Detailed information for compound 1426034

Basic information

Technical information
  • TDR Targets ID: 1426034
  • Name: N-[(2-methoxyphenyl)methyl]-2-(4-pyrrolidin-1 -ylsulfonylphenoxy)acetamide
  • MW: 404.48 | Formula: C20H24N2O5S
  • H donors: 1 H acceptors: 3 LogP: 2.34 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1CNC(=O)COc1ccc(cc1)S(=O)(=O)N1CCCC1
  • InChi: 1S/C20H24N2O5S/c1-26-19-7-3-2-6-16(19)14-21-20(23)15-27-17-8-10-18(11-9-17)28(24,25)22-12-4-5-13-22/h2-3,6-11H,4-5,12-15H2,1H3,(H,21,23)
  • InChiKey: SYLWXVINFJBVJW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(2-methoxyphenyl)methyl]-2-(4-1-pyrrolidinylsulfonylphenoxy)acetamide
  • N-(2-methoxybenzyl)-2-(4-pyrrolidin-1-ylsulfonylphenoxy)acetamide
  • N-[(2-methoxyphenyl)methyl]-2-(4-pyrrolidin-1-ylsulfonylphenoxy)ethanamide
  • ZINC00810123
  • BAS 07556191
  • N-(2-Methoxy-benzyl)-2-[4-(pyrrolidine-1-sulfonyl)-phenoxy]-acetamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis multidrug resistance protein 1 0.0582 1 1
Schistosoma mansoni multidrug resistance protein 0.0582 1 1
Echinococcus multilocularis muscleblind protein 0.018 0.218 0.1966
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0447 0.7362 1
Schistosoma mansoni tar DNA-binding protein 0.0456 0.7543 0.7475
Brugia malayi TAR-binding protein 0.0456 0.7543 0.7543
Loa Loa (eye worm) hypothetical protein 0.0177 0.2118 0.1903
Echinococcus granulosus multidrug resistance protein 1 0.0582 1 1
Onchocerca volvulus 0.0582 1 0.5
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0447 0.7362 1
Leishmania major hypothetical protein, conserved 0.0106 0.073 0.0546
Loa Loa (eye worm) hypothetical protein 0.0174 0.2061 0.1844
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.0447 0.7362 0.729
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0186 0.2283 0.213
Loa Loa (eye worm) multidrug resistance protein 3 0.0582 1 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0582 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0582 1 1
Trypanosoma cruzi ABC transporter, mitochondrial, putative 0.0186 0.2283 0.2914
Entamoeba histolytica ATP-binding cassette protein, putative 0.0186 0.2283 0.028
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0186 0.2283 0.2914
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0582 1 1
Trypanosoma cruzi ABC transporter, putative 0.0447 0.7362 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0582 1 1
Echinococcus granulosus multidrug resistance protein 1 0.0582 1 1
Schistosoma mansoni smdr1 0.0186 0.2283 0.2073
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0186 0.2283 0.213
Giardia lamblia Multidrug resistance-associated protein 1 0.0186 0.2283 0.0438
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0186 0.2283 0.213
Plasmodium vivax ABC transporter B family member 3, putative 0.0186 0.2283 0.1676
Trypanosoma cruzi ATP-binding cassette protein, putative 0.0447 0.7362 1
Loa Loa (eye worm) hypothetical protein 0.0259 0.3714 0.3542
Plasmodium falciparum ABC transporter B family member 7, putative 0.0186 0.2283 0.1676
Schistosoma mansoni tar DNA-binding protein 0.0456 0.7543 0.7475
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.0447 0.7362 0.731
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0186 0.2283 0.213
Echinococcus multilocularis ATP binding cassette sub family B 0.0186 0.2283 0.2073
Leishmania major p-glycoprotein e 0.0186 0.2283 0.213
Brugia malayi ABC transporter transmembrane region family protein 0.0186 0.2283 0.2283
Loa Loa (eye worm) MH2 domain-containing protein 0.0383 0.6126 0.6021
Echinococcus granulosus ATP binding cassette sub family G 0.0447 0.7362 0.729
Plasmodium falciparum ABC transporter B family member 6, putative 0.0186 0.2283 0.1676
Trichomonas vaginalis taga, putative 0.0582 1 1
Schistosoma mansoni tar DNA-binding protein 0.0456 0.7543 0.7475
Entamoeba histolytica P-glycoprotein 6, putative 0.0186 0.2283 0.028
Entamoeba histolytica P-glycoprotein-2 0.0582 1 1
Plasmodium vivax ABC transporter B family member 7, putative 0.0186 0.2283 0.1676
Schistosoma mansoni smdr2 0.0582 1 1
Schistosoma mansoni multidrug resistance protein 0.0186 0.2283 0.2073
Plasmodium falciparum ABC transporter G family member 2 0.0447 0.7362 0.7154
Schistosoma mansoni tar DNA-binding protein 0.0456 0.7543 0.7475
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.0447 0.7362 0.731
Trypanosoma cruzi ABC transporter of the mitochondrion, putative 0.0186 0.2283 0.2914
Entamoeba histolytica P-glyco protein 6, putative 0.0582 1 1
