Detailed information for compound 1425790

Basic information

Technical information
  • TDR Targets ID: 1425790
  • Name: [2-[[6-amino-2,4-dioxo-1-(phenylmethyl)pyrimi din-5-yl]-methylamino]-2-oxoethyl] 2-oxo-1H-q uinoline-4-carboxylate
  • MW: 475.453 | Formula: C24H21N5O6
  • H donors: 3 H acceptors: 6 LogP: 1.63 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1nc2ccccc2c(c1)C(=O)OCC(=O)N(c1c(=O)[nH]c(=O)n(c1N)Cc1ccccc1)C
  • InChi: 1S/C24H21N5O6/c1-28(20-21(25)29(24(34)27-22(20)32)12-14-7-3-2-4-8-14)19(31)13-35-23(33)16-11-18(30)26-17-10-6-5-9-15(16)17/h2-11H,12-13,25H2,1H3,(H,26,30)(H,27,32,34)
  • InChiKey: LGUOWKRWOAMKPU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [2-[[6-amino-2,4-dioxo-1-(phenylmethyl)pyrimidin-5-yl]-methyl-amino]-2-oxo-ethyl] 2-oxo-1H-quinoline-4-carboxylate
  • 2-oxo-1H-quinoline-4-carboxylic acid [2-[[6-amino-2,4-dioxo-1-(phenylmethyl)-5-pyrimidinyl]-methylamino]-2-oxoethyl] ester
  • 2-keto-1H-quinoline-4-carboxylic acid [2-[[6-amino-1-(benzyl)-2,4-diketo-pyrimidin-5-yl]-methyl-amino]-2-keto-ethyl] ester
  • T5514781

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0383 0.3878 0.5821
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.0812 0.2265
Schistosoma mansoni ran 0.0045 0.0403 0.0605
Brugia malayi CXXC zinc finger family protein 0.0033 0.0279 0.0753
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0036 0.0022
Brugia malayi hypothetical protein 0.0016 0.0109 0.0272
Schistosoma mansoni cpg binding protein 0.0035 0.0298 0.0448
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0457 0.0667
Brugia malayi RNA recognition motif domain containing protein 0.035 0.3541 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0202 0.2804
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0457 0.0686
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0671 0.1006
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.026 0.0248
Entamoeba histolytica hypothetical protein 0.0068 0.0642 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.0812 0.1202
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0327 0.0315
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0036 0.0022
Toxoplasma gondii melibiase subfamily protein 0.0104 0.1006 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.057 0.0837
Loa Loa (eye worm) inositol-1 0.0038 0.0327 0.0473
Schistosoma mansoni cellular tumor antigen P53 0.0057 0.0524 0.0786
Loa Loa (eye worm) hypothetical protein 0.0032 0.0273 0.0391
Echinococcus granulosus importin subunit beta 1 0.0061 0.057 0.0837
Schistosoma mansoni transcription factor LCR-F1 0.0068 0.0642 0.0963
Trichomonas vaginalis importin beta-1, putative 0.005 0.045 0.1796
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0327 0.2836
Schistosoma mansoni tar DNA-binding protein 0.035 0.3541 0.5314
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.0812 0.08
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0032 0.0273 0.2857
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0594 0.5649
Toxoplasma gondii Alpha-galactosidase 0.0015 0.0091 0.0335
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0104 0.1006 0.1509
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0032 0.0273 0.026
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0457 0.0667
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0327 0.5257
Echinococcus granulosus dnaJ subfamily B 0.047 0.4768 0.7152
Onchocerca volvulus 0.0033 0.0279 0.0085
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0185 0.1334
Loa Loa (eye worm) MH2 domain-containing protein 0.0105 0.1016 0.1508
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0279 0.04
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0069 0.065 0.0976
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0068 0.0642 0.0629
Schistosoma mansoni smad1 5 8 and 0.0007 0.0013 0.002
Brugia malayi MH2 domain containing protein 0.0105 0.1016 0.2842
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0202 0.2804
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0577 0.5472
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.026 0.0391
Onchocerca volvulus 0.0243 0.2433 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0577 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0327 0.1286
Schistosoma mansoni tar DNA-binding protein 0.035 0.3541 0.5314
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0654 0.6662 1
Echinococcus granulosus ubiquitin specific protease 41 0.0032 0.0273 0.0391
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0577 1
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0577 0.0866
Echinococcus multilocularis neuropeptide receptor A26 0.0509 0.5167 0.5161
Loa Loa (eye worm) hypothetical protein 0.0026 0.0202 0.0284
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0185 0.2437
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0032 0.0273 0.2857
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0185 0.2472
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0032 0.0273 0.041
Echinococcus multilocularis tar DNA binding protein 0.035 0.3541 0.3532
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0457 0.0667
Entamoeba histolytica hypothetical protein 0.0068 0.0642 1
Schistosoma mansoni tar DNA-binding protein 0.035 0.3541 0.5314
Schistosoma mansoni tar DNA-binding protein 0.035 0.3541 0.5314
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0577 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0045 0.0403 0.3638
