Detailed information for compound 1426451

Basic information

Technical information
  • TDR Targets ID: 1426451
  • Name: 1-methyl-4-oxo-N-(1-phenylethyl)-6-pyrrolidin -1-ylsulfonylquinoline-3-carboxamide
  • MW: 439.527 | Formula: C23H25N3O4S
  • H donors: 1 H acceptors: 4 LogP: 3.27 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(c1ccccc1)NC(=O)c1cn(C)c2c(c1=O)cc(cc2)S(=O)(=O)N1CCCC1
  • InChi: 1S/C23H25N3O4S/c1-16(17-8-4-3-5-9-17)24-23(28)20-15-25(2)21-11-10-18(14-19(21)22(20)27)31(29,30)26-12-6-7-13-26/h3-5,8-11,14-16H,6-7,12-13H2,1-2H3,(H,24,28)
  • InChiKey: GVIQMHUNZFYEGS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-methyl-4-oxo-N-(1-phenylethyl)-6-pyrrolidin-1-ylsulfonyl-quinoline-3-carboxamide
  • 1-methyl-4-oxo-N-(1-phenylethyl)-6-1-pyrrolidinylsulfonyl-3-quinolinecarboxamide
  • 4-keto-1-methyl-N-(1-phenylethyl)-6-pyrrolidin-1-ylsulfonyl-quinoline-3-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0032 0.2309
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0032 0.0154
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.0026 0.0045 0.287
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0026 0.0045 0.0066
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0007 0.0035
Schistosoma mansoni ran 0.0026 0.0043 0.0063
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0016 0.0007 0.0084
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.0231 0.0339
Onchocerca volvulus 0.0037 0.0086 0.009
Loa Loa (eye worm) pigment dispersing factor receptor c 0.2637 1 1
Mycobacterium leprae Probable NAD-dependent deacetylase NpdA (Regulatory protein SIR2 homolog) 0.0035 0.0078 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0245 0.088 1
Brugia malayi RasGEF domain containing protein 0.0042 0.0108 0.0108
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0051 0.0139 0.1584
Echinococcus multilocularis cpg binding protein 0.0037 0.0085 0.0273
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0026 0.0045 0.0217
Onchocerca volvulus 0.0287 0.1039 0.22
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0026 0.0045 0.0066
Brugia malayi isocitrate dehydrogenase 0.0245 0.088 0.088
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0026 0.0045 0.0145
Trypanosoma cruzi PAB1-binding protein , putative 0.0209 0.0744 0.8455
Mycobacterium ulcerans hypothetical protein 0.0026 0.0045 0.0182
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.0045 0.0066
Schistosoma mansoni hypothetical protein 0.0834 0.3127 0.4586
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.003 0.0059 0.0059
Schistosoma mansoni tar DNA-binding protein 0.0676 0.2522 0.3699
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.0026 0.0045 0.0217
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.0026 0.0045 0.0434
Mycobacterium tuberculosis Probable 3-isopropylmalate dehydrogenase LeuB (beta-IPM dehydrogenase) (IMDH) (3-IPM-DH) 0.003 0.0059 0.0317
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0026 0.0045 0.0066
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0026 0.0045 0.0066
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0026 0.0045 0.0145
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0078 0.0251
Treponema pallidum catabolite gene activator 0.0026 0.0045 1
Echinococcus multilocularis expressed conserved protein 0.0026 0.0045 0.0145
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0026 0.0045 0.0045
Echinococcus multilocularis Protein son of sevenless 0.0042 0.0108 0.0344
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0026 0.0045 0.0145
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.0026 0.0045 0.0514
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.003 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0834 0.3127 0.3127
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0086 0.0275
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0032 0.0284
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0051 0.0139 0.1513
Echinococcus multilocularis regulator of G protein signaling 7 0.006 0.0173 0.0553
Schistosoma mansoni hypothetical protein 0.0834 0.3127 0.4586
Echinococcus granulosus chromatin regulatory protein sir2 0.0016 0.0007 0.0024
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0026 0.0045 0.0045
Brugia malayi DIX domain containing protein 0.006 0.0173 0.0173
Mycobacterium ulcerans transcriptional regulatory protein 0.0026 0.0045 0.0182
Mycobacterium ulcerans hypothetical protein 0.0026 0.0045 0.0182
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0032 0.0103
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0245 0.088 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0026 0.0045 0.0045
Loa Loa (eye worm) glutaminase 0.0561 0.2084 0.2084
