Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0114 | 0.0625 | 0.2111 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0203 | 0.1161 | 0.3919 |
Loa Loa (eye worm) | nuclear factor I | 0.0063 | 0.0319 | 0.0319 |
Brugia malayi | MH1 domain containing protein | 0.0063 | 0.0319 | 0.0319 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0203 | 0.1161 | 0.1161 |
Schistosoma mansoni | dishevelled | 0.0018 | 0.0047 | 0.0157 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0641 | 0.3799 | 0.3799 |
Schistosoma mansoni | tar DNA-binding protein | 0.0502 | 0.2962 | 1 |
Loa Loa (eye worm) | DIX domain-containing protein | 0.0018 | 0.0047 | 0.0047 |
Echinococcus multilocularis | bloom syndrome protein | 0.0023 | 0.0081 | 0.0272 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0502 | 0.2962 | 0.2962 |
Brugia malayi | RNA binding protein | 0.0502 | 0.2962 | 0.2962 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0047 | 0.0047 |
Loa Loa (eye worm) | RNA binding protein | 0.0502 | 0.2962 | 0.2962 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0079 | 0.0412 | 0.1392 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0047 | 0.0047 |
Loa Loa (eye worm) | RasGEF domain-containing protein | 0.0013 | 0.0016 | 0.0016 |
Schistosoma mansoni | smad1 5 8 and | 0.0114 | 0.0625 | 0.2111 |
Brugia malayi | MH2 domain containing protein | 0.0114 | 0.0625 | 0.0625 |
Schistosoma mansoni | hypothetical protein | 0.0203 | 0.1161 | 0.3919 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.0847 | 0.0847 |
Schistosoma mansoni | Smad4 | 0.0114 | 0.0625 | 0.2111 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0052 | 0.0052 |
Loa Loa (eye worm) | hypothetical protein | 0.0641 | 0.3799 | 0.3799 |
Schistosoma mansoni | smad1 5 8 and | 0.0114 | 0.0625 | 0.2111 |
Brugia malayi | RasGEF domain containing protein | 0.0013 | 0.0016 | 0.0016 |
Mycobacterium leprae | PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) | 0.001 | 0 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0013 | 0.0016 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0502 | 0.2962 | 1 |
Trypanosoma cruzi | hypothetical protein | 0.0013 | 0.0016 | 0.0386 |
Giardia lamblia | Replication factor C, subunit 1 | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0011 | 0.0006 | 0.0019 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0051 | 0.0246 | 0.0246 |
Brugia malayi | RasGEF domain containing protein | 0.0013 | 0.0016 | 0.0016 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0013 | 0.0015 | 0.0365 |
Onchocerca volvulus | 0.0151 | 0.0847 | 0.4016 | |
Brugia malayi | DIX domain containing protein | 0.0018 | 0.0047 | 0.0047 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0047 | 0.0047 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0079 | 0.0412 | 0.1392 |
Echinococcus multilocularis | GPCR, family 2 | 0.0203 | 0.1161 | 0.3919 |
Brugia malayi | hypothetical protein | 0.0151 | 0.0847 | 0.0847 |
Echinococcus multilocularis | rap guanine nucleotide exchange factor 6 | 0.0013 | 0.0016 | 0.0054 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0013 | 0.0016 | 0.0075 |
Schistosoma mansoni | ras GTP exchange factor | 0.0013 | 0.0016 | 0.0054 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0114 | 0.0625 | 0.2111 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0079 | 0.0412 | 0.0412 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0013 | 0.0015 | 0.1864 |
Brugia malayi | Isocitrate dehydrogenase | 0.0079 | 0.0412 | 0.0412 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0114 | 0.0625 | 0.2111 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0079 | 0.0412 | 1 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0023 | 0.0081 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0502 | 0.2962 | 0.2962 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0114 | 0.0625 | 0.0625 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0079 | 0.0412 | 1 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0013 | 0.0016 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0203 | 0.1161 | 0.3919 |