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0056 0.0065
Loa Loa (eye worm) hypothetical protein 0.0031 0.026 0.0372
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0327 0.0473
Echinococcus multilocularis neuropeptide s receptor 0.0509 0.5167 0.5161
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0104 0.1006 0.0994
Loa Loa (eye worm) hypothetical protein 0.0057 0.0524 0.0768
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.0812 0.1202
Entamoeba histolytica hypothetical protein 0.0024 0.0185 0.2167
Echinococcus granulosus geminin 0.0383 0.3878 0.5812
Leishmania major GTP-binding protein, putative 0.0045 0.0403 0.6648
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0287 0.2593
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0032 0.0273 0.1061
Brugia malayi Pre-SET motif family protein 0.0213 0.2131 0.6004
Brugia malayi TAR-binding protein 0.035 0.3541 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.005 0.045 0.1796
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.026 0.0372
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.057 1
Schistosoma mansoni inositol monophosphatase 0.0038 0.0327 0.0491
Schistosoma mansoni importin beta-1 0.0061 0.057 0.0855
Loa Loa (eye worm) hypothetical protein 0.0069 0.065 0.0959
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.026 0.0391
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0202 0.1512
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0104 0.1006 0.1509
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0104 0.1006 0.0994
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0032 0.0273 0.4134
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0045 0.0403 0.1106
Leishmania major importin beta-1 subunit, putative 0.005 0.045 0.7559
Echinococcus granulosus transportin 1 0.0012 0.0059 0.0069
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0056 0.0065
Schistosoma mansoni hypothetical protein 0.0011 0.0057 0.0086
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0327 0.363
Trichomonas vaginalis Importin beta-1 subunit, putative 0.005 0.045 0.1796
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0104 0.1006 0.1492
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0045 0.0403 0.0391
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0327 0.1286
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0045 0.0403 1
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0032 0.0273 0.3675
Echinococcus multilocularis importin subunit beta 1 0.0061 0.057 0.0557
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0036 0.0034
Echinococcus granulosus neuropeptide receptor A26 0.0509 0.5167 0.7752
Schistosoma mansoni cpg binding protein 0.0035 0.0298 0.0448
Echinococcus multilocularis importin 5 0.0012 0.0059 0.0046
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0036 0.0053
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0032 0.0273 0.0391
Trichomonas vaginalis set domain proteins, putative 0.0243 0.2433 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0457 0.0686
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0242 0.0343
Echinococcus granulosus translational activator gcn1 0.0012 0.0059 0.0069
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0032 0.0273 0.026
Leishmania major hypothetical protein, conserved 0.0026 0.0202 0.2764
Entamoeba histolytica hypothetical protein 0.0068 0.0642 1
Brugia malayi RNA, U transporter 1 0.0174 0.1731 0.4869
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0032 0.0273 0.0391
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0577 0.0565
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0327 1
Plasmodium vivax importin-beta 2, putative 0.0061 0.057 1
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.0812 0.1219
Echinococcus multilocularis tumor protein p63 0.0388 0.3929 0.3921
Schistosoma mansoni ran 0.0045 0.0403 0.0605
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0104 0.1006 0.1509
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0045 0.0403 0.6744
Schistosoma mansoni smad1 5 8 and 0.0007 0.0013 0.002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.026 0.0391
Echinococcus granulosus neuropeptide s receptor 0.0509 0.5167 0.7752
Plasmodium vivax SET domain protein, putative 0.0031 0.026 0.3946
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.0403 0.8101
Brugia malayi kap beta 3 protein 0.0012 0.0059 0.013
Schistosoma mansoni hypothetical protein 0.047 0.4768 0.7157
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0036 0.0034
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0055 0.0118
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0577 1
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0202 0.2804
Echinococcus multilocularis transportin 1 0.0012 0.0059 0.0046
Echinococcus multilocularis geminin 0.0383 0.3878 0.387
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.2131 0.3185
Entamoeba histolytica Ran family GTPase 0.0045 0.0403 0.5911
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0577 0.0848
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0457 0.0686
Onchocerca volvulus 0.0085 0.0812 0.254
Brugia malayi hypothetical protein 0.0068 0.0642 0.1781
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0032 0.0273 0.0737
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0327 0.5182