Loa Loa (eye worm) sirtuin 4 0.0016 0.0007 0.0007
Schistosoma mansoni isocitrate dehydrogenase 0.003 0.0059 0.0087
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0026 0.0045 0.0066
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.003 0.0059 0.0059
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0078 0.0078
Schistosoma mansoni hypothetical protein 0.0372 0.1363 0.1999
Loa Loa (eye worm) isocitrate dehydrogenase 0.0245 0.088 0.088
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0026 0.0045 0.0145
Schistosoma mansoni hypothetical protein 0.0026 0.0045 0.0066
Echinococcus multilocularis regulator of G protein signaling 7 0.006 0.0173 0.0553
Leishmania major hypothetical protein, conserved 0.0209 0.0744 0.8442
Echinococcus multilocularis GPCR, family 2 0.0834 0.3127 1
Echinococcus granulosus snurportin 1 0.0372 0.1363 0.4358
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.0026 0.0045 0.0154
Trichomonas vaginalis ran, putative 0.0026 0.0043 0.0208
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0043 0.0043
Loa Loa (eye worm) AGC/PKG protein kinase 0.0026 0.0045 0.0045
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0016 0.0007 0.053
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0016 0.0007 0.0024
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0086 0.0275
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0042 0.0108 0.0344
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0042 0.0108 0.772
Leishmania major protein kinase A regulatory subunit, putative 0.0026 0.0045 0.0434
Toxoplasma gondii hypothetical protein 0.006 0.0173 0.1896
Brugia malayi N-terminal motif family protein 0.1211 0.4563 0.4563
Echinococcus granulosus hyperpolarization activated cyclic 0.0026 0.0045 0.0145
Toxoplasma gondii histone deacetylase SIR2 0.0051 0.0139 0.1513
Brugia malayi RasGEF domain containing protein 0.0042 0.0108 0.0108
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.0026 0.0045 0.5
Mycobacterium tuberculosis Conserved protein 0.0026 0.0045 0.0154
Loa Loa (eye worm) hypothetical protein 0.0042 0.0108 0.0108
Leishmania major hypothetical protein, conserved 0.0026 0.0045 0.0434
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0007 0.0011
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0032 0.0284
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0043 0.0492
Echinococcus multilocularis segment polarity protein dishevelled 0.006 0.0173 0.0553
Onchocerca volvulus 0.0035 0.0078 0.0072
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0051 0.0139 0.1265
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0078 0.0813
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0026 0.0045 0.0066
Echinococcus granulosus segment polarity protein dishevelled 0.006 0.0173 0.0553
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0156 0.0229
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0094 0.0304 0.0971
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0026 0.0045 0.0145
Plasmodium falciparum cGMP-dependent protein kinase 0.0026 0.0045 0.0434
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0032 0.0284
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0053 0.0255
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0032 0.0119
Brugia malayi hypothetical protein 0.006 0.0173 0.0173
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.0026 0.0045 0.0154
Plasmodium falciparum ataxin-2 like protein, putative 0.0209 0.0744 0.8442
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0016 0.0007 0.053
Toxoplasma gondii exonuclease III APE 0.0023 0.0032 0.0284
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0156 0.0156
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0245 0.088 0.2814
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0032 0.0032
Echinococcus granulosus Protein son of sevenless 0.0042 0.0108 0.0344
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0245 0.088 1
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0026 0.0045 0.0434
Brugia malayi Probable isocitrate dehydrogenase 0.003 0.0059 0.0059
Schistosoma mansoni dishevelled 0.006 0.0173 0.0253
Leishmania major hypothetical protein, conserved 0.0026 0.0045 0.0434
Brugia malayi RNA recognition motif domain containing protein 0.0676 0.2522 0.2522
Schistosoma mansoni cpg binding protein 0.0037 0.0085 0.0125
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0016 0.0007 0.0024
Plasmodium vivax importin-beta 2, putative 0.0035 0.0078 0.0813
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0245 0.088 0.2814
Treponema pallidum cyclic nucleotide binding protein 0.0026 0.0045 1
Brugia malayi RNA, U transporter 1 0.0099 0.0323 0.0323
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0026 0.0045 0.0145
