoxyphenyl)pyrazol-4-yl]methyl]-3-imidazol-1-yl-propan-1-amine
  • N-[[3-(2-chlorophenyl)-1-(4-methoxyphenyl)-4-pyrazolyl]methyl]-3-(1-imidazolyl)propan-1-amine
  • [3-(2-chlorophenyl)-1-(4-methoxyphenyl)pyrazol-4-yl]methyl-(3-imidazol-1-ylpropyl)amine
  • MLS000734282
  • N-{[3-(2-chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-4-yl]methyl}-3-(1H-imidazol-1-yl)propan-1-amine
  • SMR000317286

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens snurportin 1 No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus protein TFG 0.0039 0.0043 0.0041
Trichomonas vaginalis glucosylceramidase, putative 0.0732 0.2873 0.683
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0293 0.1081 0.1079
Loa Loa (eye worm) thioredoxin reductase 0.0095 0.0273 0.03
Echinococcus granulosus mixed lineage leukemia protein mll 0.0047 0.0075 0.0073
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0144 0.0472 0.047
Giardia lamblia Cathepsin L precursor 0.0051 0.0093 0.0767
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0051 0.0093 0.0093
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0085 0.0232 0.0858
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0093 0.0221
Loa Loa (eye worm) TK/EGFR protein kinase 0.224 0.9027 1
Toxoplasma gondii thioredoxin reductase 0.0095 0.0273 0.209
Trypanosoma cruzi cysteine peptidase, putative 0.0157 0.0525 0.1772
Trypanosoma brucei heat shock protein, putative 0.009 0.0254 0.2571
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0033 0.002 0.013
Trypanosoma cruzi heat shock protein, putative 0.006 0.013 0.0439
Trichomonas vaginalis glucosylceramidase, putative 0.1059 0.4206 1
Plasmodium falciparum thioredoxin reductase 0.0033 0.002 0.0152
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0157 0.0525 0.534
Echinococcus granulosus roundabout 2 0.0047 0.0076 0.0074
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0108 0.0257
Toxoplasma gondii AGC kinase 0.0055 0.0108 0.0815
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0079 0.0076
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0051 0.0093 0.0726
Loa Loa (eye worm) jmjC domain-containing protein 0.0126 0.0399 0.0439
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0268 0.098 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0016 0.0016
Plasmodium vivax vivapain-1 0.0104 0.0307 0.2377
Toxoplasma gondii heat shock protein 75, putative 0.006 0.013 0.0985
Brugia malayi Bromodomain containing protein 0.0157 0.0525 0.0579
Schistosoma mansoni rac gtpase activating protein 0.0039 0.0043 0.0043
Brugia malayi cathepsin Z-like cysteine proteinase 0.0051 0.0093 0.0101
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0111 0.0339 0.0806
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.014 0.0456 0.1084
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0241 0.087 0.3302
Loa Loa (eye worm) hypothetical protein 0.0051 0.0093 0.0101
Echinococcus granulosus cathepsin L cysteine proteinase 0.0111 0.0339 0.0337
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0088 0.0686
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0145 0.0142
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0217 0.0771 0.3006
Brugia malayi Hsp90 protein 0.006 0.013 0.0142
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0111 0.0339 0.2643
Entamoeba histolytica cysteine protease, putative 0.0051 0.0093 0.0749
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0088 0.0297
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.002 0.0197
Echinococcus granulosus Diacylglycerol kinase theta 0.0039 0.0043 0.0041
Entamoeba histolytica protein kinase, putative 0.0055 0.0108 0.0871
Brugia malayi Endoplasmin precursor 0.009 0.0254 0.0279
Schistosoma mansoni microtubule-associated protein tau 0.0667 0.2605 0.2605
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.003 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0029 0.0003 0.0001
Onchocerca volvulus Matrilysin homolog 0.0075 0.0191 0.066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.0339 0.0806
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0005 0.0012
Entamoeba histolytica protein kinase, putative 0.0055 0.0108 0.0871
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0027 0.0025
Trypanosoma brucei cysteine peptidase C (CPC) 0.0268 0.098 1
Giardia lamblia Cathepsin B precursor 0.0268 0.098 1
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0046 0.0109
Onchocerca volvulus Cathepsin L homolog 0.0111 0.0339 0.1192
Entamoeba histolytica cysteine protease, putative 0.0051 0.0093 0.0749
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0647 0.2526 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.0339 0.0806
Brugia malayi mbt repeat family protein 0.0047 0.0079 0.0085
Entamoeba histolytica cysteine proteinase, putative 0.0111 0.0339 0.2727
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0016 0.0016
Leishmania major heat shock protein 83-1 0.009 0.0254 0.2591
Entamoeba histolytica cysteine proteinase, putative 0.0104 0.0307 0.247
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0093 0.0265 0.2026
Loa Loa (eye worm) hypothetical protein 0.0039 0.0043 0.0045
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0031 0.0059
Schistosoma mansoni hypothetical protein 0.0039 0.0043 0.0043
Toxoplasma gondii histone lysine methyltransferase SET1 0.0346 0.1297 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0217 0.0771 0.3006
Schistosoma mansoni zinc finger protein 0.0061 0.0135 0.0135
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0016 0.0138
Loa Loa (eye worm) hypothetical protein 0.0036 0.0031 0.0032
Echinococcus granulosus jumonji domain containing protein 0.0125 0.0393 0.0391
Plasmodium vivax unspecified product 0.0104 0.0307 0.2377
Trypanosoma cruzi major cysteine proteinase, putative 0.0096 0.0279 0.094
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.002 0.0129
Schistosoma mansoni tyrosine kinase 0.1207 0.4808 0.4808
Echinococcus granulosus muscleblind protein 0.0149 0.0491 0.0489
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0111 0.0339 0.0806
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0057 0.0118 0.0116
Echinococcus granulosus histone acetyltransferase KAT2B 0.0052 0.0097 0.0094
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0051 0.0093 0.0726
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0081 0.0648
Echinococcus multilocularis cysteine protease 0.0111 0.0339 0.0337
Brugia malayi p70 ribosomal S6 kinase beta 0.0055 0.0108 0.0117
Schistosoma mansoni protein kinase C 0.0039 0.0043 0.0043
Brugia malayi Cathepsin L-like precursor 0.0052 0.0099 0.0107
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0031 0.0221
Entamoeba histolytica protein kinase, putative 0.0055 0.0108 0.0871
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.002 0.0065
Echinococcus multilocularis endoplasmin 0.0085 0.0232 0.0229
Echinococcus granulosus jumonji domain containing 1A 0.0029 0.0003 0.0001
Leishmania major cathepsin L-like protease 0.0157 0.0525 0.5352
Echinococcus multilocularis PHD finger protein rhinoceros 0.0089 0.025 0.0248
Plasmodium falciparum heat shock protein 90, putative 0.0343 0.1284 1
Entamoeba histolytica cysteine protease, putative 0.0051 0.0093 0.0749
Plasmodium falciparum serine repeat antigen 6 0.0051 0.0093 0.0726
Giardia lamblia Cathepsin B precursor 0.0051 0.0093 0.0767
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0051 0.0093 0.0101
Echinococcus granulosus importin subunit beta 1 0.0035 0.0027 0.0025
Echinococcus granulosus zinc finger protein 0.0092 0.026 0.0257
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.002 0.0197
Echinococcus multilocularis cysteine protease 0.0111 0.0339 0.0337
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0093 0.0221
Schistosoma mansoni bromodomain containing protein 0.0267 0.0973 0.0973
Loa Loa (eye worm) TK/INSR protein kinase 0.072 0.2823 0.3126
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0051 0.0092 0.0217
Brugia malayi cathepsin L precursor 0.0051 0.0093 0.0101
Plasmodium vivax vivapain-2 0.0111 0.0339 0.2627
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0108 0.0257
Trypanosoma cruzi cysteine protease, putative 0.0104 0.0307 0.1037
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0055 0.0108 0.0117
Entamoeba histolytica cysteine protease, putative 0.0104 0.0307 0.247
Brugia malayi cathepsin L-like cysteine proteinase 0.0051 0.0093 0.0101
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0111 0.0339 0.0374
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0077 0.0201 0.0199
Echinococcus multilocularis chromobox protein 1 0.0068 0.0164 0.0161
Onchocerca volvulus Matrilysin homolog 0.0034 0.0023 0.0056
Schistosoma mansoni jumonji/arid domain-containing protein 0.0126 0.0399 0.0399
Entamoeba histolytica cysteine proteinase 1, putative 0.0104 0.0307 0.247
Giardia lamblia Cysteine protease 0.0051 0.0093 0.0767
Echinococcus multilocularis lysine specific demethylase 5A 0.0108 0.0327 0.0325
Loa Loa (eye worm) fibroinase 0.0111 0.0339 0.0374
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0046 0.0109
Toxoplasma gondii preprocathepsin c precursor, putative 0.0051 0.0093 0.0699
Entamoeba histolytica hypothetical protein 0.0037 0.0037 0.0294
Schistosoma mansoni endoplasmin 0.009 0.0254 0.0254
Leishmania major heat shock protein 83-1 0.009 0.0254 0.2591
