Detailed information for compound 1425920

Basic information

Technical information
  • TDR Targets ID: 1425920
  • Name: T5253638
  • MW: 339.368 | Formula: C17H13N3O3S
  • H donors: 1 H acceptors: 3 LogP: 2.57 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1COc2c(O1)cccc2)Nc1scc(n1)c1ccccn1
  • InChi: 1S/C17H13N3O3S/c21-16(15-9-22-13-6-1-2-7-14(13)23-15)20-17-19-12(10-24-17)11-5-3-4-8-18-11/h1-8,10,15H,9H2,(H,19,20,21)
  • InChiKey: FCUDBLATUCYZEH-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • Oprea1_552241
  • MLS000100919
  • SMR000017436

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Plasmodium falciparum heat shock protein 90, putative Starlite/ChEMBL No references
Homo sapiens arachidonate 15-lipoxygenase Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens heat shock protein 90kDa alpha (cytosolic), class A member 1 Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Bacillus anthracis Anthrax lethal factor Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax heat shock protein 86, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium berghei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans hypothetical protein Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum Heat shock protein HSP 90-alpha, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Giardia lamblia Grp94/Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Plasmodium knowlesi heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Mycobacterium ulcerans heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii putative heat shock protein 81-2 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Babesia bovis hsp90 protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium berghei heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Plasmodium yoelii heat shock 90 kDa protein homolog Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma cruzi Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium falciparum heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Leishmania infantum lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum IPR003367,Thrombospondin type 3 repeat;IPR002048,Calcium-binding EF-hand,domain-containing Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus granulosus heat shock protein heat shock protein 90 alpha Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Neospora caninum HSP90, related Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Plasmodium yoelii heat shock protein 83 Get druggable targets OG5_144951 All targets in OG5_144951
Schistosoma japonicum Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Treponema pallidum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense heat shock protein 83,heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K09487 heat shock protein 90kDa beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania donovani heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein HSP 90-beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Babesia bovis heat shock protein 90 Get druggable targets OG5_144951 All targets in OG5_144951
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium hominis heat shock protein 83 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Trypanosoma congolense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum HSP90-like protein, related Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium falciparum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K04079 molecular chaperone HtpG, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax heat shock protein, putative Get druggable targets OG5_144951 All targets in OG5_144951
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma brucei gambiense lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Cryptosporidium parvum Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi Endoplasmin precursor Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii heat shock protein HSP90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Toxoplasma gondii Hsp90 domain-containing protein Get druggable targets OG5_144951 All targets in OG5_144951
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Echinococcus granulosus arachidonate 5 lipoxygenase arachidonate 15-lipoxygenase 662 aa 590 aa 23.9 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tar DNA-binding protein 0.0139 0.287 0.3251
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0037 0.0177 0.0004
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0052 0.0578 0.5
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0611 0.8846
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0037 0.0172 0.0433
Trypanosoma cruzi heat shock protein 90, putative 0.0047 0.0457 0.5696
Leishmania major heat shock protein 83-1 0.0055 0.0668 1
Loa Loa (eye worm) heat shock protein 90 0.0055 0.0668 0.1303
Echinococcus granulosus heat shock protein 90 0.0055 0.0668 0.0504
Brugia malayi hypothetical protein 0.0034 0.0113 0.0283
Leishmania major heat shock protein 83-1 0.0055 0.0668 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0666 0.0502
Onchocerca volvulus 0.0058 0.0728 0.9076
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.8542 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0067 0.0968 0.081
Schistosoma mansoni bromodomain containing protein 0.0076 0.1226 0.127
Schistosoma mansoni hypothetical protein 0.035 0.8469 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0611 0.1184
Brugia malayi Hsp90 protein 0.0037 0.0177 0.0444
Brugia malayi mbt repeat family protein 0.0058 0.0728 0.1831
Toxoplasma gondii heat shock protein HSP90 0.0055 0.0668 0.1074
Loa Loa (eye worm) hypothetical protein 0.0052 0.0567 0.1037
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.8542 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.3766 1
Giardia lamblia Grp94/Hsp90 0.0052 0.0578 0.015
Loa Loa (eye worm) hypothetical protein 0.018 0.3977 1
Echinococcus multilocularis muscleblind protein 0.018 0.3977 0.3871
Brugia malayi Bromodomain containing protein 0.0046 0.0428 0.1076
Loa Loa (eye worm) hypothetical protein 0.0058 0.0728 0.1461
Echinococcus granulosus endoplasmin 0.0052 0.0578 0.0413