Plasmodium falciparum multidrug resistance-associated protein 1 0.0186 0.2283 0.1676
Echinococcus granulosus multidrug resistance associated protein 1 0.0186 0.2283 0.2073
Entamoeba histolytica P-glycoprotein-2 0.0582 1 1
Plasmodium falciparum multidrug resistance protein 1 0.0582 1 1
Plasmodium vivax multidrug resistance protein 1, putative 0.0582 1 1
Schistosoma mansoni multidrug resistance protein 0.0582 1 1
Echinococcus granulosus ATP binding cassette sub family B 0.0186 0.2283 0.2073
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0582 1 1
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0582 1 1
Echinococcus granulosus multidrug resistance associated protein 7 0.0186 0.2283 0.2073
Brugia malayi ABC transporter family protein 0.0186 0.2283 0.2283
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0582 1 1
Plasmodium vivax multidrug resistance-associated protein 1, putative 0.0186 0.2283 0.1676
Echinococcus granulosus ATP binding cassette sub family G 0.0447 0.7362 0.729
Entamoeba histolytica multidrug resistance protein, putative 0.0186 0.2283 0.028
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0186 0.2283 0.213
Brugia malayi hypothetical protein 0.0106 0.073 0.073
Giardia lamblia Multidrug resistance-associated protein 1 0.0186 0.2283 0.0438
Schistosoma mansoni multidrug resistance protein 0.0186 0.2283 0.2073
Entamoeba histolytica P-glycoprotein 5, putative 0.0582 1 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0582 1 1
Giardia lamblia ABC transporter, putative 0.0186 0.2283 0.0438
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0186 0.2283 0.2073
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0582 1 1
Trypanosoma brucei ABC transporter, mitochondrial, putative 0.0186 0.2283 0.2914
Echinococcus multilocularis ATP binding cassette sub family G 0.0447 0.7362 0.729
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0186 0.2283 0.213
Brugia malayi multidrug resistance related protein 1 0.0186 0.2283 0.2283
Loa Loa (eye worm) hypothetical protein 0.0582 1 1
Brugia malayi ABC transporter transmembrane region family protein 0.0174 0.2061 0.2061
Loa Loa (eye worm) TAR-binding protein 0.0456 0.7543 0.7475
Echinococcus granulosus ATP binding cassette sub family G 0.0447 0.7362 0.729
Brugia malayi ABC transporter family protein 0.0186 0.2283 0.2283
Trichomonas vaginalis abcb9, putative 0.0582 1 1
Trichomonas vaginalis ABC transporter, putative 0.0582 1 1
Echinococcus granulosus ATP binding cassette sub family B 0.0174 0.2061 0.1844
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0186 0.2283 0.2914
Entamoeba histolytica P-glycoprotein-1 0.0582 1 1
Brugia malayi Muscleblind-like protein 0.018 0.218 0.218
Entamoeba histolytica ATP-binding cassette protein, putative 0.0186 0.2283 0.028
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0186 0.2283 0.5
Toxoplasma gondii ATP-binding cassette sub-family B member 5 0.0186 0.2283 0.213
Leishmania major p-glycoprotein 0.0582 1 1
Mycobacterium tuberculosis Probable conserved transmembrane ATP-binding protein ABC transporter 0.0368 0.5837 0.4605
Giardia lamblia ABC transporter 0.0435 0.7139 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0082 0.0266 0.0266
Trichomonas vaginalis ABC transporter, putative 0.0582 1 1
Schistosoma mansoni tar DNA-binding protein 0.0456 0.7543 0.7475
Brugia malayi Calcitonin receptor-like protein seb-1 0.0259 0.3714 0.3714
Trypanosoma cruzi multidrug resistance protein E, putative 0.0186 0.2283 0.2914
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0582 1 1
Schistosoma mansoni multidrug resistance protein 0.0186 0.2283 0.2073
Loa Loa (eye worm) ABC transporter 0.0186 0.2283 0.2073
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0571 0.9777 0.9771
Entamoeba histolytica ATP-binding cassette protein, putative 0.0186 0.2283 0.028
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0582 1 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0582 1 1
Brugia malayi RNA recognition motif domain containing protein 0.0456 0.7543 0.7543
Trichomonas vaginalis ABC transporter, putative 0.0582 1 1
Leishmania major ABC-thiol transporter 0.0186 0.2283 0.213
Loa Loa (eye worm) hypothetical protein 0.0571 0.9777 0.9771
Echinococcus granulosus muscleblind protein 0.018 0.218 0.1966
Trypanosoma brucei ATP-binding cassette protein, putative 0.0447 0.7362 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0582 1 1
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0186 0.2283 0.213