Leishmania major heat shock protein 83-1 0.009 0.0254 0.2591
Entamoeba histolytica cysteine proteinase, putative 0.0111 0.0339 0.2727
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.014 0.0456 0.1084
Schistosoma mansoni chromobox protein 0.0068 0.0164 0.0164
Echinococcus granulosus protein kinase c eta type 0.0039 0.0043 0.0041
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0041 0.0053 0.0147
Brugia malayi hypothetical protein 0.0032 0.0016 0.0015
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0033 0.002 0.0197
Schistosoma mansoni hypothetical protein 0.0138 0.0446 0.0446
Echinococcus granulosus chromobox protein 1 0.0068 0.0164 0.0161
Loa Loa (eye worm) PHD-finger family protein 0.0083 0.0222 0.0243
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0105 0.0103
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.0339 0.0806
Brugia malayi mbt repeat family protein 0.0047 0.0079 0.0085
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0051 0.0093 0.0706
Brugia malayi RhoGEF domain containing protein 0.0039 0.0043 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0093 0.0221
Echinococcus multilocularis fetal alzheimer antigen, falz 0.01 0.0294 0.0291
Trichomonas vaginalis glucosylceramidase, putative 0.0695 0.272 0.6467
Loa Loa (eye worm) jmjC domain-containing protein 0.0185 0.0639 0.0705
Loa Loa (eye worm) hypothetical protein 0.0051 0.0093 0.0101
Echinococcus multilocularis Immunoglobulin 0.003 0.0006 0.0003
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0104 0.0307 0.1037
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0004
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0154 0.0512 0.0512
Trypanosoma cruzi cysteine proteinase, putative 0.0104 0.0307 0.1037
Brugia malayi PHD-finger family protein 0.0089 0.025 0.0275
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0217 0.0771 0.2902
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0016 0.0054
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0003 0.0001
Trypanosoma cruzi cysteine proteinase, putative 0.0104 0.0307 0.1037
Echinococcus multilocularis serine:threonine protein kinase N2 0.0055 0.0108 0.0106
Schistosoma mansoni hypothetical protein 0.0064 0.0145 0.0145
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0081 0.0087
Plasmodium vivax unspecified product 0.0052 0.0099 0.0752
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.008 0.0213 0.0213
Echinococcus granulosus geminin 0.1359 0.5431 0.543
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0016 0.0014
Loa Loa (eye worm) TK/FAK protein kinase 0.0828 0.3264 0.3614
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.0339 0.0806
Echinococcus granulosus raf serine:threonine protein kinase 0.0057 0.0119 0.0117
Trypanosoma cruzi heat shock protein 90, putative 0.0077 0.0201 0.0677
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0142 0.014
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0081 0.0244
Loa Loa (eye worm) AGC/NDR protein kinase 0.0055 0.0108 0.0117
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0016 0.0105
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0051 0.0093 0.0093
Brugia malayi Papain family cysteine protease containing protein 0.0051 0.0093 0.0101
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0033 0.002 0.0017
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0029 0.0004 0.0015
Trypanosoma cruzi PB1 domain containing protein, putative 0.0039 0.0043 0.0145
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0027 0.0188
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0051 0.0093 0.0706
Trichomonas vaginalis helicase, putative 0.0039 0.0046 0.0109
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0161 0.0543 0.0543
Giardia lamblia PHD finger protein 15 0.0089 0.025 0.2399
Leishmania major heat shock protein 83-1 0.009 0.0254 0.2591
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0254 0.0278
Schistosoma mansoni hypothetical protein 0.0037 0.0037 0.0037
Echinococcus multilocularis cpg binding protein 0.0192 0.0667 0.0665
Trichomonas vaginalis set domain proteins, putative 0.0713 0.2793 0.664
Echinococcus granulosus JmjC domain containing protein 4 0.0029 0.0003 0.0001
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0016 0.0014
Loa Loa (eye worm) heat shock protein 75 0.006 0.013 0.0142
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0108 0.0257
Echinococcus multilocularis basement membrane specific heparan sulfate 0.003 0.0006 0.0003
Leishmania major heat shock protein 83-1 0.009 0.0254 0.2591
Plasmodium falciparum serine repeat antigen 8 0.0051 0.0093 0.0726
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.014 0.0456 0.1084
Leishmania major heat shock protein 83-1 0.009 0.0254 0.2591
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0051 0.0093 0.0706
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0108 0.0257
Plasmodium falciparum cysteine proteinase falcipain 1 0.0104 0.0307 0.2394
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0053 0.0126
Brugia malayi Protein kinase domain containing protein 0.004 0.0048 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0046 0.0109
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0051 0.0092 0.0217
Brugia malayi Papain family cysteine protease containing protein 0.0104 0.0307 0.0338
Loa Loa (eye worm) hypothetical protein 0.0049 0.0086 0.0092
Loa Loa (eye worm) CAMK/PKD protein kinase 0.004 0.0048 0.005
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0252 0.0915 0.0913
Echinococcus granulosus insulin receptor 0.072 0.2823 0.2821
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0111 0.0339 0.0806
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0497 0.1911 0.2115
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0081 0.0111
Echinococcus granulosus protein kinase c epsilon type 0.0093 0.0266 0.0264
Schistosoma mansoni hypothetical protein 0.0048 0.0081 0.0081
Entamoeba histolytica cysteine proteinase, putative 0.0104 0.0307 0.247
Echinococcus multilocularis microtubule associated protein 2 0.0667 0.2605 0.2604
Echinococcus granulosus snurportin 1 0.0372 0.1402 0.14
Loa Loa (eye worm) hypothetical protein 0.0283 0.104 0.115
Schistosoma mansoni hypothetical protein 0.0061 0.0135 0.0135
Trypanosoma cruzi ISWI complex protein 0.0061 0.0135 0.0454
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.002 0.0171
Toxoplasma gondii cathepsin B 0.0268 0.098 0.7554
Trypanosoma brucei PB1 domain containing protein, putative 0.0039 0.0043 0.0412
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0029 0.0003 0.0009
Giardia lamblia Heat shock protein HSP 90-alpha 0.0077 0.0201 0.1887
Schistosoma mansoni hypothetical protein 0.0064 0.0145 0.0145
Brugia malayi Bromodomain containing protein 0.0102 0.0303 0.0333
Schistosoma mansoni heat shock protein 0.006 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0047 0.0076 0.0081
Trichomonas vaginalis glucosylceramidase, putative 0.0695 0.272 0.6467
Schistosoma mansoni importin beta-1 0.0035 0.0027 0.0027
Echinococcus granulosus histone lysine methyltransferase setb 0.0161 0.0543 0.0541
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.002 0.0019
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0079 0.0079
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0051 0.0093 0.0093
Giardia lamblia Hypothetical protein 0.0051 0.0093 0.0767
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0108 0.0257
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0052 0.0099 0.0107
Echinococcus multilocularis serine threonine protein kinase 0.0055 0.0108 0.0106
Loa Loa (eye worm) hypothetical protein 0.0035 0.0027 0.0027
Brugia malayi Variant SH3 domain containing protein 0.0039 0.0043 0.0045
Echinococcus granulosus cpg binding protein 0.0192 0.0667 0.0665
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0051 0.0093 0.0706
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0051 0.0093 0.0093
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0123 0.0387 0.0385
Echinococcus multilocularis cathepsin L 0.0104 0.0307 0.0305
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0039 0.0043 0.0041
Echinococcus granulosus cathepsin L 0.0104 0.0307 0.0305
Echinococcus multilocularis lysine specific demethylase 6a 0.0029 0.0003 0.0001
Loa Loa (eye worm) MBCTL1 0.0054 0.0105 0.0114
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0241 0.087 0.34
Echinococcus granulosus thioredoxin glutathione reductase 0.0095 0.0273 0.0271
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0051 0.0093 0.0726
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0252 0.0915 0.0913
Trichomonas vaginalis glucosylceramidase, putative 0.0732 0.2873 0.683
Trypanosoma brucei heat shock protein, putative 0.009 0.0254 0.2571
Trichomonas vaginalis glucosylceramidase, putative 0.0695 0.272 0.6467
Brugia malayi isocitrate dehydrogenase 0.0032 0.0016 0.0016
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0145 0.0142
Brugia malayi PHD-finger family protein 0.0113 0.0347 0.0382
Echinococcus granulosus protein kinase c iota type 0.0621 0.242 0.2418
Onchocerca volvulus 0.0111 0.0339 0.1192
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0293 0.1081 0.1079
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0111 0.0339 0.0806
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0081 0.0087