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0053 0.0255
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0026 0.0045 0.0145
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0026 0.0045 0.0434
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0042 0.0108 0.0158
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0026 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0026 0.0045 0.0045
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0042 0.0108 0.772
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0007 0.0011
Leishmania major importin beta-1 subunit, putative 0.0028 0.0053 0.0526
Echinococcus granulosus cGMP dependent protein kinase 1 0.0026 0.0045 0.0145
Loa Loa (eye worm) TAR-binding protein 0.0676 0.2522 0.2522
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0042 0.0108 0.0158
Brugia malayi N-terminal motif family protein 0.0042 0.0108 0.0108
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0043 0.0412
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0026 0.0045 0.0066
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0078 0.0813
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0016 0.0007 0.0024
Mycobacterium ulcerans hypothetical protein 0.0026 0.0045 0.0182
Echinococcus granulosus cGMP dependent protein kinase 1 0.0026 0.0045 0.0145
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0086 0.0275
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0834 0.3127 1
Schistosoma mansoni hypothetical protein 0.1803 0.6819 1
Echinococcus granulosus cpg binding protein 0.0037 0.0085 0.0273
Mycobacterium ulcerans glutaminase 0.0561 0.2084 1
Brugia malayi Latrophilin receptor protein 2 0.0834 0.3127 0.3127
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0042 0.0108 0.772
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0156 0.0499
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0051 0.0139 0.1584
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0007 0.0035
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0026 0.0045 0.0514
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0245 0.088 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0834 0.3127 0.3127
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0042 0.0108 0.772
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0026 0.0045 0.0217
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0026 0.0045 0.0217
Brugia malayi glutaminase DH11.1 0.0561 0.2084 0.2084
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0026 0.0045 0.0434
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0245 0.088 1
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0042 0.0108 0.772
Mycobacterium leprae PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) 0.003 0.0059 0.4273
Mycobacterium ulcerans transmembrane transport protein 0.0026 0.0045 0.0182
Echinococcus granulosus regulator of G protein signaling 7 0.006 0.0173 0.0553
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0032 0.0366
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0026 0.0045 0.0145
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0245 0.088 0.129
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0026 0.0045 0.0154
Echinococcus granulosus regulator of G protein signaling 7 0.006 0.0173 0.0553
Mycobacterium ulcerans 3-isopropylmalate dehydrogenase 0.003 0.0059 0.0249
Trypanosoma cruzi PAB1-binding protein , putative 0.0209 0.0744 0.8455
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0026 0.0045 0.0145
Schistosoma mansoni hypothetical protein 0.0094 0.0304 0.0445
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0026 0.0045 0.0145
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.0026 0.0045 0.0434
Brugia malayi transcriptional regulator, Sir2 family protein 0.0016 0.0007 0.0007
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0026 0.0045 0.0434
Mycobacterium ulcerans regulatory protein 0.0026 0.0045 0.0182
Loa Loa (eye worm) DIX domain-containing protein 0.006 0.0173 0.0173
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0042 0.0108 0.0344
Loa Loa (eye worm) hypothetical protein 0.0037 0.0086 0.0086
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0026 0.0045 0.0145
Leishmania major isocitrate dehydrogenase, putative 0.003 0.0059 0.0592
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.0045 0.0066
Trypanosoma brucei cAMP binding protein, putative 0.0026 0.0045 0.0434
Toxoplasma gondii isocitrate dehydrogenase 0.0245 0.088 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0086 0.0126
Entamoeba histolytica hypothetical protein, conserved 0.0016 0.0007 0.053
Plasmodium vivax NAD-dependent deacetylase, putative 0.0051 0.0139 0.1513