Schistosoma mansoni hypothetical protein 0.0043 0.0354 0.0218
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.8542 1
Trypanosoma brucei heat shock protein, putative 0.0055 0.0668 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0352 0.0183
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0728 0.067
Schistosoma mansoni lipoxygenase 0.0067 0.0968 0.0959
Leishmania major heat shock protein 83-1 0.0055 0.0668 1
Echinococcus multilocularis heat shock protein 0.0055 0.0668 0.0504
Entamoeba histolytica hypothetical protein 0.0043 0.0354 0.0211
Echinococcus multilocularis heat shock protein 90 0.0047 0.0457 0.0289
Trypanosoma cruzi heat shock protein 85, putative 0.0047 0.0457 0.5696
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0354 0.0184
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0227 0.521 0.5126
Brugia malayi Latrophilin receptor protein 2 0.0037 0.0172 0.0433
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0139 0.287 0.709
Schistosoma mansoni tar DNA-binding protein 0.0139 0.287 0.3251
Leishmania major heat shock protein 83-1 0.0055 0.0668 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0611 0.1184
Trypanosoma brucei heat shock protein 90, putative 0.0055 0.0668 1
Trypanosoma brucei heat shock protein, putative 0.0055 0.0668 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0939 0.078
Trypanosoma brucei heat shock protein, putative 0.0055 0.0668 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0666 0.0502
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0666 0.0502
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0939 0.0924
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0728 0.0566
Echinococcus multilocularis endoplasmin 0.0052 0.0578 0.0413
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0116 0.2264 0.5498
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.8542 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0666 0.0595
Brugia malayi TAR-binding protein 0.0139 0.287 0.7216
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.8542 1
Plasmodium falciparum heat shock protein 90, putative 0.021 0.4753 1
Echinococcus multilocularis tar DNA binding protein 0.0139 0.287 0.2745
Plasmodium vivax endoplasmin, putative 0.0055 0.0668 0.1074
Loa Loa (eye worm) MBCTL1 0.0066 0.0939 0.2015
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0728 0.1461
Loa Loa (eye worm) hypothetical protein 0.0066 0.0939 0.2015
Plasmodium falciparum heat shock protein 90 0.0055 0.0668 0.1305
Trypanosoma brucei Heat shock protein 83, putative 0.0055 0.0668 1
Trypanosoma brucei heat shock protein, putative 0.0055 0.0668 1
Leishmania major hypothetical protein, conserved 0.0053 0.0611 0.8846
Trypanosoma cruzi heat shock protein 90, putative 0.0055 0.0668 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.043 0.0677
Leishmania major heat shock protein 83-1 0.0055 0.0668 1
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0354 0.0218
Loa Loa (eye worm) TAR-binding protein 0.0139 0.287 0.709
Leishmania major heat shock protein 83-1 0.0055 0.0668 1
Entamoeba histolytica hypothetical protein 0.0043 0.0354 0.0211
Leishmania major heat shock protein 83-1 0.0055 0.0668 1
Plasmodium falciparum endoplasmin, putative 0.004 0.0267 0.045
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.3766 1
Leishmania major heat shock protein 83-1 0.0055 0.0668 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0728 0.0566
Toxoplasma gondii Hsp90 domain-containing protein 0.021 0.4753 1
Echinococcus granulosus tar DNA binding protein 0.0139 0.287 0.2745
Plasmodium vivax heat shock protein 86, putative 0.0055 0.0668 0.1074
Trypanosoma cruzi heat shock protein 85, putative 0.0055 0.0668 1
Echinococcus multilocularis tumor protein p63 0.0408 1 1
Schistosoma mansoni heat shock protein 0.0055 0.0668 0.0598
Trypanosoma cruzi heat shock protein 85, putative 0.0055 0.0668 1
Loa Loa (eye worm) heat shock protein 75 0.0037 0.0177 0.0012
Schistosoma mansoni hypothetical protein 0.0079 0.1296 0.1354
Leishmania major heat shock protein 83-1 0.0055 0.0668 1
Brugia malayi heat shock protein 90 0.0055 0.0668 0.168
Trypanosoma brucei heat shock protein, putative 0.0055 0.0668 1
Loa Loa (eye worm) hypothetical protein 0.018 0.3977 1
Leishmania major heat shock protein 83-1 0.0055 0.0668 1
Leishmania major heat shock protein 83-1 0.0055 0.0668 1
Schistosoma mansoni tar DNA-binding protein 0.0139 0.287 0.3251
Brugia malayi hypothetical protein 0.0043 0.0354 0.0889
Brugia malayi RNA recognition motif domain containing protein 0.0139 0.287 0.7216
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0052 0.0578 0.817
Trypanosoma brucei heat shock protein 90, putative 0.0055 0.0668 1
Trichomonas vaginalis heat shock protein, putative 0.0055 0.0668 0.0722
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0728 0.067
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0047 0.0457 0.0289
Plasmodium vivax heat shock protein, putative 0.021 0.4753 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0352 0.0183
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0227 0.521 0.5126
Trypanosoma cruzi Heat shock protein 83, putative 0.0055 0.0668 1
Schistosoma mansoni endoplasmin 0.0055 0.0668 0.0598
Loa Loa (eye worm) hypothetical protein 0.006 0.0784 0.1609
Loa Loa (eye worm) hypothetical protein 0.0053 0.0611 0.1154
Loa Loa (eye worm) hypothetical protein 0.0085 0.1464 0.3394
Leishmania major heat shock protein 83-1 0.0055 0.0668 1
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0037 0.0177 0.0004
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0611 0.095
Entamoeba histolytica heat shock protein 90, putative 0.0055 0.0668 0.0587
Brugia malayi latrophilin 2 splice variant baaae 0.0079 0.1296 0.3259
Loa Loa (eye worm) hypothetical protein 0.0049 0.0506 0.0876
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0939 0.2361
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.8542 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.8542 1
Brugia malayi Muscleblind-like protein 0.018 0.3977 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0067 0.0968 0.081