Echinococcus granulosus protein kinase C gamma type 0.0055 0.0108 0.0106
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0023 0.0028
Loa Loa (eye worm) hypothetical protein 0.0051 0.0093 0.0101
Loa Loa (eye worm) hypothetical protein 0.0051 0.0093 0.0101
Brugia malayi TAR-binding protein 0.0063 0.0142 0.0155
Brugia malayi AF-10 protein 0.0029 0.0004 0.0002
Toxoplasma gondii heat shock protein 90, putative 0.009 0.0254 0.1942
Schistosoma mansoni vav2 0.0039 0.0043 0.0043
Trypanosoma cruzi heat shock protein 85, putative 0.009 0.0254 0.0858
Entamoeba histolytica hypothetical protein 0.0051 0.0093 0.0749
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.006 0.013 0.0128
Echinococcus granulosus heat shock protein 90 0.0077 0.0201 0.0199
Loa Loa (eye worm) ctsf protein 0.0111 0.0339 0.0374
Echinococcus granulosus neuroglian 0.0037 0.0036 0.0034
Giardia lamblia Cathepsin L precursor 0.0051 0.0093 0.0767
Brugia malayi glutathione reductase 0.0095 0.0273 0.03
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0606 0.2359 0.2612
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0254 0.0251
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0041 0.0097
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0266 0.0266
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0079 0.0255
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.0339 0.0806
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0111 0.0339 0.0337
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0051 0.0093 0.0093
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0055 0.0108 0.0117
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.1059 0.4206 0.4658
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0254 0.0278
Onchocerca volvulus 0.0039 0.0043 0.0128
Entamoeba histolytica cysteine protease, putative 0.0051 0.0093 0.0749
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0027 0.009
Brugia malayi Pre-SET motif family protein 0.0627 0.2442 0.2703
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0154 0.0512 0.051
Entamoeba histolytica hypothetical protein 0.0035 0.0027 0.0216
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.014 0.0456 0.3664
Brugia malayi Hr1 repeat family protein 0.0055 0.0108 0.0117
Schistosoma mansoni hypothetical protein 0.0029 0.0004 0.0004
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0111 0.0339 0.0337
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0027 0.0063
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0369 0.0407
Onchocerca volvulus Cathepsin F homolog 0.0111 0.0339 0.1192
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0333 0.1244 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0157 0.0525 0.534
Onchocerca volvulus 0.0047 0.0079 0.0255
Brugia malayi hypothetical protein 0.0296 0.1094 0.1209
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.072 0.2823 0.2821
Brugia malayi RNA, U transporter 1 0.0099 0.0289 0.0318
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0051 0.0093 0.0749
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0046 0.0109
Giardia lamblia Cathepsin B precursor 0.0268 0.098 1
Trichomonas vaginalis glucosylceramidase, putative 0.0695 0.272 0.6467
Entamoeba histolytica cysteine protease, putative 0.0104 0.0307 0.247
Loa Loa (eye worm) endoplasmin 0.009 0.0254 0.0279
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0055 0.0108 0.0117
Echinococcus granulosus cathepsin l1 0.0111 0.0339 0.0337
Echinococcus granulosus phd:f box containing protein 0.0029 0.0003 0.0001
Trypanosoma cruzi heat shock protein 85, putative 0.009 0.0254 0.0858
Brugia malayi Protein kinase domain containing protein 0.004 0.0048 0.005
Trypanosoma cruzi heat shock protein 85, putative 0.0077 0.0201 0.0677
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0104 0.0311 0.0311
Brugia malayi Papain family cysteine protease containing protein 0.0051 0.0093 0.0101
Leishmania major heat shock protein 83-1 0.009 0.0254 0.2591
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0145 0.0142
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0164 0.0389
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0051 0.0093 0.0221
Entamoeba histolytica cysteine protease, putative 0.0104 0.0307 0.247
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0627 0.2442 0.2703
Leishmania major cathepsin L-like protease 0.0111 0.0339 0.346
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0039 0.0043 0.0045
Toxoplasma gondii PHD-finger domain-containing protein 0.0089 0.025 0.1911
Leishmania major cathepsin L-like protease 0.0111 0.0339 0.346
Toxoplasma gondii PHD-finger domain-containing protein 0.0089 0.025 0.1911
Loa Loa (eye worm) hypothetical protein 0.0036 0.0031 0.0032
Echinococcus granulosus NDR protein kinase 0.0055 0.0108 0.0106
Brugia malayi cathepsin B-like cysteine proteinase 0.0754 0.2962 0.3279
Echinococcus granulosus protein tyrosine kinase 0.0819 0.3225 0.3223
Loa Loa (eye worm) hypothetical protein 0.0036 0.0031 0.0032
Schistosoma mansoni cpg binding protein 0.0192 0.0667 0.0667
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0047 0.0075 0.0073
Giardia lamblia Cysteine protease 0.0051 0.0093 0.0767
Echinococcus granulosus PHD finger protein rhinoceros 0.0089 0.025 0.0248
Brugia malayi Ras association domain family 1 isoform A 0.0039 0.0043 0.0045
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0088 0.0297
Onchocerca volvulus Glucosylceramidase homolog 0.0695 0.272 0.9739
Brugia malayi Cathepsin L-like cysteine proteinase 0.0059 0.0125 0.0136
Loa Loa (eye worm) hypothetical protein 0.0184 0.0636 0.0702
Brugia malayi F/Y-rich N-terminus family protein 0.0093 0.0266 0.0292
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0142 0.0142
Schistosoma mansoni cathepsin F (C01 family) 0.0111 0.0339 0.0339
Brugia malayi Cathepsin L-like precursor 0.0059 0.0125 0.0136
Brugia malayi fibroinase precursor 0.0051 0.0093 0.0101
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0104 0.0311 0.1048
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0023 0.0028
Trichomonas vaginalis glucosylceramidase, putative 0.1059 0.4206 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0111 0.0339 0.0806
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.006 0.013 0.0441
Brugia malayi jmjC domain containing protein 0.0126 0.0399 0.0439
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0051 0.0093 0.0093
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0157 0.0525 0.534
Echinococcus multilocularis jumonji domain containing 1A 0.0029 0.0003 0.0001
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0016 0.0164
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0108 0.0257
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0142 0.0155
Leishmania major cathepsin L-like protease 0.0157 0.0525 0.5352
Schistosoma mansoni jumonji/arid domain-containing protein 0.0126 0.0399 0.0399
Echinococcus multilocularis insulin receptor 0.072 0.2823 0.2821
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.0339 0.0806
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0027 0.0248
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0051 0.0093 0.0221
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0108 0.0257
Entamoeba histolytica hypothetical protein 0.0028 0 0.0002
Loa Loa (eye worm) hypothetical protein 0.0089 0.025 0.0275
Trypanosoma brucei heat shock protein 90, putative 0.009 0.0254 0.2571
Mycobacterium ulcerans hydrolase 0.0041 0.0053 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0046 0.0109
Echinococcus multilocularis protein TFG 0.0039 0.0043 0.0041
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0051 0.0093 0.0706
Echinococcus granulosus insulin growth factor 1 receptor beta 0.072 0.2823 0.2821
Leishmania major heat shock protein 83-1 0.009 0.0254 0.2591
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0108 0.0257
Leishmania major heat shock protein 83-1 0.009 0.0254 0.2591
Giardia lamblia Cathepsin L-like protease 0.0051 0.0093 0.0767
Echinococcus granulosus cathepsin l1 0.0059 0.0125 0.0123
Echinococcus multilocularis protein kinase c eta type 0.0039 0.0043 0.0041
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0105 0.0103
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0029 0.0004 0.0011
Schistosoma mansoni tyrosine kinase 0.1188 0.4732 0.4732
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0031 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0033 0.002 0.0171
Brugia malayi acetyltransferase, GNAT family protein 0.0154 0.0512 0.0565
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0085 0.0232 0.0721
Onchocerca volvulus 0.0111 0.0339 0.1192
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0052 0.0097 0.0732
Echinococcus multilocularis protein tyrosine kinase 0.0819 0.3225 0.3223
Schistosoma mansoni unc-13 (munc13) 0.0039 0.0043 0.0043
Brugia malayi Protein kinase c protein 2 0.004 0.0048 0.005
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0044 0.035
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0054 0.0104 0.0246
Loa Loa (eye worm) cathepsin B 0.0268 0.098 0.1084
Echinococcus multilocularis protein kinase c iota type 0.0621 0.242 0.2418
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0647 0.2526 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0037 0.0034
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0089 0.025 0.025