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0185 0.2472
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0577 0.0866
Trichomonas vaginalis ran, putative 0.0045 0.0403 0.16
Plasmodium falciparum importin beta, putative 0.0061 0.057 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0045 0.0403 0.6744
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0032 0.0273 0.4193
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0202 0.2804
Echinococcus granulosus tar DNA binding protein 0.035 0.3541 0.5305
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0068 0.0642 0.0945
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0577 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0327 0.5044
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0273 0.1061
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0185 0.1334
Schistosoma mansoni smad1 5 8 and 0.0007 0.0013 0.002
Echinococcus multilocularis cpg binding protein 0.0035 0.0298 0.0285
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0057 0.0067
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0457 0.1258
Brugia malayi RNA binding protein 0.035 0.3541 1
Loa Loa (eye worm) importin-beta domain-containing protein 0.0012 0.0059 0.0069
Brugia malayi Inositol-1 0.0038 0.0327 0.0891
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0032 0.0273 0.041
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.026 0.0248
Trypanosoma cruzi importin beta-1 subunit, putative 0.005 0.045 1
Entamoeba histolytica hypothetical protein 0.005 0.045 0.6721
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0185 0.2472
Onchocerca volvulus 0.0057 0.0524 0.1212
Entamoeba histolytica hypothetical protein 0.0068 0.0642 1
Echinococcus multilocularis snurportin 1 0.0654 0.6662 0.6658
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.026 0.2129
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.035 0.3541 0.5305
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0287 1
Toxoplasma gondii HEAT repeat-containing protein 0.0061 0.057 0.5394
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0045 0.0403 0.0587
Loa Loa (eye worm) kap beta 3 protein 0.0012 0.0059 0.0069
Echinococcus granulosus tumor protein p63 0.0388 0.3929 0.5889
Echinococcus granulosus importin 5 0.0012 0.0059 0.0069
Brugia malayi hypothetical protein 0.0026 0.0202 0.0536
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0104 0.1006 0.1509
Echinococcus multilocularis ubiquitin specific protease 41 0.0032 0.0273 0.026
Schistosoma mansoni tar DNA-binding protein 0.035 0.3541 0.5314
Loa Loa (eye worm) TAR-binding protein 0.035 0.3541 0.5305
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0057 0.0044
Brugia malayi Pre-SET motif family protein 0.0031 0.026 0.0701
Brugia malayi Melibiase family protein 0.0069 0.065 0.1807
Schistosoma mansoni cpg binding protein 0.0033 0.0279 0.0419
Schistosoma mansoni smad 0.0007 0.0013 0.002
Schistosoma mansoni importin-beta 2 0.0012 0.0059 0.0088
Echinococcus multilocularis translational activator gcn1 0.0012 0.0059 0.0046
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0056 0.0043
Echinococcus granulosus cpg binding protein 0.0035 0.0298 0.0429
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0069 0.065 0.0976
Trichomonas vaginalis hypothetical protein 0.0012 0.0059 0.0175
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0185 0.5
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0327 0.5044
Loa Loa (eye worm) RNA binding protein 0.035 0.3541 0.5305
Echinococcus granulosus GTP binding nuclear protein Ran 0.0045 0.0403 0.0587
Schistosoma mansoni hypothetical protein 0.0383 0.3878 0.5821
Echinococcus multilocularis dnaJ subfamily B 0.047 0.4768 0.4762
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.057 1
Loa Loa (eye worm) transcription factor SMAD2 0.0105 0.1016 0.1508
Brugia malayi Importin beta-1 subunit 0.0061 0.057 0.1577
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0032 0.0273 0.1061
Schistosoma mansoni hypothetical protein 0.0068 0.0642 0.0963
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0185 0.5
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0327 0.4608
Schistosoma mansoni Smad4 0.0007 0.0013 0.002
Schistosoma mansoni inositol monophosphatase 0.0038 0.0327 0.0491
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0007 0.0013 0.002
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0327 0.1286
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0015 0.0091 0.0136
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0457 0.0444
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0069 0.065 0.2624
Echinococcus granulosus snurportin 1 0.0654 0.6662 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.0403 0.8101
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0045 0.0403 0.6744
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0457 0.0444
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.026 0.0391
Schistosoma mansoni hypothetical protein 0.0654 0.6662 1

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 195 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Confirmation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1). (Class of assay: confirmatory) [Related pubchem assays: 2118 (Project Summary), 2098 (Primary HTS)] ChEMBL. No reference
Potency (functional) 8.1961 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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