Schistosoma mansoni | dep domain containing protein | 0.0018 | 0.0047 | 0.0157 |
Echinococcus granulosus | smad | 0.0114 | 0.0625 | 0.2111 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0013 | 0.0016 | 1 |
Treponema pallidum | DNA ligase (lig) | 0.001 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0502 | 0.2962 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0079 | 0.0412 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0079 | 0.0412 | 1 |
Schistosoma mansoni | Smad4 | 0.0051 | 0.0246 | 0.0831 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0079 | 0.0412 | 0.1392 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0013 | 0.0016 | 0.0054 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0013 | 0.0015 | 0.0365 |
Echinococcus granulosus | mothers against decapentaplegic 6 | 0.0051 | 0.0246 | 0.0831 |
Echinococcus granulosus | rap guanine nucleotide exchange factor 6 | 0.0013 | 0.0016 | 0.0054 |
Loa Loa (eye worm) | RasGEF domain-containing protein | 0.0013 | 0.0016 | 0.0016 |
Schistosoma mansoni | tar DNA-binding protein | 0.0502 | 0.2962 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0502 | 0.2962 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0641 | 0.3799 | 0.3799 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0641 | 0.3799 | 0.3799 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0013 | 0.0016 | 0.0054 |
Leishmania major | hypothetical protein, conserved | 0.0024 | 0.0087 | 0.1801 |
Loa Loa (eye worm) | hypothetical protein | 0.0438 | 0.2578 | 0.2578 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0018 | 0.0047 | 0.0047 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0013 | 0.0016 | 1 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0018 | 0.0047 | 0.0157 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0079 | 0.0412 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0087 | 0.0087 |
Echinococcus multilocularis | mothers against decapentaplegic 2 | 0.0051 | 0.0246 | 0.0831 |
Schistosoma mansoni | hypothetical protein | 0.0011 | 0.0006 | 0.0019 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0016 | 0.0034 | 0.0822 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0024 | 0.0087 | 0.2099 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0079 | 0.0412 | 0.1392 |
Echinococcus granulosus | ras GTP exchange factor | 0.0013 | 0.0016 | 0.0054 |
Trichomonas vaginalis | ras GTP exchange factor, putative | 0.0013 | 0.0016 | 0.1973 |
Entamoeba histolytica | recQ family helicase, putative | 0.0013 | 0.0015 | 0.9451 |
Brugia malayi | N-terminal motif family protein | 0.0361 | 0.2109 | 0.2109 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0018 | 0.0047 | 0.0157 |
Brugia malayi | N-terminal motif family protein | 0.0013 | 0.0016 | 0.0016 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0203 | 0.1161 | 0.1161 |
Echinococcus granulosus | Protein son of sevenless | 0.0013 | 0.0016 | 0.0054 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0079 | 0.0412 | 1 |
Brugia malayi | N-terminal motif family protein | 0.0013 | 0.0016 | 0.0016 |
Echinococcus granulosus | son of sevenless 1 | 0.0013 | 0.0016 | 0.0054 |
Schistosoma mansoni | hypothetical protein | 0.0438 | 0.2578 | 0.8703 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0018 | 0.0047 | 0.0157 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.1161 | 0.1161 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0018 | 0.0047 | 0.0047 |
Loa Loa (eye worm) | RecQ helicase | 0.0023 | 0.0081 | 0.0081 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0114 | 0.0625 | 0.0625 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0035 | 0.0035 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0018 | 0.0047 | 0.0157 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0438 | 0.2578 | 0.2578 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0114 | 0.0625 | 0.2111 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.0087 | 0.2099 |
Echinococcus granulosus | Smad4 | 0.0114 | 0.0625 | 0.2111 |
Brugia malayi | mothers against decapentaplegic homolog 3 | 0.0051 | 0.0246 | 0.0246 |