Loa Loa (eye worm) hypothetical protein 0.0047 0.0076 0.0081
Toxoplasma gondii cathepsin CPC1 0.0051 0.0093 0.0699
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0085 0.0232 0.236
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0027 0.0187
Loa Loa (eye worm) STE/STE11/MEKK2 protein kinase 0.004 0.0048 0.0051
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0051 0.0093 0.0221
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.0339 0.0806
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0093 0.0221
Loa Loa (eye worm) AGC/PKN protein kinase 0.0055 0.0108 0.0117
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0088 0.0872
Giardia lamblia Cysteine protease 0.0051 0.0093 0.0767
Echinococcus multilocularis serine:threonine protein kinase 38 0.0055 0.0108 0.0106
Loa Loa (eye worm) hypothetical protein 0.0149 0.0491 0.0542
Loa Loa (eye worm) matrixin family protein 0.0075 0.0191 0.021
Brugia malayi diacylglycerol kinase 0.0039 0.0043 0.0045
Echinococcus multilocularis zinc finger protein 0.0092 0.026 0.0257
Echinococcus multilocularis cathepsin L cysteine protease 0.0111 0.0339 0.0337
Brugia malayi Partitioning defective-6 homolog alpha 0.0039 0.0043 0.0045
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0081 0.0257
Brugia malayi cathepsin L-like precursor 0.0059 0.0125 0.0136
Echinococcus granulosus twitchin 0.0038 0.0041 0.0039
Trypanosoma cruzi Heat shock protein 83, putative 0.009 0.0254 0.0858
Echinococcus granulosus Protein kinase C brain isozyme 0.0093 0.0266 0.0264
Trypanosoma cruzi ISWI complex protein 0.0061 0.0135 0.0454
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0003 0.0001
Plasmodium falciparum serine repeat antigen 1 0.0051 0.0093 0.0726
Leishmania major hypothetical protein, conserved 0.0029 0.0003 0.0027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0125 0.0297
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.002 0.0046
Brugia malayi Immunoglobulin I-set domain containing protein 0.003 0.0006 0.0004
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0081 0.0821
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0055 0.0108 0.0106
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0016 0.0014
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0164 0.0389
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.002 0.0065
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0111 0.0339 0.0374
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0081 0.0648
Loa Loa (eye worm) cysteine protease 0.0111 0.0339 0.0374
Entamoeba histolytica diacylglycerol kinase, putative 0.0039 0.0043 0.0345
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0144 0.0472 0.047
Giardia lamblia Cathepsin B precursor 0.0051 0.0093 0.0767
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0142 0.0155
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0093 0.0221
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0081 0.0821
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0145 0.0158
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0039 0.0043 0.0041
Echinococcus multilocularis neuroglian 0.0037 0.0036 0.0034
Schistosoma mansoni cpg binding protein 0.0174 0.0595 0.0595
Schistosoma mansoni phd/f-box containing protein 0.0029 0.0003 0.0003
Plasmodium falciparum heat shock protein 90 0.009 0.0254 0.1979
Echinococcus granulosus Immunoglobulin 0.003 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.0754 0.2962 0.3279
Loa Loa (eye worm) hypothetical protein 0.0039 0.0043 0.0045
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0111 0.0339 0.2643
Loa Loa (eye worm) hypothetical protein 0.0055 0.0108 0.0117
Brugia malayi Papain family cysteine protease containing protein 0.0104 0.0307 0.0338
Leishmania major heat shock protein 83-1 0.009 0.0254 0.2591
Leishmania major hypothetical protein, conserved 0.0061 0.0135 0.1373
Echinococcus granulosus cathepsin l cysteine peptidase 0.0111 0.0339 0.0337
Onchocerca volvulus 0.0111 0.0339 0.1192
Entamoeba histolytica cysteine protease, putative 0.0111 0.0339 0.2727
Trypanosoma cruzi cruzipain precursor, putative 0.0157 0.0525 0.1772
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0157 0.0525 0.534
Echinococcus granulosus transcription factor btf3 0.0035 0.0027 0.0025
Echinococcus granulosus unc 13 munc13 0.0039 0.0043 0.0041
Loa Loa (eye worm) AGC/AKT protein kinase 0.0055 0.0108 0.0117
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0145 0.0142
Onchocerca volvulus 0.0059 0.0125 0.0423
Loa Loa (eye worm) hypothetical protein 0.0064 0.0145 0.0158
Onchocerca volvulus 0.0713 0.2793 1
Trypanosoma cruzi PB1 domain containing protein, putative 0.0039 0.0043 0.0145
Loa Loa (eye worm) matrixin family protein 0.0082 0.0219 0.024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0254 0.0254
Giardia lamblia Cathepsin B precursor 0.0051 0.0093 0.0767
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0157 0.0525 0.534
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0016 0.0054
Loa Loa (eye worm) hypothetical protein 0.0048 0.0081 0.0087
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0268 0.098 0.331
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0041 0.0121
Entamoeba histolytica heat shock protein 90, putative 0.009 0.0254 0.2043
Schistosoma mansoni jumonji domain containing protein 0.0233 0.0835 0.0835
Brugia malayi cathepsin F-like cysteine proteinase 0.0051 0.0093 0.0101
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0048 0.0048
Entamoeba histolytica hypothetical protein 0.0037 0.0037 0.0294
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0254 0.0251
Trichomonas vaginalis bromodomain-containing protein, putative 0.0052 0.0097 0.0229
Plasmodium falciparum serine repeat antigen 3 0.0051 0.0093 0.0726
Echinococcus multilocularis cathepsin L cysteine protease 0.0111 0.0339 0.0337
Entamoeba histolytica hypothetical protein 0.0037 0.0037 0.0294
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0254 0.0251
Plasmodium vivax serine-repeat antigen (SERA) 0.0051 0.0093 0.0706
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0268 0.098 0.098
Loa Loa (eye worm) hypothetical protein 0.0059 0.0125 0.0136
Echinococcus granulosus epidermal growth factor receptor 0.224 0.9027 0.9027
Echinococcus granulosus lysine specific demethylase 6a 0.0029 0.0003 0.0001
Onchocerca volvulus 0.004 0.0048 0.0145
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0047 0.0075 0.0073
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0029 0.0003 0.0003
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0108 0.0257
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0051 0.0093 0.0221
Onchocerca volvulus 0.0039 0.0043 0.0127
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0108 0.0257
Brugia malayi Cathepsin L-like precursor 0.0111 0.0339 0.0374
Onchocerca volvulus 0.0111 0.0339 0.1192
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0034 0.0023 0.0023
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0033 0.002 0.0197
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0051 0.0093 0.0767
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0037 0.0034
Onchocerca volvulus 0.0051 0.0093 0.0308
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0051 0.0092 0.0217
Mycobacterium ulcerans hypothetical protein 0.0048 0.0081 0.0244
Brugia malayi Cathepsin L-like precursor 0.0111 0.0339 0.0374
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0055 0.0108 0.0106
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0039 0.0043 0.0041
Plasmodium falciparum endoplasmin, putative 0.0066 0.0153 0.1191
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0093 0.0314
Trichomonas vaginalis endoplasmin, putative 0.0066 0.0153 0.0363
Giardia lamblia Cathepsin B precursor 0.0051 0.0093 0.0767
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0046 0.0075 0.0072
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0046 0.0075 0.0072
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0108 0.0108
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0108 0.0108
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0081 0.0244
Loa Loa (eye worm) glutathione reductase 0.0095 0.0273 0.03
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0033 0.002 0.002
Schistosoma mansoni heat shock protein 0.009 0.0254 0.0254
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0023 0.0028
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.002 0.0065
Echinococcus granulosus cathepsin b 0.0754 0.2962 0.296
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0016 0.0138
Giardia lamblia Cathepsin L precursor 0.0051 0.0093 0.0767
Leishmania major cathepsin L-like protease 0.0157 0.0525 0.5352
Entamoeba histolytica cysteine protease, putative 0.0104 0.0307 0.247
Entamoeba histolytica diacylglycerol kinase, putative 0.0039 0.0043 0.0345
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.0339 0.0806
Onchocerca volvulus 0.0174 0.0595 0.211
Onchocerca volvulus 0.0104 0.0311 0.1088
Loa Loa (eye worm) hypothetical protein 0.0047 0.0076 0.0082
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0052 0.0097 0.0229
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0027 0.0248
Loa Loa (eye worm) RasGEF domain-containing protein 0.0039 0.0043 0.0045
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.1207 0.4808 0.4807
Plasmodium falciparum serine repeat antigen 7 0.0051 0.0093 0.0726