Mycobacterium ulcerans NAD-dependent deacetylase 0.0051 0.0139 0.0636
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0007 0.0035
Wolbachia endosymbiont of Brugia malayi isocitrate dehydrogenase 0.003 0.0059 1
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0045 0.0066
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0042 0.0108 0.772
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0042 0.0108 0.772
Trichomonas vaginalis glutaminase, putative 0.0561 0.2084 1
Schistosoma mansoni importin beta-1 0.0035 0.0078 0.0115
Trypanosoma cruzi protein kinase A regulatory subunit 0.0026 0.0045 0.0514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0043 0.0412
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0026 0.0045 0.0145
Loa Loa (eye worm) hypothetical protein 0.006 0.0173 0.0173
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.0045 0.0066
Leishmania major regulatory subunit of protein kinase a-like protein 0.0026 0.0045 0.0434
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0032 0.0366
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.006 0.0173 0.0173
Trichomonas vaginalis set domain proteins, putative 0.0287 0.1039 0.4986
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.003 0.0059 0.0189
Loa Loa (eye worm) glutaminase 2 0.0561 0.2084 0.2084
Brugia malayi Probable isocitrate dehydrogenase 0.003 0.0059 0.0059
Echinococcus granulosus cGMP dependent protein kinase 0.0026 0.0045 0.0145
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0026 0.0045 0.0145
Echinococcus multilocularis voltage gated potassium channel 0.0026 0.0045 0.0145
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0156 0.0499
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0026 0.0045 0.0066
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0834 0.3127 0.3127
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0007 0.0011
Loa Loa (eye worm) hypothetical protein 0.1211 0.4563 0.4563
Echinococcus multilocularis isocitrate dehydrogenase 0.0245 0.088 0.2814
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0026 0.0045 0.0145
Loa Loa (eye worm) RasGEF domain-containing protein 0.0042 0.0108 0.0108
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0026 0.0045 0.0145
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.0907 0.0907
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0042 0.0108 0.772
Plasmodium vivax SET domain protein, putative 0.0037 0.0086 0.09
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.0026 0.0045 0.0217
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0051 0.0139 0.0669
Schistosoma mansoni dep domain containing protein 0.006 0.0173 0.0253
Schistosoma mansoni hypothetical protein 0.0834 0.3127 0.4586
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0007 0.0011
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0042 0.0108 0.772
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.003 0.0059 0.0059
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.0045 0.0066
Schistosoma mansoni ras GTP exchange factor 0.0042 0.0108 0.0158
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0026 0.0045 0.0066
Entamoeba histolytica Ran family GTPase 0.0026 0.0043 0.3106
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0201 0.2221
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0007 0.0035
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0026 0.0045 0.0145
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0026 0.0045 0.0045
Trichomonas vaginalis ras GTP exchange factor, putative 0.0042 0.0108 0.0516
Brugia malayi Pre-SET motif family protein 0.0037 0.0086 0.0086
Trypanosoma cruzi cAMP response protein 1, putative 0.0026 0.0045 0.0514
Brugia malayi RNA binding protein 0.0676 0.2522 0.2522
Echinococcus granulosus voltage gated potassium channel 0.0026 0.0045 0.0145
Loa Loa (eye worm) hypothetical protein 0.0042 0.0108 0.0108
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0026 0.0045 0.0145
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0086 0.09
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0007
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0043 0.0138
Trypanosoma cruzi cAMP response protein 1 0.0026 0.0045 0.0514
Loa Loa (eye worm) hypothetical protein 0.006 0.0173 0.0173
Echinococcus multilocularis snurportin 1 0.0372 0.1363 0.4358
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0045 0.0066
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0078 0.0249
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0245 0.088 1
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0042 0.0108 0.772
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0043 0.0412
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.0026 0.0045 0.0434
