Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cell division cycle 25A | Starlite/ChEMBL | References |
Homo sapiens | cell division cycle 25B | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0164 | 0.0322 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.0322 | 0.0322 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0164 | 0.0322 | 0.0322 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 0.0322 | 0.0322 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0968 | 1 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0164 | 0.0322 | 0.0322 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.0322 | 0.0322 |
Echinococcus granulosus | acetylcholinesterase | 0.0968 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0164 | 0.0322 | 0.0322 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.0322 | 0.0322 |
Onchocerca volvulus | 0.0164 | 0.0322 | 1 | |
Brugia malayi | hypothetical protein | 0.0164 | 0.0322 | 0.0322 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0164 | 0.0322 | 0.0322 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 0.0322 | 0.0322 |
Loa Loa (eye worm) | hypothetical protein | 0.0968 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0968 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0968 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0968 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.0322 | 0.0322 |
Echinococcus multilocularis | acetylcholinesterase | 0.0968 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0968 | 1 | 1 |
Onchocerca volvulus | 0.0164 | 0.0322 | 1 | |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0137 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.0322 | 0.0322 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 0.0322 | 0.0322 |
Schistosoma mansoni | gliotactin | 0.0164 | 0.0322 | 0.0322 |
Echinococcus granulosus | neuroligin | 0.0164 | 0.0322 | 0.0322 |
Onchocerca volvulus | 0.0164 | 0.0322 | 1 | |
Echinococcus granulosus | acetylcholinesterase | 0.0968 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.0322 | 0.0322 |
Loa Loa (eye worm) | hypothetical protein | 0.0968 | 1 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0164 | 0.0322 | 0.0322 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.0322 | 0.0322 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0164 | 0.0322 | 0.0322 |
Onchocerca volvulus | 0.0164 | 0.0322 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.0322 | 0.0322 |
Loa Loa (eye worm) | carboxylesterase | 0.0164 | 0.0322 | 0.0322 |
Echinococcus multilocularis | neuroligin | 0.0164 | 0.0322 | 0.0322 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0164 | 0.0322 | 0.0322 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0137 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0968 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0164 | 0.0322 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.0322 | 0.0322 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0164 | 0.0322 | 0.5 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0164 | 0.0322 | 0.0322 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0164 | 0.0322 | 0.5 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0164 | 0.0322 | 0.0322 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0164 | 0.0322 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0164 | 0.0322 | 0.5 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0137 | 0 | 0.5 |
Onchocerca volvulus | 0.0164 | 0.0322 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.0322 | 0.0322 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.0322 | 0.0322 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0164 | 0.0322 | 0.0322 |
Loa Loa (eye worm) | carboxylesterase | 0.0968 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.2 uM | Eight point inhibitory concentration against Cell division cycle 25A was determined | ChEMBL. | 12801222 |
IC50 (binding) | = 4.2 uM | Eight point inhibitory concentration against Cell division cycle 25A was determined | ChEMBL. | 12801222 |
IC50 (binding) | = 14 uM | Eight point inhibitory concentration against Cell division cycle 25B was determined | ChEMBL. | 12801222 |
IC50 (binding) | = 14 uM | Eight point inhibitory concentration against Cell division cycle 25B was determined | ChEMBL. | 12801222 |
IC50 (binding) | = 40 uM | Eight point inhibitory concentration against Cell division cycle 25 degree C was determined | ChEMBL. | 12801222 |
IC50 (binding) | = 40 uM | Eight point inhibitory concentration against Cell division cycle 25 degree C was determined | ChEMBL. | 12801222 |
Inhibition (binding) | = 81 % | Percent inhibition of cell division cycle 25 degree C at 50 microM. | ChEMBL. | 12801222 |
Inhibition (binding) | = 81 % | Percent inhibition of cell division cycle 25 degree C at 50 microM. | ChEMBL. | 12801222 |
Inhibition (binding) | = 92 % | Percent inhibition of cell division cycle 25B at 50 microM. | ChEMBL. | 12801222 |
Inhibition (binding) | = 92 % | Percent inhibition of cell division cycle 25B at 50 microM. | ChEMBL. | 12801222 |
Inhibition (binding) | = 100 % | Percent inhibition of cell division cycle 25A at 50 microM. | ChEMBL. | 12801222 |
Inhibition (binding) | = 100 % | Percent inhibition of cell division cycle 25A at 50 microM. | ChEMBL. | 12801222 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.