Trichomonas vaginalis glucosylceramidase, putative 0.1059 0.4206 1
Plasmodium falciparum serine repeat antigen 5 0.0051 0.0093 0.0726
Brugia malayi Cathepsin L-like precursor 0.0059 0.0125 0.0136
Onchocerca volvulus 0.0049 0.0086 0.0281
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0039 0.0045 0.0043
Schistosoma mansoni protein phosphatase 2C 0.0029 0.0003 0.0003
Onchocerca volvulus 0.0048 0.0081 0.0263
Loa Loa (eye worm) hypothetical protein 0.0161 0.0543 0.06
Trypanosoma cruzi trypanothione reductase, putative 0.0095 0.0273 0.0922
Brugia malayi Matrixin family protein 0.0082 0.0219 0.024
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0051 0.0093 0.0706
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0105 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0046 0.0109
Echinococcus multilocularis tumor protein p63 0.0336 0.1256 0.1254
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0157 0.0525 0.534
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0105 0.0114
Giardia lamblia Fructose-bisphosphate aldolase 0.014 0.0456 0.4542
Loa Loa (eye worm) matrix metalloproteinase 0.0034 0.0023 0.0023
Onchocerca volvulus 0.0034 0.0023 0.0056
Brugia malayi C1-like domain containing protein 0.004 0.0048 0.005
Leishmania major hypothetical protein, conserved 0.005 0.0088 0.0896
Leishmania major heat shock protein 83-1 0.009 0.0254 0.2591
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0034 0.0023 0.0023
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.002 0.0065
Echinococcus granulosus defective proboscis extension response 0.003 0.0006 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0093 0.0221
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0041 0.0053 0.0056
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0086 0.0086
Brugia malayi RhoGAP domain containing protein 0.0039 0.0043 0.0045
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0142 0.0142
Loa Loa (eye worm) RNA binding protein 0.0063 0.0142 0.0155
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0081 0.0244
Schistosoma mansoni zinc finger protein 0.0092 0.026 0.026
Plasmodium falciparum heat shock protein 90, putative 0.0053 0.01 0.0776
Loa Loa (eye worm) hypothetical protein 0.0167 0.0565 0.0623
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0051 0.0093 0.0706
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0104 0.0307 0.3115
Onchocerca volvulus 0.0111 0.0339 0.1192
Schistosoma mansoni phosphatidylserine receptor 0.0029 0.0003 0.0003
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0003 0.0001
Entamoeba histolytica cysteine protease, putative 0.0104 0.0307 0.247
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0016 0.0127
Echinococcus multilocularis 0.0692 0.2707 0.2705
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0754 0.2962 0.2962
Plasmodium falciparum glutathione reductase 0.0095 0.0273 0.2128
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0055 0.0108 0.0106
Entamoeba histolytica cysteine protease, putative 0.0104 0.0307 0.247
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0088 0.0665
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0191 0.0663 0.0661
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.002 0.0065
Giardia lamblia Heat shock protein HSP 90-alpha 0.009 0.0254 0.2442
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0053 0.0126
Brugia malayi diacylglycerol kinase 0.0039 0.0043 0.0045
Loa Loa (eye worm) hypothetical protein 0.0333 0.1244 0.1376
Brugia malayi Matrixin family protein 0.0034 0.0023 0.0023
Plasmodium falciparum cysteine proteinase falcipain 3 0.0111 0.0339 0.2643
Onchocerca volvulus Protein TFG homolog 0.0039 0.0043 0.0128
Schistosoma mansoni tyrosine kinase 0.224 0.9027 0.9027
Loa Loa (eye worm) hypothetical protein 0.0034 0.0023 0.0023
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0016 0.0016
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0039 0.0043 0.0041
Echinococcus multilocularis raf serine:threonine protein kinase 0.0057 0.0119 0.0117
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0016 0.0014
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0093 0.0266 0.0264
Echinococcus multilocularis epidermal growth factor receptor 0.224 0.9027 0.9027
Entamoeba histolytica cysteine protease, putative 0.0104 0.0307 0.247
Schistosoma mansoni hypothetical protein 0.1359 0.5431 0.5431
Entamoeba histolytica 90 kDa heat shock protein, putative 0.006 0.013 0.1047
Brugia malayi jmjC domain containing protein 0.0293 0.1081 0.1195
Onchocerca volvulus Tyrosine kinase homolog 0.0465 0.1782 0.6371
Echinococcus granulosus cysteine protease 0.0104 0.0307 0.0305
Trypanosoma brucei heat shock protein, putative 0.009 0.0254 0.2571
Brugia malayi beta-NAC-like protein 0.0035 0.0027 0.0027
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0086 0.0236 0.0234
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0027 0.0027
Entamoeba histolytica cysteine protease, putative 0.0104 0.0307 0.247
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0051 0.0093 0.0767
Trypanosoma brucei Heat shock protein 83, putative 0.009 0.0254 0.2571
Trypanosoma cruzi heat shock protein 90, putative 0.009 0.0254 0.0858
Brugia malayi Immunoglobulin I-set domain containing protein 0.0497 0.1911 0.2115
Leishmania major heat shock protein 83-1 0.009 0.0254 0.2591
Brugia malayi cathepsin F-like cysteine proteinase 0.0052 0.0099 0.0107
Echinococcus granulosus cathepsin L 0.0051 0.0093 0.0091
Schistosoma mansoni atypical protein kinase C 0.066 0.2578 0.2578
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.004 0.0048 0.0371
Loa Loa (eye worm) acetyltransferase 0.0154 0.0512 0.0565
Schistosoma mansoni diacylglycerol kinase theta 0.0039 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0104 0.0307 0.073
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0111 0.0339 0.0806
Trypanosoma cruzi cruzipain precursor, putative 0.0052 0.0099 0.0334
Brugia malayi Pleckstrin Homology Domain 0.0039 0.0043 0.0045
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.004 0.0048 0.0045
Schistosoma mansoni diacylglycerol kinase theta 0.0039 0.0043 0.0043
Trypanosoma brucei heat shock protein, putative 0.009 0.0254 0.2571
Entamoeba histolytica cysteine proteinase, putative 0.0104 0.0307 0.247
Trypanosoma brucei ISWI complex protein 0.0061 0.0135 0.135
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0051 0.0093 0.0706
Schistosoma mansoni methyl-cpg binding protein mbd 0.0068 0.0163 0.0163
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0033 0.002 0.0013
Loa Loa (eye worm) CXXC zinc finger family protein 0.0174 0.0595 0.0657
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0217 0.0771 0.3006
Loa Loa (eye worm) heat shock protein 90 0.009 0.0254 0.0279
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0051 0.0093 0.0101
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0754 0.2962 0.2962
Mycobacterium tuberculosis Probable reductase 0.0217 0.0771 0.3006
Loa Loa (eye worm) hypothetical protein 0.0296 0.1094 0.1209
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0053 0.0164
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0046 0.0109
Echinococcus granulosus Rac GTPase activating protein 1 0.0039 0.0043 0.0041
Echinococcus multilocularis heat shock protein 90 0.009 0.0254 0.0252
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0051 0.0093 0.0093
Plasmodium vivax heat shock protein 86, putative 0.009 0.0254 0.1961
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.002 0.0065
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0031 0.0047
Echinococcus granulosus chromobox protein 1 0.0068 0.0164 0.0161
Brugia malayi Fibronectin type III domain containing protein 0.003 0.0006 0.0004
Entamoeba histolytica hypothetical protein, conserved 0.0039 0.0043 0.0347
Entamoeba histolytica cysteine proteinase, putative 0.0059 0.0125 0.1007
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0088 0.0659
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0081 0.0821
Trypanosoma brucei heat shock protein 84, putative 0.006 0.013 0.1303
Toxoplasma gondii diacylglycerol kinase, putative 0.0039 0.0043 0.0309
Loa Loa (eye worm) hypothetical protein 0.0059 0.0125 0.0136
Onchocerca volvulus 0.0048 0.0081 0.0264
Brugia malayi RNA binding protein 0.0063 0.0142 0.0155
Brugia malayi CXXC zinc finger family protein 0.0174 0.0595 0.0657
Echinococcus multilocularis heat shock protein 0.009 0.0254 0.0252
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0157 0.0525 0.534
Leishmania major cathepsin L-like protease 0.0111 0.0339 0.346
Brugia malayi Hemopexin family protein 0.0048 0.0081 0.0087
Plasmodium vivax endoplasmin, putative 0.009 0.0254 0.1961
Brugia malayi Protein kinase domain containing protein 0.072 0.2823 0.3126
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0044 0.025
Echinococcus granulosus peregrin 0.0102 0.0303 0.0301
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0123 0.0387 0.0385
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0029 0.0003 0.0009
Echinococcus multilocularis roundabout 2 0.0047 0.0076 0.0074
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.014 0.0456 0.1084
Toxoplasma gondii cathepsin CPC2 0.0051 0.0093 0.0699
Loa Loa (eye worm) PAR-6 protein 0.0039 0.0043 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.0339 0.0806