Trichomonas vaginalis heat shock protein, putative 0.004 0.0267 0.0249
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.8542 1
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0728 0.067
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0939 0.078
Schistosoma mansoni tar DNA-binding protein 0.0139 0.287 0.3251
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0728 0.0566
Trypanosoma brucei heat shock protein, putative 0.0055 0.0668 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.8542 1
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0578 0.0616
Leishmania major heat shock protein 83-1 0.0055 0.0668 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0055 0.0668 0.0262
Echinococcus multilocularis muscleblind protein 1 0.018 0.3977 0.3871
Toxoplasma gondii heat shock protein 90, putative 0.0055 0.0668 0.1074
Brugia malayi Bromodomain containing protein 0.0091 0.16 0.4024
Brugia malayi Endoplasmin precursor 0.0055 0.0668 0.168
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.1112 0.0956
Brugia malayi hypothetical protein 0.0053 0.0611 0.1537
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.3766 1
Echinococcus granulosus muscleblind protein 0.018 0.3977 0.3871
Trichomonas vaginalis heat shock protein, putative 0.0047 0.0457 0.0473
Schistosoma mansoni heat shock protein 0.0037 0.0177 0.0005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0666 0.0595
Trichomonas vaginalis endoplasmin, putative 0.004 0.0267 0.0249
Loa Loa (eye worm) hypothetical protein 0.0079 0.1296 0.2953
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.8542 1
Loa Loa (eye worm) endoplasmin 0.0055 0.0668 0.1303
Brugia malayi RNA binding protein 0.0139 0.287 0.7216
Schistosoma mansoni endoplasmin 0.0055 0.0668 0.0598
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0611 0.8846
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0578 0.0616
Loa Loa (eye worm) hypothetical protein 0.0116 0.2264 0.5498
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.8542 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.8542 1
Entamoeba histolytica heat shock protein 90, putative 0.0055 0.0668 0.0587
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0666 0.1296
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0784 0.0738
Brugia malayi Calcitonin receptor-like protein seb-1 0.0116 0.2264 0.5693
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0666 0.0502
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.0728 0.9076
Trypanosoma brucei heat shock protein, putative 0.0055 0.0668 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0116 0.2264 0.5693
Onchocerca volvulus 0.006 0.0784 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.1112 0.0956
Entamoeba histolytica hypothetical protein 0.0043 0.0354 0.0211
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0939 0.078
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0611 0.095
Leishmania major heat shock protein 83-1 0.0055 0.0668 1
Trypanosoma brucei heat shock protein, putative 0.0055 0.0668 1
Echinococcus granulosus heat shock protein 0.0055 0.0668 0.0504
Schistosoma mansoni tar DNA-binding protein 0.0139 0.287 0.3251
Leishmania major heat shock protein 83-1 0.0055 0.0668 1
Loa Loa (eye worm) RNA binding protein 0.0139 0.287 0.709
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0666 0.0595
Brugia malayi mbt repeat family protein 0.0058 0.0728 0.1831
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0939 0.078
Entamoeba histolytica hypothetical protein 0.0043 0.0354 0.0211
Echinococcus multilocularis heat shock protein 90 0.0055 0.0668 0.0504
Echinococcus granulosus heat shock protein 90 0.0047 0.0457 0.0289
Trypanosoma cruzi heat shock protein 85, putative 0.0055 0.0668 1
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0611 0.8846
Schistosoma mansoni heat shock protein 0.0055 0.0668 0.0598
Leishmania major heat shock protein 83-1 0.0055 0.0668 1
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0728 0.0566
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0354 0.0184
Leishmania major heat shock protein 83-1 0.0055 0.0668 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0666 0.1674

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 5.845 uM PUBCHEM_BIOASSAY: HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504596] ChEMBL. No reference
AC50 (functional) = 8.852 uM PUBCHEM_BIOASSAY: Anti-Malarial Hsp90 Inhibitors Measured in Microorganism System Using Plate Reader - 2121-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504596] ChEMBL. No reference
EC50 (functional) 23.4 uM PUBCHEM_BIOASSAY: Inhibitors of T-Type Calcium Channel. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID449739, AID463087, AID493021, AID493022, AID493023, AID493041, AID504579, AID504584, AID504619, AID504628] ChEMBL. No reference
IC50 (functional) 10.654 uM PUBCHEM_BIOASSAY: Discovery of Small Molecule Probes for H1N1 Influenza NS1A. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504399] ChEMBL. No reference
Potency (functional) = 0.1995 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.3696 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 0.631 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Permissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.8913 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.7783 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.7783 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 3.9811 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.1995 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 8.2753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.9173 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1: Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485292] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7407 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 26.8545 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 63.0957 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Saccharomyces cerevisiae ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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