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.003 0.0059 0.0087
Echinococcus granulosus geminin 0.0205 0.0726 0.2321
Plasmodium falciparum ataxin-2 like protein, putative 0.0209 0.0744 0.8442
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.1211 0.4563 1
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0042 0.0108 0.0158
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0032 0.0284
Schistosoma mansoni cpg binding protein 0.0037 0.0085 0.0125
Treponema pallidum cyclic nucleotide binding protein 0.0026 0.0045 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0245 0.088 0.2814
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.1363 0.1363
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0026 0.0045 0.0066
Toxoplasma gondii isocitrate dehydrogenase 0.0245 0.088 1
Echinococcus granulosus segment polarity protein dishevelled 0.006 0.0173 0.0553
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0026 0.0045 0.0434
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0026 0.0045 0.0434
Schistosoma mansoni hypothetical protein 0.0205 0.0726 0.1064
Schistosoma mansoni unc-13 (munc13) 0.003 0.0059 0.0087
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0026 0.0045 0.0434
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0094 0.0304 0.0971
Echinococcus multilocularis hyperpolarization activated cyclic 0.0026 0.0045 0.0145
Echinococcus granulosus importin subunit beta 1 0.0035 0.0078 0.0251
Brugia malayi latrophilin 2 splice variant baaae 0.1803 0.6819 0.6819
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0032 0.0032
Schistosoma mansoni ap endonuclease 0.0023 0.0032 0.0047
Brugia malayi transcriptional regulator, Sir2 family protein 0.0016 0.0007 0.0007
Brugia malayi Pre-SET motif family protein 0.0252 0.0907 0.0907
Trypanosoma brucei Flagellar Member 6 0.0026 0.0045 0.0434
Treponema pallidum catabolite gene activator (Crp) 0.0026 0.0045 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0026 0.0045 0.0154
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0156 0.0156
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0026 0.0045 0.0217
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0676 0.2522 0.2522
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0026 0.0045 0.0145
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0026 0.0045 0.0066
Brugia malayi NAD-dependent deacetylase SIRT1 0.0016 0.0007 0.0007
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0043 0.0138
Loa Loa (eye worm) hypothetical protein 0.0209 0.0744 0.0744
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0051 0.0139 0.1513
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.0045 0.0066
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0042 0.0108 0.0344
Loa Loa (eye worm) transcriptional regulator 0.0016 0.0007 0.0007
Echinococcus granulosus son of sevenless 1 0.0042 0.0108 0.0344
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0043 0.0492
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0245 0.088 0.2814
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0026 0.0045 0.0045
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.0026 0.0045 0.0434
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.0042 0.0108 0.0516
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0026 0.0045 0.0066
Schistosoma mansoni tar DNA-binding protein 0.0676 0.2522 0.3699
Brugia malayi Importin beta-1 subunit 0.0035 0.0078 0.0078
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0032 0.0154
Schistosoma mansoni z-protein (S1r protein) 0.006 0.0173 0.0253
Leishmania major protein kinase, putative 0.0026 0.0045 0.0434
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0045 0.0066
Schistosoma mansoni glutaminase 0.0561 0.2084 0.3056
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.003 0.0059 0.0189
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0051 0.0139 0.0669
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0086 0.0126
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0016 0.0007 0.0024
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0053 0.0255
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0026 0.0045 0.0514
Brugia malayi hypothetical protein 0.0135 0.0461 0.0461
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.006 0.0173 0.0253
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0032 0.0103
Onchocerca volvulus 0.0042 0.0108 0.0138
Schistosoma mansoni tar DNA-binding protein 0.0676 0.2522 0.3699
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0834 0.3127 1
Brugia malayi transcriptional regulator, Sir2 family protein 0.0016 0.0007 0.0007
Loa Loa (eye worm) RasGEF domain-containing protein 0.0042 0.0108 0.0108
Brugia malayi hypothetical protein 0.0209 0.0744 0.0744