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0079 0.0079
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0081 0.0257
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0004
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0039 0.0043 0.0045
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0052 0.0097 0.0725
Giardia lamblia Cysteine protease 0.0051 0.0093 0.0767
Brugia malayi Heterochromatin protein 1 0.0068 0.0164 0.0179
Echinococcus multilocularis Immunoglobulin 0.003 0.0006 0.0003
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0145 0.0158
Loa Loa (eye worm) hypothetical protein 0.0052 0.0099 0.0107
Trypanosoma cruzi cysteine peptidase, putative 0.0157 0.0525 0.1772
Plasmodium vivax hypothetical protein, conserved 0.0089 0.025 0.193
Loa Loa (eye worm) hypothetical protein 0.0039 0.0043 0.0045
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.0457 0.0454
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.014 0.0456 0.1084
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0079 0.0076
Brugia malayi Pre-SET motif family protein 0.0093 0.0265 0.0291
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0016 0.0104
Giardia lamblia Cathepsin L-like protease 0.0051 0.0093 0.0767
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0051 0.0093 0.0093
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0016 0.0104
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0033 0.002 0.0171
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0046 0.0109
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.002 0.0129
Plasmodium falciparum JmjC domain-containing protein, putative 0.0029 0.0003 0.0022
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0191 0.0663 0.0661
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0051 0.0093 0.0221
Trichomonas vaginalis glucosylceramidase, putative 0.0695 0.272 0.6467
Leishmania major heat shock protein 83-1 0.009 0.0254 0.2591
Trypanosoma cruzi cysteine peptidase, putative 0.0111 0.0339 0.1145
Loa Loa (eye worm) hypothetical protein 0.0052 0.0099 0.0107
Loa Loa (eye worm) hypothetical protein 0.0039 0.0043 0.0045
Schistosoma mansoni cathepsin F (C01 family) 0.0111 0.0339 0.0339
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.01 0.0294 0.0294
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0079 0.0076
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0055 0.0108 0.0106
Toxoplasma gondii cathepsin CPL 0.0111 0.0339 0.2601
Trypanosoma brucei heat shock protein, putative 0.009 0.0254 0.2571
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.002 0.0065
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0051 0.0092 0.0217
Entamoeba histolytica cysteine proteinase 2 0.0104 0.0307 0.247
Trichomonas vaginalis glucosylceramidase, putative 0.1059 0.4206 1
Brugia malayi jmjC domain containing protein 0.0029 0.0003 0.0001
Trichomonas vaginalis heat shock protein, putative 0.0066 0.0153 0.0363
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0051 0.0093 0.0101
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0051 0.0092 0.0217
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0093 0.0266 0.0292
Giardia lamblia Hypothetical protein 0.0051 0.0093 0.0767
Loa Loa (eye worm) hypothetical protein 0.0029 0.0003 0.0001
Leishmania major heat shock protein, putative 0.006 0.013 0.1327
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0051 0.0092 0.0217
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.002 0.0046
Plasmodium falciparum serine repeat antigen 2 0.0051 0.0093 0.0726
Brugia malayi Muscleblind-like protein 0.0149 0.0491 0.0542
Brugia malayi Protein kinase domain containing protein 0.0055 0.0108 0.0117
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0051 0.0093 0.0749
Trypanosoma cruzi cysteine peptidase, putative 0.0157 0.0525 0.1772
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0041 0.0097
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0079 0.0079
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0033 0.002 0.0152
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0037 0.0037
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0157 0.0525 0.534
Brugia malayi jmjC domain containing protein 0.0029 0.0003 0.0001
Schistosoma mansoni cpg binding protein 0.0192 0.0667 0.0667
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0201 0.0706 0.078
Trichomonas vaginalis glucosylceramidase, putative 0.0695 0.272 0.6467
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0157 0.0525 0.534
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0076 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.0039 0.0043 0.0045
Echinococcus multilocularis transcription factor btf3 0.0035 0.0027 0.0025
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0051 0.0092 0.0217
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0142 0.0155
Echinococcus granulosus serine:threonine protein kinase N2 0.0055 0.0108 0.0106
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0105 0.0105
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.002 0.0065
Schistosoma mansoni cell adhesion molecule 0.0039 0.0045 0.0045
Plasmodium vivax unspecified product 0.0051 0.0093 0.0706
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0142 0.0142
Plasmodium falciparum thioredoxin reductase 0.0095 0.0273 0.2128
Leishmania major hypothetical protein, conserved 0.0039 0.0043 0.0438
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0145 0.0158
Echinococcus multilocularis cathepsin b 0.0754 0.2962 0.296
Echinococcus multilocularis partitioning defective protein 6 0.0039 0.0043 0.0041
Loa Loa (eye worm) hypothetical protein 0.005 0.0088 0.0095
Brugia malayi Cathepsin L-like precursor 0.0111 0.0339 0.0374
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0254 0.0254
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.014 0.0456 0.1084
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0027 0.0063
Schistosoma mansoni hypothetical protein 0.0292 0.1077 0.1077
Echinococcus multilocularis JmjC domain containing protein 4 0.0029 0.0003 0.0001
Echinococcus granulosus tar DNA binding protein 0.0063 0.0142 0.014
Leishmania major trypanothione reductase 0.0095 0.0273 0.2786
Loa Loa (eye worm) hypothetical protein 0.0039 0.0043 0.0045
Brugia malayi RhoGAP domain containing protein 0.0039 0.0043 0.0045
Giardia lamblia Cathepsin L precursor 0.0051 0.0093 0.0767
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0754 0.2962 0.2962
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0161 0.0543 0.0541
Echinococcus granulosus heat shock protein 0.009 0.0254 0.0252
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0055 0.0108 0.0117
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0081 0.0087
Entamoeba histolytica hypothetical protein 0.0039 0.0043 0.0345
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0088 0.0686
Brugia malayi MH2 domain containing protein 0.0119 0.0369 0.0407
Plasmodium falciparum serine repeat antigen 4 0.0051 0.0093 0.0726
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0027 0.0246
Onchocerca volvulus 0.0296 0.1094 0.3899
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0081 0.0244
Schistosoma mansoni hypothetical protein 0.0089 0.025 0.025
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0017 0.004
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.1059 0.4206 0.4658
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0111 0.0339 0.0806
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0093 0.0265 0.0263
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0157 0.0525 0.534
Echinococcus multilocularis chromobox protein 1 0.0068 0.0164 0.0161
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0057 0.0118 0.0116
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0268 0.098 0.2331
Entamoeba histolytica cysteine protease, putative 0.0104 0.0307 0.247
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.0099 0.0334
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0105 0.0103
Echinococcus multilocularis Diacylglycerol kinase theta 0.0039 0.0043 0.0041
Loa Loa (eye worm) hypothetical protein 0.0039 0.0043 0.0045
Brugia malayi Matrixin family protein 0.0034 0.0023 0.0023
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0104 0.0307 0.0307
Plasmodium vivax SET domain protein, putative 0.0093 0.0265 0.2046
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.004 0.0133
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0111 0.0339 0.0806
Trypanosoma brucei heat shock protein 90, putative 0.009 0.0254 0.2571
Plasmodium vivax thioredoxin reductase, putative 0.0095 0.0273 0.2111
Plasmodium vivax heat shock protein 90, putative 0.006 0.013 0.0994
Schistosoma mansoni chromobox protein 0.0068 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0047 0.0079 0.0085
Plasmodium falciparum glutathione reductase 0.0033 0.002 0.0152
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0108 0.0108
Echinococcus granulosus N chimaerin 0.0039 0.0043 0.0041
Trichomonas vaginalis glucosylceramidase, putative 0.1059 0.4206 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.014 0.0456 0.3664
Giardia lamblia Cathepsin B precursor 0.0268 0.098 1
Loa Loa (eye worm) hypothetical protein 0.0201 0.0706 0.078
Schistosoma mansoni tyrosine kinase 0.1207 0.4808 0.4808
Schistosoma mansoni tyrosine kinase 0.0819 0.3225 0.3225