Echinococcus multilocularis ATP binding cassette sub family G 0.0447 0.7362 0.729
Trypanosoma brucei ABC transporter of the mitochondrion, putative 0.0186 0.2283 0.2914
Loa Loa (eye worm) hypothetical protein 0.0174 0.2061 0.1844
Brugia malayi ABC transporter family protein 0.038 0.6059 0.6059
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0582 1 1
Plasmodium falciparum ABC transporter B family member 4, putative 0.0186 0.2283 0.1676
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0174 0.2061 0.1844
Echinococcus multilocularis multidrug resistance protein 1 0.0408 0.6609 0.6516
Plasmodium falciparum ABC transporter B family member 5, putative 0.0186 0.2283 0.1676
Loa Loa (eye worm) ABC transporter 0.038 0.6059 0.5952
Loa Loa (eye worm) ABC transporter 0.0186 0.2283 0.2073
Plasmodium vivax ABC transporter B family member 6, putative 0.0186 0.2283 0.1676
Loa Loa (eye worm) hypothetical protein 0.0186 0.2283 0.2073
Loa Loa (eye worm) ABC transporter 0.0186 0.2283 0.2073
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0186 0.2283 0.028
Trypanosoma cruzi PAB1-binding protein , putative 0.0106 0.073 0.0747
Trichomonas vaginalis abcb9, putative 0.0582 1 1
Echinococcus multilocularis ATP binding cassette sub family B 0.0571 0.9777 0.9771
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0186 0.2283 0.213
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0582 1 1
Echinococcus multilocularis ATP binding cassette sub family B 0.0186 0.2283 0.2073
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.0186 0.2283 0.5
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0582 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0582 1 1
Trypanosoma brucei p-glycoprotein 0.0186 0.2283 0.2914
Echinococcus multilocularis muscleblind protein 1 0.018 0.218 0.1966
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0259 0.3714 0.3714
Echinococcus granulosus multidrug resistance protein 1 0.0408 0.6609 0.6516
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0186 0.2283 0.2073
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0582 1 1
Toxoplasma gondii LsmAD domain-containing protein 0.0106 0.073 0.0546
Entamoeba histolytica hypothetical protein 0.0186 0.2283 0.028
Echinococcus multilocularis ATP binding cassette sub family B 0.0186 0.2283 0.2073
Schistosoma mansoni hypothetical protein 0.0368 0.5837 0.5723
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0582 1 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0408 0.6609 0.5729
Leishmania major ATP-binding cassette protein subfamily B, member 1, putative 0.0186 0.2283 0.213
Brugia malayi latrophilin 2 splice variant baaae 0.0177 0.2118 0.2118
Brugia malayi MH2 domain containing protein 0.0383 0.6126 0.6126
Brugia malayi Latrophilin receptor protein 2 0.0082 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0186 0.2283 0.2073
Loa Loa (eye worm) hypothetical protein 0.0106 0.073 0.0477
Plasmodium vivax multidrug resistance-associated protein 2, putative 0.0186 0.2283 0.1676
Schistosoma mansoni ABC transporter 0.038 0.6059 0.5952
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0582 1 1
Echinococcus multilocularis multidrug resistance associated protein 7 0.0186 0.2283 0.2073
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0582 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0106 0.073 0.0747
Schistosoma mansoni hypothetical protein 0.0177 0.2118 0.1903
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0582 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0582 1 1
Echinococcus granulosus ATP binding cassette sub family B 0.0186 0.2283 0.2073
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0582 1 1
Loa Loa (eye worm) hypothetical protein 0.018 0.218 0.1966
Brugia malayi ABC transporter transmembrane region family protein 0.0186 0.2283 0.2283
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0582 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0582 1 1
Brugia malayi ABC transporter 0.0186 0.2283 0.2283
Trypanosoma brucei ABC transporter, putative 0.0447 0.7362 1
Brugia malayi ABC transporter 0.0174 0.2061 0.2061
Loa Loa (eye worm) RNA binding protein 0.0456 0.7543 0.7475
Plasmodium vivax multidrug resistance protein 2, putative 0.0186 0.2283 0.1676
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0186 0.2283 0.5
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0582 1 1
Leishmania major pentamidine resistance protein 1 0.0186 0.2283 0.213