Brugia malayi | isocitrate dehydrogenase | 0.0079 | 0.0412 | 0.0412 |
Echinococcus granulosus | Pleckstrin G protein interacting region | 0.0018 | 0.0047 | 0.0157 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0203 | 0.1161 | 0.3919 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0013 | 0.0016 | 0.0054 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0079 | 0.0412 | 1 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0018 | 0.0047 | 0.0157 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0024 | 0.0087 | 0.2099 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0114 | 0.0625 | 0.2111 |
Brugia malayi | MH2 domain containing protein | 0.0114 | 0.0625 | 0.0625 |
Wolbachia endosymbiont of Brugia malayi | NAD-dependent DNA ligase, Lig | 0.001 | 0 | 0.5 |
Trichomonas vaginalis | guanine nucleotide exchange factor, putative | 0.0013 | 0.0016 | 0.1973 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.1672 | 1 | 1 |
Schistosoma mansoni | smad | 0.0051 | 0.0246 | 0.0831 |
Trichomonas vaginalis | ras GTP exchange factor, putative | 0.0013 | 0.0016 | 0.1973 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0013 | 0.0016 | 1 |
Echinococcus multilocularis | rap guanine nucleotide exchange factor 1 | 0.0013 | 0.0016 | 0.0054 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0024 | 0.0087 | 0.2099 |
Schistosoma mansoni | camp-dependent rap1 guanine-nucleotide exchange factor | 0.0012 | 0.0012 | 0.0041 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0013 | 0.0016 | 1 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0079 | 0.0412 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0079 | 0.0412 | 1 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0361 | 0.2109 | 1 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0018 | 0.0047 | 0.0047 |
Onchocerca volvulus | Segment polarity protein dishevelled homolog | 0.0018 | 0.0047 | 0.0221 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0016 | 0.0016 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0018 | 0.0047 | 0.0047 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0013 | 0.0016 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0203 | 0.1161 | 0.1161 |
Schistosoma mansoni | hypothetical protein | 0.0203 | 0.1161 | 0.3919 |
Schistosoma mansoni | fyve finger-containing phosphoinositide kinase fyv1 | 0.0018 | 0.0047 | 0.0157 |
Brugia malayi | MH1 domain containing protein | 0.0114 | 0.0625 | 0.0625 |
Onchocerca volvulus | 0.0013 | 0.0016 | 0.0075 | |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0018 | 0.0047 | 0.0157 |
Loa Loa (eye worm) | Smad1 | 0.0114 | 0.0625 | 0.0625 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0246 | 0.0246 |
Loa Loa (eye worm) | RasGEF domain-containing protein | 0.0013 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0047 | 0.0047 |
Toxoplasma gondii | hypothetical protein | 0.0018 | 0.0047 | 0.1129 |
Trypanosoma cruzi | hypothetical protein | 0.0013 | 0.0016 | 0.0386 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0021 | 0.0064 | 0.1541 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0011 | 0.0006 | 0.0019 |
Schistosoma mansoni | tar DNA-binding protein | 0.0502 | 0.2962 | 1 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0013 | 0.0016 | 1 |
Onchocerca volvulus | 0.0018 | 0.0047 | 0.0221 | |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0016 | 0.0016 |
Schistosoma mansoni | Smad4 | 0.0051 | 0.0246 | 0.0831 |
Loa Loa (eye worm) | hypothetical protein | 0.0361 | 0.2109 | 0.2109 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0203 | 0.1161 | 0.3919 |
Brugia malayi | Smad1 | 0.0114 | 0.0625 | 0.0625 |
Brugia malayi | MH1 domain containing protein | 0.0114 | 0.0625 | 0.0625 |
Schistosoma mansoni | dishevelled | 0.0018 | 0.0047 | 0.0157 |
Echinococcus multilocularis | Smad4 | 0.0114 | 0.0625 | 0.2111 |
Schistosoma mansoni | smad1 5 8 and | 0.0114 | 0.0625 | 0.2111 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0319 | 0.0319 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0051 | 0.0246 | 0.0246 |