Schistosoma mansoni heat shock protein 0.009 0.0254 0.0254
Brugia malayi hypothetical protein 0.005 0.0088 0.0095
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0647 0.2526 1
Plasmodium vivax importin-beta 2, putative 0.0035 0.0027 0.0189
Schistosoma mansoni vesicular amine transporter 0.003 0.0006 0.0006
Entamoeba histolytica cysteine protease, putative 0.0104 0.0307 0.247
Loa Loa (eye worm) hypothetical protein 0.0039 0.0043 0.0045
Brugia malayi Papain family cysteine protease containing protein 0.0111 0.0339 0.0374
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0027 0.0063
Leishmania major heat shock protein 83-1 0.009 0.0254 0.2591
Loa Loa (eye worm) hypothetical protein 0.0039 0.0043 0.0045
Schistosoma mansoni cell polarity protein 0.0039 0.0043 0.0043
Loa Loa (eye worm) histone methyltransferase 0.0057 0.0118 0.0128
Echinococcus multilocularis jumonji domain containing protein 0.0125 0.0393 0.0391
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0093 0.0221
Schistosoma mansoni tyrosine kinase 0.0036 0.0032 0.0032
Onchocerca volvulus Cathepsin L homolog 0.0051 0.0093 0.0308
Echinococcus granulosus tumor protein p63 0.0336 0.1256 0.1254
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0111 0.0339 0.0374
Schistosoma mansoni unc-13 (munc13) 0.0043 0.0059 0.0059
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.1402 0.1551
Brugia malayi jmjC domain containing protein 0.0029 0.0003 0.0001
Brugia malayi Matrixin family protein 0.0034 0.0023 0.0023
Plasmodium vivax heat shock protein, putative 0.0343 0.1284 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0051 0.0093 0.0101
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0051 0.0093 0.0221
Plasmodium vivax vivapain-2 0.0111 0.0339 0.2627
Loa Loa (eye worm) hypothetical protein 0.0039 0.0043 0.0045
Loa Loa (eye worm) hypothetical protein 0.0048 0.0081 0.0087
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0111 0.0339 0.0806
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0031 0.0243
Schistosoma mansoni Neurotrimin precursor (hNT) 0.003 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0038 0.0041 0.0043
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0027 0.009
Leishmania major cysteine peptidase A (CPA) 0.0111 0.0339 0.346
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0023 0.0028
Entamoeba histolytica cysteine protease, putative 0.0051 0.0093 0.0749
Trypanosoma brucei heat shock protein, putative 0.009 0.0254 0.2571
Trichomonas vaginalis glucosylceramidase, putative 0.0695 0.272 0.6467
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0104 0.0307 0.0307
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0104 0.0307 0.073
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0111 0.0339 0.0806
Entamoeba histolytica cysteine protease, putative 0.0104 0.0307 0.247
Trichomonas vaginalis glucosylceramidase, putative 0.1059 0.4206 1
Echinococcus granulosus epidermal growth factor receptor 0.1207 0.4808 0.4807
Schistosoma mansoni tyrosine kinase 0.072 0.2823 0.2823
Loa Loa (eye worm) PHD-finger family protein 0.0089 0.025 0.0275
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0081 0.0244
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0093 0.0221
Brugia malayi jmjC domain containing protein 0.0029 0.0003 0.0001
Plasmodium vivax serine-repeat antigen (SERA) 0.0051 0.0093 0.0706
Brugia malayi Cathepsin L-like precursor 0.0111 0.0339 0.0374
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0079 0.0085
Schistosoma mansoni hypothetical protein 0.0064 0.0145 0.0145
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0029 0.0004 0.0015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0157 0.0525 0.534
Plasmodium vivax glutathione reductase, putative 0.0095 0.0273 0.2111
Plasmodium falciparum serine repeat antigen 9 0.0051 0.0093 0.0726
Trypanosoma cruzi cysteine peptidase, putative 0.0104 0.0307 0.1037
Echinococcus multilocularis snurportin 1 0.0372 0.1402 0.14
Echinococcus multilocularis muscleblind protein 0.0149 0.0491 0.0489
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.0339 0.0806
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0004
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0039 0.0043 0.0045
Loa Loa (eye worm) zinc finger protein 0.0039 0.0043 0.0045
Schistosoma mansoni tyrosine kinase 0.1188 0.4732 0.4732
Loa Loa (eye worm) hypothetical protein 0.0036 0.0031 0.0032
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0266 0.0266
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0051 0.0093 0.0706
Echinococcus multilocularis cathepsin L 0.0051 0.0093 0.0091
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0016 0.0014
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0039 0.0043 0.0043
Giardia lamblia Grp94/Hsp90 0.0085 0.0232 0.2206
Echinococcus multilocularis heat shock protein 90 0.0077 0.0201 0.0199
Onchocerca volvulus Alhambra homolog 0.0089 0.025 0.0871
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0016 0.0014
Loa Loa (eye worm) hypothetical protein 0.0039 0.0043 0.0045
Onchocerca volvulus 0.0111 0.0339 0.1192
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.004 0.0048 0.0045
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0081 0.0648
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0048 0.0048
Schistosoma mansoni hypothetical protein 0.0372 0.1402 0.1402
Brugia malayi hypothetical protein 0.0037 0.0037 0.0038
Brugia malayi chromobox protein homolog 3 0.0038 0.0041 0.0043
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0108 0.0108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.0339 0.0806
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0095 0.0273 0.1024
Brugia malayi latrophilin 2 splice variant baaae 0.0138 0.0446 0.0492
Echinococcus granulosus cathepsin L cysteine protease 0.0104 0.0307 0.0305
Entamoeba histolytica cysteine proteinase, putative 0.0104 0.0307 0.247
Echinococcus multilocularis phd:f box containing protein 0.0029 0.0003 0.0001
Schistosoma mansoni jumonji domain containing protein 0.0029 0.0003 0.0003
Brugia malayi Papain family cysteine protease containing protein 0.0051 0.0093 0.0101
Brugia malayi Matrixin family protein 0.0034 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0036 0.0031 0.0032
Brugia malayi heat shock protein 90 0.009 0.0254 0.0279
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.002 0.0065
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0161 0.0543 0.0543
Loa Loa (eye worm) hypothetical protein 0.0154 0.0512 0.0564
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0108 0.0257
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0754 0.2962 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0093 0.0221
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0372 0.1405 0.1405
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0104 0.0307 0.3115
Brugia malayi Protein kinase domain containing protein 0.0055 0.0108 0.0117
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.0339 0.0806
Plasmodium vivax hypothetical protein, conserved 0.004 0.0048 0.035
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0369 0.0407
Echinococcus granulosus microtubule associated protein 2 0.0667 0.2605 0.2604
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0079 0.0076
Loa Loa (eye worm) hypothetical protein 0.0031 0.001 0.0008
Schistosoma mansoni cathepsin S (C01 family) 0.0051 0.0093 0.0093
Leishmania major heat shock protein 83-1 0.009 0.0254 0.2591
Loa Loa (eye worm) hypothetical protein 0.0138 0.0446 0.0492
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0201 0.0706 0.078
Entamoeba histolytica heat shock protein 90, putative 0.009 0.0254 0.2043
Echinococcus multilocularis epidermal growth factor receptor 0.1207 0.4808 0.4807
Echinococcus multilocularis peregrin 0.0102 0.0303 0.0301
Mycobacterium ulcerans heat shock protein 90 0.0085 0.0232 0.0846
Echinococcus multilocularis unc 13 (munc13) 0.0039 0.0043 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0046 0.0109
Leishmania major heat shock protein 83-1 0.009 0.0254 0.2591
Trypanosoma brucei heat shock protein, putative 0.009 0.0254 0.2571
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0093 0.0221
Trichomonas vaginalis heat shock protein, putative 0.0053 0.01 0.0236
Brugia malayi Cathepsin L-like precursor 0.0111 0.0339 0.0374
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0081 0.0244
Echinococcus granulosus GPCR family 2 0.0064 0.0145 0.0142
Entamoeba histolytica protein kinase, putative 0.0055 0.0108 0.0871
Schistosoma mansoni hypothetical protein 0.2479 1 1
Echinococcus multilocularis myotubularin protein 13 0.0039 0.0043 0.0041
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0051 0.0093 0.0093
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0093 0.0265 0.0265
Brugia malayi Cathepsin L-like precursor 0.0111 0.0339 0.0374
Schistosoma mansoni hypothetical protein 0.0083 0.0222 0.0222
Leishmania major cathepsin L-like protease 0.0111 0.0339 0.346
Echinococcus granulosus lysine specific demethylase 5A 0.0126 0.0399 0.0396
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0051 0.0092 0.0217
Onchocerca volvulus Matrix metalloproteinase homolog 0.0075 0.0191 0.066
Loa Loa (eye worm) hypothetical protein 0.0059 0.0125 0.0136
Loa Loa (eye worm) raf kinase 0.0039 0.0043 0.0045
Entamoeba histolytica hypothetical protein 0.0037 0.0037 0.0294