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.004 0.01 0.0146
Brugia malayi Cyclic-nucleotide gated cation channel 0.0026 0.0045 0.0045
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0042 0.0108 0.772
Loa Loa (eye worm) hypothetical protein 0.0035 0.0078 0.0078
Echinococcus granulosus GPCR family 2 0.0834 0.3127 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0032 0.1878
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0245 0.088 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0086 0.0126
Loa Loa (eye worm) hypothetical protein 0.1803 0.6819 0.6819
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0078 0.0813
Plasmodium vivax ataxin-2 like protein, putative 0.0209 0.0744 0.8442
Trypanosoma cruzi hypothetical protein 0.0042 0.0108 0.1223
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0051 0.0139 1
Brugia malayi RasGEF domain containing protein 0.0042 0.0108 0.0108
Mycobacterium ulcerans hypothetical protein 0.0026 0.0045 0.0182
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0026 0.0045 0.0045
Echinococcus multilocularis hyperpolarization activated cyclic 0.0026 0.0045 0.0145
Schistosoma mansoni hypothetical protein 0.0834 0.3127 0.4586
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0007 0.0011
Mycobacterium tuberculosis Conserved hypothetical protein 0.0026 0.0045 0.0154
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0007 0.0035
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0016 0.0007 0.053
Leishmania major cyclic nucleotide-binding protein-like protein 0.0026 0.0045 0.0434
Schistosoma mansoni regulator of G protein signaling 0.006 0.0173 0.0253
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.006 0.0173 0.0173
Schistosoma mansoni dishevelled 0.006 0.0173 0.0253
Trichomonas vaginalis ras GTP exchange factor, putative 0.0042 0.0108 0.0516
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0042 0.0108 0.0138
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0007 0.0035
Trypanosoma brucei cAMP response protein 1, putative 0.0026 0.0045 0.0434
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0043 0.0412
Echinococcus granulosus hyperpolarization activated cyclic 0.0026 0.0045 0.0145
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0026 0.0045 0.0145
Trypanosoma brucei PAB1-binding protein , putative 0.0209 0.0744 0.8442
Brugia malayi CXXC zinc finger family protein 0.0035 0.0078 0.0078
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.006 0.0173 0.0553
Schistosoma mansoni ap endonuclease 0.0023 0.0032 0.0047
Trichomonas vaginalis isocitrate dehydrogenase, putative 0.003 0.0059 0.0283
Loa Loa (eye worm) RNA binding protein 0.0676 0.2522 0.2522
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0156 0.0499
Schistosoma mansoni tar DNA-binding protein 0.0676 0.2522 0.3699
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0156 0.0499
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.006 0.0173 0.0282
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0026 0.0045 0.0066
Leishmania major hypothetical protein, unknown function 0.0026 0.0045 0.0434
Brugia malayi TAR-binding protein 0.0676 0.2522 0.2522
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0026 0.0045 0.0145
Echinococcus multilocularis geminin 0.0205 0.0726 0.2321
Brugia malayi Isocitrate dehydrogenase 0.0245 0.088 0.088
Schistosoma mansoni hypothetical protein 0.0205 0.0726 0.1064
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0156 0.0229
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0045 0.0217
Entamoeba histolytica hypothetical protein 0.0042 0.0108 0.772
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0026 0.0045 0.0045
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0043 0.0043
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0042 0.0108 0.772
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0042 0.0108 0.0516
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.0042 0.0108 0.1223
Trypanosoma cruzi cAMP binding protein, putative 0.0026 0.0045 0.0514
Brugia malayi Calcitonin receptor-like protein seb-1 0.2637 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0156 0.0229
Echinococcus multilocularis son of sevenless 1 0.0042 0.0108 0.0344
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0245 0.088 1
Loa Loa (eye worm) RasGEF domain-containing protein 0.0042 0.0108 0.0108
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0042 0.0108 0.0344
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0026 0.0045 0.0066
Brugia malayi regulator of G-protein signaling egl-10 0.006 0.0173 0.0173
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0016 0.0007 0.0024
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0007 0.0011