Echinococcus granulosus | rap guanine nucleotide exchange factor 1 | 0.0013 | 0.0016 | 0.0054 |
Chlamydia trachomatis | DNA ligase | 0.001 | 0 | 0.5 |
Onchocerca volvulus | Mothers against decapentaplegic homolog | 0.0051 | 0.0246 | 0.1167 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0018 | 0.0051 | 0.0172 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0023 | 0.0081 | 0.0081 |
Echinococcus granulosus | GPCR family 2 | 0.0203 | 0.1161 | 0.3919 |
Echinococcus multilocularis | Protein son of sevenless | 0.0013 | 0.0016 | 0.0054 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0087 | 0.0087 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0018 | 0.0047 | 0.0157 |
Echinococcus multilocularis | smad | 0.0114 | 0.0625 | 0.2111 |
Echinococcus multilocularis | son of sevenless 1 | 0.0013 | 0.0016 | 0.0054 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0023 | 0.0081 | 1 |
Brugia malayi | TAR-binding protein | 0.0502 | 0.2962 | 0.2962 |
Brugia malayi | RasGEF domain containing protein | 0.0013 | 0.0016 | 0.0016 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0018 | 0.0047 | 0.0157 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0013 | 0.0016 | 1 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0016 | 0.0035 | 0.0849 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0013 | 0.0016 | 1 |
Schistosoma mansoni | guanine-nucleotide-exchange-factor | 0.0013 | 0.0016 | 0.0054 |
Entamoeba histolytica | hypothetical protein | 0.0013 | 0.0016 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0203 | 0.1161 | 0.3919 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0013 | 0.0016 | 1 |
Mycobacterium ulcerans | NAD-dependent DNA ligase LigA | 0.001 | 0 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.0087 | 0.2099 |
Echinococcus granulosus | mothers against decapentaplegic 2 | 0.0051 | 0.0246 | 0.0831 |
Brugia malayi | MH1 domain containing protein | 0.0063 | 0.0319 | 0.0319 |
Echinococcus multilocularis | mothers against decapentaplegic 6 | 0.0051 | 0.0246 | 0.0831 |
Echinococcus granulosus | bloom syndrome protein | 0.0023 | 0.0081 | 0.0272 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0087 | 0.2099 |
Brugia malayi | MH2 domain containing protein | 0.0051 | 0.0246 | 0.0246 |
Trichomonas vaginalis | ras GTP exchange factor, son of sevenless, putative | 0.0013 | 0.0016 | 0.1973 |
Schistosoma mansoni | regulator of G protein signaling | 0.0018 | 0.0047 | 0.0157 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0087 | 0.2099 |
Trypanosoma cruzi | guanine nucleotide releasing protein, putative | 0.0013 | 0.0016 | 0.0386 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0047 | 0.0047 |
Schistosoma mansoni | hypothetical protein | 0.0203 | 0.1161 | 0.3919 |
Schistosoma mansoni | smad | 0.0114 | 0.0625 | 0.2111 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0018 | 0.0047 | 0.0157 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.1672 | 1 | 1 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0013 | 0.0016 | 1 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0079 | 0.0412 | 1 |
Echinococcus multilocularis | Pleckstrin G protein, interacting region | 0.0018 | 0.0047 | 0.0157 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0079 | 0.0412 | 0.1392 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0013 | 0.0016 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0502 | 0.2962 | 0.2962 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0079 | 0.0412 | 0.1392 |
Echinococcus multilocularis | ras GTP exchange factor | 0.0013 | 0.0016 | 0.0054 |
Echinococcus granulosus | tar DNA binding protein | 0.0502 | 0.2962 | 1 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0079 | 0.0412 | 0.1392 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 20.5878 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 32.6427 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 50.1187 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] | ChEMBL. | No reference |
Potency (functional) | = 50.1187 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.