Echinococcus multilocularis multidrug resistance protein 1 0.0582 1 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0186 0.2283 0.213
Entamoeba histolytica P-glycoprotein-5 0.0582 1 1
Schistosoma mansoni multidrug resistance protein 0.0186 0.2283 0.2073
Echinococcus multilocularis tar DNA binding protein 0.0456 0.7543 0.7475
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0582 1 0.5
Loa Loa (eye worm) hypothetical protein 0.018 0.218 0.1966
Entamoeba histolytica ABC transporter, putative 0.0447 0.7362 0.6677
Plasmodium vivax ABC transporter B family member 4, putative 0.0186 0.2283 0.1676
Loa Loa (eye worm) hypothetical protein 0.0186 0.2283 0.2073
Echinococcus multilocularis ATP binding cassette sub family G 0.0447 0.7362 0.729
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.0447 0.7362 0.731
Loa Loa (eye worm) transcription factor SMAD2 0.0383 0.6126 0.6021
Leishmania major ATP-binding cassette protein subfamily B, member 3, putative 0.0186 0.2283 0.213
Toxoplasma gondii ABC transporter family protein 0.0186 0.2283 0.213
Brugia malayi P-glycoprotein-like protein 0.0186 0.2283 0.2283
Plasmodium falciparum ABC transporter B family member 3, putative 0.0186 0.2283 0.1676
Toxoplasma gondii ABC transporter, putative 0.0186 0.2283 0.213
Trichomonas vaginalis ABC transporter, putative 0.0582 1 1
Entamoeba histolytica P-glycoprotein 6, putative 0.0186 0.2283 0.028
Echinococcus granulosus multidrug resistance protein 1 0.0408 0.6609 0.6516
Schistosoma mansoni multidrug resistance protein 0.0174 0.2061 0.1844
Schistosoma mansoni multidrug resistance protein 0.0186 0.2283 0.2073
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0582 1 1
Schistosoma mansoni multidrug resistance protein 0.0582 1 1
Trichomonas vaginalis abcb9, putative 0.0582 1 1
Plasmodium vivax ABC transporter B family member 5, putative 0.0186 0.2283 0.1676
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0582 1 1
Loa Loa (eye worm) hypothetical protein 0.0582 1 1
Echinococcus multilocularis ATP binding cassette sub family B 0.0186 0.2283 0.2073
Echinococcus granulosus multidrug resistance protein 1 0.0582 1 1
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0186 0.2283 0.2283
Entamoeba histolytica ATP-binding cassette protein, putative 0.0186 0.2283 0.028
Brugia malayi RNA binding protein 0.0456 0.7543 0.7543
Echinococcus granulosus tar DNA binding protein 0.0456 0.7543 0.7475
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0582 1 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0456 0.7543 0.7475
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0582 1 1
Echinococcus multilocularis 0.0186 0.2283 0.2073
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0186 0.2283 0.2914
Giardia lamblia MRP-like ABC transporter 0.0186 0.2283 0.0438
Entamoeba histolytica ABC transporter, putative 0.0186 0.2283 0.028
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0259 0.3714 0.3542
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0582 1 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0582 1 1
Brugia malayi hypothetical protein 0.0186 0.2283 0.2283
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0582 1 1
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0186 0.2283 0.2914
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0186 0.2283 0.213
Brugia malayi ABC transporter family protein 0.0186 0.2283 0.2283
Trypanosoma brucei multidrug resistance protein E 0.0186 0.2283 0.2914
Plasmodium vivax ABC transporter G family member 2, putative 0.0447 0.7362 0.7154
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0447 0.7362 1
Entamoeba histolytica P-glycoprotein-2, putative 0.0582 1 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0582 1 1
Echinococcus multilocularis multidrug resistance associated protein 1 0.0186 0.2283 0.2073
Plasmodium falciparum multidrug resistance protein 2 0.0186 0.2283 0.1676
Brugia malayi ABC transporter family protein 0.0582 1 1
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.0186 0.2283 0.5
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0582 1 1
Plasmodium falciparum multidrug resistance-associated protein 2 0.0186 0.2283 0.1676
Trypanosoma brucei PAB1-binding protein , putative 0.0106 0.073 0.0747
Leishmania major ATP-binding cassette protein subfamily C, member 8, putative 0.0186 0.2283 0.213

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.122 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (binding) 7.9433 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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