Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | conserved hypothetical protein | 0.0554 | 0.2656 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.0179 | 0.0179 |
Brugia malayi | RNA binding protein | 0.0076 | 0.0179 | 0.0179 |
Brugia malayi | maoC like domain containing protein | 0.0083 | 0.0213 | 0.0213 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0554 | 0.2656 | 1 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0554 | 0.2656 | 0.5 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0554 | 0.2656 | 0.5 |
Echinococcus multilocularis | geminin | 0.0205 | 0.0843 | 0.0677 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.0179 | 0.0179 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0554 | 0.2656 | 0.5 |
Onchocerca volvulus | 0.197 | 1 | 0.5 | |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase superfamily protein | 0.0554 | 0.2656 | 1 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase domain-containing protein | 0.0554 | 0.2656 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0554 | 0.2656 | 0.5 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.197 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.197 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.0843 | 0.0677 |
Mycobacterium tuberculosis | Probable 3-hydroxyacyl-thioester dehydratase HtdY | 0.0083 | 0.0213 | 0.0803 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.0179 | 0.0179 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.0179 | 0.0179 |
Entamoeba histolytica | hypothetical protein | 0.0554 | 0.2656 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.0213 | 0.0213 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.0843 | 0.0677 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.0718 | 0.0718 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.197 | 1 | 1 |
Mycobacterium ulcerans | dehydratase | 0.0083 | 0.0213 | 0.0803 |
Echinococcus granulosus | geminin | 0.0205 | 0.0843 | 0.0677 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 0.0718 | 0.0549 |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0554 | 0.2656 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase. Possible 2-enoyl acyl-CoA hydratase. | 0.0083 | 0.0213 | 0.0803 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 0.0718 | 0.0549 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.197 | 1 | 1 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0554 | 0.2656 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.0179 | 0.0179 |
Brugia malayi | Muscleblind-like protein | 0.018 | 0.0718 | 0.0718 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.0718 | 0.0718 |
Mycobacterium ulcerans | hypothetical protein | 0.0083 | 0.0213 | 0.0803 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0554 | 0.2656 | 0.5 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0554 | 0.2656 | 0.5 |
Echinococcus granulosus | muscleblind protein | 0.018 | 0.0718 | 0.0549 |
Toxoplasma gondii | sterol carrier protein-2 HAD-2SCP-2 | 0.0075 | 0.0169 | 0.048 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0554 | 0.2656 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 6.5131 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | 15.8489 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.