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0051 0.0093 0.0101
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.0339 0.0806
Brugia malayi hypothetical protein 0.003 0.0006 0.0004
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.006 0.013 0.0128
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0754 0.2962 0.2962
Trichomonas vaginalis heat shock protein, putative 0.009 0.0254 0.0604
Plasmodium vivax vivapain-3 0.0104 0.0307 0.2377
Schistosoma mansoni methyl-cpg binding protein mbd 0.0068 0.0163 0.0163
Onchocerca volvulus 0.0111 0.0339 0.1192
Schistosoma mansoni transcription factor btf3 0.0035 0.0027 0.0027
Loa Loa (eye worm) bromodomain containing protein 0.0074 0.0188 0.0206
Leishmania major basic transcription factor 3a, putative 0.0035 0.0027 0.0272
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0033 0.002 0.0152
Echinococcus granulosus methyl CpG binding domain protein 2 0.0068 0.0163 0.0161
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0051 0.0093 0.0706
Mycobacterium tuberculosis Probable oxidoreductase 0.0241 0.087 0.34
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0051 0.0093 0.0221
Echinococcus granulosus heat shock protein 90 0.009 0.0254 0.0252
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0052 0.0099 0.0107
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0068 0.0163 0.0161
Giardia lamblia Cathepsin L precursor 0.0051 0.0093 0.0767
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0052 0.0097 0.0725
Giardia lamblia Cathepsin L precursor 0.0051 0.0093 0.0767
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0004 0.0011
Schistosoma mansoni cathepsin C 0.0051 0.0093 0.0093
Trypanosoma brucei trypanothione reductase 0.0095 0.0273 0.2766
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0027 0.0209
Onchocerca volvulus Cathepsin L homolog 0.0111 0.0339 0.1192
Echinococcus multilocularis dnaJ subfamily B 0.2479 1 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0217 0.0771 0.3006
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0164 0.0179
Plasmodium falciparum importin beta, putative 0.0035 0.0027 0.0211
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0254 0.0254
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0085 0.0232 1
Leishmania major cathepsin L-like protease 0.0111 0.0339 0.346
Giardia lamblia Encystation-specific protease 0.0051 0.0093 0.0767
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.004 0.0048 0.005
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0039 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0153 0.0511 0.0564
Brugia malayi PHD-finger family protein 0.0047 0.0076 0.0082
Schistosoma mansoni endoplasmin 0.009 0.0254 0.0254
Plasmodium falciparum phd finger protein, putative 0.0089 0.025 0.1948
Onchocerca volvulus 0.0039 0.0043 0.0127
Echinococcus multilocularis geminin 0.1359 0.5431 0.543
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0093 0.0221
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0241 0.087 0.34
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.014 0.0456 0.1084
Trichomonas vaginalis heat shock protein, putative 0.0077 0.0201 0.0477
Echinococcus multilocularis thioredoxin glutathione reductase 0.0095 0.0273 0.0271
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.014 0.0456 0.1084
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.002 0.0171
Trypanosoma cruzi heat shock protein 85, putative 0.009 0.0254 0.0858
Schistosoma mansoni hypothetical protein 0.1359 0.5431 0.5431
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0029 0.0002 0.0002
Schistosoma mansoni tyrosine kinase 0.1188 0.4732 0.4732
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0254 0.0251
Brugia malayi Importin beta-1 subunit 0.0035 0.0027 0.0027
Echinococcus multilocularis cathepsin b 0.0754 0.2962 0.296
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.0339 0.0806
Echinococcus granulosus myotubularin protein 13 0.0039 0.0043 0.0041
Loa Loa (eye worm) hypothetical protein 0.0051 0.0093 0.0101
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0004
Brugia malayi Furin-like cysteine rich region family protein 0.224 0.9027 1
Echinococcus granulosus cathepsin b 0.0754 0.2962 0.296
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0051 0.0093 0.0767
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0081 0.0111
Brugia malayi Bromodomain containing protein 0.0314 0.1164 0.1288
Schistosoma mansoni cathepsin s 0.0052 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0039 0.0045 0.0047
Loa Loa (eye worm) hypothetical protein 0.0054 0.0105 0.0114
Entamoeba histolytica cysteine protease, putative 0.0104 0.0307 0.247
Giardia lamblia Cathepsin B precursor 0.0051 0.0093 0.0767
Loa Loa (eye worm) hypothetical protein 0.0034 0.0023 0.0023
Schistosoma mansoni hypothetical protein 0.0064 0.0145 0.0145
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0217 0.0771 0.3006
Schistosoma mansoni protein kinase C mu 0.0039 0.0043 0.0043
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0333 0.1244 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0111 0.0339 0.0806
Loa Loa (eye worm) hypothetical protein 0.0052 0.0099 0.0107
Schistosoma mansoni tyrosine kinase 0.072 0.2823 0.2823
Loa Loa (eye worm) hypothetical protein 0.0051 0.0093 0.0101
Treponema pallidum heat shock protein 90 0.0085 0.0232 0.4856
Trypanosoma brucei heat shock protein, putative 0.009 0.0254 0.2571
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0142 0.0142
Echinococcus multilocularis muscleblind protein 1 0.0149 0.0491 0.0489
Onchocerca volvulus 0.0039 0.0043 0.0127
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0033 0.002 0.013
Echinococcus multilocularis Rac GTPase activating protein 1 0.0039 0.0043 0.0041
Trichomonas vaginalis heat shock protein, putative 0.0085 0.0232 0.055
Schistosoma mansoni cathepsin B (C01 family) 0.0051 0.0093 0.0093
Brugia malayi Calcitonin receptor-like protein seb-1 0.0201 0.0706 0.078
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0044 0.0339
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0027 0.0216
Schistosoma mansoni bromodomain containing protein 0.0031 0.001 0.001
Treponema pallidum fructose-bisphosphate aldolase 0.014 0.0456 1
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0027 0.0186
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0032 0.0017 0.004
Trypanosoma brucei rac serine-threonine kinase, putative 0.0055 0.0108 0.1079
Loa Loa (eye worm) hypothetical protein 0.0039 0.0043 0.0045
Brugia malayi Thioredoxin reductase 0.0095 0.0273 0.03
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0266 0.0266
Brugia malayi protein kinase C3,putative 0.0568 0.2201 0.2437
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0142 0.0142
Brugia malayi Protein kinase domain containing protein 0.0828 0.3264 0.3614
Echinococcus granulosus fetal alzheimer antigen falz 0.01 0.0294 0.0291
Echinococcus multilocularis GPCR, family 2 0.0064 0.0145 0.0142
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0055 0.0108 0.0106
Toxoplasma gondii heat shock protein HSP90 0.009 0.0254 0.1942
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0051 0.0093 0.0221
Entamoeba histolytica cysteine protease, putative 0.0104 0.0307 0.247
Schistosoma mansoni nephrin 0.0037 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0149 0.0491 0.0542
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0104 0.0307 0.0307
Toxoplasma gondii Hsp90 domain-containing protein 0.0343 0.1284 0.9901
Onchocerca volvulus 0.0439 0.1675 0.5986
Echinococcus multilocularis serine:threonine protein kinase N2 0.0055 0.0108 0.0106
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0081 0.0244
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0047 0.0075 0.0073
Schistosoma mansoni serine/threonine kinase 0.0055 0.0108 0.0108
Schistosoma mansoni cathepsin F (C01 family) 0.0059 0.0125 0.0125
Entamoeba histolytica cysteine protease, putative 0.0051 0.0093 0.0749
Brugia malayi protein kinase C II. 0.0093 0.0266 0.0292
Loa Loa (eye worm) hypothetical protein 0.0041 0.0053 0.0056
Echinococcus multilocularis protein kinase c epsilon type 0.0093 0.0266 0.0264
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0125 0.0297
Loa Loa (eye worm) hypothetical protein 0.0039 0.0043 0.0045
Trichomonas vaginalis heat shock protein, putative 0.0085 0.0232 0.055
Brugia malayi Protein kinase domain containing protein 0.0055 0.0108 0.0117
Echinococcus granulosus endoplasmin 0.0085 0.0232 0.0229
Loa Loa (eye worm) hypothetical protein 0.0048 0.0081 0.0087
Leishmania major heat shock protein 83-1 0.009 0.0254 0.2591
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0055 0.0108 0.0106
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0051 0.0093 0.0767
Echinococcus multilocularis N chimaerin 0.0039 0.0043 0.0041
Schistosoma mansoni protein kinase C mu 0.004 0.0048 0.0048
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0033 0.002 0.0017

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0037 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.3663 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.4716 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.581 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (binding) = 44.6684 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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