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0026 0.0045 0.0217
Loa Loa (eye worm) hypothetical protein 0.0026 0.0045 0.0045
Echinococcus granulosus tar DNA binding protein 0.0676 0.2522 0.8066
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0026 0.0045 0.0066
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0042 0.0108 0.0158
Echinococcus multilocularis chromatin regulatory protein sir2 0.0016 0.0007 0.0024
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0042 0.0108 0.772
Schistosoma mansoni cpg binding protein 0.0035 0.0078 0.0114
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0026 0.0045 0.0145
Leishmania major hypothetical protein, conserved 0.0026 0.0045 0.0434
Schistosoma mansoni tar DNA-binding protein 0.0676 0.2522 0.3699
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0016 0.0007 0.0084
Echinococcus granulosus ras GTP exchange factor 0.0042 0.0108 0.0344
Onchocerca volvulus 0.006 0.0173 0.0282
Echinococcus multilocularis ras GTP exchange factor 0.0042 0.0108 0.0344
Leishmania major GTP-binding protein, putative 0.0026 0.0043 0.0412
Loa Loa (eye worm) transcriptional regulator 0.0016 0.0007 0.0007
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0007 0.0035
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0016 0.0007 0.0024
Entamoeba histolytica hypothetical protein 0.0028 0.0053 0.382
Echinococcus multilocularis segment polarity protein dishevelled 0.006 0.0173 0.0553
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0026 0.0045 0.0045
Toxoplasma gondii LsmAD domain-containing protein 0.0209 0.0744 0.8442
Trypanosoma brucei protein kinase A regulatory subunit 0.0026 0.0045 0.0434
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0245 0.088 0.2814
Schistosoma mansoni ran 0.0026 0.0043 0.0063
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0051 0.0139 0.0669
Trypanosoma cruzi hypothetical protein 0.0042 0.0108 0.1223
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0834 0.3127 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0026 0.0045 0.0217
Brugia malayi Egg laying defective protein 4 0.0026 0.0045 0.0045
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0016 0.0007 0.0024
Loa Loa (eye worm) hypothetical protein 0.0026 0.0045 0.0045
Echinococcus multilocularis tar DNA binding protein 0.0676 0.2522 0.8066
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0051 0.0139 0.1513
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.0007 0.0035
Loa Loa (eye worm) hypothetical protein 0.006 0.0173 0.0173
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.006 0.0173 0.0173
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.0026 0.0045 0.0154
Echinococcus granulosus patatin phospholipase domain containing protein 0.0026 0.0045 0.0145
Loa Loa (eye worm) hypothetical protein 0.003 0.0059 0.0059
Plasmodium falciparum importin beta, putative 0.0035 0.0078 0.0813
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0026 0.0045 0.0145
Entamoeba histolytica tartrate dehydrogenase, putative 0.003 0.0059 0.4238
Loa Loa (eye worm) transcriptional regulator 0.0016 0.0007 0.0007
Giardia lamblia Transcriptional regulator, Sir2 family 0.0051 0.0139 1
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0016 0.0007 0.0024
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0026 0.0045 0.0145
Schistosoma mansoni chromatin regulatory protein sir2 0.0051 0.0139 0.0204
Leishmania major protein kinase, putative 0.0026 0.0045 0.0434
Echinococcus granulosus Pleckstrin G protein interacting region 0.006 0.0173 0.0553
Brugia malayi N-terminal motif family protein 0.0042 0.0108 0.0108
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0045 0.0514
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.003 0.0059 0.0189
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0834 0.3127 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0026 0.0045 0.0066
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0043 0.2721
Trypanosoma cruzi Flagellar Member 6 0.0026 0.0045 0.0514
Echinococcus granulosus isocitrate dehydrogenase NAD 0.003 0.0059 0.0189
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0086 0.0126
Brugia malayi hypothetical protein 0.006 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.2637 1 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0053 0.0605

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.2818 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 1.8356 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.1192 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.8184 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.581 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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