Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | euchromatic histone-lysine N-methyltransferase 2 | Starlite/ChEMBL | No references |
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Brugia malayi | Pre-SET motif family protein | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Trichomonas vaginalis | set domain proteins, putative | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Onchocerca volvulus | Get druggable targets OG5_131470 | All targets in OG5_131470 | |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.0348 | 0.0311 |
Onchocerca volvulus | 0.0043 | 0.0348 | 0.0297 | |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0.0348 | 0.5 |
Brugia malayi | beta-lactamase | 0.0043 | 0.0348 | 0.0311 |
Brugia malayi | TAR-binding protein | 0.0196 | 0.6413 | 0.6687 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0348 | 0.0311 |
Trichomonas vaginalis | set domain proteins, putative | 0.0286 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0196 | 0.6413 | 0.6687 |
Loa Loa (eye worm) | TAR-binding protein | 0.0196 | 0.6413 | 0.6687 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0348 | 0.0311 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0348 | 0.0311 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0036 | 0.0053 | 0.0082 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0348 | 0.0311 |
Loa Loa (eye worm) | RNA binding protein | 0.0196 | 0.6413 | 0.6687 |
Echinococcus multilocularis | tar DNA binding protein | 0.0196 | 0.6413 | 1 |
Brugia malayi | RNA binding protein | 0.0196 | 0.6413 | 0.6687 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0.0348 | 0.0311 |
Schistosoma mansoni | tar DNA-binding protein | 0.0196 | 0.6413 | 0.6687 |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0.0348 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0348 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0348 | 0.0311 |
Schistosoma mansoni | tar DNA-binding protein | 0.0196 | 0.6413 | 0.6687 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0348 | 0.0311 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0043 | 0.0348 | 0.0465 |
Mycobacterium leprae | conserved hypothetical protein | 0.0043 | 0.0348 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0.0348 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0.0348 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.9671 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.8618 | 0.9006 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0348 | 0.5 |
Schistosoma mansoni | glutaminase | 0.0275 | 0.9564 | 1 |
Mycobacterium ulcerans | glutaminase | 0.0275 | 0.9564 | 1 |
Brugia malayi | glutaminase DH11.1 | 0.0275 | 0.9564 | 1 |
Loa Loa (eye worm) | glutaminase | 0.0275 | 0.9564 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0348 | 0.0311 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0348 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0196 | 0.6413 | 0.6687 |
Loa Loa (eye worm) | glutaminase 2 | 0.0275 | 0.9564 | 1 |
Onchocerca volvulus | 0.0043 | 0.0348 | 0.0297 | |
Toxoplasma gondii | ABC1 family protein | 0.0043 | 0.0348 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0043 | 0.0348 | 0.0543 |
Schistosoma mansoni | tar DNA-binding protein | 0.0196 | 0.6413 | 0.6687 |
Mycobacterium leprae | Probable lipase LipE | 0.0043 | 0.0348 | 0.5 |
Trichomonas vaginalis | glutaminase, putative | 0.0275 | 0.9564 | 0.9548 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0348 | 0.0311 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.8618 | 0.9006 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0348 | 0.0311 |
Echinococcus granulosus | tar DNA binding protein | 0.0196 | 0.6413 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0196 | 0.6413 | 0.6687 |
Onchocerca volvulus | 0.0043 | 0.0348 | 0.0297 | |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0196 | 0.6413 | 0.6687 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 2.8184 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.